Dieter Eis

Robert Koch Institut, Berlin, Land Berlin, Germany

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Publications (34)44.37 Total impact

  • D. Eis
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    ABSTRACT: Im Rahmen der umweltmedizinischen Expositionserfassung, Diagnostik, Beratung, Therapie, Prophylaxe und Sanierung wird eine kaum mehr überschaubare Zahl unterschiedlichster, zum Teil nichtvalidierter Verfahren bei oftmals fragwürdiger Indikation eingesetzt. Die umweltmedizinische Qualitätssicherung (QS) ist damit zum Problem geworden. Ein Hauptanliegen der neu eingerichteten RKI-Kommission “Methoden und Qualitätssicherung in der Umweltmedizin” besteht in der Erarbeitung von Expertisen und abgestimmten Stellungnaahmen (Konsensuspapieren). Die Kommission will damit Beiträge zur Vereinheitlichung und Standardisierung von Methoden und Prozeduren im Bereich der praktischen Umweltmedizin leisten und auf eine stärkere Berücksichtigung von Prinzipien der “evidence based medicine” sowie auf die Verbesserung der Struktur-, Prozess- und Ergebnisqualität hinwirken. Das Gremium wird sich zunächst mit den Belangen der klinischen (patientenbezogenen) Umweltmedizin befassen, da hier die größeren QS-Probleme gesehen werden. Die Kommission geht dabei von den in umweltmedizinischen Ambulanzen, Praxen oder Kliniken vorherrschenden Problemlagen und den dort praktizierten Verfahren aus. Die Arbeit der Kommission wird durch die ebenfalls neu eingerichtete Zentrale Erfassungs- und Bewertungsstelle für umweltmedizinische Methoden (ZEBUM) des RKI unterstützt. An almost bewildering number of widely differing methods and techniques, often not validated, are being applied often inappropriately in the field of environmental medicine to answer questions regarding exposure assessment, diagnosis, treatment, counselling and prevention. Therefore quality control within the field of environmental medicine is quite problematic. A primary goal of the newly formed RKI-Commission “Methods and Quality Assurance in Environmental Medicine” is to form a panel of experts in the field, who evaluate the situation and generate consensus documents containing respective recommendations. By this the commission will contribute to standardization and agreement on appropriate methods, procedures and their correct application in the practice of environmental medicine. Hopefully it will also achieve a stronger, more consistent use of evidence-based-medicine and improve the quality of the structure, processes and results of research and practice in this field. The committee will initially deal with the issue of clinical environmental medicine, because here the largest problems in quality assurance are seen. In this context the commission work look at the problem areas of environmental-medical outpatient units and environmental clinics. The work of the commission will be supported by the newly formed Documentation and Evaluation Center for Methods in Environmental Medicine (Zentrale Erfassungs- und Bewertungsstelle fuer umweltmedizinische Methoden, ZEBUM) at the Robert Koch Institute.
    Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 04/2012; 43(5):336-342. · 0.72 Impact Factor
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    ABSTRACT: In this study, associations between current asthma and possible determinants were studied using data of the German Health Interview and Examination Survey for Children and Adolescents ("Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland," KiGGS). In this nationwide cross-sectional survey, 17,461 subjects aged 0-17 years were examined between 2003 and 2006. Data collection included a medical examination of the child, an interview of the parents, and written questionnaires. Apart from prevalence estimates, multivariate logistic regression analyses were performed. Increasing age and male sex, previous atopic diseases of the child, a positive family history of allergic diseases and low birth weight were significant risk factors of asthma, as were overweight and moldy walls in the residence. Breast feeding was not associated with a reduced risk of asthma. Low age at delivery of the mother and living in rural or provincial regions were shown to be protected. Overall, this study suggests that allergies of the parents and previous atopic disease of the child are the strongest determinants of asthma. However, environmental factors (mold on walls, living in rural and provincial towns) and lifestyle factors could also modify asthma risk.
    Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 03/2012; 55(3):308-17. · 0.72 Impact Factor
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    ABSTRACT: Since long, socio-economic status, often expressed as an index, is known to correlate with health outcomes like behavioural problems. We constructed a new index that encapsulated not only economic and social but also environmental stressors (ESES), using data of the German Health Interview and Examination Survey for Children and Adolescents, a nation-wide representative surveillance of 17,641 participants aged between 0-17 years. Different factors were selected to account for socio-economic stress (low parental education, low household income, low occupational status of the householder), domestic stress (living in large cities, exposure to tobacco smoke at home, crowded housing, mouldy walls), and prenatal stress (maternal smoking during pregnancy, drinking alcohol during pregnancy). Prior to the calculation of ESES, the different factors were multiplied by weights which were estimated by multivariate linear regression on a number of health outcomes. ESES was then used to predict emotional and social problems (SDQ scores). The resulting ORs were compared with those obtained for an established socio-economic index (SEI). ESES was superior to SEI as it could more clearly identify children and adolescents with emotional or social problems. Different types of stressors (i.e. socio-economic stress, domestic stress and prenatal stress) contributed independently to emotional and social problems.
    Central European journal of public health 03/2010; 18(1):3-7. · 0.80 Impact Factor
  • Dieter Eis
    International journal of hygiene and environmental health 06/2009; · 2.64 Impact Factor
  • Detlef Laußmann, Dieter Eis
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    ABSTRACT: Within a subsample of an out-patient based study on environment related complaints we investigated, whether VOC concentrations and ventilation rates in patients‘ dwellings are statistically associated with complaints, e.g. fatigue and appraised affinity towards infections. In the dwellings of around 50 "environmental patients", volatile organic compounds, ventilation rates and humidity were measured, each under worst case conditions. An environmentalmedicine questionnaire (including items regarding fatigue, competitiveness and infections) was administered. Statistical analysis indicates an association between ventilation rate and complaints (low ventilation leads to more self-reported fatigue and infections) but no association between VOC and complaints, although a significant correlation exists between ventilation and VOC. This study focussing on home environ ments is consistent with findings of epidemiological studies in other environmental settings (e. g. office buildings). Because of the small sample size and some methodological limitations, the results of this study needs to be interpreted carefully. Further home environmental studies are needed in order to consolidate findings or to draw firm conclusions.
    01/2009;
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    ABSTRACT: In this multicentre study on multiple chemical sensitivity (MCS) 291 consecutive environmental medicine (EM) outpatients were examined in several environmental medicine outpatient centres/units throughout Germany in 2000/2003. Of the EM outpatients, 89 were male (30.6%) and 202 were female (69.4%), aged 22-80 (mean 48 years, S.D.=12 years). The sample was representative for university-based environmental outpatient departments and represented a cross-sectional study design with an integrated clinical-based case-control comparison (MCS vs. non-MCS). Three classifications of MCS were used: self-reported MCS (sMCS), clinically diagnosed MCS (cMCS), and formalised computer-assisted MCS with two variants (f1MCS, f2MCS). Data were collected by means of an environmental medicine questionnaire, psychosocial questionnaires, the German version of the Composite International Diagnostic Interview (CIDI), and a medical baseline documentation, as well as special examinations in partial projects on olfaction and genetic susceptibility markers. The hypothesis guided evaluation of the project showed that the patients' heterogenic health complaints did not indicate a characteristic set of symptoms for MCS. No systematic connection could be observed between complaints and the triggers implicated, nor was there any evidence for a genetic predisposition, or obvious disturbances of the olfactory system. The standardised psychiatric diagnostics applying CIDI demonstrated that the EM patients in general and the subgroup with MCS in particular suffered more often from mental disorders compared to an age and gender matched sample of the general population and that in most patients these disorders commenced many years before environment-related health complaints. Our results do not support the assumption of a toxicogenic-somatic basis of the MCS phenomenon. In contrast, numerous indicators for the relevance of behavioural accentuations, psychic alterations or psychosomatic impairments were found in the group of EM-outpatients with subjective "environmental illness".
