[Show abstract][Hide abstract] ABSTRACT: A 55-year-old woman underwent a total thyroidectomy for carcinoma showing thymus-like differentiation (CASTLE). The patient was referred to our hospital after the tumor was found to have directly invaded the cervical esophagus and the entire circumference of the trachea. A total thyroidectomy was performed, followed by end-to-end anastomosis of the trachea, suprahyoid release and dissection of bilateral pulmonary ligaments. No major complications, including anastomotic dehiscence or stenosis, were observed. The patient experienced some swallowing disturbances and hoarseness during the perioperative period but fully recovered. Radiotherapy to the neck was performed as an adjuvant therapy. Eleven months after surgery, lower back pain and right leg numbness developed and led to gait inability. Multiple lung and bone recurrences were observed, but no local recurrence. Palliative radiotherapy to the bone metastasis was performed. The patient died of pleural metastasis 14 months after the initial diagnosis of CASTLE.
Case Reports in Oncology 09/2014; 7(3):840-4. DOI:10.1159/000370306
[Show abstract][Hide abstract] ABSTRACT: A 41-year-old woman noticed a tumor on the left side of her neck. Cervical ultrasonography showed a cystic mass in the left lateral neck region. The mass was further enlarged at follow-up, and hence, the patient was referred to our hospital. A cystic tumor with an internal anechoic area and clear boundary was seen outside the thyroid gland. No abnormal cells were observed on aspiration cytology. The patient underwent tumorectomy. The tumor was present on the outside of the left internal jugular vein. It could be exfoliated easily. Pathologically, a follicular gland with poor dysplasia in the mural nodule and cyst wall was observed, so a pathological diagnosis of ectopic adenomatous goiter was made. Lateral cervical cystic tumors should be treated by surgical resection because of the possibility of malignancy as well as recurrence after aspiration.
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 01/2014; 75(11):2971-2975. DOI:10.3919/jjsa.75.2971
[Show abstract][Hide abstract] ABSTRACT: Background:
We evaluated the expression of aldehyde dehydrogenase 1 (ALDH1) between primary breast lesions and pulmonary metastatic (PM) lesions in breast cancer patients.
We retrospectively analyzed the clinicopathological features and the expression statuses of ER, PR, HER2, Ki-67 and ALDH-1 in both primary and metastatic breast cancer lesions and evaluated the discordance rates in the expressions of these markers between the primary and metastatic lesions, and also the prognostic value of these factors.
None of the PM patients had metastases at any other sites, and all had undergone curative breast cancer surgery. The pulmonary operation was partial resection in 15 (88 %) patients and lobectomy in 2 (12 %) patients. The median overall survival (OS) after resection of the PNs (OS) was 48 months. The discordance rates in the expressions of ER, PR, HER2, Ki67 and ALDH-1 between the primary and metastatic lesions were 0, 29, 21, 43 and 50 %, respectively.
There was significant discordance in the biomarkers between the primary tumors and the metastatic lesions.
Breast Cancer 01/2013; 21(6). DOI:10.1007/s12282-013-0445-7 · 1.59 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Background:
There is little information about the impact of breast cancer subtype on prognosis after ipsilateral breast tumor recurrence (IBTR).
One hundred eighty-five patients were classified according to breast cancer subtype, as approximated by estrogen receptor, human epidermal growth factor receptor 2 (HER2), and Ki-67, of IBTR, and we evaluated whether breast cancer subtype was associated with distant recurrence after IBTR.
There was a significant difference in distant disease-free survival (DDFS) after IBTR according to breast cancer subtype defined by a cutoff of the Ki-67 index of 20 % (p = 0.0074, log-rank test). The 5-year DDFS rates for patients with luminal A, luminal B, triple-negative, and HER2 types were 86.3, 57.1, 56.6, and 65.9 %, respectively. In addition, breast cancer subtype was significantly associated with distant recurrence after IBTR on adjustment for various clinicopathologic factors (p = 0.0027, Cox proportional hazards model).
Our study suggests that breast cancer subtype based on immunohistochemical staining predicts the outcomes of patients with IBTR. Further analyses are needed (UMIN-CTR number UMIN000008136).
[Show abstract][Hide abstract] ABSTRACT: BACKGROUND: Recently, evidence in support of the cancer stem cell (CSC) hypothesis has been accumulating. On the other hand, it has been reported that the expression of aldehyde dehydrogenase 1 (ALDH1) in primary breast cancer is a powerful predictor of a poor clinical outcome, and that breast cancer stem cells express ALDH1. According to the CSC hypothesis, development of metastases requires the dissemination of CSC that may remain dormant and be reactivated to cause tumor recurrence. In this study, we investigated whether the detection of CSC in axillary lymph node metastases (ALNM) might be a significant prognostic factor in patients with breast cancer. METHODS: From 1998 to 2006, 40 primary breast cancer patients with ALNM, the number of metastatic nodes varying in number from 1 to 3, underwent surgery at Okayama University; of these, 15 patients developed tumor recurrence. We retrospectively evaluated the common clinicopathological features and the expression of ER, HER2, ALDH1, and Ki67 in both the primary lesions and the ALNM, and analyzed the correlations between the expression of these biological markers and the disease-free survival (DFS). RESULTS: Expression of ALDH1 in the ALNM was significantly associated with the DFS (P = 0.037). CONCLUSION: Evaluation of biomarker expression in ALNM could be useful for prognosis in breast cancer patients with 1-3 metastatic lymph nodes.
Breast Cancer 03/2012; 21(1). DOI:10.1007/s12282-012-0350-5 · 1.59 Impact Factor