Publications (2)8.69 Total impact
-
Article: Simultaneous Imaging of Lung Structure and Function with Triple-Nuclear Hybrid MR Imaging.
[show abstract] [hide abstract]
ABSTRACT: Purpose:To re-engineer a standard clinical magnetic resonance (MR) imaging system to enable the acquisition, in the same breath hold, of lung images from two hyperpolarized gases (helium 3 [(3)He] and xenon 129 [(129)Xe]) with simultaneous registered anatomic proton (hydrogen 1 [(1)H]) MR images of lung structure.Materials and Methods:Studies with (3)He and (129)Xe were performed with National Research Ethics Committee approval, with informed consent from the volunteer. (1)H-(3)He-(129)Xe MR imaging was achieved in the same breath by using mutually decoupled nested radiofrequency coil hardware capable of transmit and receive on each respective nucleus without power cross talk. MR pulse sequences were also developed for rapid switching between each nucleus. The system is demonstrated with triple-nuclear lung images in a healthy individual following inhalation of a mixture of (3)He and (129)Xe gases.Results:Spatially and temporally registered images of all three nuclei were obtained with high signal to noise ratio and high spatial resolution in the same breath.Conclusion:The multinuclear technique is capable of providing registered lung images with mutually complementary functional and structural spatial information.© RSNA, 2012.Radiology 12/2012; · 5.73 Impact Factor -
Article: Hyperpolarized (129) Xe gas lung MRI-SNR and T(2) (*) comparisons at 1.5 T and 3 T.
[show abstract] [hide abstract]
ABSTRACT: In this study, the signal-to-noise ratio of hyperpolarized (129) Xe human lung magnetic resonance imaging was compared at 1.5 T and 3 T. Experiments were performed at both B(0) fields with quadrature double Helmholtz transmit-receive chest coils of the same geometry with the same subject loads. Differences in sensitivity between the two field strengths were assessed from the signal-to-noise ratio of multi-slice 2D (129) Xe ventilation lung images obtained at the two field strengths with a spatial resolution of 15 mm × 4 mm × 4 mm. There was a systematically higher signal-to-noise ratio observed at 3 T than at 1.5 T by a factor of 1.25. Mean image signal-to-noise ratio was in the range 27-44 at 1.5 T and 36-51 at 3 T. T 2* of (129) Xe gas in the partially inflated lungs was measured to be 25 ms and 18 ms at 1.5 T and 3 T, respectively. T 2* of (129) Xe gas in fully inflated lungs was measured to be 52 ms and 24 ms at 1.5 T and 3 T, respectively. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.Magnetic Resonance in Medicine 01/2012; · 2.96 Impact Factor
