Sang Ho Kim

Soonchunhyang University, Onyang, Chungcheongnam-do, South Korea

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Publications (108)205.23 Total impact

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    ABSTRACT: Acetic acid has been shown to promote glycogen replenishment in skeletal muscle during exercise training. In this study, we investigated the effects of acetic acid on endurance capacity and muscle oxidative metabolism in the exercise training using in vivo mice model. In exercised mice, acetic acid induced a significant increase in endurance capacity accompanying a reduction in visceral adipose depots. Serum levels of non-esterified fatty acid and urea nitrogen were significantly lower in acetic acid-fed mice in the exercised mice. Importantly, in the mice, acetic acid significantly increased the muscle expression of key enzymes involved in fatty acid oxidation and glycolytic-to-oxidative fiber-type transformation. Taken together, these findings suggest that acetic acid improves endurance exercise capacity by promoting muscle oxidative properties, in part through the AMPK-mediated fatty acid oxidation and provide an important basis for the application of acetic acid as a major component of novel ergogenic aids.
    Bioscience Biotechnology and Biochemistry 05/2015; DOI:10.1080/09168451.2015.1034652 · 1.21 Impact Factor
  • 03/2015; 57(2):15-26. DOI:10.5389/KSAE.2015.57.2.015
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    ABSTRACT: Purpose Transient Horner’s syndrome is an uncommon complication of epidural anesthesia, though its exact incidence in thoracic epidural anesthesia is not clear. Therefore, this study prospectively evaluated the incidence of Horner’s syndrome after thoracic epidural anesthesia for mastectomy. Methods Patients scheduled for mastectomy, with or without breast reconstruction, were enrolled in this prospective observational study from September 2010 to December 2013. Intraoperative thoracic epidural anesthesia was established using 0.375% or 0.5% ropivacaine 15 mL with thoracic epidural analgesia continued postoperatively with a continuous infusion of 0.15% ropivacaine 2 mL·hr−1 with fentanyl 8 μg·hr−1. Signs of Horner’s syndrome (miosis, ptosis, and hyperemia) were assessed at one and two hours as well as one, two, and three days postoperatively. Results Thoracic epidural anesthesia was successful in 439 patients, with six (1.4%) of these patients acquiring Horner’s syndrome. All signs of Horner’s syndrome resolved gradually within 180 min of discontinuing the epidural infusion. In one patient with Horner’s syndrome, a radiographic contrast injection confirmed that the drug had spread to the cervical epidural level. Conclusion The incidence of Horner’s syndrome following thoracic epidural anesthesia and continuous thoracic epidural analgesia for mastectomy was 1.4%. The mechanism was consistent with cephalic spread of the epidural local anesthetic. This trial was registered at: Clinicaltrials.gov, number: NCT02130739.
    Canadian Journal of Anaesthesia 01/2015; 62(3). DOI:10.1007/s12630-014-0284-9 · 2.50 Impact Factor
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    ABSTRACT: This paper focuses on aerodynamic and inertial modeling of the propeller for its applications in flight dynamics analyses of a propeller-driven airplane. Unsteady aerodynamic and inertial loads generated by the propeller are formulated using the blade element method, where the local velocity and acceleration vectors for each blade element are obtained from exact kinematic relations for general maneuvering conditions. Vortex theory is applied to obtain the flow velocities induced by the propeller wake, which are used in the computation of the aerodynamic forces and moments generated by the propeller and other aerodynamic surfaces. The vortex lattice method is adopted to obtain the induced velocity over the wing and empennage components and the related influence coefficients are computed, taking into account the propeller induced velocities by tracing the wake trajectory trailing from each of the propeller blades. Aerodynamic forces and moments of the fuselage and other aerodynamic surfaces are computed by using the wind tunnel database and applying strip theory to incorporate viscous flow effects. The propeller models proposed in this paper are applied to predict isolated propeller performances under steady flight conditions. Trimmed level forward and turn flights are analyzed to investigate the effects of the propeller on the flight characteristics of a propeller-driven light-sports airplane. Flight test results for a series of maneuvering flights using a scaled model are employed to run the flight dynamic analysis program for the proposed propeller models. The simulations are compared with the flight test results to validate the usefulness of the approach. The resultant good correlations between the two data sets shows the propeller models proposed in this paper can predict flight characteristics with good accuracy.
