Yun Zhang

Guilin University of Technology, Ling-ch’uan, Guangxi Zhuangzu Zizhiqu, China

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Publications (532)1583.21 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: We demonstrated the distinguishing between plasmonic absorption modes by exploiting an inversed architecture with tunable atomic-layer-deposited dielectric spacer layer. The dielectric spacer layer was manipulated between the bottom metal-nanoparticle monolayer and the upper metal film to inspect the contributions of metal nanoparticles and dielectric film in a step-by-step manner. The experimental and simulated differences between the two peak absorption positions (Δf) and between the corresponding half width at half maxima (Δw) confirmed the evolutions of gap plasmon and interference-enhanced local surface plasmon resonance absorption modes in the plasmonic metamaterial absorbers (PMAs), which were useful for understanding the underlying mechanism of amorphous PMAs.
    Nanotechnology 12/2014; 25(50):504004. · 3.84 Impact Factor
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    ABSTRACT: Diverse single crystalline spinel LiMn2O4 cathode materials are prepared deriving from spherical and cubic MnCO3 as precursors obtained by a general pH-mediated chemical precipitation approach. With careful pre-controls over the particle properties of MnCO3 precursors upon pH adjustment, five LiMn2O4 samples with average size of 0.5-1.0 μm are prepared. Among these samples, the LiMn2O4 prepared at pH value of 7.0 exhibits a well-defined truncated octahedral crystal structure, in which most surfaces are aligned to the {111} crystalline orientations with minimal Mn dissolution, while a small portion of the structure is truncated along the {110} orientations to support Li diffusion. Benefiting from the unique crystal structure, the synthesized LiMn2O4 as cathode manifests superior rate capability and prolonged cycle stability, especially at elevated temperatures: the capacity retention of 86.7% after 1000 cycles at 5C under 25 ºC and of 80.7% after 250 cycles with 1C under 55 ºC. These results demonstrate that the morphology of MnCO3 precursor prepared by precipitation method has a significant influence on the crystal structure and electrochemical properties of resultant LiMn2O4. The work described here also shows a great potential in practical industrial application toward developing high performance LiMn2O4 electrode materials for lithium ion batteries.
    J. Mater. Chem. A. 12/2014;
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    ABSTRACT: We describe the darkening and re-brightening photoluminescence (PL) of colloidal quantum dots (CQDs) in an aqueous environment with high proton concentration (i.e., low pH value). The PL intensity of CQDs suffers obvious decay in severe acidic condition, and can be enhanced again by an excitation of ultraviolet (UV) irradiation. Proton concentration and inorganic capping layer are responsible for dominating the proton-initiated darkening and UV-irradiated re-brightening PL processes of CQDs. A faster variation ratio of PL quantum yield (QY) than PL lifetime is revealed in the temporal decay of PL by steady state and time-resolved spectra.
    Journal of Nanoengineering and Nanomanufacturing. 12/2014; 4(4).
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    ABSTRACT: Silicon nanowire (SiNW) arrays with controllable size were fabricated by an Au catalyzed chemical etching combined with colloidal lithography. The diameter, center-to-center distance and interspacing of SiNWs can be controlled by the original size of polystyrene (PS) spheres and plasma etching parameters while the length of SiNWs can be easily tuned by the etching duration. Compared with polished silicon, the SiNW arrays show excellent antireflection property due to their multiple scattering or light trapping effects. A coating of aluminum-doped zinc oxide (AZO) film by atomic layer deposition (ALD), especially thicker AZO film, can further alleviate reflection over a wide wavelength range. The average reflectance of the SiNW arrays decreases from 14.0% to 2.7% in the wavelength range 400∼850 nm after a coating of ∼50 nm AZO. The investigations on the SiNWs coated by AZO film can provide helpful guideline for the design of nanowire based cells.
    Journal of Nanoengineering and Nanomanufacturing. 12/2014; 4(4).
