Denise J Jamieson

Emory University, Atlanta, Georgia, United States

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Publications (379)2193.08 Total impact

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    ABSTRACT: To evaluate whether initiation of a contraceptive implant, a method of long-acting reversible contraception (LARC), reduces condom use, as measured by a biomarker of recent semen exposure (prostate-specific antigen (PSA)). We conducted a randomized controlled clinical trial in which 414 Jamaican women at high risk for sexually transmitted infections (STIs) attending family planning clinics received the contraceptive implant at baseline ("immediate" insertion arm, N=208) or at the end ("delayed" insertion arm, N=206) of a three-month study period. Participants were tested for PSA at baseline and two follow-up study visits, and asked about their sexual activity and condom use. At baseline, 24.9% of women tested positive for PSA. At both follow-up visits, the prevalence of PSA detection did not significantly differ between the immediate versus delayed insertion arm (1-month: 26.1% vs. 20.2%; prevalence ratio (PR) = 1.3; (95% confidence interval (CI) = 0.9-1.9); 3-month: 25.6% vs. 23.1%; PR= 1.1; (95% CI = 0.8-1.6)). The change in PSA positivity over the 3 study visits was not significantly larger in the immediate arm compared to the delayed arm (1-sided p-value=0.15). Contraceptive implants can be successfully introduced into a population at high risk of unintended pregnancy and STIs without a biologically detectable difference in unprotected sex in the short-term. This information strengthens the evidence to support promotion of implants in such populations and can help refine counseling for promoting and maintaining use of condoms among women who choose to use implants. Sex unprotected by a condom was not higher over 3 months in women receiving a contraceptive implant, compared with those not receiving the implant. Copyright © 2015. Published by Elsevier Inc.
    Contraception 06/2015; DOI:10.1016/j.contraception.2015.06.009
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    ABSTRACT: To use linked assisted reproductive technology (ART) surveillance and birth certificate data to compare ET practices and perinatal outcomes for a state with a comprehensive mandate requiring coverage of IVF services versus states without a mandate. Retrospective cohort study. Not applicable. Live-birth deliveries ascertained from linked 2007-2009 National ART Surveillance System and birth certificate data for a state with an insurance mandate (Massachusetts) and two states without a mandate (Florida and Michigan). None. Number of embryos transferred, multiple births, low birth weight, preterm delivery. Of the 230,038 deliveries in the mandate state and 1,026,804 deliveries in the nonmandate states, 6,651 (2.9%) and 8,417 (0.8%), respectively, were conceived by ART. Transfer of three or more embryos was more common in nonmandate states, although the effect was attenuated for women 35 years or older (33.6% vs. 39.7%; adjusted relative risk [RR], 1.46; 95% confidence interval [CI], 1.17-1.81) versus women younger than 35 (7.0% vs. 26.9%; adjusted RR, 4.18; 95% CI, 2.74-6.36). Lack of an insurance mandate was positively associated with triplet/higher order deliveries (1.0% vs. 2.3%; adjusted RR, 2.44; 95% CI, 1.81-3.28), preterm delivery (22.6% vs. 30.7%; adjusted RR, 1.31; 95% CI, 1.20-1.42), and low birth weight (22.3% vs. 29.5%; adjusted RR, 1.28; 95% CI, 1.17-1.40). Compared with nonmandate states, the mandate state had higher overall rates of ART use. Among ART births, lack of an infertility insurance mandate was associated with increased risk for adverse perinatal outcomes. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
    Fertility and sterility 06/2015; DOI:10.1016/j.fertnstert.2015.05.015
  • A.P. Kourtis, J.S. Read, D.J. Jamieson
    Obstetric Anesthesia Digest 06/2015; 35(2):67-68. DOI:10.1097/01.aoa.0000463812.15481.00
  • Journal of Women's Health 05/2015; DOI:10.1089/jwh.2014.5102
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    ABSTRACT: Previous studies report associations between conception with assisted reproductive technology (ART) and autism. Whether these associations reflect an ascertainment or biologic effect is undetermined. We assessed diagnosis age and initial autism symptom severity among >30,000 children with autism from a linkage study of California Department of Developmental Services records, birth records, and the National ART Surveillance System. Median diagnosis age and symptom severity levels were significantly lower for ART-conceived than non-ART-conceived children. After adjustment for differences in the socio-demographic profiles of the two groups, the diagnosis age differentials were greatly attenuated and there were no differences in autism symptomatology. Thus, ascertainment issues related to SES, not ART per se, are likely the driving influence of the differences we initially observed.
