A. Toledano

Publications (3)1.21 Total impact

• Article: Objective Assessment of Olfactory Function Using Functional Magnetic Resonance Imaging (fMRI)

  S. Borromeo, J.A. Hernandez-Tamames, G. Luna, F. Machado, N. Malpica, A. Toledano
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  ABSTRACT: Impairment of the olfactory sensibility can be an indicator of neurode generative disorders, such as Alzheimer's disease and Parkinson's disease. The problem lies in obtaining an objective quantitative analysis of olfactory response. For this task, we will use functional magnetic resonance imaging (fMRI) and a device that will provide a selective and controlled stimulation of the olfactory system. The novel issues of our design are synchronization between the acquisition and the olfactory task, and automated control of experimental parameters, odorants sequences, and frequency. We present a review of the basic fMRI experimental design of event-related stimulus paradigms versus block design experiments, and their use in olfactory experiments. Finally, we present the preliminary results obtained on a real 3-T magnetic resonance imaging (MRI) scanner.
  IEEE Transactions on Instrumentation and Measurement 11/2010; · 1.21 Impact Factor
• Article: Objective Assessment of Olfactory Function Using Functional Magnetic Resonance Imaging (fMRI).

  Susana Borromeo, Juan Antonio Hernández Tamames, G. Luna, F. Machado, Norberto Malpica, A. Toledano
  IEEE T. Instrumentation and Measurement. 01/2010; 59:2602-2608.
• Source

  Available from: urjc.es

  Conference Proceeding: Objetive assessment of olfactory function using functional magnetic resonance (fMRI)

  S. Borromeo, J.A. Hernandez-Tamames, G. Luna, F. Machado, N. Malpica, A. Toledano
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  ABSTRACT: In this work, a device for generating automated olfactory stimuli in functional magnetic resonance imaging (fMRI) studies is described. The novel issues of our design are: synchronization between the acquisition and the olfactory task, automated control of experimental parameters (odorants sequences, frequency, time and concentration of stimuli). Finally, we present the preliminary results obtained on a General Electric 3 Tesla MRI scanner belong to The Alzheimer Project of the Fundacion Reina Sofia.
  Medical Measurements and Applications, 2009. MeMeA 2009. IEEE International Workshop on; 06/2009