Leila Zare

Publications (5)9.19 Total impact

• Article: Olive (Olea europaea L.) leaf extract and its main component (oleuropein) attenuate the development of morphine physical dependence in rats

  Saeed Esmaeili Mahani, Leila Zare
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  ABSTRACT: Introduction: Recently, it has been demonstRated that olive leaf extract and its main component have calcium channel blocker, anti-inflammatory and anti-oxidative properties. However, the effects of olive leaf extract on opioid dependence have not yet been clarified. Methods: To develop morphine dependence, morphine was injected twice daily for 7 days according to an escalating dose in Rats. On day 7, the animals received naloxone (3 mg/kg, i.p.) 5 h after the last injection of morphine. Withdrawal signs (weight loss, abdominal contraction, diarrhea, teeth chattering, jumping, grooming and ptosis) were evaluated during 1h after naloxone. To determine the effect of OLE and oleuropein on the development of morphine dependence, OLE was given at doses of 200, 300 and 500 mg/kg and oleuropin with 10 mg/kg (i.p.) concomitant with morphine. Results: Our results showed that Rats chronically injected with morphine showed physical dependence. OLE (300 mg/kg) and oleuropin (10 mg/kg) could attenuate naloxone-induced withdrawal syndrome. Conclusion: Our data revealed that olive leaf extract had a beneficial effect on chronic morphine-induced side effects such as physical dependence and can be useful in the period of drug withdrawal and its main component, oleuropein, is responsible for such observed effects.
  Physiology and Pharmacology. 02/2013; 1(360-370).
• Article: Ultrasound-promoted regio and chemoselective synthesis of pyridazinones and phthalazinones catalyzed by ionic liquid [bmim]Br/AlCl3.

  Leila Zare, Nosrat Ollah Mahmoodi, Asieh Yahyazadeh, Mohammad Nikpassand
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  ABSTRACT: The first ultrasound-promoted multicomponent synthesis of pyridazinones and phthalazinones from arenes, cyclic anhydrides and ArNHNH(2) in the presence of an efficient recyclable catalyst, [bmim]Br/AlCl(3), in high yield and short reaction time is reported.
  Ultrasonics Sonochemistry 07/2012; 19(4):740-4. · 3.57 Impact Factor
• Article: Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in rats.

  Fatemeh Darvishzadeh-Mahani, Saeed Esmaeili-Mahani, Gholamreza Komeili, Vahid Sheibani, Leila Zare
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  ABSTRACT: Ginger (Zingiber officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments such as opiates withdrawal-induced disorders. However, its influences on opioid tolerance and dependence have not yet been clarified. Adult male Wistar rats were rendered tolerant to analgesic effect of morphine by injection of morphine (10 mg/kg, i.p.) twice daily for 8 days. To develop morphine dependence, rats given escalating doses of chronic morphine. To determine the effect of ginger on the development of morphine tolerance and dependence, different doses of ginger were administrated before morphine. The tail-flick and naloxone precipitation tests were used to assess the degree of tolerance and dependence, respectively. Our results showed that chronic morphine-injected rats displayed tolerance to the analgesic effect of morphine as well as morphine dependence. Ginger (50 and 100 mg/kg) completely prevented the development of morphine tolerance. In addition, concomitant treatment of morphine with 100 and 150 mg/kg attenuated almost all of the naloxone-induced withdrawal sings which include weight lose, abdominal contraction, diarrhea, petosis, teeth chattering, and jumping. In addition, morphine-induced L-type calcium channel over-expression in spinal cord was reversed by 100 mg/kg ginger. The data indicate that ginger extract has a potential anti-tolerant/anti-dependence property against chronic usage of morphine.
  Journal of ethnopharmacology 03/2012; 141(3):901-7. · 2.32 Impact Factor
• Article: Oleuropein, Chief Constituent of Olive Leaf Extract, Prevents the Development of Morphine Antinociceptive Tolerance through Inhibition of Morphine-induced L-type Calcium Channel Overexpression.

  Leila Zare, Saeed Esmaeili-Mahani, Mehdi Abbasnejad, Bahram Rasoulian, Vahid Sheibani, Hedayat Sahraei, Ayat Kaeidi
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  ABSTRACT: It has been shown that blockade of L-type calcium channels could abolish the development of opioid-induced antinociceptive tolerance. Here, the antitolerant effects of olive leaf extract (OLE) and its main component, oleuropein, which have a calcium channel blocker property were determined. Adult male Wistar rats were injected with morphine (20 mg/kg, i.p.) for 8 days to induce antinociceptive tolerance. Then OLE (50-200 mg/kg i.g.) and oleuropein (1-10 mg/kg i.p.) were injected concomitantly with morphine. The tail-flick test was used to assess the nociceptive threshold. The dorsal half of the lumbar spinal cord was assayed for the expression of L-type calcium channel using semiquantitative RT-PCR. The results showed that OLE (200 mg/kg) completely prevented morphine tolerance development. In addition, oleuropein in dose of 10 mg/kg, but not in 5 mg/kg, prevented the development of morphine antinociceptive tolerance. In addition, a significant increase in the mRNA levels of calcium channel (43.9%) was observed in the lumbar spinal cord of tolerant animals, which was reversed by effective of dose OLE. In conclusion, the results indicate that olive leaf extract has a potential antitolerant property against the chronic usage of morphine and that its main component, oleuropein, is responsible for such effect. Copyright © 2012 John Wiley & Sons, Ltd.
  Phytotherapy Research 03/2012; 26(11):1731-7. · 2.09 Impact Factor
• Article: An efficient one‐pot synthesis of pyridazinones and phthalazinones using HY‐zeolite

  Leila Zare, Nosratollah Mahmoodi, Asieh Yahyazadeh, Manouchehr Mamaghani, Khalil Tabatabaeian
  Journal of Heterocyclic Chemistry 04/2011; 48(4):864 - 867. · 1.22 Impact Factor