    Journal of Autism and Developmental Disorders 05/2015; DOI:10.1007/s10803-015-2462-1
  • Human Reproduction 05/2015; DOI:10.1093/humrep/dev107
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    ABSTRACT: Approximately half of in vitro fertilization (IVF) cycles are double embryo transfers, often resulting in multiple gestations, which increases maternal and neonatal morbidity. We assessed trends and predictors of "perfect implantation" in double embryo transfer (both embryos implant) to further identify candidates for elective single embryo transfer. We analyzed 1,793,067 fresh, autologous cycles reported to the National Assisted Reproductive Technology Surveillance System from 2000 to 2012. We calculated trends of perfect implantation in double embryo transfer, identified as cycles with number of hearts on 6-week ultrasonography equal to or greater than number of embryos transferred. Adjusted risk ratios (RRs) for perfect implantation were estimated using log binomial models, adjusted for demographic and clinical characteristics, after stratifying by prognosis. Favorable prognosis was defined as first-time IVF with supernumerary embryo(s). Average prognosis was defined as first-time IVF without supernumerary embryos, prior unsuccessful IVF with supernumerary embryo(s), prior IVF with previous birth(s) resulting from IVF, or natural conception. During 2000-2012, rates of perfect implantation with double embryo transfer increased from 13.4% to 18.1% (P for trend <.001). Perfect implantation was positively associated with blastocyst (compared with cleavage) transfer in favorable (adjusted RR 1.58 [1.51-1.65]) and average (adjusted RR 1.67 [1.60-1.75]) prognosis groups and negatively associated with age older than 35 years in both prognosis groups. For average prognosis patients, perfect implantation was associated with retrieving more than 10 oocytes (adjusted RR 1.22 [1.18-1.24]). Regardless of prognosis, patients who are younger than 35 years with blastocyst-stage embryos, and average prognosis patients from whom more than 10 oocytes are retrieved, may be good candidates for elective single embryo transfer, which would reduce multiple gestations and associated complications.
    Obstetrics and Gynecology 05/2015; 125 Suppl 1:54S. DOI:10.1097/01.AOG.0000463697.33456.a3
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    ABSTRACT: To estimate the maternal and fetal risks of smallpox vaccination during pregnancy. MEDLINE, Web of Science, EMBASE, Global Health,, and CINHAL from inception to September 2014. We included published articles containing primary data regarding smallpox vaccination during pregnancy that reported maternal or fetal outcomes (spontaneous abortion, congenital defect, stillbirth, preterm birth, or fetal vaccinia). The primary search yielded 887 articles. After hand-searching, 37 articles were included: 18 articles with fetal outcome data and 19 case reports of fetal vaccinia. Outcomes of smallpox vaccination in 12,201 pregnant women were included. Smallpox vaccination was not associated with an increased risk of spontaneous abortion (pooled relative risk [RR] 1.03, confidence interval [CI] 0.76-1.41), stillbirth (pooled RR 1.03, CI 0.75-1.40), or preterm birth (pooled RR 0.84, CI 0.62-1.15). When vaccination in any trimester was considered, smallpox vaccination was not associated with an increased risk of congenital defects (pooled RR 1.25, CI 0.99-1.56); however, first-trimester exposure was associated with an increased risk of congenital defects (2.4% compared with 1.5%, pooled RR 1.34, CI 1.02-1.77). No cases of fetal vaccinia were reported in the studies examining fetal outcomes; 21 cases of fetal vaccinia were identified in the literature, of which three neonates survived. The overall risk associated with maternal smallpox vaccination appears low. No association between smallpox vaccination and spontaneous abortion, preterm birth, or stillbirth was identified. First-trimester vaccination was associated with a small increase in congenital defects, but the effect size was small and based on limited data. Fetal vaccinia appears to be a rare consequence of maternal smallpox vaccination but is associated with a high rate of fetal loss.
