Hyung Jin Kim

Chungbuk National University, Chinsen, Chungcheongbuk-do, South Korea

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Publications (177)307.09 Total impact

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    ABSTRACT: We evaluated the tumor response and survival according to the KRAS oncogene status in locally advanced rectal cancer. One hundred patients with locally advanced rectal cancer (cT3-4N0-2M0) received preoperative radiation of 50.4 Gy in 28 fractions with 5-fluorouracil and total mesorectal excision. Tumor DNA from each patient was obtained from pretreatment biopsy tissues. A Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation was found in 26 (26%) of the 100 patients. Downstaging (ypT0-2N0M0) rates after preoperative chemoradiotheray were not statistically different between the wild-type and mutant-type KRAS groups (30.8% vs 27.0%, P = 0.715, respectively). After a median follow-up time of 34 months, there was no statistically significant difference in the 3-year relapse-free survival (82.2% vs 82.6%, P = 0.512) and overall survival (94.7% vs 92.3%, P = 0.249) rates between wild-type and mutant-type KRAS groups, respectively. The KRAS mutation status does not influence the tumor response to the radiotherapy and survival in locally advanced rectal cancer patients who received preoperative chemoradiotherapy and curative surgery.
    Medicine 08/2015; 94(31):e1284. DOI:10.1097/MD.0000000000001284 · 4.87 Impact Factor
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    Sang Hun Kim · Hyung Jin Kim · Ki Tae Jung
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    ABSTRACT: Increase in intracranial pressure (ICP) is one of the physiologic changes during laparoscopic surgery, which is known to be associated with positional changes. Changes of ICP can be measured directly by invasive method, but ultrasonographic measurement of optic nerve sheath diameter (ONSD) is known to be a rapidly applicable technique for evaluating ICP. The aim of this study is to investigate the change of ONSD according to the positional change during laparoscopic surgery. Female patients scheduled to undergo laparoscopic surgery were enrolled. Fifty-seven patients were assigned according to the position during surgery (Group T: gynecological surgery, Trendelenburg position, n = 27 vs. Group RT: laparoscopic cholecystectomy, Reverse trendelenburg position, n = 30). After induction of anesthesia, ONSD, PaCO2, end-tidal carbon dioxide (ETCO2), and mean arterial pressure (MAP) were measured. Parameters were measured at 6 time points during surgery. There were no significant differences in the demographic data of patients, procedure time, and anesthesia. After pneumoperitoneum and positional change, ONSD, ETCO2, and MAP increased in both groups until 15 min and returned to the baseline. However, no significant differences in changes of ONSD, PaCO2, ETCO2, and MAP were observed between two groups. ONSD during laparoscopic surgery with pneumoperitoneum increased slightly until 15 minutes, but there were no significant differences according to the position. Increases in ICP during laparoscopic surgery with short period of pneumoperitoneum would be small in disregard of position in patients without intracranial pathology.
    Korean journal of anesthesiology 08/2015; 68(4):358-63. DOI:10.4097/kjae.2015.68.4.358
  • Hyung Jin Kim · YS Shin · H Choi · M K Kim · YB Jeong · J K Park
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    ABSTRACT: We present a case of undiagnosed nephrogenic diabetes insipidus as a cause of acute urinary retention in a 21-year-old male soldier. Soldiers live in close quarters, and have a regimented lifestyle that may not allow for frequent voiding; therefore, undiagnosed nephrogenic diabetes insipidus may result in acute urinary retention. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
    Journal of the Royal Army Medical Corps 07/2015; DOI:10.1136/jramc-2015-000471 · 0.81 Impact Factor
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    ABSTRACT: Effective intracellular level of a platinum anti-cancer drug, cisplatin, following repeated injections can be decreased either by the active efflux via ATP pump or by interactions with glutathione and metallothionein. Cisplatin in cytoplasm preferably binds to cysteine-rich proteins such as glutathione and metallothionein (MT). Detoxification of cisplatin by intracellular thiol-containing proteins has been considered to be major hurdles to overcome. The short hairpin RNA targeting MT (shMT) was tested to down-regulate MT and recover cisplatin resistance. A reducible polymer, poly(oligo-D-arginine) (rPOA), formed stable complex with shMT and demonstrated superior transfection efficiency. Efficient transfection of shMT/rPOA oligo-peptoplexes was found to significantly inhibit MT over-expression, resulting in 45% decrease of cell viability compared to the cisplatin alone group. This decrease was mediated by synergistic effect of shMT/rPOA oligo-peptoplex and cisplatin. Co-administration of shMT/rPOA oligo-peptoplex and cisplatin in in vivo tumor model showed noticeable tumor-suppressing effect by inducing reversal of cisplatin resistance following effective intracellular delivery of shMT by rPOA. Combination therapy through co-administration of shMT/rPOA oligo-peptoplex and cisplatin was found to effectively reverse cisplatin resistance by RNA interference and consequently improve anti-cancer activity of cisplatin. Copyright © 2015. Published by Elsevier B.V.