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    ABSTRACT: ANXA7 interacts with TIA1 in COS7 cells and HUVECs.•ABO promotes the interaction between TIA1 and ANXA7 and inhibits TIA1 phosphorylation.•ANXA7 modulates TIA1 phosphorylation.•TIA1 is involved in ANXA7-mediated autophagy.•Inhibition of TIA1 phosphorylation by ABO increases the levels of FLJ11812 and ATG13, and then promotes autophagy.
    The International Journal of Biochemistry & Cell Biology. 12/2014; 57.
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    ABSTRACT: The 3'UTR-associated RNAs (uaRNAs) have important roles in various biological processes, especially in development. However, because they overlap with protein-coding mRNAs, uaRNAs are difficult to study by RNA interference techniques. We recently identified a chemical molecule, 3BDO, that could induce hESCs differentiation, meanwhile selectively and efficiently downregulate the uaRNA FLJ11812. By acting as a competing endogenous RNA, downregulated FLJ11812 by 3BDO further increased miR-4459 level in hESCs. miR-4459 could decrease the expression of its targets, CDC20B, LARP1 and ATG13, and thus altered stemness via cell cycle, mRNA stability and autophagy. Our results revealed that FLJ11812 played a key role in maintenance of stemness of hESCs for the first time. The findings provide new clues and a powerful tool for investigating the action mechanism of FLJ11812 in early development.
    Stem cells and development. 12/2014;
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    ABSTRACT: Cerium fluoride (CeF3) coated lithium-rich layered Li1.2Mn0.54Ni0.13Co0.13O2 particles are synthesized using a facile chemical deposition route. The structural and electrochemical properties of pristine and CeF3-coated electrodes are investigated by X-ray diffraction (XRD), thermogravimetric-differential scanning calorimetry (TG-DSC), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), galvanostatic charge/discharge tests, electrochemical impedance spectra (EIS) and cyclic voltammetry (CV). The results indicate that the cathode particles are uniformly covered with a CeF3 layer (∼10 nm thick) after 2 wt.% CeF3 surface coating. The coated electrode shows an enhanced initial coulombic efficiency of 80.8% compared to 75.2% for the pristine electrode. Moreover, the coated electrode demonstrates better cyclic performance, which exhibits capacity retention of 91.7% after 50 cycles compared with only 82.1% for the pristine one. Furthermore, the CeF3-coated electrode delivers a superior high-rate capacity of 103.1 mAh g-1 at 5C, higher than 82.2 mAh g-1 for the pristine one. The remarkably improved cycling stability and high-rate capacity of the surface-modified electrode is ascribed to the presence of a stable and thin CeF3 coating layer which effectively reduces the damage of electrode structure and suppresses the increase of impedance during cycling by preventing direct contact of electrode with electrolyte.
    Journal of Power Sources 11/2014; 267. · 5.26 Impact Factor
  • International journal of cardiology. 11/2014; 181C:8-10.
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    ABSTRACT: Group I metabotropic glutamate receptors, mGluR1 and mGluR5, are associated with sympathetic nerve activity. Sympathetic nerve stimulation exerts a crucial effect on modulating phosphorylation status and distribution of connexin43 (Cx43) in rat heart. Hence, mGluR1 and mGluR5 have an indirect effect on regulating the function of gap junction channels, which is affected by the availability of Cx43 protein. Additionally, it has been demonstrated that mGluR1/5 are present in ventricular myocardium in particular intercalated disks where Cx43 is the principal component of ventricular gap junction channels. We, therefore, hypothesized that mGluR1/5 might regulate Cx43 phosphorylation and gap junctional intercellular communication (GJIC) directly, independent of sympathetic nerve stimulation. After documenting the presence of mGluR1 and mGluR5 in H9c2 cardiomyoblast cells, addition of the selective mGluR1/5 agonist (S)-3,5-dihydroxyphenylglycine hydrate (DHPG) induced Cx43 phosphorylation and GJIC inhibition in both concentration- and time-dependent manner. The effects of DHPG were abolished by the mGluR1 antagonist LY367385 and the specific inhibitor of MEK1, PD98059 which also reduced phosphorylation of extracellular-signal-regulated protein kinase 1/2 (ERK1/2); but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride or the selective inhibitor of protein kinase C (PKC). In conclusion, in H9c2 cardiomyoblast cells mGluR1 increases Cx43 phosphorylation level and suppresses GJIC involving ERK1/2 but not PKC.
