Hyung Jin Kim

St. Vincent Hospital, Green Bay, Wisconsin, United States

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Publications (132)186.14 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective This study aimed to optimize the fibrinogen concentration in fibrin and atelocollagen (AT-COL) (fibrin/AT-COL) composite gel for improving bone regeneration.Methods and materialsThe fibrin/AT-COL composite gels were fabricated using various fibrinogen concentrations, and the microstructure and mechanical properties of the resulting composite gels analyzed. The cytocompatibility of the composite gels was examined using human mesenchymal stem cell (hMSCs). Furthermore, in nine rabbits, the in vivo bone regeneration efficiency was evaluated using a rabbit calvarial defects model at 2 weeks (n = 3), 4 weeks (n = 3), and 8 weeks (n = 3).ResultsScanning electron microscopy analysis revealed the formation of a fibrin layer matrix and collagen fibril networks. The composite gel containing 40 mg/ml fibrinogen showed a densely packed fibrin matrix and displayed superior mechanical properties. Cells cultured in the composite gels prepared with 5–20 mg/ml fibrinogen appeared elongated, with a spindle-like morphology. At a higher fibrinogen concentration (40 mg/ml), many cells were rounded and showed limited viability. In an in vivo study, at 8 weeks, the volume of fibrin/AT-COL gel (P = 0.02) was significantly higher than that of fibrin gel alone in the newly formed bone. Histological analysis revealed more islands of newly formed bone filling the central area of the defect in the fibrin/AT-COL gel-implanted animals.Conclusion Our results demonstrate that optimization of the fibrinogen content of fibrin/AT-COL composites should be beneficial for bone tissue engineering.
    Clinical Oral Implants Research 07/2014; · 3.43 Impact Factor
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    ABSTRACT: We report the performance of natural orifice transluminal endoscopic surgery (NOTES) low anterior resection in animals using transanal total mesorectal excision (TME) with laparoscopic assistance and endoscopic inferior mesenteric artery (IMA) dissection.
    Annals of surgical treatment and research. 07/2014; 87(1):1-4.
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    ABSTRACT: We present a case of primary benign intraosseous meningioma in the sphenoid bone mimicking malignancy. A 44-year-old female patient who had a protruding right eye and headache came to our hospital. MRI showed a large, destructive, heterogeneously well-enhancing soft tissue mass in the right sphenoid bone suggesting malignancy. (18)F-FDG PET/CT showed a hypermetabolic mass in the same site with an SUVmax of 9.1 The pathological diagnosis by surgery revealed that this tumor was a WHO grade I transitional meningioma. This case suggests that primary benign intraosseous meningioma may show high (18)F-FDG uptake mimicking a malignancy.
    Nuclear medicine and molecular imaging. 06/2014; 48(2):153-156.
  • Ji Yong Kim, Hyung Jin Kim
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    ABSTRACT: The sensitivity of urine cytology is higher for carcinoma in situ and poorly differentiated tumors in bladder cancer, while being fairly low for low-grade or well-differentiated tumors. Development of a sensitive diagnostic test to detect bladder carcinoma would significantly facilitate patient management and allow earlier treatment of this disease. This study compared ThinPrep urine cytology (Cytyc Co.) and conventional Cytospin urine cytology (Shandon Scientific Ltd.) in the diagnosis of bladder cancer.
    Korean journal of urology. 06/2014; 55(6):390-4.
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    ABSTRACT: Abstract Introduction: Single-port laparoscopic surgery (SPLS), one of the advanced techniques of laparoscopic surgery, is performed through a single multichannel port. Regarding colorectal surgery, several colorectal procedures, including right colectomy, sigmoidectomy, and total proctocelectomy with ileal pouch anal anastomosis, have been performed successfully. The aim of this study was to elucidate the feasibility and safety of SPLS for the treatment of the patient with colorectal cancer in Korea. Subjects and Methods: Data were collected retrospectively from six hospitals through a Web-based case reporting form, which requested baseline characteristics of the patient, intraoperative findings, postoperative course, pathologic results of the tumor, and postoperative surveillance. Results: From May 2009 to June 2012, 257 patients were included in this study. Anterior resection was performed in 117 patients, low anterior resection in 66 patients, and right colectomy in 53 patients. The primary entry incision site was umbilicus in all patients except for 2 cases; in these, stoma sites were used for the entry of the single port. The total mean incision length was 3.8±2.3 cm. Among 257 initially SPLS-attempted patients, 45 (17.5%) patients needed additional ports (one additional port in 44 patients), and 2 patients (0.78%) had to be converted to open laparotomy. Intraoperative complications were noted in 5 patients, including anastomotic failures in 3 patients and bleeding in 1 patient. Postoperative complications were noted in 34 patients (13.2%). Anastomotic leak developed in 11 patients, urinary retention in 5 patients, and wound complications in 4 patients. Re-admission was needed in 15 patients (5.8%). Conclusions: SPLS could be performed safely and appropriately in selected colorectal cancer cases by experts in laparoscopic colorectal surgery in Korea. Prospective randomized trials to demonstrate the benefit and effectiveness of SPLS in colorectal cancer surgery with long-term oncologic results are needed.