    Journal of Controlled Release 07/2015; DOI:10.1016/j.jconrel.2015.07.015 · 7.26 Impact Factor
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    ABSTRACT: Screening for second primary cancer (SPC) is one of the key components to survivorship care. We aim to evaluate the oncologists' experience with SPCs and assess the current practice, perceived barriers, and recommendations related to SPC screening. A nationwide survey was conducted with a representative sample of 496 Korean oncologists. A questionnaire based on the findings from our previous qualitative study was administered. More than three-fourths of oncologists (76.3%), who participated in the study, had experience with SPC patients. Over half of them (51.9%) stated that it was an embarrassing experience. While the current management practice for SPC varies, most oncologists (80.2%) agreed on the necessity in proactively providing information on SPC screening. A short consultation time (52.3%), lack of guidelines and evidence on SPC screening (47.7%), and patients' lack of knowledge about SPCs (45.1%) or SPC screening (41.4%) were most frequently reported as barriers to providing appropriate care for managing SPC. Oncologists recommended the development of specific screening programs or guidelines in accordance to the type of primary cancer (65.9%), the development of an internal system for SPC screening within the hospital (59.7%) or systematic connection with the national cancer screening program (44.3%), and education of oncologists (41.4%) as well as patients (48.9%) regarding SPC screening. Many oncologists reported the occurrence of SPC as an embarrassing experience. Given the variations in current practice and the lack of consensus, further studies are warranted to develop the optimal clinical strategy to provide SPC screening for cancer survivors.
    Cancer Research and Treatment 02/2015; DOI:10.4143/crt.2014.162 · 2.98 Impact Factor
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    ABSTRACT: The Rare Isotope Science Project (RISP) has been proposed as a multi-purpose accelerator facility for providing beams of exotic rare isotopes of various energies. The RISP driver linac, which is used to accelerate the beam, for example, uranium ions from 0.5 MeV/u to 200 MeV/u, consists of superconducting RF cavities and warm quadrupole magnets for focusing heavy-ion beams. The requirements for the linac design are especially high for acceleration of multiple charge beams. In this paper, we present the RISP linac’s design, the superconducting cavity, the cryomodule system, and the requirements in the dynamic errors to minimize the beam centroid’s oscillation.
    Journal- Korean Physical Society 02/2015; 66(3):413-418. DOI:10.3938/jkps.66.413 · 0.43 Impact Factor
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    Hyuk Jin Cha · Hoe Chun Jung · Hyung Jin Kim
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    ABSTRACT: The design and the fabrication of superconducting cavities for the Korean heavy ion accelerator, RAON, are in progress. In this paper, we present the progress towards the design of a SSR1 single spoke resonator (β = 0.3 and f = 325 MHz). Not only electromagnetic and mechanical analyses for the cavity but also the issues that should be considered when fabricating and operating the cavity are discussed. In addition, a variant of the SSR1 cavity for more efficient performance is proposed with its electromagnetic analyses.
