[Show abstract][Hide abstract] ABSTRACT: To evaluate the antidiarrhoeal property of methanol extract of the leaves of Rauwolfia serpentina (R. serpentina) in experimental diarrhoea induced by castor oil in mice.
Doses of 100, 200 and 400 mg/kg R. serpentina leaf methanol extracts were administered to castor oil induced diarrhoea mice to determine its antidiarrhoeal activity.
All doses of the extract and the reference drug atropine sulphate (3 mg/kg, i.p.) produced a dose-dependent reduction in intestinal weight and fluid volume. The extracts also significantly reduced the intestinal transit in charcoal meal test when compared to diphenoxylate Hcl (5 mg/kg, p.o.).
The results show that the extract of R. serpentina leaves has a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.
Asian Pacific Journal of Tropical Biomedicine 06/2012; 2(6):430-2. DOI:10.1016/S2221-1691(12)60070-7
[Show abstract][Hide abstract] ABSTRACT: To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.
The methanol leaf extract of Pterocarpus erinaceus was evaluated using different doses (100, 200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea, charcoal meal transit time and castor oil-induced enteropooling in different groups of albino Wistar mice. The activity of the extract at different doses were compared to diphenoxylate (5 mg/kg) and atropine sulphate (3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice.
The extract at the doses used caused a significant (P< 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea, decreased the distance travelled by the charcoal meal by up to 54.8% and also caused a dose dependent and significant (P< 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling.
Our results indicate that Pterocarpus erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion.
Asian Pacific Journal of Tropical Medicine 02/2012; 5(2):147-50. DOI:10.1016/S1995-7645(12)60014-5 · 0.93 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The study was conducted to investigate the effect of egg size groupings from which keets were hatched had on the fertility, hatchability and early growth traits of two varieties of guinea fowl (Pearl and Lavender). The different egg sizes were in categories A (25g-36g), B (37g-47g) with corresponding average hatch weight of 26.19g and 31.67g respectively. A total of 360 day old keets of the two varieties generated from a base population of 120 adult guinea fowl were used in a factorial experiment in a randomized complete block design. Parameters measured include percent fertility and hatchability of the eggs, number of dead in shell, number of keets emerged, number piped, linear body traits and efficiency of production. Results showed that birds hatched from egg size group B had better fertility and hatchability in the two varieties. It was noted that fertility and hatchability were low at first batch of the eggs set and increased thereafter with Lavender guinea fowl having better fertility and hatchability. Result indicates significant difference in feed intake (FI) between egg size groupings and between guinea fowl varieties at week 5. Birds in egg size group B had significantly (P<0.05) heavier keets than in group A. Birds from egg size group B had lesser (P<0.05) feed conversion ratio than those from egg size group A suggesting that group B are more efficient in converting feed mass into increased body mass. Body weight showed significant (P<0.05) difference between the egg size grouping from 3 to 9 weeks, with B grouping showing higher values throughout the experimental period. However, no significant difference (P > 0.05) was noted in percent mortality and linear body traits. Body girth at week 3 and 9 showed significant difference P<0.05) between egg size grouping suggesting a high positive correlation between the two traits. It may be concluded that guinea fowl hatched from larger eggs have higher body weight and better production performance than those from smaller egg sizes. Breeders should select egg sizes of 37-47g for breeding in the humid tropics.