    Journal of Laparoendoscopic & Advanced Surgical Techniques 05/2014; · 1.07 Impact Factor
  • Hyung Jin Kim, Kwang Wook Kim, Byungyou Hong
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    ABSTRACT: We investigated the effect of the drying time on the active layer based on a regioregular poly(3-hexylthiophene) (RR-P3HT):[6,6]-phenyl-C61-butyric acid methyl ester (PCBM), as well as the performance of polymer-based organic photovoltaic (OPV) devices. The devices were fabricated with different combinations of spin speed and solution concentration at a fixed thickness of the active layer. These conditions varied the properties of the active layer in terms of the polymer crystallinity and the phase separation in the blend. We identified distinct differences for different drying times of the solvent during the spin-coating process. The active layers were characterized by using analysis methods such as X-ray diffraction (XRD), ultraviolet-visible (UV-visible) spectroscopy and atomic force microscopy (AFM). The qualitative property of the active layer and the highest power conversion efficiency were obtained with the slowest coated active layer with the lowest solution concentration under AM 1.5 G spectral illumination of 100 mW/cm2.
    02/2014; 64(6).
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    Hyung Jin Kim, Seong Taek Oh
    Annals of coloproctology. 02/2014; 30(1):3-4.
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    ABSTRACT: Next-generation sequencing (NGS) has enabled the high-throughput discovery of germline and somatic mutations. However, NGS-based variant detection is still prone to errors, resulting in inaccurate variant calls. Here, we categorized the variants detected by NGS according to total read depth (TD) and SNP quality (SNPQ), and performed Sanger sequencing with 348 selected non-synonymous single nucleotide variants (SNVs) for validation. Using the SAMtools and GATK algorithms, the validation rate was positively correlated with SNPQ but showed no correlation with TD. In addition, common variants called by both programs had a higher validation rate than caller-specific variants. We further examined several parameters to improve the validation rate, and found that strand bias (SB) was a key parameter. SB in NGS data showed a strong difference between the variants passing validation and those that failed validation, showing a validation rate of more than 92% (filtering cutoff value: alternate allele forward [AF]≥20 and AF<80 in SAMtools, SB<-10 in GATK). Moreover, the validation rate increased significantly (up to 97-99%) when the variant was filtered together with the suggested values of mapping quality (MQ), SNPQ and SB. This detailed and systematic study provides comprehensive recommendations for improving validation rates, saving time and lowering cost in NGS analyses.
    PLoS ONE 01/2014; 9(1):e86664. · 3.73 Impact Factor
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    ABSTRACT: A unique composite of TiO2 nanoparticles (NPs) and nanorods (NRs) has been used to fabricate a photoelectrode for developing dye-sensitized solar cells (DSSCs) with higher sensitivity. The TiO2 nanorods were synthesized using a mechanical process, in which electrospun TiO2 nanofibers was grinded in a controlled way to obtain uniform size distribution. The characteristics of electron transport, recombination lifetime and charge collection were investigated by intensity-modulated photocurrent spectroscopy (IMPS) and intensity-modulated photovoltage spectroscopy (IMVS). Photoelectrodes prepared with the composites of NRs and NPs showed significant improvements in electron transportation compared to only NP photoelectrodes, which would enhance the photovoltaic performance of DSSCs. IMPS and IMVS measurements show that fast electron transport and slightly decreased recombination lifetime resulted in the improvement of efficiency. The highest energy conversion efficiency obtained from the photoelectrodes fabricated with the as-prepared rutile TiO2 nanofibers at 5 wt% NR content was up to 6.1% under AM1.5G solar illumination. The results demonstrate that the composite nanostructure can take advantage of both the fast electron transport of the nanorods and the high surface area of the nanoparticles.