    12/2014; 15(4):345-355. DOI:10.5139/IJASS.2014.15.4.345
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    ABSTRACT: This paper is the second in a series and aims to build a high-fidelity mathematical model for a propeller-driven airplane using the propeller's aerodynamics and inertial models, as developed in the first paper. It focuses on aerodynamic models for the fuselage, the main wing, and the stabilizers under the influence of the wake trailed from the propeller. For this, application of the vortex lattice method is proposed to reflect the propeller's wake effect on those aerodynamic surfaces. By considering the maneuvering flight states and the flow field generated by the propeller wake, the induced velocity at any point on the aerodynamic surfaces can be computed for general flight conditions. Thus, strip theory is well suited to predict the distribution of air loads over wing components and the viscous flow effect can be duly considered using the 2D aerodynamic coefficients for the airfoils used in each wing. These approaches are implemented in building a high-fidelity mathematical model for a propeller-driven airplane. Flight dynamic analysis modules for the trim, linearization, and simulation analyses were developed using the proposed techniques. The flight test results for a series of maneuvering flights with a scaled model were used for comparison with those obtained using the flight dynamics analysis modules to validate the usefulness of the present approaches. The resulting good correlations between the two data sets demonstrate that the flight characteristics of the propeller-driven airplane can be analyzed effectively through the integrated framework with the propeller and airframe aerodynamic models proposed in this study.
    12/2014; 15(4):356-365. DOI:10.5139/IJASS.2014.15.4.356
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    Korean journal of anesthesiology 12/2014; 67(Suppl):S51-2. DOI:10.4097/kjae.2014.67.S.S51
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    ABSTRACT: Transverse abdominis plane (TAP) block can be recommended as a multimodal method to reduce postoperative pain in laparoscopic abdominal surgery. However, it is unclear whether TAP block following local anesthetic infiltration is effective. We planned this study to evaluate the effectiveness of the latter technique in laparoscopic totally extraperitoneal hernia repair (TEP). We randomly divided patients into two groups: the control group (n = 37) and TAP group (n = 37). Following the induction of general anesthesia, as a preemptive method, all of the patients were subjected to local anesthetic infiltration at the trocar sites, and the TAP group was subjected to ultrasound-guided bilateral TAP block with 30 ml of 0.375% ropivacaine in addition before TEP. Pain was assessed in the recovery room and post-surgery at 4, 8, and 24 h. Additionally, during the postoperative 24 h, the total injected dose of analgesics and incidence of nausea were recorded. On arrival in the recovery room, the pain score of the TAP group (4.33 ± 1.83) was found to be significantly lower than that of the control group (5.73 ± 2.04). However, the pain score was not significantly different between the TAP group and control group at 4, 8, and 24 h post-surgery. The total amounts of analgesics used in the TAP group were significantly less than in the control group. No significant difference was found in the incidence of nausea between the two groups. TAP block following local infiltration had a clinical advantage only in the recovery room.
    Korean journal of anesthesiology 12/2014; 67(6):398-403. DOI:10.4097/kjae.2014.67.6.398
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    Sang Ho Kim, Rekha Jakhar, Sun Chul Kang
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    ABSTRACT: Mushrooms are known to complement chemotherapy and radiation therapy by countering the side effects of cancer. Recently, there has been great interest in isolation of novel bioactive compounds from mushrooms due to their numerous health beneficial effects. Chemically water-extractable polysaccharide (MFKF-AP1β), with a molecular weight of 12 kDa, was isolated from fruiting bodies of mushroom Fomes fomentarius. In this research, we investigated the anti-tumor effects of MFKF-AP1β on human lung carcinoma A549 cells. Results showed that MFKF-AP1β markedly inhibited A549 cell growth in a dose-dependent manner based on the amount of lactate dehydrogenase (LDH) released and morphological alterations. In addition, MFKF-AP1β induced cellular apoptosis by causing single-stranded DNA breakage, as evidenced by apoptosis assay. Furthermore, MFKF-AP1β (25–100 μg/ml) significantly induced single-stranded DNA breakage in A549 cells, as shown by comet assay. Taken together, our results demonstrate that MFKF-AP1β has strong anti-tumor effects mediated through induction of apoptosis. Therefore, MFKF-AP1β could be useful in lung chemotherapy.
