Publications (2)4.65 Total impact
-
Article: Altered cortical and subcortical local coherence in obstructive sleep apnoea: a functional magnetic resonance imaging study.
[show abstract] [hide abstract]
ABSTRACT: Obstructive sleep apnoea (OSA) syndrome is the most common sleep-related breathing disorder, characterized by excessive snoring and repetitive apnoeas and arousals, which leads to fragmented sleep and, most importantly, to intermittent nocturnal hypoxaemia during apnoeas. Considering previous studies about morphovolumetric alterations in sleep apnoea, in this study we aimed to investigate for the first time the functional connectivity profile of OSA patients and age-gender-matched healthy controls, using resting-state functional magnetic resonance imaging (fMRI). Twenty severe OSA patients (mean age 43.2 ± 8 years; mean apnoea-hypopnoea index, 36.3 h(-1) ) and 20 non-apnoeic age-gender-body mass index (BMI)-matched controls underwent fMRI and polysomnographic (PSG) registration, as well as mood and sleepiness evaluation. Cerebro-cerebellar regional homogeneity (ReHo) values were calculated from fMRI acquisition, in order to identify pathology-related alterations in the local coherence of low-frequency signal (<0.1 Hz). Multivariate pattern classification was also performed using ReHo values as features. We found a significant pattern of cortical and subcortical abnormal local connectivity in OSA patients, suggesting an overall rearrangement of hemispheric connectivity balance, with a decrease of local coherence observed in right temporal, parietal and frontal lobe regions. Moreover, an increase in bilateral thalamic and somatosensory/motor cortices coherence have been found, a finding due possibly to an aberrant adaptation to incomplete sleep-wake transitions during nocturnal apnoeic episodes, induced by repetitive choke sensation and physical efforts attempting to restore breathing. Different hemispheric roles into sleep processes and a possible thalamus key role in OSA neurophysiopathology are intriguing issues that future studies should attempt to clarify.Journal of Sleep Research 11/2012; · 3.16 Impact Factor -
Article: Transient periodic lateralised epileptiform discharges (PLEDs) following internal carotid artery stenting.
[show abstract] [hide abstract]
ABSTRACT: Background. Periodic lateralised epileptiform discharges (PLEDs) are EEG patterns consisting of periodic or pseudoperiodic unilateral, focal or hemispheric epileptiform discharges at a rate of 1-2 Hz. PLEDs may be triggered by acute brain injuries or systemic metabolic changes such as fever, hyperglycaemia or electrolyte imbalance and may result in disturbance of consciousness and/or neurological deficits. Case report. A 58-year-old female with a history of focal epilepsy and deep brain haematoma presented with acute change in awareness, associated with EEG evidence of PLEDs, three days after a left internal carotid artery stenting procedure. Clinical examination, laboratory testing and MRI were unchanged with respect to pre-stenting investigations. Conclusion. In this patient, PLEDs may have been triggered by local haemodynamic changes due to reperfusion after stenting in a previously damaged brain area.Epileptic disorders: international epilepsy journal with videotape 03/2012; 14(1):85-9. · 1.50 Impact Factor