    Current Applied Physics 01/2014; 14(3):294–299. · 2.03 Impact Factor
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    ABSTRACT: In inner ear development, phosphatase and tensin homolog (PTEN) is necessary for neuronal maintenance, such as neuronal survival and accurate nerve innervations of hair cells. We previously reported that Pten conditional knockout (cKO) mice exhibited disorganized fasciculus with neuronal apoptosis in spiral ganglion neurons (SGNs). To better understand the genes and signaling networks related to auditory neuron maintenance, we compared the profiles of differentially expressed genes (DEGs) using microarray analysis of the inner ear in E14.5 Pten cKO and wild-type mice. We identified 46 statistically significant transcripts using significance analysis of microarrays, with the false-discovery rate set at 0%. Among the DEGs, expression levels of candidate genes and expression domains were validated by quantitative real-time RT-PCR and in situ hybridization, respectively. Ingenuity pathway analysis using DEGs identified significant signaling networks associated with apoptosis, cellular movement, and axon guidance (i.e., secreted phosphoprotein 1 (Spp1)-mediated cellular movement and regulator of G-protein signaling 4 (Rgs4)-mediated axon guidance). This result was consistent with the phenotypic defects of SGNs in Pten cKO mice (e.g., neuronal apoptosis, abnormal migration, and irregular nerve fiber patterns of SGNs). From this study, we suggest two key regulatory signaling networks mediated by Spp1 and Rgs4, which may play potential roles in neuronal differentiation of developing auditory neurons.
    PLoS ONE 01/2014; 9(6):e97544. · 3.73 Impact Factor
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    ABSTRACT: Serum glycated albumin (GA) has been recently used as another glycemic marker that reflects shorter term glycemic control than glycated hemoglobin (HbA1c). Insulin secretory function and glycemic fluctuation might be correlated with the ratio of GA to HbA1c (GA/HbA1c) in diabetic adult patients. This study investigated the association of GA and GA/HbA1c ratio with the levels of fasting C-peptide, fasting plasma glucose in type 1 and type 2 pediatric diabetes.
    Annals of pediatric endocrinology & metabolism. 12/2013; 18(4):208-13.
  • Dae-Young Kim, Jae Nyoung Kim, Hyung Jin Kim
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    ABSTRACT: For developing intramolecular charge transfer (ICT) chemosensors for low pH values, 2-{2-[4-(dimethylamino)phenyl]-6-methyl-4H-pyran-4-ylidene}malononitrile (DPM) was designed and synthesized. The spectroscopic and pH-sensing properties of DPM were investigated by UV-Vis and fluorescence spectroscopy. This sensor exhibited a pH-dependent ratiometric absorption property in the range of pH 0-3, along with a reversible color change from yellow to colorless with increasing acid concentration. The fluorescence intensity of the sensor was increased with increasing pH within the pH range of 0-2.
    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy 11/2013; 122C:304-308. · 1.98 Impact Factor
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    ABSTRACT: A wide variety of delivery systems have been developed and many products based on the drug delivery technology are commercially available. The development of controlled-release technologies accelerated new dosage form design by altering pharmacokinetic and pharmacodynamics profiles of given drugs, resulting in improved efficacy and safety. Various natural or synthetic polymers have been applied to make matrix, reservoir or implant forms due to the characteristics of polymers, especially ease of control for modifications of biocompatibility, biodegradation, porosity, charge, mechanical strength and hydrophobicity/hydrophilicity. Hydrogel is a hydrophilic, polymeric network capable of imbibing large amount of water and biological fluids. This review article introduces various applications of natural and synthetic polymer-based hydrogels from pharmaceutical, biomedical and bioengineering points of view.