    Saudi Journal of Biological Sciences 11/2014; 11(4). DOI:10.1016/j.sjbs.2014.11.022 · 0.74 Impact Factor
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    ABSTRACT: Background Neck and shoulder pain is fairly common among adolescents in Korea and results in significant health problem. The aims of this prospective study was to identify the effects of education, in terms of recognition of this issue and posture correction, on prevalence and severity of neck and shoulder pain in Korean adolescents. Methods A prospective, observational cohort design was used. The 912 students from two academic high schools in the city of Seoul were eligible for the current study and 887 completed this study. After a baseline cross-sectional survey, students listened to a lecture about cervical health, focusing on good posture, habits, and stretching exercises to protect the spine, and were encouraged by their teachers to keep the appropriate position. And follow-ups were conducted 3 months later, to evaluate the effect of education. Results The prevalence of neck and shoulder pain was decreased 19.5% (from 82.5 to 66.4%). The baseline mean usual and worst numeric rating scale were 19.9/100 (95% CI, 18.1-21.7) and 31.2/100 (95% CI, 28.7-33.2), respectively. On the follow-up survey, the mean usual and worst numeric rating scale were decreased significantly by 24.1 and 21.7%, respectively, compared with baseline (P < 0.01). Of the 570 students reporting neck and shoulder pain, 16.4% responded that they had experienced improvement during the 3 months. Conclusions Education; recognition of this issue and posture correction, for cervical health appeared to be effective in decreasing the prevalence and severity of neck and shoulder pain at a 3 month follow-up.
    Korean journal of anesthesiology 09/2014; 67(3):198-204. DOI:10.4097/kjae.2014.67.3.198
  • Journal of Korea Water Resources Association 08/2014; 47(8):717-728. DOI:10.3741/JKWRA.2014.47.8.717
  • Journal of Korea Water Resources Association 06/2014; 47(6):561-572. DOI:10.3741/JKWRA.2014.47.6.561
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    ABSTRACT: Purpose To evaluate the risk factors of hepatocellular carcinoma (HCC) extension into the right atrium (RA) and determine poor prognostic factors for HCC extension to the heart. Materials and Methods A total of 665 patients who were newly diagnosed with HCC were analyzed retrospectively from January 2004 to July 2012. The patients were divided into two groups: 33 patients with HCC extending into the RA and 632 HCC patients during the same period. The patients with HCC extending into the RA were subdivided into shorter survival group (<2 months) and longer survival group (≥2 months). Results The prevalence of HCC extending to the RA was 4.96%. In multivariate analysis, a modified Union Internationale Contre le Cancer (UICC) stage higher than IVA, hepatic vein invasion, concomitant inferior vena cava and portal vein invasion, and multinodular tumor type were risk factors for HCC extending to the RA. In multivariate analysis, Cancer of the Liver Italian Program (CLIP) score >3 (p=0.016, OR: 13.89) and active treatment (p=0.024, OR: 0.054) were associated with prognostic factors in patients HCC extending into the RA. Active treatment such as radiation (n=1), transcatheter arterial chemoembolization (TACE) (n=11), Sorafenib (n=1), and combined modalities (n=2) were performed. Conclusion Modified UICC stage higher than IVA, vascular invasion and multinodular tumor type are independent risk factors for HCC extending to the RA. Active treatment may prolong survival in patients HCC extending into the RA.
