Yong Cheng Poh

Publications (2)2.28 Total impact

• Source

  Available from: edu.sg

  Article: A Preliminary Model of Gastrointestinal Electromechanical Coupling

  Peng Du, Yong Cheng Poh, Jee Lean Lim, V. Gajendiran, G. OrGrady, M.L. Buist, A.J. Pullan, L.K. Cheng
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  ABSTRACT: Gastrointestinal (GI) motility is coordinated by several cooperating mechanisms, including electrical slow wave activity, the enteric nervous system (ENS), and other factors. Slow waves generated in interstitial cells of Cajal (ICC) depolarize smooth muscle cells (SMC), generating basic GI contractions. This unique electrical coupling presents an added layer of complexity to GI electromechanical models, and a current barrier to further progress is the lack of a framework for ICC-SMC-contraction coupling. In this study, an initial framework for the electromechanical coupling was developed in a 2-D model. At each solution step, the slow wave propagation was solved first and in the SMC model was related to a -tension-extension relationship to simulate active contraction. With identification of more GI-specific constitutive laws and material parameters, the ICC-SMC-contraction approach may underpin future GI electromechanical models of health and disease states.
  IEEE Transactions on Biomedical Engineering 01/2012; · 2.28 Impact Factor
• Article: A Preliminary Model of Gastrointestinal Electromechanical Coupling.

  Peng Du, Yong Cheng Poh, Jee Lean Lim, Viveka Gajendiran, Greg O'Grady, Martin L. Buist, Andrew J. Pullan, Leo K. Cheng
  IEEE Trans. Biomed. Engineering. 01/2011; 58:3491-3495.