Matthew W Warren

University of Texas Southwestern Medical Center, Dallas, Texas, United States

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Publications (4)8.57 Total impact

  • Matthew W Warren, Linda S Hynan, Myron F Weiner
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    ABSTRACT: Leptin has been reported to have positive effects on cognition but has not been studied in a population-based sample or stratified by race or gender. Leptin and fat mass were measured in 2,731 subjects, including 50% African Americans. Eight years later, subjects were administered the Montreal Cognitive Assessment (MoCA). Demographic factors and baseline measures, including a deficiency in leptin or levels in excess of what was predicted by fat, were investigated to see which predicted cognitive performance. There was a statistical trend for lower leptin levels to be associated with higher cognitive scores. Once stratified by race and gender, excessive leptin was associated with lower MoCA total scores and delayed recall domain score for black men, but white men demonstrated a reverse relationship. Excess leptin appears to have differential effects on delayed recall in black and white men.
    Dementia and Geriatric Cognitive Disorders 07/2012; 33(6):410-5. · 2.79 Impact Factor
  • Matthew W Warren, Myron F Weiner
    American family physician 04/2012; 85(8):e1; author reply e1-2. · 1.61 Impact Factor
  • Matthew W Warren, Linda S Hynan, Myron F Weiner
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    ABSTRACT: To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.
    Journal of Alzheimer's disease: JAD 01/2012; 29(1):151-7. · 4.17 Impact Factor
  • Matthew W. Warren, Kevin S. King, Myron F. Weiner
    The American Journal of Geriatric Psychiatry. 21(3):S76.