Franco Moriconi

Università degli Studi di Perugia, Perugia, Umbria, Italy

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Publications (8)11.33 Total impact

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    ABSTRACT: A 20-year-old Argentinian gelding was evaluated for sudden weakness, muscular tremors, tachypnea, and reluctance to move. On admission, a mild bilateral hyperextension of the carpi was noticed. On the basis of the clinical, laboratory, and ultrasonographic findings, a diagnosis of diaphragmatic hernia was made. During confinement, the hyperextension of the carpi worsened. Because radiographic examination of both carpi revealed palmar-lateral diastasis of the accessory carpal bone, bilateral rupture of the palmar carpal ligament (PCL) was suspected. Gross pathology confirmed the diaphragmatic hernia and the bilateral rupture of the PCL. Rupture of a PCL in a horse has been previously described, and conformation of the forelimb of that horse was similar to that of the horse in the case described in this article.
    Journal of Equine Veterinary Science 05/2012; 33(1):57-61. · 0.62 Impact Factor
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    ABSTRACT: Osteoarthritis (OA) and osteochondrosis (OC) are two of the main challenges in orthopedics, whose definitive diagnosis is usually based on radiographic/arthroscopic evidences. Their early diagnosis should allow preventive or timely therapeutic actions, which are generally precluded from the poor relationships occurring between symptomatologic and radiographic evidences. These limitations should be overcome by improving the knowledge on articular tissue metabolism and on molecular factors regulating its normal homeostasis, also identifying novel OA and OC biomarkers suitable for their earlier diagnoses, whenever clinical/pathological inflammatory scenarios between these joint diseases seem somewhat related. To identify proteins involved in their aetiology and progression, we undertook a differential proteomic analysis of equine synovial fluid (SF), which compared the protein pattern of OA or OC patients with that of healthy individuals. Deregulated proteins in OA and OC included components related to inflammatory state, coagulation pathways, oxidative stress and matrix damage, which were suggestive of pathological alterations in articular homeostasis, plasma-SF exchange, joint nutritional status and vessel permeability. Some proteins seemed commonly deregulated in both pathologies indicating that, regardless of the stimulus, common pathways are affected and/or the animal joint uses the same molecular mechanisms to restore its homeostasis. On the other hand, the increased number of deregulated proteins observed in OA with respect to OC, together with their nature, confirmed the high inflammatory character of this disease. Some deregulated proteins in OA found a verification by analyzing the SF of injured arthritic joints following autologous conditioned serum treatment, an emergent therapy that provides positive results for both human and equine OA. Being the horse involved in occupational/sporting activities and considered as an excellent animal model for human joint diseases, our data provide suggestive information for tentative biomedical extrapolations, allowing to overcome the limitations in joint size and workload that are typical of other small animal models.
    Journal of proteomics 02/2012; 75(14):4478-93. · 5.07 Impact Factor
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    ABSTRACT: To evaluate changes in the cortical bone of the proximal phalanx of the fore-limbs of Thoroughbreds in response to training. Twenty-seven 2-year-old Thoroughbreds (20 females, 2 males, and 5 geldings). Horses were principally in training for races in a straight line and in a clockwise direction. Lateromedial and dorsopalmar radiographic views of each metacarpophalangeal joint were obtained before the horses started training and 1 year after starting exercise and racing. Width of the dorsal, palmar, lateral, and medial cortex and the width and thickness of the medulla were measured. Ratios (rather than absolute values) were used to remove the effect of differences in bone size among horses. 10 horses were lost from the study. Radiographs were obtained for 17 horses 1 year after starting training (9 horses raced in a clockwise direction, and 8 raced in clockwise and counterclockwise directions). There was no difference between the cortical bone in the right and left forelimbs at the start of the study. After training for 1 year, the palmar cortex in the right forelimb was significantly thicker than that in the left forelimb. The strain patterns, biomechanics of rapid exercise, and type of training most probably determined differences in the adaptive responses of the proximal phalanx. The data reported here can be used in the evaluation of weight-bearing distribution along the proximal phalanx and evaluation of the relationship between exercise and bone remodelling of the proximal phalanx.
    American Journal of Veterinary Research 11/2011; 72(11):1482-8. · 1.35 Impact Factor
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    ABSTRACT: Nannarone, S., Gialletti, R., Veschini, I., Bufalari, A. and Moriconi, F., 2007. The use of alpha-2 agonists in the equine practice: comparison between three molecules. Veterinary Research Communications, 31(Suppl. 1), 309–312
    Veterinary Research Communications 09/2007; 31 Suppl 1:309-12. · 1.08 Impact Factor
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    ABSTRACT: To describe a laparoscopic technique for sterilization of the male donkey using an endoscopic linear stapler (ELS). Clinical report. Male Sardinia donkeys (n=6), aged 24-36 months. Laparoscopic sterilization was performed under standing sedation or recumbent under general anesthesia. An endoscopic linear stapler was used to transect, and control hemorrhage of, the spermatic cord. Serum testosterone concentrations were measured preoperatively and at 3, 6, and 12 months after sterilization. One testis from each of 2 donkeys was collected at 12 months for histologic examination. Sterilization was successfully achieved. The only minor intraoperative complication experienced was hemorrhage from 1 spermatic cord stump, which was re-stapled. No other major short- or long-term complications occurred. Serum testosterone concentrations were < 15 ng/dL at 3, 6, and 12 months after surgery in all donkeys. Testicular atrophy without evidence of revascularization was observed in the 2 testes examined histologically. Sterilization of descended testes by intraabdominal laparoscopic transection of the spermatic cord is a simple practical method, with minimal intraoperative or postoperative complications. Testicular revascularization did not occur. Laparoscopic sterilization in donkey can be performed using an endoscopic linear stapler as an alternative to scrotal castration.
    Veterinary Surgery 01/2005; 34(3):260-4. · 1.24 Impact Factor
  • Transplantation Proceedings 03/1998; 30(2):482-3. · 0.95 Impact Factor
  • Transplantation Proceedings - TRANSPLANT PROC. 01/1998; 30(2):482-483.
  • Veterinary and Comparative Orthopaedics and Traumatology 01/1996; · 1.01 Impact Factor