    Journal- Korean Physical Society 02/2015; 66(3):330-335. DOI:10.3938/jkps.66.330 · 0.43 Impact Factor
  • Dae-Young Kim · Hyung Jin Kim
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    ABSTRACT: Highly sensitive pH optode membranes for operation at low pH values were fabricated by the covalent immobilization of an ICT dye (DPA) on a silanized glass surface. The photo-initiated copolymerization of DPA with 2-hydroxyethyl methacrylate (HEMA) and diacrylamidated poly(dimethylsiloxane) (PSA) or triethylene glycol dimethacrylate as a cross-linker gave pH-sensitive optode membranes (M1 and M2) capable of working in highly acidic condition. The fluorescence intensities of the membranes increased with increasing pH in the pH range of −1.0 to 2.0. Both membranes were useful as a ratiometric pH optode in the same acidic pH range. Optode membrane M1 prepared by using PSA was more sensitive to pH change than was M2. The prepared membranes were characterized in terms of pKa values, optimal thickness, effect of ionic strength, response time, and leaching of dye.
    Sensors and Actuators B Chemical 01/2015; 206:508-515. DOI:10.1016/j.snb.2014.09.096 · 4.29 Impact Factor
  • Hyung Jin Kim · Jae Hoon Jung · Jung Bin Lee · Sang Min Kim · Joon Heo
    12/2014; 22(4):175-181. DOI:10.7319/kogsis.2014.22.4.175
  • Hyung Jin Kim · Dong Hyun Kim · Yong Hoon Jun · Ji Eun Lee
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    ABSTRACT: A 13-year-old Asian boy presented with an 8 h history of lethargy and vomiting. He had a 3-week history of polyuria, polydipsia and a 6 kg weight loss over a period of 1 month. Fluid intake prior to admission was over 6 L of sports drinks and cola per day. Initial biochemical findings were as follows: plasma glucose 1351 mg/dL, serum sodium 154 mEq/L, serum osmolarity 425 mOsm/L, arterial blood pH 6.96 and urine ketone of 3+. He was treated with intensive fluid resuscitation and an insulin infusion. He completely recovered without any neurological deficits. Severe hypernatremia is rare in diabetic ketoacidosis (DKA) but was exhibited in this case. Excess intake of carbonated carbohydrate-rich beverages may exacerbate the initial severe presentation of type I diabetes mellitus (T1DM). To the best of our knowledge, this is the first case of an Asian child with DKA combined with severe hypernatremic hyperosmolarity at onset of T1DM. 2014 BMJ Publishing Group Ltd.
    Case Reports 12/2014; 2014(dec17 1). DOI:10.1136/bcr-2014-208016
  • Kang Il Byun · Hyung Jin Kim · Byeong Hee Kim · Young Ho Seo
    12/2014; 23(6):555-560. DOI:10.7735/ksmte.2014.23.6.555
  • Korean journal of anesthesiology 12/2014; 67(Suppl):S56-7. DOI:10.4097/kjae.2014.67.S.S56
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    ABSTRACT: In this study, the coating of synthesized carbon nanowalls (CNWs) with various metal layers (Ni, Cu, and W) was investigated. CNWs were synthesized by microwave plasma enhanced chemical vapor deposition (PECVD) with a methane (CH4) and hydrogen (H2) gas mixture on a p-type Si wafer, and then coated with metal films (Ni, Cu, and W) using an RF magnetron sputtering system with fourinch targets. Different sputtering times (5, 10, 20, and 30 min) were established to obtain different thicknesses of the metal layers with which the CNWs were coated. Field emission scanning electron microscopy (FE-SEM) was used to examine the cross-sectional and planar conditions of the CNWs, and energy dispersive spectroscopy (EDS) was used to analyze the CNW elements. The FE-SEM analysis of the cross-sectional and planar images confirmed that the metal layers were synthesized to a depth of 0.5 μm from the surfaces of the CNWs, and to a greater depth at the ends of the CNWs, irrespective of the deposition time and the metal species. The resistivity of the as-deposited CNWs appeared as 4.18×10−3 Ω cm; that of the metal-coated CNWs was slightly lower; and that of the Ni-coated CNWs was the lowest (1.74×10−3 Ω cm). The mobility of the metal-coated CNWs was almost unchanged, and that of the as-deposited CNWs was 1.23×103 cm2 V−1 s−1.
