The distribution of single intake atorvastatin in the content of very low, low and high density lipoproteins extracted from blood plasma of healthy volunteers by means of ultracentrifugal separation was investigated. The impact of atorvastatin on the composition of lipoprotein complexes was assessed. It is demonstrated that atorvastatin and its active derivatives transport mainly in the composition of high density lipoproteins. The distribution of atorvastatin and its biologically active metabolites has gender differences. It is established that in males atorvastatin increases the content of triacylglycerides of low density lipoproteins and cholesterol of high density lipoproteins in females.
Klinicheskaia laboratornaia diagnostika 08/2011;