Brian L. Pearlman

Publications (3)0 Total impact

• Article: Coordinated evolution among hepatitis C virus genomic sites is coupled to host factors and resistance to interferon.

  James Lara, John E Tavis, Maureen J Donlin, William M Lee, He-Jun Yuan, Brian L Pearlman, Gilberto Vaughan, Joseph C Forbi, Guo-Liang Xia, Yury E Khudyakov
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  ABSTRACT: Machine-learning methods in the form of Bayesian networks (BN), linear projection (LP) and self-organizing tree (SOT) models were used to explore association among polymorphic sites within the HVR1 and NS5a regions of the HCV genome, host demographic factors (ethnicity, gender and age) and response to the combined interferon (IFN) and ribavirin (RBV) therapy. The BN models predicted therapy outcomes, gender and ethnicity with accuracy of 90%, 90% and 88.9%, respectively. The LP and SOT models strongly confirmed associations of the HVR1 and NS5A structures with response to therapy and demographic host factors identified by BN. The data indicate host specificity of HCV evolution and suggest the application of these models to predict outcomes of IFN/RBV therapy.
  In silico biology 01/2012; 11(5):213-24.
• Source

  Available from: Lilia Ganova-Raeva

  Conference Proceeding: Assessments of intra- and inter-host diversity of hepatitis C virus using Next Generation Sequencing and Mass spectrometry.

  Zoya Dimitrova, David S. Campo, Sumathi Ramachandran, Gilberto Vaughan, Lilia Ganova-Raeva, Yulin Lin, Joseph C. Forbi, Guo-liang Xia, Pavel Skums, Brian L. Pearlman, Yuri Khudyakov
  2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW), Atlanta, GA, USA, November 12-15, 2011; 01/2011
• Conference Proceeding: Host-specific HCV evolution and response to the combined interferon and ribavirin therapy.

  James Lara, John E. Tavis, Maureen J. Donlin, William M. Lee, He-Jun Yuan, Brian L. Pearlman, Gilberto Vaughan, Joseph C. Forbi, Guo-liang Xia, Yuri Khudyakov
  2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW), Atlanta, GA, USA, November 12-15, 2011; 01/2011