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ABSTRACT: We demonstrate image signal transmission for wireless intra-brain communication. As a preliminary experiment, transmission characteristics of the brain phantom were measured. The baseband output signal from an implantable complementary metal-oxide-semiconductor (CMOS) image sensor is transmitted through the phantom. The image was successfully reproduced from the received signal.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 08/2012; 2012:6011-4.
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Takuma Kobayashi,
Mayumi Motoyama,
Hiroyuki Masuda,
Yasumi Ohta,
Makito Haruta,
Toshihiko Noda,
Kiyotaka Sasagawa,
Takashi Tokuda,
Hideki Tamura,
Yasuyuki Ishikawa,
Sadao Shiosaka,
Jun Ohta
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ABSTRACT: Techniques for fast, noninvasive measurement of neuronal excitability within a broad area will be of major importance for analyzing and understanding neuronal networks and animal behavior in neuroscience field. In this research, a novel implantable imaging system for fluorescence potentiometry was developed using a complementary metal-oxide semiconductor (CMOS) technology, and its application to the analysis of cultured brain slices and the brain of a living mouse is described. A CMOS image sensor, small enough to be implanted into the brain, with light-emitting diodes and an absorbing filter was developed to enable real-time fluorescence imaging. The sensor, in conjunction with a voltage-sensitive dye, was certainly able to visualize the potential statuses of neurons and obtain physiological responses in both right and left visual cortex simultaneously by using multiple sensors for the first time. This accomplished multiplanar and multipoint measurement provides multidimensional information from different aspects. The light microsensors do not disturb the animal behavior. This implies that the imaging system can combine functional fluorescence imaging in the brain with behavioral experiments in a freely moving animal.
Biosensors & bioelectronics 06/2012; 38(1):321-30. · 5.43 Impact Factor
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Arata Nakajima,
Hiroshi Kimura,
Yosmongkol Sawadsaringkarn,
Yasuyo Maezawa, Takuma Kobayashi,
Toshihiko Noda,
Kiyotaka Sasagawa,
Takashi Tokuda,
Yasuyuki Ishikawa,
Sadao Shiosaka,
Jun Ohta
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ABSTRACT: We developed a complementary metal oxide semiconductor (CMOS) integrated device for optogenetic applications. This device can interface via neuronal tissue with three functional modalities: imaging, optical stimulation and electrical recording. The CMOS image sensor was fabricated on 0.35 μm standard CMOS process with built-in control circuits for an on-chip blue light-emitting diode (LED) array. The effective imaging area was 2.0 × 1.8 mm². The pixel array was composed of 7.5 × 7.5 μm² 3-transistor active pixel sensors (APSs). The LED array had 10 × 8 micro-LEDs measuring 192 × 225 μm². We integrated the device with a commercial multichannel recording system to make electrical recordings.
Optics Express 03/2012; 20(6):6097-108. · 3.59 Impact Factor
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ABSTRACT: We demonstrate wireless image data transmission through a mouse brain. The transmission characteristics of mouse brain is measured. By inserting electrodes into the brain, the transmission efficiency is drastically increased. An AM signal modulated with the image data from an implantable image sensor was launched into the brain and the received signal was demodulated. The data was successfully transmitted through the brain and the image was reproduced.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 08/2011; 2011:2917-20.
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IEEE/IFIP 19th International Conference on VLSI and System-on-Chip, VLSI-SoC 2011, Kowloon, Hong Kong, China, October 3-5, 2011; 01/2011
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IEICE Transactions. 01/2011; 94-B:2454-2460.