    Journal of Nanoscience and Nanotechnology 12/2014; 14(12):9189-93. DOI:10.1166/jnn.2014.10107 · 1.34 Impact Factor
  • Hyung Jin Kim · Chanam Lee · Marcia Ory · Deanna Hoelscher
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    ABSTRACT: Objectives: While built environmental correlates of walking to school (WTS) have been well documented, the roles of social factors are understudied. This study examines WTS as an important source of daily physical activity among school-aged children, and how the neighborhood’s social environments may contribute to promoting WTS. Methods: Surveys were conducted among 1,774 parents of 4th grade students from 81 elementary schools in diverse communities across Texas. The social environmental variables included social participation items, such as voting in elections, contacting government officials about community issue, attending governmental meetings (e.g. school board, city council), volunteering at the child’s school, and volunteering for community organizations; and social perception items, such as social trust, individualism, safety concerns, belongingness, and willingness to participate in community problem-solving. Generalized linear mixed models for logistic regression were used to predict the odds of children’s WTS, treating school as a random effect and controlling for student gender, social economic disadvantage, years living at current address, travel time to school, and objectively-measured home-to-school street network distance. Findings: Our analysis identified two significant social environmental variables, but both were negatively associated with WTS: attending any official government body’s meeting (OR=.580, P=.039) and volunteering at child’s school (OR=.583, P=.006), both of which were social participation items. None of the social perception items were significant in our study. Conclusions: Unlike most previous studies on social environments that have reported positive impacts on various health-related outcomes, this study found their roles to be insignificant or negative for WTS. Further studies are needed to examine interactive roles among the personal, social, and built environmental factors and to assess additional dimensions of social environments that may be more closely linked to WTS, which will be important to guide the development of effective intervention strategies for promoting WTS at the community level.
    142nd APHA Annual Meeting and Exposition 2014; 11/2014
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    ABSTRACT: Purpose Korean children have their own unique lifestyle based on their living environment and culture. This study aimed to develop a questionnaire to evaluate the quality of life in Korean children with allergic rhinitis. Methods After a preliminary survey, an initial questionnaire was developed. Questions were modified to be easily understood by young children aged 6 to 7 years. The modified questionnaire was tested on children aged 6 to 12 years old. Item scores, defined as the proportion of children whose answer score was 1 point or higher was multiplied by the average answer score of each question, were used to identify questions that have practical application to the quality of life in Korean children with allergic rhinitis. Differences in answer scores between children with allergic rhinitis and those who were healthy were assessed by a Wilcoxon rank-sum test. The relationship between nasal index scores and quality of life scores was determined by a Spearman rank order test. Results An initial questionnaire was composed of 21 items. We identified 19 questions with item scores above 0.5 in children with allergic rhinitis, many of which were related to nasal symptoms and 10 questions that were different between the allergic rhinitis group and the control group. The final questionnaire included the 10 questions that had both high item scores and a significant difference in the answer scores between the two groups. Conclusions The developed questionnaire is essential and practical for assessing discomfort related to the symptoms felt by Korean children with allergic rhinitis.
    Allergy, asthma & immunology research 11/2014; 6(6):541-7. DOI:10.4168/aair.2014.6.6.541 · 3.08 Impact Factor
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    ABSTRACT: Commercial anti-obesity drugs acting in the gastrointestinal tract or the central nervous system have been shown to have limited efficacy and severe side effects. Anti-obesity drug development is thus focusing on targeting adipocytes that store excess fat. Here, we show that an adipocyte-targeting fusion-oligopeptide gene carrier consisting of an adipocyte-targeting sequence and 9-arginine (ATS-9R) selectively transfects mature adipocytes by binding to prohibitin. Injection of ATS-9R into obese mice confirmed specific binding of ATS-9R to fat vasculature, internalization and gene expression in adipocytes. We also constructed a short-hairpin RNA (shRNA) for silencing fatty-acid-binding protein 4 (shFABP4), a key lipid chaperone in fatty-acid uptake and lipid storage in adipocytes. Treatment of obese mice with ATS-9R/shFABP4 led to metabolic recovery and body-weight reduction (>20%). The ATS-9R/shFABP4 oligopeptide complex could prove to be a safe therapeutic approach to regress and treat obesity as well as obesity-induced metabolic syndromes.