    Obstetrics and Gynecology 05/2015; 125(6):1. DOI:10.1097/AOG.0000000000000857
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    ABSTRACT: More than 100,000 bariatric procedures are performed yearly in the United States. Women account for the majority of cases. Guidelines cosponsored by the American Association of Clinical Endocrinologists, The Obesity Society, and the American Society of Metabolic and Bariatric Surgery recommend women avoid pregnancy preoperatively and 12-18 months after surgery. This survey aims to identify the family planning knowledge, attitudes, and practices of bariatric providers in the perioperative period. We developed a quantitative survey from qualitative data of semistructured health care provider interviews and mailed it to American Society of Metabolic and Bariatric Surgery members. We collected data from a convenience sample of the first 275 responders to perform a descriptive analysis. A total of 272 participants consented to the study. More than 70% of respondents recommend women avoid pregnancy for 12-24 months after bariatric procedures. The majority considers the most effective contraceptive methods to be safe for women after gastric bypass; however, the minority (35.3%) provides contraceptive services or referrals. Although most (73.0%) consider female reproductive health discussions very important, the majority (70.4%) never or almost never feels comfortable with these discussions. Respondents most frequently prefer the patient's own gynecologist (80.9%) and the bariatric surgeon (71.0%) discuss contraception. Bariatric providers consider reproductive health very important; however, most are not comfortable having these conversations and would prefer patients see their gynecologists to discuss contraception. This is an opportunity for gynecologists to educate themselves and colleagues about contraception recommendations after bariatric surgery and collaborate with bariatric centers in their area to meet the needs of these patients.
    Obstetrics and Gynecology 05/2015; 125 Suppl 1:67S-68S. DOI:10.1097/01.AOG.0000463109.32807.7b
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    ABSTRACT: Background. Cotrimoxazole preventive therapy (CPT) is recommended for all HIV-exposed infants to avoid opportunistic infections. Cotrimoxazole has antimalarial effects and appears to reduce clinical malaria infections, but the impact on asymptomatic malaria infections is unknown. Methods. We conducted an observational cohort study using data and dried blood spots (DBS) from the Breastfeeding, Antiretrovirals and Nutrition study to evaluate the impact of CPT on malaria infection during peak malaria season in Lilongwe, Malawi. We compared malaria incidence one year before and after CPT implementation (292 and 682 CPT-unexposed and CPT-exposed infants, respectively), including only infants who remained HIV-negative by 36 weeks of age. Malaria was defined as clinical, asymptomatic (using DBS at 12, 24 and 36 weeks), or a composite outcome of clinical or asymptomatic. Linear and binomial regression with generalized estimating equations were used to estimate the association between CPT and malaria. Differences in characteristics of parasitemias and drug resistance polymorphisms by CPT status were also assessed in the asymptomatic infections. Results. CPT was associated with a 70% (95% CI: 53-81%) relative reduction in the risk of asymptomatic infection between 6-36 weeks of age. CPT appeared to provide temporary protection against clinical malaria and more sustained protection against asymptomatic infections, with no difference in parasitemia characteristics. Conclusions. CPT appears to reduce overall malaria infections with more prolonged impacts on asymptomatic infections. Asymptomatic infections are potentially important reservoirs for malaria transmission. Therefore, CPT prophylaxis may have important individual and public health benefits.
