Pierre Gressens

Université Paris Diderot - Paris 7, Paris, Ile-de-France, France

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Publications (2)15.37 Total impact

Article: [JAK/STAT: from inflammation to memory].

Céline S Nicolas, Zsolt Csaba, Assia Fafouri, Charlotte Javalet, Pierre Gressens, Pascal Dournaud, Stéphane Peineau

Medecine sciences: M/S 05/2012; 28(5):456-8. · 0.64 Impact Factor
Article: The Jak/STAT pathway is involved in synaptic plasticity.

Céline S Nicolas, Stéphane Peineau, Mascia Amici, Zsolt Csaba, Assia Fafouri, Charlotte Javalet, Valerie J Collett, Lars Hildebrandt, Gillian Seaton, Sun-Lim Choi, [......], Clarrisa Bradley, Kyungmin Lee, Min Zhuo, Bong-Kiun Kaang, Pierre Gressens, Pascal Dournaud, Stephen M Fitzjohn, Zuner A Bortolotto, Kwangwook Cho, Graham L Collingridge

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ABSTRACT: The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcription of many genes. Of the four JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD). Here, we demonstrate a new neuronal function for the JAK/STAT pathway. Using a variety of complementary approaches, we show that the JAK/STAT pathway plays an essential role in the induction of NMDA-receptor dependent long-term depression (NMDAR-LTD) in the hippocampus. Therefore, in addition to established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in the brain.

Neuron 01/2012; 73(2):374-90. · 14.74 Impact Factor