Zhixian Chen

Publications (3)6.51 Total impact

• Article: Pancreatic head cryosurgery: safety and efficiency in vivo-a pilot study.

  Jialiang Li, Liang Zhou, Jibing Chen, Binghui Wu, Jianying Zeng, Gang Fang, Chunjuan Deng, Shengquan Huang, Fei Yao, Zhixian Chen, [......], Min Deng, Chunmei Deng, Bo Zhang, Gang Zhou, Lihua He, Maoxin Liao, David Chiu, Lizhi Niu, Jiansheng Zuo, Kecheng Xu
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  ABSTRACT: Pancreatic cancer is the fourth leading cause of cancer-related death. Cryosurgery has emerged as a promising new technique for treatment. Although 80% of pancreatic cancers are located in the pancreatic head, no research has been conducted on the safety and efficacy of cryosurgery for these tumors. Two groups of Tibetan miniature pigs (n = 4 per group) underwent cryosurgery to the pancreatic head with either the deep freezing protocol (100% argon output) or shallow freezing protocol (10% argon output), and compared to sham-operated pigs. Serum inflammatory factors and amylase increased during the 5 days after cryoablation in both groups but acute pancreatitis did not occur. Adhesions were observed between the pancreatic head and adjacent organs, and only minor trauma was caused to the stomach, duodenum, small intestine, and liver. Ice balls with a radius of 0.5 cm beyond the tumor edge were sufficient to cause complete necrosis of the pancreatic tissue, and decreased the degree of cold injury to surrounding tissues. Shallow freezing protocol seemed to be safer than, and just as effective as, the deep freezing protocol. This preliminary study suggests that cryosurgery could potentially be an effective treatment of cancer of the pancreatic head.
  Pancreas 06/2012; 41(8):1285-91. · 2.39 Impact Factor
• Article: Comparison of dual- and triple-freeze protocols for hepatic cryoablation in a Tibet pig model.

  Jialiang Li, Jibing Chen, Liang Zhou, Jianying Zeng, Fei Yao, Binghui Wu, Gang Fang, Chunjuan Deng, Zhixian Chen, Yin Leng, Keqiang Xu, Lizhi Niu, Jiansheng Zuo, Kecheng Xu
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  ABSTRACT: The purpose of this study was to compare a dual-freeze protocol with a triple-freeze protocol for hepatic cryoablation in a porcine model. Eighteen cryoablations were performed over an exposed operation field in nine normal porcine livers, using dual- (10-5-10-5) and triple-freeze (5-5-5-5-10-5) protocols. Changes in the temperature of the cryoprobes and the diameter of the iceballs were recorded during the ablation, and pathological changes in the cryozones (zones of tissue destruction) were assessed seven days after the procedure. Use of two and three freeze-thaw cycles produced iceballs of different diameters. Seven days after cryosurgery, the triple-freeze protocol was associated with a larger zone of complete necrosis than the dual-freeze protocol, although the two protocols produced cryozones and cryolesions of similar length, and in both cases the cryozones contained five areas of destruction. With the same freezing time (20 min), the triple-freeze protocol may be a more powerful liver ablation method than the dual-freeze protocol.
  Cryobiology 04/2012; 65(1):68-71. · 2.06 Impact Factor
• Article: Comparison of dual- and triple-freeze protocols for pulmonary cryoablation in a Tibet pig model.

  Lizhi Niu, Jialiang Li, Jibing Chen, Liang Zhou, Binghui Wu, Jianying Zeng, Gang Fang, Chunjuan Deng, Fei Yao, Zhixian Chen, Yin Leng, Min Deng, Chunmei Deng, Bo Zhang, Maoxin Liao, Keqiang Xu, Jiansheng Zuo, Kecheng Xu
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  ABSTRACT: The purpose of this study was to compare a dual-freeze protocol with a triple-freeze protocol for pulmonary cryoablation in a porcine lung model. Five dual- (10-5-10-5) and five triple-freeze (5-5-5-5-10-5) cryoablations were performed on an exposed operation field in normal porcine lung. Changes in the temperature of the cryoprobes and the diameter of the iceballs were measured during the ablation and pathologic changes in the cryozones (zones of tissue destruction) were reviewed 7 days after the procedure. The diameter of the iceball surface differed between the two protocols. Pathologically, the triple-freeze protocol was associated with a longer complete necrosis zone than the dual-freeze protocol, though the two protocols produced cryolesions and cryozones of similar length, and in both cases there were five areas of tissue destruction. With the same duration of freezing (20 min), the triple-freeze protocol may be better for pulmonary cryoablation than the dual-freeze protocol.
  Cryobiology 02/2012; 64(3):245-9. · 2.06 Impact Factor