    Archives of Pharmacal Research 11/2013; · 1.54 Impact Factor
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    ABSTRACT: To identify significant CT findings for the differentiation of large (≥5cm) gastric gastrointestinal stromal tumors (GIST) from benign subepithelial tumors and to assess whether radiologists' performance in differentiation is improved with knowledge of significant CT criteria. One-hundred twenty patients with pathologically proven large (≥5cm) GISTs (n=99), schwannomas (n=16), and leiomyomas (n=5) who underwent CT were enrolled. Two radiologists (A and B) retrospectively reviewed their CT images in consensus for the location, size, degree and pattern of enhancement, contour, growth pattern and the presence of calcification, necrosis, surface ulceration, or enlarged lymph nodes. CT findings considered significant for differentiation were determined using uni- and multivariate statistical analyses. Thereafter, two successive review sessions for the differentiation of GIST from non-GIST were independently performed by two other reviewers (C and D) with different expertise of 2 and 9 years using a 5-point confidence scale. At the first session, reviewers interpreted CT images without knowledge of significant CT findings. At the second session, the results of statistical analyses were provided to the reviewers. To assess improvement in radiologists' performance, a pairwise comparison of receiver operating curves (ROC) was performed. Heterogeneous enhancement, presence of necrosis, absence of lymph nodes, and mean size of ≥6cm were found to be significant for differentiating GIST from schwannoma (P<0.05). Non-cardial location, heterogeneous enhancement, and presence of necrosis were differential CT features of GIST from leiomyoma (P<0.05). Multivariate analyses indicated that absence of enlarged LNs was the only statistically significant variable for GIST differentiating from schwannoma. The area under the curve of both reviewers obtained using ROC significantly increased from 0.682 and 0.613 to 0.903 and 0.904, respectively, with information of the significant CT findings differentiating GISTs from non-GISTs (P<0.001). Non-cardial location, heterogeneous enhancement, presence of necrosis, larger lesion size, and absence of lymphadenopathy are highly suggestive CT findings for large GISTs in differentiation from schwannomas or leiomyomas. Regardless of radiologists' expertise, diagnostic performance in differentiation can be significantly improved with knowledge of these CT findings.
    European journal of radiology 11/2013; · 2.65 Impact Factor
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    ABSTRACT: The purpose of this study was to prospectively evaluate clinical and radiographic outcomes following anatomic medial patellofemoral ligament (MPFL) reconstruction using patellar suture anchor fixation for recurrent patellar instability. Twenty patients (20 knees) were enrolled in this study. The median age was 21 years, and the median follow-up was 34.5 months. Reconstruction was performed using a hamstring autograft fixed with two suture anchors at native patellar site of the MPFL. No patient had undergone additional medial tibial tuberosity transfer. Clinical scores (Kujala, Lysholm, and Tegner score) and apprehension test were completed preoperatively and at the follow-up. Preoperative and follow-up radiographic assessments included modified Insall-Salvati ratio, congruence angle, and lateral patellofemoral angle. The preoperative Kujala and Lysholm scores were 52.6 ± 12.4 and 49.2 ± 10.7, and at follow-up visits, corresponding values were 90.9 ± 4.5 (p < 0.001) and 90.9 ± 5.2 (p < 0.001). Tegner score increased from 3.0 (range 1-4) to 5.0 (range 4-7) (p < 0.001). The apprehension test was positive in all patients preoperatively, but only positive in one patient at follow-up. All radiographic assessments were significantly improved; modified Insall-Salvati index (from 1.75 to 1.65) (p = 0.002), congruence angle (from 6.3° to -7.0°) (p < 0.001), and lateral patellofemoral angle (from 2.1° to 4.9°) (p = 0.008). No patient experienced a patellar fracture or redislocation. These results are comparable to those of bone tunnel techniques reported in the literature. This study shows that anatomic MPFL reconstruction using two suture anchors is a reliable treatment option. Case series with no comparison group, Level IV.
    Knee Surgery Sports Traumatology Arthroscopy 10/2013; · 2.68 Impact Factor
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    ABSTRACT: The bromides (I) are synthesized by literature-known procedures from Morita—Baylis—Hillman-alcohols by treatment with HBr or PBr3.
    ChemInform 10/2013; 44(40).
  • Hyung Jin Kim, Bongsik Shin, Hogeun Lee
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    ABSTRACT: A substantial body of previous research on the client–vendor relationship has identified inter-organizational partnerships and formal contracts as important governance mechanisms for outsourcing performance. Successful IS development through outsourcing, however, may be more dependent on the people who execute the project in the field than on inter-firm relationships and agreed-upon formalities. Among individual-level variables, the special importance of psychological contracts has recently been noted in IS literature. This study investigates the mediating role of psychological contract breach between these two firm-level governance factors and outsourcing performance. By analyzing matched responses from project managers, vendor participants, and system users, we found that the effects of explicit legal contracts and partnership quality on outsourcing outcome are fully mediated by the client's perception of breach by the vendor. This study offers an extended theoretical perspective on the governance of firm-level collaboration, especially revealing that the benefits of formal contracts and inter-organizational partnerships eventually translate into satisfactory outsourcing outcomes for system users through each party's perception of breach on the individual level. Moreover, discrepancy was observed in this study between the client and vendor regarding the impact of legal contracts on individuals’ psychological contract while that of partnership was prominent in both sides.
