Seyed Abolghasem Fatemi

University of Tehran, Teheran, Tehrān, Iran

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Publications (4)4.02 Total impact

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    ABSTRACT: STAT5A/B proteins are the important modulators of growth hormone, growth hormone receptor, IGF-I, prolactin and insulin signaling pathway, which are involved in growth and reproduction. Knowledge of genetic markers in such candidate genes and their association with economical traits, probably make breeding plans more efficient through MAS programs. The aim of the current study was to investigate the possible association of two SNP in chicken STAT5B gene with breeding value of growth and reproductive traits. Total of 205 individuals from breeding station of Mazandaran Indigenous Chicken were selected randomly and they were genotyped for two SNPs of C4535156T and G4533675C using PCR-RFLP technique and HhaI and RsaI restriction enzymes respectively. To estimate breeding value of the growth and reproductive traits, phenotypic information of 18 successive generations of selection in breeding station of Mazandaran Indigenous Chicken (north of Iran) was analyzed using a univariate animal model in ASREML procedure. Finally, marker-trait association analyses were performed using estimated breeding value of the traits, as dependent variable, in GLM procedure of SAS 9.1. Two alleles and three genotypes were identified for each SNP. Significant associations between C4535156T SNP with breeding value of body weight at hatch and between G4533675C SNP with breeding value of first egg weight were found. We can conclude that two SNPs in STAT5B gene are promising markers for future use in selection to increase body weight at hatch and first egg weight.
    Livestock Science 08/2012; 147(s 1–3):198–202. DOI:10.1016/j.livsci.2012.04.015 · 1.10 Impact Factor
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    ABSTRACT: Neuropeptide Y (NPY) and gonadotrophin-releasing hormone receptor (GnRHR) are two candidate genes with a wide variety of physiological functions in growth and especially in reproduction processes. We examined the association of one SNP from each of these genes with growth- and egg production-related traits in Mazandaran native chickens. Two hundred and six individuals were genotyped by PCR-RFLP. Marker-trait association analyses were performed using both breeding value and phenotypic information. The data came from 18 successive generations of selection at a Mazandaran native chicken breeding station in Iran. Data were analyzed with a univariate animal model in an ASREML procedure to estimate breeding values of the birds for these traits. Two alleles were found for both genes, A and a alleles for GnRHR, with frequencies of 0.614 and 0.386, B and b alleles for NPY, with frequencies of 0.780 and 0.221, respectively. The additive genetic effects of the GnRHR gene on egg number and egg mass were significant. Also, body weight at sexual maturity was significantly influenced by the NPY gene. We conclude that GnRHR and NPY genes are associated with egg production and growth traits, respectively.
    Genetics and molecular research: GMR 07/2012; 11(3):2539-47. DOI:10.4238/2012.July.10.9 · 0.85 Impact Factor
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    ABSTRACT: STAT5A/B proteins are the important modulators of growth hormone, growth hormone receptor, IGF-I, prolactin, and insulin signaling pathway, which are involved in growth and reproduction. Knowledge of genetic markers in such candidate genes and their association with economical traits, probably make breeding plans more efficient through MAS programs. The aim of the current study was to investigate the possible association of two SNP in chicken STaT5B gene with breeding value of growth and reproductive traits. Total of 205 individuals from breeding station of Mazandaran Indigenous Chicken were selected randomly and they were genotyped for two SNPs of C4535156T and G4533675C using PCR-RFLP technique and HhaI and RsaI restriction enzymes respectively. To estimate breeding value of the growth and reproductive traits, phenotypic information of 18 successive generations of selection in breeding station of Mazandaran Indigenous Chicken (north of Iran) was analyzed using a univariate animal model in ASREML procedure. Finally, marker-trait association analyses were performed using estimated breeding value of the traits, as dependent variable, in GLM procedure of SAS 9.1. Two alleles and three genotypes were identified for each SNP, Significant associations between C4535156T SNP with breeding value of body weight at hatch and between G4533675C SNP with breeding value of first egg weight were found. We can conclude that two SNPs in STAT5B gene are promising markers for future use in selection to increase body weight at hatch and first egg weight.
    Livestock Science 04/2012; 10(1016). · 1.10 Impact Factor
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    ABSTRACT: Native chicken breeding station of Mazandaran was established in 1988 with two main objectives: genetic improvement through selection programs and dissemination of indigenous Mazandarani birds. (Co)variance components and genetic parameters for economically important traits were estimated using (bi) univariate animal models with ASREML procedure in Mazandarani native chicken. The data were from 18 generations of selection (1988-2009). Heritability estimates for body weight at different ages [at hatch (bw1), 8 (bw8), 12 (bw12) weeks of ages and sex maturation (wsm)] ranged from 0.24 ± 0.00 to 0.47 ± 0.01. Heritability for reproductive traits including age at sex maturation (asm); egg number (en); weight of first egg (ew1); average egg weight at 28 (ew28), 30 (ew30), and 32 (ew32) weeks of age; their averages (av); average egg weight for the first 12 weeks of production (ew12); egg mass (em); and egg intensity (eint) varied from 0.16 ± 0.01 to 0.43 ± 0.01. Generally, the magnitudes of heritability for the investigated traits were moderate. However, egg production traits showed smaller heritability compared with growth traits. Genetic correlations among egg weight at different ages were mostly higher than 0.8. On the one hand, body weight at different ages showed positive and relatively moderate genetic correlations with egg weight traits (ew1, ew28, ew30, ew32, ew12, and av) and varied from 0.30 ± 0.03 to 0.59 ± 0.02. On the other hand, low negative genetic correlations were obtained between body weight traits (bw1, bw8, bw12, and wsm) and egg number (en). Also, there is low negative genetic correlation (-24 ± 0.04 to -29 ± 0.05) between egg number and egg weight. Therefore, during simultaneous selection process for both growth and egg production traits, probable reduction in egg production due to low reduction in egg number may be compensated by increases in egg weight.
    Tropical Animal Health and Production 01/2012; 44(7). DOI:10.1007/s11250-012-0084-6 · 0.97 Impact Factor