    Yonsei medical journal 03/2014; 55(2):379-86. DOI:10.3349/ymj.2014.55.2.379 · 1.26 Impact Factor
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    ABSTRACT: Conventional biomarkers cannot always establish the cause of pleural effusions; thus, alternative tests permitting rapid and accurate diagnosis are required. The primary aim of this study is to assess the ability of pentraxin-3 (PTX3) in order to diagnose the cause of pleural effusion and compare its efficacy to that of other previously identified biomarkers. We studied 118 patients with pleural effusion, classified as transudates and exudates including malignant, tuberculous, and parapneumonic effusions (MPE, TPE, and PPE). The levels of PTX3, C-reactive protein (CRP), procalcitonin (PCT) and lactate in the pleural fluid were assessed. The levels of pleural fluid PTX3 were significantly higher in patients with PPE than in those with MPE or TPE. PTX3 yielded the most favorable discriminating ability to predict PPE from MPE or TPE by providing the following: area under the curve, 0.74 (95% confidence interval, 0.63-0.84), sensitivity, 62.07%; and specificity, 81.08% with a cut-off point of 25.00 ng/mL. Our data suggests that PTX3 may allow improved differentiation of PPE from MPE or TPE compared to the previously identified biomarkers CRP and PCT.
    Tuberculosis and Respiratory Diseases 12/2013; 75(6):244-9. DOI:10.4046/trd.2013.75.6.244
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    ABSTRACT: The purpose of this study is to evaluate the suspended solids and eutrophication processes relationships in Chungju lake using CE-QUAL-W2, two-dimensional (2D) longitudinal/vertical hydrodynamic and water quality model. For water quality modeling, the lake segmentation was configured as 7 branches system according to their shape and tributary distribution. The model was calibrated (2010) and validated (2008) using 2 years of field data of water temperature, suspended solids (SS), total nitrogen (TN), total phosphorus (TP) and algae (Chl-a). The water temperature began to increase in depth from April and the stratification occurred at about 10 m early July heavy rain. The high SS concentration of the interflow density currents entering from the watershed was well simulated especially for July 2008 heavy rainfall event. The simulated concentration range of TN and TP was acceptable, but the errors might occur form the poor reflection for sedimentation velocity of nitrogen component and adsorption-sediment of phosphorus in model. The concentration of Chl-a was simulated well with the algal growth patterns in summer of 2010 and 2008, but the error of under estimation may come from the use of width-averaged velocity and concentration, not considering the actual to one side inclination by wind effect.
    Journal of Korea Water Resources Association 11/2013; 46(11). DOI:10.3741/JKWRA.2013.46.11.1115
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    ABSTRACT: This study is to evaluate the use of dual-polarization radar data for storm runoff modeling in Namgang dam (2,293 ) watershed using KIMSTORM (Grid-based KIneMatic wave STOrm Runoff Model). The Bisl dual-polarization radar data for 3 typhoons (Khanun, Bolaven, Sanba) and 1 heavy rain event in 2012 were obtained from Han River Flood Control Office. Even the radar data were overall less than the ground data in areal average, the spatio-temporal pattern between the two data was good showing the coefficient of determination () and bias with 0.97 and 0.84 respectively. For the case of heavy rain, the radar data caught the rain passing through the ground stations. The KIMSTORM was set to m resolution and a total of 21,372 cells (156 rows137 columns) for the watershed. Using 28 ground rainfall data, the model was calibrated using discharge data at 5 stations with , Nash and Sutcliffe Model Efficiency (ME) and Volume Conservation Index (VCI) with 0.85, 0.78 and 1.09 respectively. The calibration results by radar rainfall showed , ME and VCI were 0.85, 0.79, and 1.04 respectively. The VCI by radar data was enhanced by 5 %.
    11/2013; 55(6). DOI:10.5389/KSAE.2013.55.6.019
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    ABSTRACT: Duodenal neuroendocrine tumors (NETs) are rare neoplasms. In this study, the medical records of 14 patients with duodenal NETs diagnosed at Chonnam National University Hospital from July 2001 to August 2011 were reviewed and analyzed retrospectively. Four patients were diagnosed in the first 5 years, and 10 patients were diagnosed in the latter 5 years of the study. Ten of 12 patients (83.3%) who underwent endoscopic biopsy were confirmed to have NET before resection. Endoscopic resection was performed in 12 patients, surgical resection in one patient, and regular follow-up in one patient who refused resection. None of the patients showed recurrence or distant metastasis. Duodenal NETs are increasingly observed and are mostly detected during screening upper gastrointestinal endoscopy. Careful endoscopic examination and biopsy can improve the diagnostic yield of NETs. Most well-differentiated, nonfunctional duodenal NETs that are limited to the mucosa/submucosa can be treated effectively with endoscopic resection.
