Murat Deniz

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Publications (2)1.7 Total impact

  • Article: The polymorphisms of the MBL2 and MIF genes associated with Pediatric Cochlear Implant Patients.
    Elif Baysal, Sibel Oguzkan-Balci, Orhan Tunc, Fatih Celenk, Murat Deniz, Muzaffer Kanlikama, Merve Kahraman, Sacide Pehlivan
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    ABSTRACT: OBJECTIVES: Mannose-binding lectin and macrophage migration inhibitory factor gene polymorphisms are associated with several acute/chronic autoimmune or inflammatory diseases. The aim of this study was to investigate if there was any association between mannose-binding lectin 2 (MBL2) and macrophage migration inhibitory factor (MIF) gene polymorphisms and profound congenital sensorineural hearing loss in children who underwent cochlear implantation. METHODS: A total of 62 patients with congenital hearing loss and 80 age- and sex-matched healthy controls were evaluated for codon 54 A/B polymorphisms in MBL2 and the-173 G/C polymorphism in MIF by using the polymerase chain reaction and restriction fragment length polymorphism method. RESULTS: The frequency of the BB genotype of MBL2 and MIF -173 GC genotype were statistically significantly higher in the patient group than in the controls (p=0.0127, p=0.0408, respectively). CONCLUSION: In this study, we found that a subject who is homozygous for the variant allele B of codon 54 of the MBL2and heterozygous for variant allele C of -173 MIF has a risk factor for sensorineural hearing loss.
    International journal of pediatric otorhinolaryngology 12/2012; · 0.85 Impact Factor
  • Article: Intra- and postoperative electrically evoked stapedius reflex thresholds in children with cochlear implants.
    Elif Baysal, Erkan Karatas, Murat Deniz, Tekin Baglam, Cengiz Durucu, Zeynel Abidin Karatas, Semih Mumbuc, Muzaffer Kanlikama
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    ABSTRACT: The aim of this study was to investigate whether there is a significant correlation between intra- and postoperative electrically evoked stapedius reflex thresholds (eSRTs) in children with cochlear implants. Sixty-five pediatric cochlear implant users were included in this study. All patients had congenital prelingual hearing loss. The round window approach was used in all patients. The eSRTs were intraoperatively measured using the 1st, 3rd, 6th and 12th electrodes of the cochlear implant. The measurements taken during the first fitting of the device were taken again one month after surgery. We used paired-sample t-tests to determine the correlation between intra- and postoperative eSRTs. The eSRT analysis revealed a statistically significant difference between the intra- and postoperative thresholds. A correlation analysis did not reveal any correlation between intra- and postoperative eSRTs. Intraoperative eSRT measurements were unable to predict early postoperative eSRTs.
    International journal of pediatric otorhinolaryngology 02/2012; 76(5):649-52. · 0.85 Impact Factor
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