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ABSTRACT: The aim of segmentation of tumor regions in positron emission tomography (PET) is to provide more accurate measurements of tumor size and extension into adjacent structures, than is possible with visual assessment alone and hence improve patient management decisions. We propose a segmentation energy function for the graph cuts technique to improve lung tumor segmentation with PET. Our segmentation energy is based on an analysis of the tumor voxels in PET images combined with a standardized uptake value (SUV) cost function and a monotonic downhill SUV feature. The monotonic downhill feature avoids segmentation leakage into surrounding tissues with similar or higher PET tracer uptake than the tumor and the SUV cost function improves the boundary definition and also addresses situations where the lung tumor is heterogeneous. We evaluated the method in 42 clinical PET volumes from patients with non-small cell lung cancer (NSCLC). Our method improves segmentation and performs better than region growing approaches, the watershed technique, fuzzy-c-means, region-based active contour and tumor customized downhill.
Computer methods and programs in biomedicine 11/2012; · 1.14 Impact Factor
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ABSTRACT: A robust lesion segmentation method is critical for quantification of lesion activity in positron emission tomography (PET), especially for the cases where lesion boundary is not discernible in the corresponding computed tomography (CT). However, lesion delineation in PET is a challenging task, especially for small lesions, due to the low intrinsic resolution, image noise and partial volume effect. The combinations of different reconstruction methods and post-reconstruction smoothing on PET images also affect the segmentation result significantly which has always been overlooked. Therefore, the aim of this study was to investigate the impact of different reconstruction methods on semi-automated small lesion segmentation for PET images. Four conventional segmentation methods were evaluated including region growing technique based on maximum intensity (RGmax) and mean intensity (RGmean) thresholds, Fuzzy c-mean (FCM) and watershed (WS) technique. All these methods were evaluated on a physical phantom scan which was reconstructed with Ordered Subset Expectation Maximization (OSEM) with Gaussian post-smoothing and Maximum a Posteriori (MAP) with quadratic prior respectively. The results demonstrate that: 1) the performance of all the segmentation methods subject to the smoothness constraint applied on the reconstructed images; 2) FCM method applied on MAP reconstructed images yielded overall superior performance than other evaluated combinations.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 08/2011; 2011:8483-36.
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ABSTRACT: Automatic segmentation and detection of lungs and tumors in FDG PET-CT images is potentially beneficial in the diagnosis and staging of patients with non-small cell lung cancer (NSCLC). However, simultaneous lung segmentation and tumor detection is not a trivial task, particularly due to noise in the datasets, proximity of the lung lesion to the mediastinum and chest wall in certain instances, and disease involvement of non-enlarged lymph nodes.
Nuclear Science Symposium Conference Record, 2008. NSS '08. IEEE; 11/2008