    Clinical Infectious Diseases 04/2015; DOI:10.1093/cid/civ309
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    Sonja A Rasmussen, Denise J Jamieson
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    ABSTRACT: From January 1 to April 3, 2015, 159 people from 18 states and the District of Columbia were reported as having measles. Most cases are part of an outbreak linked to a California amusement park. Because measles was eliminated in the United States in 2000, most U.S. clinicians are unfamiliar with the condition. We reviewed information on the current outbreak, measles manifestations, diagnostic methods, treatment, and infection-control recommendations. To identify information on measles and pregnancy, we reviewed reports with 20 or more measles cases during pregnancy that included data on effects on pregnant women or pregnancy outcomes. These reports were identified through MEDLINE from inception through February 2015 using the following strategy: (((pregnan*) AND measles) AND English[Language]) NOT review[Publication Type]. Reference lists also were reviewed to identify additional articles. Pregnant women infected with measles are more likely to be hospitalized, develop pneumonia, and die than nonpregnant women. Adverse pregnancy outcomes, including pregnancy loss, preterm birth, and low birth weight, are associated with maternal measles; however, the risk of congenital defects does not appear to be increased. No antiviral therapy is available; treatment is supportive. Early identification of possible cases is needed so that appropriate infection control can be instituted promptly. The recent measles outbreak highlights the role that obstetric health care providers play in vaccine-preventable illnesses; obstetrician-gynecologists should ensure that patients are up to date on all vaccines, including measles-containing vaccines, and should recommend and ideally offer a measles-containing vaccine to women without evidence of measles immunity before or after pregnancy.
    Obstetrics and Gynecology 04/2015; DOI:10.1097/AOG.0000000000000903
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    ABSTRACT: To assess endometriosis-associated infertility trends among assisted reproductive technology (ART) cycles, and to compare cancellation and hyperstimulation risks and pregnancy and live birth rates among women using ART for endometriosis-associated vs. male factor infertility. Descriptive and multivariable analyses of Centers for Disease Control and Prevention (CDC) National ART Surveillance System data. Fertility centers. All reported fresh autologous ART cycles in the United States between 2000 and 2011 (n = 1,589,079). None. Oocyte yield, hyperstimulation, cancellation, implantation, pregnancy, live birth. The absolute number of ART cycles with an endometriosis diagnosis fell in recent years, from 16,751 (2000) to 15,311 (2011); the percentage fell over time, from 17.0% (2000) to 9.6% (2011) of all cycles. Compared with male factor (n = 375,557), endometriosis-associated cycles (n = 112,475) yielded fewer oocytes (50.5% vs. 42.5% of cycles with only 0-10 oocytes retrieved), lower risk of hyperstimulation (1.1% vs. 1.3%, adjusted risk ratio [aRR] 0.82, 95% confidence interval [CI] 0.74-0.91), and an increased risk of cancellation (12.9% vs. 10.1%, aRR 1.30, 95% CI 1.25-1.35). Endometriosis was associated with a statistically decreased but likely clinically insignificant difference in the following outcomes: chance of pregnancy per transfer (43.7% vs. 44.8%, aRR 0.96, 95% CI 0.95-0.98) among couples who did not also have tubal factor infertility and live birth per transfer (37.2% vs. 37.6%, aRR 0.96, 95% CI 0.94-0.98). The percentage of endometriosis-associated ART cycles has decreased over time. As compared with male factor infertility, endometriosis is associated with increased cancellation and decreased hyperstimulation risks. Despite decreased oocyte yield and higher medication dose, the difference in pregnancy and live birth rates may be of limited clinical significance, suggesting comparable pregnancy outcomes per transfer. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
    Fertility and sterility 04/2015; 103(6). DOI:10.1016/j.fertnstert.2015.03.003
  • Source
    PLoS ONE 03/2015; 10(3):e0121039. DOI:10.1371/journal.pone.0121039
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    ABSTRACT: We assessed the association between assisted reproductive technology (ART) and diagnosed autistic disorder in a population-based sample of California births. We performed an observational cohort study using linked records from the California Birth Master Files for 1997 through 2007, the California Department of Developmental Services autism caseload for 1997 through 2011, and the Centers for Disease Control and Prevention's National ART Surveillance System for live births in 1997 through 2007. Participants were all 5 926 251 live births, including 48 865 ART-originated infants and 32 922 cases of autism diagnosed by the Department of Developmental Services. We compared births originated using ART with births originated without ART for incidence of autism. In the full population, the incidence of diagnosed autism was twice as high for ART as non-ART births. The association was diminished by excluding mothers unlikely to use ART; adjustment for demographic and adverse prenatal and perinatal outcomes reduced the association substantially, although statistical significance persisted for mothers aged 20 to 34 years. The association between ART and autism is primarily explained by adverse prenatal and perinatal outcomes and multiple births. (Am J Public Health. Published online ahead of print March 19, 2015: e1-e9. doi:10.2105/AJPH.2014.302383).