    International Journal of Hygiene and Environmental Health 06/2008; 211(5-6):658-81. · 3.05 Impact Factor
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    ABSTRACT: A single-blinded study was performed to analyze whether indoor environments with and without mold infestation differ significantly in microbial volatile organic compounds (MVOC) concentrations. Air sampling for MVOC was performed in 40 dwellings with evident mold damage and in 44 dwellings, where mold damage was excluded after a thorough investigation. The characteristics of the dwellings, climatic parameters, airborne particles and air exchange rates (AER) were recorded. The parameters mold status, characteristics of the interiors and measured climatic parameters were included in the multiple regression model. The results show no significant association between most of the analyzed MVOC and the mold status. Only the compounds 2-methyl-1-butanol and 1-octen-3-ol indicated a statistically significant, but weak association with the mold status. However, the concentrations of the so-called MVOC were mainly influenced by other indoor factors. 2-Methylfuran and 3-methylfuran, often used as main indicators for mold damage, had a highly significant correlation with the smoking status. These compounds were also significantly correlated with the humidity and the AER. The compounds 3-methyl-1-butanol, 2-hexanone, 3-heptanone and dimethyl disulfide were weakly correlated with the recorded parameters, the humidity being the strongest influencing factor. Only 2-methyl-1-butanol and 1-octen-3-ol showed a statistically significant association with the mold status; however, only a small portion (10% in this case) of the total variability could be explained by the predictor mold status; they do not qualify as indicator compounds, because such minor correlations lead to a too excessive part of incorrect classifications, meaning that the diagnostic sensitivity and specificity of these compounds are too low. PRACTICAL IMPLICATIONS: The assumption that mold infestations might be detected by microbial VOC emissions must be considered with great reservation. The major part of the total variability of the measured MVOC concentrations originates from not known influencing factors and/or from factors not directly associated with the mold status of the dwellings (confounders). More specific and sensitive markers for the assessment of the mold status should be found, if the screening for mold infestations should be performed by volatile organic compounds.
    Indoor Air 05/2008; 18(2):113-24. · 3.30 Impact Factor
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    ABSTRACT: A single-blinded study was performed to analyze whether indoor environments with and without mold infestation differ significantly in microbial volatile organic compounds (MVOC) concentrations. Air sampling for MVOC was performed in 40 dwellings with evident mold damage and in 44 dwellings, where mold damage was excluded after a thorough investigation. The characteristics of the dwellings, climatic parameters, airborne particles and air exchange rates (AER) were recorded. Une épreuve à simple insu a été réalisée dans le but d'analyser si les concentrations de composés organiques volatils microbiens (COVM) différaient dans une mesure appréciable selon que les milieux intérieurs étudiés étaient infestés ou non de moisissures. L'échantillonnage de l'air pour fin de contrôle des COVM a été réalisé dans 40 logements présentant des signes évidents d'endommagement dû aux moisissures et dans 44 logements où un examen approfondi permettait de confirmer l'absence de tels dommages. Les caractéristiques des logements, les paramètres climatiques, les particules en suspension dans l'air et les taux de renouvellement d'air (TRA) ont été enregistrés. RES
    Indoor Air 04/2008; · 3.30 Impact Factor
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    ABSTRACT: The aim of this article was to re-evaluate and possibly modify the standardized Environmental Worry Scale (EWS) by Hodapp et al. [1996. Evaluation eines Fragebogens zur Erfassung von Umweltbesorgnis. Z. Gesundheitspsychologie IV(1), 22-36] with regard to its content and structure. In order to do this, 161 participants were chosen as a reference group to take part in a survey. The data were analyzed and a factor analysis yielded two instead of one component of worry, namely "personal" and "general" environmental worry, leading to a new evaluation method. This revised evaluation method was then applied to patients (n=227) with or without self-reported multiple chemical sensitivity (MCS) and thus used in the context of reported health complaints. The outlined results indicate that the assessment of worry as proposed by Hodapp et al. [1996. Evaluation eines Fragebogens zur Erfassung von Umweltbesorgnis. Z. Gesundheitspsychologie IV(1), 22-36] should be elaborated by the newly developed evaluation method with which a ratio determined by "personal" and "general" worry can be calculated. In addition to analyzing the absolute quantity of worry, the calculated ratio allows to draw conclusions on the structure of worry. It will be discussed to what extent the results present new insights into the role of worry among patients suffering from environmental diseases.
    International Journal of Hygiene and Environmental Health 04/2008; 211(1-2):105-13. · 3.05 Impact Factor
  • Dieter Helm, Dieter Eis
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    ABSTRACT: Between 1999 and 2003 all consecutive outpatients of the environmental medicine unit of the Charité hospital in Berlin were invited to participate in a study on environmentally related disorders. One hundred and sixty-nine of the patients completed a psychosocial questionnaire which comprised SCL-90-R and 14 other tests. When compared with clinical controls, SCL-90-R mean scores of the environmental patients (EP) were found to lie in between those of inpatients of a psychosomatic clinic and melanoma aftercare patients; but they were, with exception of the somatisation dimension, much closer to the latter. Application of the TwoStep Cluster component of SPSS resulted in three subgroups with high, moderate and low scores which were significantly different (p<0.001) although separation was incomplete (87% correct identification; cross-validated discriminant analysis). With all subgroups, scores for somatisation, depression and obsessive compulsion were highest and those for phobic anxiety and psychoticism were lowest. SCL-90-R scores correlated well with results of the Freiburg Personality Inventory, Whiteley Index of hypochondriasis, the short form health questionnaire (SF-36), and the Composite International Diagnostic Interview (CIDI). Hierarchical grouping (average linkage between groups), performed with involvement of SCL-90-R data from literature, resulted in a dendrogram with three distinct groups and three outliers. EP with low SCL-90-R scores were assigned to a group which comprised also general populations (USA, Germany), allergy patients, and melanoma controls. Those with moderate SCL-90-R scores were placed in a group together with chronic pain patients, and 26 'environmentally ill' subjects. The third subgroup of EP formed a cluster with our psychosomatic controls, psychosomatic patients from another study, depressed people, and patients undergoing psychotherapy. The three outliers of the dendrogram, however, were SCL-90-R profiles obtained from persons with toxic waste exposure, neurotoxic workplace exposure or with solvent-induced chronic toxic encephalopathy.