    European Journal of Information Systems 09/2013; 22(5). · 1.56 Impact Factor
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    ABSTRACT: Iron deficiency remains a very common nutritional problem despite the improvement in nutrition and increased understanding of methods for its prevention. Thus, we try to create a new method for screening iron nutrition through infant nutrition history. Among the children who visited Inha University Hospital from March 2006 to July 2012, 181 children with iron deficiency anemia (IDA) and 52 children without IDA ranging from 6 to 36 months of age were reviewed in this study. We used the age when they began to wean food, the type of sort weaning foods, the time required for successful weaning, iron content in weaning foods, and the duration of breastfeeding for scoring infant nutrition history based on a questionnaire. The mean score of the IDA group was 7.8±2.6 points, which was significantly higher than that of the control group (5.6±2.1) (p=0.000). If we set up the cutoff value at 6 points, this screening has 86.8% sensitivity and 36% specificity. In addition, as the IDA score increased, there was a falling trend of hemoglobin. The IDA score does not have high specificity or high sensitivity. However, this study conveys that those patients who record a high score have low hemoglobin. Therefore, we suggest this score system for screening more IDA patients via nonpainful techniques.
    Pediatric gastroenterology, hepatology & nutrition. 06/2013; 16(2):95-103.
  • Hyung Jin Kim, Jumi Kim, Byungyou Hong
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    ABSTRACT: We report an efficient method to improve the efficiency and stability of DSSC with nano-structured TiO2. A low temperature RF plasma-enhanced chemical vapor deposition (PECVD) system was utilized for hydrogen plasma treatment on nano-structured TiO2 film. We confirmed that the efficiency of DSSCs was significantly dependent on the plasma power. This increased the hydrophilic property, the excess electrons and dye adsorption on its surface. The relative change in surface chemistry and hydrophilic characteristics with plasma treatment was investigated using various analysis methods. In our study, we showed that DSSC with plasma-treated TiO2 had a power conversion efficiency of 6.94%, which is 21% higher than that without plasma treatment. It was found that the plasma treatment caused both increased dye adsorption and significant longer electron lifetime.
    Applied Surface Science 06/2013; 274:171–175. · 2.54 Impact Factor
  • Hyung Jin Kim, Byungyou Hong
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    ABSTRACT: This paper reports an efficient approach to control both the density and direction of highly aligned DNA molecules and thus DNA-templated gold nanowires (AuNWs) on Si chips. We utilized tilting method to prepare stretched DNA structures on SiO2/Si substrate and found important parameters in the alignment process that tilt angle, DNA concentration, and surface potential are controlled the density and structure of DNA aligned on the surface. In additional, we also can be directly connected DNA-templated AuNWs between two terminal electrodes on Si chips. This method also describes a simple way to form singled, bundled and networked DNA arrays on Si substrates.
    Japanese Journal of Applied Physics 03/2013; 52(3):5003-. · 1.07 Impact Factor

Publication Stats

585 Citations
186.14 Total Impact Points


  • 2014
    • St. Vincent Hospital
      Green Bay, Wisconsin, United States
    • Gumi Electronics and Information Technology Research Institute
      Kibi, North Gyeongsang, South Korea
  • 2009–2014
    • Sungkyunkwan University
      • College of Information and Communication Engineering (SoICE)
      Sŏul, Seoul, South Korea
  • 2006–2014
    • Wonkwang University
      • Department of Dentistry
      Riri, North Jeolla, South Korea
  • 2004–2014
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
    • Kwandong University
      Gangneung, Gangwon, South Korea
    • Hongik University
      • Department of Chemical Engineering
      Seoul, Seoul, South Korea
  • 2002–2014
    • Chonnam National University
      • • School of Applied Chemical Engineering
      • • Department of Chemistry
      Gwangju, Gwangju, South Korea
  • 2013
    • National University of Singapore
      Tumasik, Singapore
    • Inha University Hospital
      Sinhyeon, South Gyeongsang, South Korea
  • 2011
    • University of Suwon
      Suigen, Gyeonggi Province, South Korea
    • Hanbat National University
      • Department of Electrical Engineering
      Taiden, Daejeon, South Korea
  • 2006–2011
    • Korea University
      • Department of Pediatrics
      Seoul, Seoul, South Korea
  • 2003–2011
    • Yonsei University
      • Department of Urban Planning and Engineering
      Sŏul, Seoul, South Korea
  • 2010
    • Korea Centers for Disease Control and Prevention
      Daiden, Daejeon, South Korea
  • 2009–2010
    • Catholic University of Korea
      • College of Medicine
      Seoul, Seoul, South Korea
  • 2005
    • Hong-ik university
      United States
  • 1995
    • Seoul National University
      • 원자핵공학과
      Seoul, Seoul, South Korea