    11/2013; 46(6):656-61. DOI:10.5946/ce.2013.46.6.656
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    ABSTRACT: Aim: To evaluate the factors predicting for recurrence and to analyze survival of patients with hepatocellular carcinoma (HCC). A total of 743 patients who were consecutively diagnosed and treated with HCC were retrospectively analyzed from January 2004 to December 2012 at our institution. We analyzed their survival and tumor recurrence. On multivariate analysis, age >50 years, CLIP score <3, ALP <120 U/l, LDH <450 IU/l, CRP <0.8 mg/dl, tumor size <6 cm, no distant metastasis, and curative treatment modality were predictors for 1-year survival. CRP <0.8 mg/dl, Child-Pugh score <7, curative treatment modality and tumor size <6 cm were predictors for 3-year survival. Absence of vascular invasion and uninodular tumor type were predictors for 5-year survival. Multinodular tumor, tumor size >4 cm, and palliative treatment were independent risk factors for 1-year recurrence after initial treatment. This large study provides a comprehensive overview of the survival outcomes and prognostic factors regarding HCC, according to clinical characteristics, various treatment modalities, and the results will help in the selection of effective treatment strategies future.
    Anticancer research 09/2013; 33(9):4129-4134. · 1.87 Impact Factor
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    ABSTRACT: Chalcones are known to act on various physiological targets. As a result, structural modifications of chalcones have been studied extensively. Benzochalcones, in which the A-ring of chalcone is substituted with a naphthalene unit, inhibits breast cancer resistance protein. Chalcones in which the α,β-unsaturated carbonyl group is switched with a pyrazoline moiety are potent cytotoxic agents against various cancer cell lines, and chalcones with a pyrazoline-1-carbothioamide group instead of an α,β-unsaturated carbonyl group exhibit antimicrobial activities. The present report describes hybrid molecules designed from benzochalcone and pyrazoline-carbothioamide. Methoxylation of plant-derived polyphenols alters their hydrophobicity, resulting in changes in biological function and intracellular compartmentation. In the current study, 22 novel methoxylated 3-(naphthalen-2-yl)-N,5-diphenyl-pyrazoline-1-carbothioamide derivatives were prepared. This report provides complete assignments of their (1) H and (13) C NMR data, which can be used to subsequently identify chalcones bearing pyrazoline-carbothioamide groups. Copyright © 2013 John Wiley & Sons, Ltd.
    Magnetic Resonance in Chemistry 08/2013; 51(8). DOI:10.1002/mrc.3971 · 1.56 Impact Factor
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    ABSTRACT: The objective of this study was to investigate the effects of administration methods for on Garcinia cambogia on blood Garcinia cambogia concentration and antioxidative levels. Rats were divided into three groups: G1 (normal group), G2 (one administration of Garcinia cambogia extract 2,800 mg/kg b.w.), G3 (three separate administrations every 6 h of Garcinia cambogia extract 750, 850, and 1,200 mg/kg b.w. for 18 h). Blood samples were collected every hour, and animals sacrificed 18 h after the oral administration of Garcinia cambogia extract. We examined changes in the serum concentration of Garcinia cambogia by HPLC analysis. Two hours following an oral administration of Garcinia cambogia extract (2,800 mg/kg b.w.), serum Garcinia cambogia levels reached their maximum, but gradually decreased until 10 hours when it was no longer detectable. In contrast, serum Garcinia cambogia levels under G3 administration were maintained above a certain level after 18 h. To determine whether this level of Garcinia cambogia could affect blood oxidative levels, we measured serum lipid peroxidation by TBARS levels. TBARS levels from G3 treatment were significantly lower than G1 and G2. To analyze other antioxidative activities, radical scavenging activities were measured by the DPPH and ABTS radical scavenging assays. There were no significant differences between the groups in DPPH radical scavenging activity. However, ABTS radical scavenging activity significantly increased with G3 treatment compared with G1 and G2. In conclusion, our data show that three times administration of Garcinia cambogia every 6 h may helpful for maintaining serum Garcinia cambogia levels and antioxidative effects.
