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Publications (2)5.98 Total impact

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    ABSTRACT: Phytochemical investigation of the ethyl acetate extract of the edible macrofungus, Cortinarius purpurascens, led to the isolation of nine anthraquinone-related pigments, citreorosein 6,8-dimethyl ether (1), physcione (2), rufoolivacin (3), rufoolivacin C (4), rufoolivacin D (5), leucorufoolivacin (6), verbindung cr11 (7), verbindung cr60 (8) and 1-Hydroxy-3-methyl-2-isopropanyl-6,8-dimethoxyanthraquinone (9). The structures of these isolated compounds were characterised by spectroscopic methods and comparison with published data. Among the tested compounds, 3-6 exhibited potent DPPH radical-scavenging activity with IC50 values in the range of 3-8μg/ml. The results indicated that the fungus is a possible source of natural products with potential antioxidant activity.
    Food Chemistry 12/2013; 141(4):3424-7. · 3.33 Impact Factor
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    ABSTRACT: A novel cyathane diterpenoid, designated scabronine M (1), was isolated from the fruiting bodies of the mushroom Sarcodon scabrosus together with 10 known compounds. The structure of the new compound was elucidated on the basis of extensive spectroscopic analysis including 2D-NMR. Among these compounds, only scabronine M (1) significantly inhibited dose-dependently NGF-induced neurite outgrowth in PC12 cells without cytotoxicity, possibly through suppressing the phosphorylation of the receptor Trk A and the extracellular signal regulated kinases (ERK). This is the first report of novel neurite outgrowth-inhibiting activity in PC12 cells of this group of diterpenoids.
    Bioorganic & medicinal chemistry letters 02/2012; 22(7):2401-6. · 2.65 Impact Factor