    American Journal of Public Health 03/2015; 105(5):e1-e9. DOI:10.2105/AJPH.2014.302383
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    ABSTRACT: The U.S. Department of Health and Human Services (HHS), CDC, other U.S. government agencies, the World Health Organization (WHO), and international partners are taking multiple steps to respond to the current Ebola virus disease (Ebola) outbreak in West Africa to reduce its toll there and to reduce the chances of international spread. At the same time, CDC and HHS are working to ensure that persons who have a risk factor for exposure to Ebola and who develop symptoms while in the United States are rapidly identified and isolated, and safely receive treatment. HHS and CDC have actively worked with state and local public health authorities and other partners to accelerate health care preparedness to care for persons under investigation (PUI) for Ebola or with confirmed Ebola. This report describes some of these efforts and their impact.
    MMWR. Morbidity and mortality weekly report 03/2015; 64(8):222-5.
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    ABSTRACT: To suggest options for oral and intramuscular antibiotic treatment of early postpartum endometritis in low-resource community settings where intravenous antibiotics are unavailable. Studies were identified through MEDLINE from inception through December 2014. Search terms included [("anti-bacterial agents [MeSH]" or "anti-infective agents [MeSH]") and ("endometritis [MeSH]" or "puerperal infection [MeSH]")]. A second search using the terms [("endometritis or endomyometritis or puerperal infection) and ("antibiotics or antimicrobials or anti-bacterial agents or anti-infective agents)"] was also used. Additionally, all references from selected articles were reviewed, a hand-search of a subject matter expert library was conducted, and a search of was performed. We conducted a systematic review of the literature in two phases. Phase I provides a summary of clinical cure data from prospective studies of oral and intramuscular antimicrobial regimens as well as summarizes evidence from trials of intravenous antimicrobials. Phase II is a quantitative analysis of pathogens from intrauterine postpartum endometritis samples. Based on these results, and with consideration of existing recommendations for antibiotic use during breastfeeding, we suggest oral and intramuscular antimicrobial options for the treatment of early postpartum endometritis after vaginal delivery in low-resource settings. Reports involving oral or intramuscular antimicrobial treatment of postpartum endometritis are rare and of generally poor quality. Antimicrobial trials of postpartum endometritis treatment and intrauterine microbiology studies suggest five antimicrobial regimens may be effective: oral clindamycin plus intramuscular gentamicin, oral amoxicillin-clavulanate, intramuscular cefotetan, intramuscular meropenem or imipenem-cilastatin, and oral amoxicillin in combination with oral metronidazole. This review provides suggestions for oral, intramuscular, and combined antimicrobial regimens that may warrant additional study. Experimental trials should consider clinical effectiveness, safety and side effects profiles, and feasibility of community-based treatment.
    Obstetrics and Gynecology 03/2015; 125(4). DOI:10.1097/AOG.0000000000000732
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    ABSTRACT: We used data from a prospective study of 300 women attending a sexually transmitted infection clinic in Kingston, Jamaica, to compare participant self-report of recent semen exposure to actual semen exposure measured by prostate-specific antigen in vaginal swabs. Underreporting of semen exposure was significantly more frequent at follow-up than baseline, suggesting that the accuracy of reports of sexual behavior may vary over time.