    Nature Material 10/2014; 13:1157–1164. DOI:10.1038/nmat4092 · 36.43 Impact Factor
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    ABSTRACT: Purpose Long-acting gonadotropin-releasing hormone agonists (GnRHa) are commonly used to treat central precocious puberty (CPP) in Korea. Although rare, there have been reports on the characteristic of adverse reactions of GnRHa in CPP among the Korean population. This study was intended to report on our clinical experience regarding significant adverse reactions to long-acting GnRHa in CPP and early onset puberty and to evaluate the prevalence rate of serious side effects. Methods This retrospective study included children with CPP and early onset puberty, who were administered monthly with long-acting GnRHa (leuprolide acetate, triptorelin acetate) at the outpatient clinic of Department of Pediatrics, at Inha University Hospital, between January 2011 and December 2013. We analyzed the clinical characteristics of patients who experienced significant adverse reactions and evaluated the prevalence rate. Results Six serious side effects (0.9%) were observed among total of 621 CPP and early onset puberty children with GnRHa therapy. The number of sterile abscess formation was four in three patients (4 events of 621). Anaphylaxis occurred in only one patient, and unilateral slipped capital femoral epiphysis (SCFE) in another one patient. Anaphylaxis occurred after the 6th administration of the monthly depot triptorelin acetate. Unilateral SCFE developed in GnRHa therapy. Conclusion Sterile abscess formation occurred in 0.6% of CPP and early onset puberty patients from the administration of a monthly depot GnRHa therapy. The occurrences of anaphylaxis and SCFE are extremely rare, but can have serious implications on patients. Clinicians should be aware of these potential adverse effects related to GnRHa therapy in CPP.
    09/2014; 19(3):135-40. DOI:10.6065/apem.2014.19.3.135
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    ABSTRACT: Cobalt-immobilized SBA-15 6a-c was synthesized from alkyne-attached SBA 5a-c by the reaction with Co-2(CO)(8) in toluene. Alkyne group was introduced into amino SBA-15 (4) by imine-linkage or,subStitution with propargyl bromide to afford iminoalkyne 5a and aminoalkyne 5b; respectively. Meanwhile, alkyne 5c was prepared in one-step by reacting triethoxysilyl hexyne with SBA-15. Dicobalt-complexes 6a-c were characterized by means of FT-IR, solid-state NMR and elemental analysis.
    Bulletin- Korean Chemical Society 07/2014; 35(7):2077-2080. DOI:10.5012/bkcs.2014.35.7.2077 · 0.84 Impact Factor
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    ABSTRACT: Objective This study aimed to optimize the fibrinogen concentration in fibrin and atelocollagen (AT-COL) (fibrin/AT-COL) composite gel for improving bone regeneration.Methods and materialsThe fibrin/AT-COL composite gels were fabricated using various fibrinogen concentrations, and the microstructure and mechanical properties of the resulting composite gels analyzed. The cytocompatibility of the composite gels was examined using human mesenchymal stem cell (hMSCs). Furthermore, in nine rabbits, the in vivo bone regeneration efficiency was evaluated using a rabbit calvarial defects model at 2 weeks (n = 3), 4 weeks (n = 3), and 8 weeks (n = 3).ResultsScanning electron microscopy analysis revealed the formation of a fibrin layer matrix and collagen fibril networks. The composite gel containing 40 mg/ml fibrinogen showed a densely packed fibrin matrix and displayed superior mechanical properties. Cells cultured in the composite gels prepared with 5–20 mg/ml fibrinogen appeared elongated, with a spindle-like morphology. At a higher fibrinogen concentration (40 mg/ml), many cells were rounded and showed limited viability. In an in vivo study, at 8 weeks, the volume of fibrin/AT-COL gel (P = 0.02) was significantly higher than that of fibrin gel alone in the newly formed bone. Histological analysis revealed more islands of newly formed bone filling the central area of the defect in the fibrin/AT-COL gel-implanted animals.Conclusion Our results demonstrate that optimization of the fibrinogen content of fibrin/AT-COL composites should be beneficial for bone tissue engineering.
