Jianjun Zhang

Publications (3)2.21 Total impact

• Article: Development and validation of a stability indicating HPLC method for the analysis of lornoxicam in powder for injection.

  Jianjun Zhang, Li Li, Yuan Gao, Weiming Fan
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  ABSTRACT: A rapid, isocratic stability indicating high performance liquid chromatographic method was developed and validated for the estimation of lornoxicam in its powder for injection. The analysis was performed on a Shimadzu VP-ODS (4. 6 mm x 15 cm, 5 µm) column. The mobile phase consisted of sodium acetate (pH 5.8; 0.05 M) and methanol (45:55) flowed at 1.0 ml/min. Detection was carried out at 290 nm. The developed method had the good ability to separate lornoxicam well from the degradation products. The regression data showed good linear relationship at the concentration range of 4.04-20.20 μ/mL with r(2)=0.9999. Specificity, linearity, accuracy, precision and robustness of the method were evaluated to validate the proposed method. Stressed degradation studies were conducted to provide an indication of its stability indicating property. The limits of detection and quantitation were 9.70 and 33.94 ng /ml, respectively. Lornoxicam was found to be stable in the mobile phase in 24 h. The co-existed excipients had no interference with the analytical procedure. Additional peaks appeared in the chromatograms of five kinds of forced degraded samples (light, heat, acid, base and oxidation degradation). Mean recovery assessed at three levels was from 99. 7 to 100.3%, indicating the good accuracy of the method. Repeatability and inter-day RSD of the method was determined to be 0.38% and 0.81%, respectively. The HPLC method was demonstrated to be robust for intentional minor changes of ratio, pH change, salt concentration and column temperature. The method should be utilized as the routine analysis and quality control of lornoxicam in injectable formulation.
  Pakistan journal of pharmaceutical sciences 04/2012; 25(2):371-5. · 1.10 Impact Factor
• Article: Simultaneous determination of triacetin, acetic ether, butyl acetate and amorolfine hydrochloride in amorolfine liniment by HPLC.

  Yuan Gao, Li Li, Jianjun Zhang, Wenjuan Shu, Liqiong Gao
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  ABSTRACT: A simple, rapid, specific and precise reversed-phase high-performance liquid chromatographic method was developed for simultaneous estimation of triacetin, acetic ether, butyl acetate and amorolfine in marketed pharmaceutical liniment. Chromatographic separation was performed on a Shimadzu VP-ODS C(18) column using the mixture of citric acid-hydrochloric acid-sodium hydrate buffer (pH 3.0), acetonitrile and methanol (32:30:38) as the mobile phase at a flow rate of 1.0 mL/min with UV-detection at 215 nm. The method separated the four components simultaneously in less than 10 min. The validation of the method was performed with respect to specificity, linearity, accuracy, and precision. The calibration curves were linear in the range of 35.1-81.9 μ/mL for triacetin, 431.1-1005.9 μ/mL for acetic ether, 167.0-389.7 μ/mL for butyl acetate and 151.0-352.3 μ/mL for amorolfine. The mean 100% spiked recovery for triacetin, acetic ether, butyl acetate and amorolfine is 99.43 ± 0.42, 101.5 ± 1.09, 101.4 ± 1.02 and 100.8 ± 0.69, respectively. The intra-day and inter-day relative standard deviation values were <2.0%. The limits of detection of these compounds ranged from 0.08 to 5.88 ng. The utility of the procedure was verified by its application to the commercial liniment.
  Pakistan journal of pharmaceutical sciences 04/2012; 25(2):389-94. · 1.10 Impact Factor
• Conference Proceeding: From the Logical Point of View: The Chain Store Paradox Revisited.

  Li Li, Robert C. Koons, Jianjun Zhang
  Logic, Rationality, and Interaction, Second International Workshop, LORI 2009, Chongqing, China, October 8-11, 2009. Proceedings; 01/2009