    International Journal of Hygiene and Environmental Health 01/2008; 210(6):701-13. · 3.05 Impact Factor
  • Dieter Eis, Dieter Helm
    Psychosomatic Medicine 05/2007; 69(3):292-3; author reply 293-4. · 4.08 Impact Factor
  • Psychotherapie Psychosomatik Medizinische Psychologie - PSYCHOTHER PSYCHOSOM MED PSYC. 01/2006; 56:162-171.
  • DMW - Deutsche Medizinische Wochenschrift 12/2005; 130(47):2713-8. · 0.65 Impact Factor
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    ABSTRACT: Laboratory trials were performed in order to search for the variety of the production of microbial volatile organic compounds (MVOC), which could be used as indicators for hidden mold damage. Concerning MVOC production the experiments showed a dependency on the mold genus/species, the different strains used and the building materials used as substrate. It could be proved that the production of certain MVOC is not consistent at all times. On the whole low emission rates in terms of microg/h/m2 of the MVOC were found. Extrapolating the emissions rates from the laboratory trails to an indoor air situation results in concentrations below the analytical detection limit in most cases. According to these results only heavy or very large fungal contaminations might be detected by this method in indoor air. The studies were performed at the Institute of Hygiene and Environmental Medicine, Charite, Germany. PRACTICAL IMPLICATIONS: Microorganisms like bacteria and molds produce a huge variety of substances, and a part of them are released into the environment. Some compounds like, e.g. alcohols or ketones are volatile, therefore found in the air and called MVOC. Those compounds were considered helpful to track especially hidden mold damage. The study presented here showed, that the emission pattern varies from genus to genus and sometimes even from fungal strain to fungal strain. The results concerning the emission rates from different infested building materials proved, that the concentrations produced are much too low to be detected in indoor air, especially considering the dilution because of ventilation. Therefore, we conclude that MVOC should not be used as predictors for mold damage in indoor environments.
    Indoor Air 02/2005; 15 Suppl 9:98-104. · 3.30 Impact Factor
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    ABSTRACT: In order to validate microbial methods for the detection of mold infestations in indoor areas in a first step the sampling of airborne fungal spores with an impaction method was checked. When the group ?moldy apartments? was compared with the group ?non-moldy apartments?, only the genera Aspergillus and Penicillium were in significantly higher concentrations in the infested rooms (nutrient: malt extract agar). As these two genera appeared complementarily in moldy homes as a rule, a sum score was calculated by the logistic regression model. With this sum score cutoff50 values were calculated: 110 cfu/m³ for airborne fungal spores (S A + P) without correction for the outdoor situation and 80 cfu/m³ (S A + P) with correction for the outdoor air concentration. With these cutoff50 values a very good classification (high sensitivity and high specificity) concerning moldy and non-moldy apartments was achieved. Dans le but de valider les méthodes microbiennes employées pour la détection des infestations de moisissures dans les environnements intérieurs, on a vérifié dans un premier temps l'échantillonnage de spores fongiques dans l'atmosphère selon une méthode par impaction. Lorsque le groupe des « appartements infestés » a été comparé au groupe des « appartements non infestés », seuls les genres Aspergillus et Penicillium sont apparus en concentrations plus élevés dans un ordre appréciable dans les pièces infestées (substance nutritive : gélose extrait de malt). Comme ces deux genres étaient présents de façon complémentaire dans les maisons infestées, en principe, on a calculé une cote somme au moyen du modèle de régression logistique. Avec cette cote somme, des valeurs seuils 50 ont été calculées : 110 cfu/m³ (cellules souches indéterminés pluripotentielles par mètre cube), dans le cas des spores fongiques dans l'atmosphère (S A + P), sans correction en fonction de la situation à l'extérieur, et 80 cfu/m³ (S A + P), avec correction en fonction de la concentration atmosphérique à l'extérieur. À partir de ces valeurs seuils 50, il a été possible de parvenir à une classification très satisfaisante (sensibilité et spécificité élevées) des appartements infestés de moisissures et des appartements non infestés. RES