    Clinical Oral Implants Research 07/2014; DOI:10.1111/clr.12455 · 3.12 Impact Factor

Publication Stats

1k Citations
307.09 Total Impact Points

Institutions

  • 2015
    • Chungbuk National University
      Chinsen, Chungcheongbuk-do, South Korea
    • Korea Basic Science Institute KBSI
      Sŏul, Seoul, South Korea
  • 2007–2015
    • Hanyang University
      • • College of Engineering
      • • Department of Computer Science and Engineering
      • • Division of Chemical Engineering and Bioengineering
      Sŏul, Seoul, South Korea
  • 2014
    • Gumi Electronics and Information Technology Research Institute
      Kibi, Gyeongsangbuk-do, South Korea
    • Kansas State University
      • Department of Landscape Architecture/Regional and Community Planning
      Kansas, United States
    • Inha University
      • Department of Pediatrics
      Chemulpo, Incheon, South Korea
    • Chosun University
      Gwangju, Gwangju, South Korea
  • 2013–2014
    • Kangwon National University
      • Department of Mechanical and Mechatronics Engineering
      Shunsen, Gangwon-do, South Korea
    • National University of Singapore
      Tumasik, Singapore
    • Hallym University
      Sŏul, Seoul, South Korea
    • Seoul National University Hospital
      • Department of Radiology
      Sŏul, Seoul, South Korea
  • 2010–2014
    • St. Vincent Hospital
      Green Bay, Wisconsin, United States
    • Korea Centers for Disease Control and Prevention
      Daiden, Daejeon, South Korea
    • National Cancer Center Korea
      QYK, Gyeonggi-do, South Korea
  • 2008–2014
    • Catholic University of Korea
      • College of Medicine
      Sŏul, Seoul, South Korea
    • Kyung Hee University
      • Department of Mechanical Engineering
      Sŏul, Seoul, South Korea
  • 2007–2014
    • Sungkyunkwan University
      • • Department of Radiology
      • • College of Information and Communication Engineering (SoICE)
      Sŏul, Seoul, South Korea
  • 2006–2014
    • Wonkwang University
      • Department of Dentistry
      Riri, North Jeolla, South Korea
    • Yonsei University Hospital
      Sŏul, Seoul, South Korea
  • 2004–2014
    • Chonbuk National University Hospital
      Sŏul, Seoul, South Korea
    • Kwandong University
      Gangneung, Gangwon, South Korea
  • 2003–2014
    • Chonnam National University
      • • School of Applied Chemical Engineering
      • • Department of Chemistry
      Gwangju, Gwangju, South Korea
  • 2002–2014
    • Inha University Hospital
      Sinhyeon, Gyeongsangnam-do, South Korea
  • 2006–2012
    • Seoul National University
      • • Department of Pathology
      • • Department of Physics and Astronomy
      Sŏul, Seoul, South Korea
  • 2011
    • University of Suwon
      Suigen, Gyeonggi Province, South Korea
    • Texas A&M University
      • Department of Landscape Architecture and Urban Planning
      College Station, Texas, United States
    • Seoul Medical Center
      Sŏul, Seoul, South Korea
  • 2003–2011
    • Yonsei University
      • Department of Urban Planning and Engineering
      Sŏul, Seoul, South Korea
  • 2005–2010
    • Samsung Medical Center
      • Department of Radiology
      Sŏul, Seoul, South Korea
    • Hong-ik university
      United States
    • Johns Hopkins University
      • Department of Chemistry
      Baltimore, Maryland, United States
  • 2006–2009
    • Korea University
      • Department of Pediatrics
      Sŏul, Seoul, South Korea
  • 2005–2006
    • The Australian Society of Otolaryngology Head & Neck Surgery
      Evans Head, New South Wales, Australia