Maxim Shevchenko

Publications (2)3.93 Total impact

• Article: Multimodal visibility of a modified polyzene-F-coated spherical embolic agent for liver embolization: feasibility study in a porcine model.

  Ulrike Stampfl, Christof-Matthias Sommer, Nadine Bellemann, Maria Holzschuh, Alexander Kueller, Jacques Bluemmel, Tobias Gehrig, Maxim Shevchenko, Hannes Kenngott, Hans-Ulrich Kauczor, Boris Radeleff
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  ABSTRACT: To evaluate multimodal visibility of modified currently available microspheres on radiography, magnetic resonance (MR) imaging, and computed tomography (CT) in a porcine liver model. Livers of four pigs were embolized with two sizes (100 μm ± 25 and 700 μm ± 50) of modified Embozene Microspheres embedded with different densities of barium sulfate and iodine as radiopaque materials (intensity groups A-C, with increasing intensity from A to C for 100 μm and intensities A and C for 700 μm) and iron oxide as magnetic substance for MR imaging visibility. Pigs embolized with currently available Embozene Microspheres served as control groups. Pre- and postinterventional MR imaging (T1- and T2-weighted) and CT were performed. Qualitative and quantitative (ie, determination of signal-to-noise ratio [SNR]) particle visibility was evaluated on radiography, MR imaging, and CT. Modified particles of both sizes were visible on radiography, MR imaging, and CT. Particles in the control group were not visible. For modified particles of both sizes, SNRs measured on MR imaging decreased significantly after embolization (eg, cluster analysis of group A, 100 μm ± 50 particles, T1-weighted, -74.6% ± 3.4; P = .03). For modified particles of both sizes, SNR measured on CT increased significantly after embolization (eg, cluster analysis of group A, 700 μm ± 25 particles, +54.3% ± 13.5; P = .03). Modification of currently available Embozene Microspheres was successful, with multimodal visibility on radiography, MR imaging, and CT in porcine liver. In the future, this might improve procedure accuracy and allow monitoring, control, and improvement of embolotherapy during and after the procedure.
  Journal of vascular and interventional radiology: JVIR 07/2012; 23(9):1225-31.e2. · 1.81 Impact Factor
• Article: Early detection of metabolic changes using microdialysis during and after experimental kidney transplantation in a porcine model.

  Hamidreza Fonouni, Majid Esmaeilzadeh, Parvin Jarahian, Morva Tahmasbi Rad, Mohammad Golriz, Alireza Faridar, Mohammadreza Hafezi, Shadi Jafarieh, Arash Kashfi, Seid Hashem Fani Yazdi, Mehrdad Soleimani, Thomas Longerich, Maxim Shevchenko, Oliver Sakowitz, Jan Schmidt, Arianeb Mehrabi
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  ABSTRACT: Microdialysis (MD) can detect organ-related metabolic changes before they become measurable in plasma through the biochemical parameters. This study aims to evaluate the early detection of metabolic changes during experimental kidney transplantation (KTx). During preparation of 8 donor kidneys, one MD catheter was inserted in the renal cortex and samples were collected. After a 6-hour cold ischemia time (CIT), kidneys were implanted in the 8 recipient pigs. Throughout the warm ischemia time (WIT) and after reperfusion, kidneys were monitored. The interstitial glucose, lactate, pyruvate, glutamate, and glycerol concentrations were evaluated. A significant decline in glucose level was observed at the end of CIT. The lactate level was reduced to the minimum point of 0.35 ± 0.08 mmol/L in CIT. After reperfusion, lactate values raised significantly. During the WIT, the pyruvate level increased, continued until the end of the WIT. For glutamate, a steady increase was noted during explantation, CIT, WIT, and early reperfusion phases. The increase of glycerol value continued in the early postreperfusion, which was then followed by a sharp decline. MD is a fast and simple minimally invasive method for measurement of metabolic substrates in renal parenchyma during KTx. MD offers the option of detecting minor changes of interstitial glucose, lactate, pyruvate, glutamate, and glycerol in every stage of KTx. Through the use of MD, metabolic changes can be continuously monitored during the entire procedure of KTx.
  Surgical Innovation 12/2011; 18(4):321-8. · 2.13 Impact Factor