    Journal of the Korean Society of Food Science and Nutrition 06/2013; 42(6). DOI:10.3746/jkfn.2013.42.6.856
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    ABSTRACT: The opioid sparing effect of low dose ketamine is influenced by bolus dose, infusion rate, duration of infusion, and differences in the intensity of postoperative pain. In this study, we investigated the opioid sparing effect of low dose ketamine in patients with intravenous patient-controlled analgesia (PCA) using fentanyl after lumbar spinal fusion surgery, which can cause severe postoperative pain. Sixty patients scheduled for elective lumbar spinal fusion surgery were randomly assigned to receive one of three study medications (K1 group: ketamine infusion of 1 µg/kg/min following bolus 0.5 mg/kg, K2 group: ketamine infusion of 2 µg/kg/min following bolus 0.5 mg/kg, Control group: saline infusion following bolus of saline). Continuous infusion of ketamine began before skin incision intraoperatively, and continued until 48 h postoperatively. For postoperative pain control, patients were administered fentanyl using IV-PCA (bolus dose 15 µg of fentanyl, lockout interval of 5 min, no basal infusion). For 48 h postoperatively, the total amount of fentanyl consumption, postoperative pain score, adverse effects and patients' satisfaction were evaluated. The total amount of fentanyl consumption was significantly lower in the K2 group (474 µg) compared to the control group (826 µg) and the K1 group (756 µg) during the 48 h after surgery. Pain scores at rest or with movement, the incidence of adverse events and patient satisfaction were not significantly different among the groups. Low-dose ketamine at 2 µg/kg/min following bolus 0.5 mg/kg significantly reduced the total amount of fentanyl consumption during the 48 h after lumbar spinal fusion surgery without increasing adverse effects.
    Korean journal of anesthesiology 06/2013; 64(6):524-8. DOI:10.4097/kjae.2013.64.6.524

Publication Stats

2k Citations
205.23 Total Impact Points

Institutions

  • 2010–2015
    • Soonchunhyang University
      • College of Medicine
      Onyang, Chungcheongnam-do, South Korea
  • 2014
    • Konkuk University
      • Department of Aerospace Information Engineering
      Sŏul, Seoul, South Korea
  • 2007–2014
    • Daegu University
      • • Department of Biotechnology
      • • Department of Journalism and Mass Communication
      Daikyū, Daegu, South Korea
  • 2010–2013
    • Dong-A University
      • Department of Neurology
      Tsau-liang-hai, Busan, South Korea
  • 2009–2013
    • National Institute of Animal Science
      Sŏul, Seoul, South Korea
  • 2007–2013
    • Chonnam National University
      • • Department of Gastroenterology
      • • Department of Internal Medicine
      Gwangju, Gwangju, South Korea
  • 2002–2013
    • Catholic University of Korea
      • Department of Pathology
      Sŏul, Seoul, South Korea
  • 2011
    • Seoul National University of Science and Technology
      Sŏul, Seoul, South Korea
  • 2004–2011
    • Korea University of Technology and Education
      Changnyeong, Gyeongsangnam-do, South Korea
    • Sejong University
      • Department of Electronic Engineering
      Sŏul, Seoul, South Korea
    • Kyushu University
      • Department of Clinical Chemistry and Laboratory Medicine
      Hukuoka, Fukuoka, Japan
  • 2005
    • Kyungpook National University
      • Computer System Engineering
      Daikyū, Daegu, South Korea
    • Wonkwang University
      Riri, North Jeolla, South Korea
    • Chungbuk National University
      Chinsen, North Chungcheong, South Korea
  • 1998
    • Chonbuk National University
      Tsiuentcheou, North Jeolla, South Korea
  • 1994
    • University of Seoul
      Sŏul, Seoul, South Korea
  • 1991–1992
    • Korea Advanced Institute of Science and Technology
      • Department of Materials Science and Engineering
      Seoul, Seoul, South Korea
  • 1989
    • Electronics and Telecommunications Research Institute
      • Components and Materials Research Laboratory
      Sŏul, Seoul, South Korea