    01/2005;
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    ABSTRACT: The German Environmental Survey for Children (GerES IV) is the environment-oriented module of the National Health Interview and Examination Survey for Children and Adolescents (KiGGS) which is being performed nationwide in Germany. From 2003 to 2006, a random subsample of 1800 children aged 3-14 years is being studied with regard to their body burden and health impairments linked to housing conditions and the personal environment- and health-relevant behaviour. The basic study programme includes the analysis of blood, urine, tap water and house dust as well as the application of an extensive questionnaire. The data gained from this population sample, which is representative for Germany's children, are the basis for deriving reference values to characterise the background exposure of children aged 3-14 years. Trends over time can be detected and the success of environmental policies verified by comparing the data with those of the German Environmental Survey 1990/92 (GerES II), also conducted in close cooperation with the National Health Survey, which included children aged 6-14 years. By linking the data from the Environmental and the Health Surveys, health-relevant environmental exposures can be detected and different scientific hypotheses can be tested. The main subjects that are being dealt with using subcollectives of GerES IV are 'VOC and eye and nasopharynx irritation', 'indoor allergens and allergic diseases of the respiratory system', 'chromium, nickel, fragrances and contact allergens', and 'noise, hearing capacity and stress hormones'.
    Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 12/2004; 47(11):1066-72. · 0.72 Impact Factor
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    ABSTRACT: To evaluate frequently used methods that discriminate between moldy and nonmoldy indoor environments, 45 homes with visible mold growth and 47 definitively non-infested homes, both confirmed by inspection, were investigated by microbiological and chemical analytical methods. The study was laboratory blinded in relation to the confirmed mold status of the rooms. Statistical evaluation of the results of the applied mycological methods with the Receiver Operating Characteristic (ROC) curve analysis showed that these methods (impaction, open Petri dish method, and determination of mold spores in house dust samples) performed very well in discriminating between rooms with visible mold growth and nonmoldy rooms when the sum score of the mold genera Aspergillus and Penicillium was used as an indicator. The calculated areas under the ROC curves (AUC) of the three mycological methods were: 0.992 (95% CI 0.942-0.997) for mold spores in house dust samples, 0.996 (95% CI 0.940-0.998) for the open Petri dish method, and 0.999 (95% CI 0.957-1.000) for the determination of airborne spores with the Andersen impactor, respectively. A perfect discrimination would lead to an AUC of 1. These results were obtained with DG 18-agar as well as with malt extract agar. In contrast to the results of the mycological methods, the chemical analytical method under the same study conditions showed a distinctly lower performance in discriminating rooms according to their mold status when a sum score (concentration of eight typical MVOC) was used as an indicator. The area under the ROC curve (AUC) had a value of 0.620 (95% CI 0.509-0.723). A completely useless test would have an AUC of 0.5. As the lower limit of the 95% confidence interval of the area under the ROC curve is close to 0.5, the results obtained with the MVOC method do not differ from the classification results which can be obtained simply by chance. Possible methodological biases which could have lead to this interpretation are discussed.
    Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 12/2004; 47(11):1078-94. · 0.72 Impact Factor
  • D Eis, H Knopf
    Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 12/2004; 47(11):1025-6. · 0.72 Impact Factor
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    ABSTRACT: Fr die Bewertung der prdiktiven Wertigkeit hufig angewandter Methoden, die zum Nachweis von Schimmelpilzbefllen in Innenrumen eingesetzt werden, wurden in 45 Schimmel- und in 47 Nichtschimmelwohnungen mykologische und chemisch- analytische Untersuchungen vorgenommen. Die Studie wurde laborverblindet in Bezug auf den durch Inspektion ermittelten Schimmelstatus der Wohnungen durchgefhrt. Die Ergebnisse der einzelnen Bestimmungsmethoden wurden anhand ihrer Receiver Operating Characteristic-(ROC-)Kurven miteinander verglichen. Im Ergebnis dieser statistischen Analyse zeigte sich, dass die etablierten mykologischen Bestimmungsmethoden: Erfassung luftgetragener Schimmelpilze mit dem Andersen-Impaktor, sedimentierender Schimmelpilze auf Petri-Schalen und sedimentierter Schimmelpilze in Hausstaub unter den gewhlten Studienbedingungen eine hohe diskriminatorische Fhigkeit zur Unterscheidung von Schimmel- und Nichtschimmelwohnungen besitzen, wenn ein Summenscore aus den Gattungen Aspergillus und Penicillium verwendet wurde. Die errechneten Flchen unter den jeweiligen ROC-Kurven (AUC) reichten von AUC=0,992 (95%-KI 0,942–0,997) fr die Methode der Bestimmung sedimentierter Pilze im Hausstaub ber AUC=0,996 (95%-KI 0,940–0,998) fr das Sedimentationsverfahren bis zu AUC=0,999 (95%-KI 0,957– 1,000) fr die Methode der Erfassung luftgetragener Schimmelpilze mittels Andersen- Impaktor. Im paarweisen Vergleich erwiesen sich diese Flchen unter den ROC-Kurven als nicht statistisch signifikant voneinander verschieden. Diese Ergebnisse wurden mit DG-18-Agar als Kulturmedium erzielt. Gleichwertige Ergebnisse ergaben sich fr Malzextrakt-Agar. Im Vergleich dazu war die Methode der Bestimmung von mikrobiell bedingten flchtigen organischen Verbindungen (MVOC) mithilfe eines aus 8 Einzelverbindungen gebildeten Summenwertes den mykologischen Verfahren deutlich unterlegen: AUC=0,620 (95%-KI 0,509–0,723). Betrachtet man die untere Grenze des 95%-Konfidenzintervalls der Flche unter der ROC-Kurve, so ist diese kaum von 0,5 verschieden. Dieses Ergebnis bedeutet, dass sich die Diskriminationsfhigkeit dieser Methode nur geringfgig von der einer zuflligen Klassifizierung unterscheidet. Mgliche methodische Einflsse, die zu dieser Einschtzung gefhrt haben, werden diskutiert.To evaluate frequently used methods that discriminate between moldy and nonmoldy indoor environments, 45 homes with visible mold growth and 47 definitively non-infested homes, both confirmed by inspection, were investigated by microbiological and chemical analytical methods. The study was laboratory blinded in relation to the confirmed mold status of the rooms. Statistical evaluation of the results of the applied mycological methods with the Receiver Operating Characteristic (ROC) curve analysis showed that these methods (impaction, open Petri dish method, and determination of mold spores in house dust samples) performed very well in discriminating between rooms with visible mold growth and nonmoldy rooms when the sum score of the mold genera Aspergillus and Penicillium was used as an indicator. The calculated areas under the ROC curves (AUC) of the three mycological methods were: 0.992 (95% CI 0.942–0.997) for mold spores in house dust samples, 0.996 (95% CI 0.940–0.998) for the open Petri dish method, and 0.999 (95% CI 0.957–1.000) for the determination of airborne spores with the Andersen impactor, respectively. A perfect discrimination would lead to an AUC of 1. These results were obtained with DG 18-agar as well as with malt extract agar. In contrast to the results of the mycological methods, the chemical analytical method under the same study conditions showed a distinctly lower performance in discriminating rooms according to their mold status when a sum score (concentration of eight typical MVOC) was used as an indicator. The area under the ROC curve (AUC) had a value of 0.620 (95% CI 0.509–0.723). A completely useless test would have an AUC of 0.5. As the lower limit of the 95% confidence interval of the area under the ROC curve is close to 0.5, the results obtained with the MVOC method do not differ from the classification results which can be obtained simply by chance. Possible methodological biases which could have lead to this interpretation are discussed.
    Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 01/2004; 47(11):1078-1094. · 0.72 Impact Factor
  • D. Eis, H. Knopf
    Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 01/2004; 47(11):1025-1026. · 0.72 Impact Factor

Publication Stats

128 Citations
44.37 Total Impact Points

Institutions

  • 1999–2012
    • Robert Koch Institut
      • Department of Epidemiology and Health Reporting
      Berlin, Land Berlin, Germany
  • 2005
    • University Hospital München
      München, Bavaria, Germany
  • 2004
    • Federal Environmental Agency
      Berlín, Berlin, Germany
  • 2002
    • Justus-Liebig-Universität Gießen
      Gieben, Hesse, Germany