    Sex Transm Dis 03/2015; 42(3):160-161. DOI:10.1097/OLQ.0000000000000243
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    ABSTRACT: In resource-limited settings without safe alternatives to breastfeeding, the WHO recommends exclusive breastfeeding and antiretroviral (ARV) prophylaxis. Given the high prevalence of anemia among HIV-infected women, mothers and their infants (via fetal iron accretion) may be at risk of iron deficiency. We assessed the effects of maternal micronutrient-fortified lipid-based nutrient supplements (LNS) and maternal ARV treatment or infant ARV prophylaxis on maternal and infant iron status during exclusive breastfeeding from birth to 24 weeks. The Breastfeeding, Antiretrovirals, and Nutrition Study was a randomized controlled trial conducted in Lilongwe, Malawi from 2004-2010. HIV-infected mothers (CD4>200 cells/ul) and their infants were randomly assigned to 28-week interventions: maternal-LNS/maternal-ARV (n=424), maternal-LNS/infant-ARV (n=426), maternal-LNS (n=334), maternal-ARV (n=425), infant-ARV (n=426), or control (n=334). Longitudinal models tested intervention effects on hemoglobin (Hb). In a subsample (n=537) with multiple iron indicators, intervention effects on Hb, transferrin receptors (TfR) and ferritin were tested with linear and Poisson regression. In longitudinal models, LNS effects on maternal and infant Hb were minimal. In subsample mothers, maternal ARVs were associated with tissue iron depletion (TfR>8.3 mg/L) (Risk ratio (RR): 3.1, p<0.01), but not in ARV-treated mothers receiving LNS (p=0.17). LNS without ARVs, was not associated with iron deficiency or anemia (p>0.1). In subsample infants, interventions were not associated with impaired iron status (all p-values>0.1). Maternal ARV treatment with protease inhibitors is associated with maternal tissue iron depletion; but LNS mitigates adverse effects. ARVs do not appear to influence infant iron status; however, extended use needs to be evaluated.
    JAIDS Journal of Acquired Immune Deficiency Syndromes 02/2015; DOI:10.1097/QAI.0000000000000588
  • Dana Meaney-Delman, Lisa M Koonin, Denise J Jamieson
    American Journal of Obstetrics and Gynecology 02/2015; 212(4). DOI:10.1016/j.ajog.2015.01.018
  • American Journal of Obstetrics and Gynecology 01/2015; 212(1):S371-S372. DOI:10.1016/j.ajog.2014.10.971

Publication Stats

7k Citations
2,193.08 Total Impact Points


  • 2001–2015
    • Emory University
      • • Department of Gynecology and Obstetrics
      • • Department of Pediatrics
      Atlanta, Georgia, United States
  • 2000–2015
    • Centers for Disease Control and Prevention
      • • Division of Reproductive Health
      • • National Center for Emerging and Zoonotic Infectious Diseases
      • • Epidemiology and Analysis Program Office
      Атланта, Michigan, United States
  • 2005–2013
    • University of North Carolina at Chapel Hill
      • • Department of Medicine
      • • Department of Epidemiology
      North Carolina, United States
  • 2012
    • University of Texas Southwestern Medical Center
      Dallas, Texas, United States
  • 2011
    • California Department of Public Health
      Richmond, California, United States
  • 2010
    • New York City Department of Health and Mental Hygiene
      לאנג איילענד סיטי, New York, United States
    • Kenya Medical Research Institute
      • Centre for Microbiology Research (CMR)
      Nairobi, Nairobi Province, Kenya
    • University of Texas Medical Branch at Galveston
      • Department of Obstetrics and Gynecology
      Galveston, TX, United States
  • 2009
    • Ibis Reproductive Health
      Cambridge, Massachusetts, United States
  • 2008
    • Kenya Centers for Disease Control and Prevention
      Winam, Kisumu, Kenya
    • Fred Hutchinson Cancer Research Center
      Seattle, Washington, United States
  • 2006
    • Eastern Virginia Medical School
      • Division of Obstetrics and Gynecology
      Norfolk, Virginia, United States
    • Johns Hopkins Medicine
      • Department of Gynecology & Obstetrics
      Baltimore, MD, United States
    • Brown University
      Providence, Rhode Island, United States
  • 2004
    • University of Alabama at Birmingham
      • School of Public Health
      Birmingham, AL, United States
    • Princeton University
      • Office of Population Research
      Princeton, New Jersey, United States
  • 2002
    • Johns Hopkins University
      Baltimore, Maryland, United States