    Molecular and Cellular Biochemistry 11/2014; · 2.33 Impact Factor
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    ABSTRACT: Adiponectin (APN) is an important anti‑atherogenic adipocytokine. The aim of the present study was to investigate the role of adiponectin in atherosclerotic plaque formation and clarify its mechanisms. An atherosclerosis model was induced by in vivo perivascular constrictive silica collar placement on the left common carotid arteries in male apolipoprotein E‑deficient (ApoE‑/‑) mice. All of the mice were fed a high‑fat diet, and divided into phosphate‑buffered saline, adenovirus (Ad)‑β‑galactosidase and Ad‑APN treatment groups. Compared with treatment of Ad‑β‑gal or PBS, Ad‑APN treatment markedly reduced inducible nitric oxide synthase (iNOS) protein expression, decreased in nitric oxide/superoxide production, blocked peroxynitrite formation and reversed the progression of atherosclerotic lesions. Adiponectin may be a natural molecule that reduces atherosclerosis by inhibiting iNOS and consequently diminishing oxidative/nitrative stress.
    Molecular Medicine Reports 11/2014; · 1.17 Impact Factor
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    ABSTRACT: Traditional Chinese medication (TCM) is increasingly used to treat cardiovascular disease (CVD) in China and some other Asian countries. However, therapeutic efficacy and adverse effects of TCM are difficult to evaluate because few large-scale, randomized controlled trials (RCTs) enrolling patients with CVD have been performed. In this Review, we critically examine the current evidence on the cardiovascular effects of TCM. We reviewed 68 RCTs that included a total of 16,171 patients. The methodological quality of the trials was generally low. Only three reports described adverse cardiovascular events specifically, although in most studies TCM was associated with significant improvements in surrogate end points for hypertension, coronary heart disease, cardiac arrhythmias, and heart failure. The risk of adverse effects was not increased compared with no intervention, placebo, or Western medications. However, whether TCM is effective in reducing the all-cause or cardiovascular mortality in patients with CVD remains unknown and must be tested in large-scale RCTs with adverse cardiovascular events as primary end points.
    Nature Reviews Cardiology 11/2014; · 10.40 Impact Factor
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    ABSTRACT: AimsEndothelium-derived protein disulfide isomerase (PDI) is required for thrombus formation in vivo. But, how to control PDI overproduction in oxidized low-density lipoprotein (oxLDL)-activated vascular endothelial cells (VECs) is not well understood. In this study, we try to answer this question by using our newly identified activator of mTOC1 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2 (3H)-one (3BDO) that has been shown to protect VECs.Methods First, we performed a proteomics analysis on the oxLDL-activated vascular VECs in the precence or absence of 3BDO. Next, we constructed the heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) mutants at Ser43 and used the RNA-ChIP technique to investigate the relationship between hnRNP E1 and PDI production. Furthermore, we examined the effect of 3BDO on oxLDL-altered phosphorylation of Akt1 and Akt2. Finally, we studied the effect of 3BDO on oxLDL-altered PDI protein level in apolipoprotein E-/- mice with advanced atherosclerosis.ResultsIn VECs, oxLDL increased PDI protein level, induced hnRNP E1 phosphorylation at Ser43, suppressed the binding of hnRNP E1 to PDI 5'UTR and induced the phosphorylation of Akt2 but not Akt1. All of these processes were blocked by 3BDO. Importantly, Ser43 mutant of hnRNP E1 inhibited the increase of PDI protein level and the decrease of the binding of hnRNP E1 and PDI 5'UTR induced by oxLDL. Furthermore, 3BDO suppressed oxLDL-induced PDI protein increase in the serum and plaque endothelium of apolipoprotein E-/- mice.ConclusionhnRNP E1 is a new regulator of PDI translation in oxLDL-activated VECs, and 3BDO is a powerful agent for controlling PDI overproduction.This article is protected by copyright. All rights reserved.
    Acta Physiologica 11/2014; · 4.38 Impact Factor
  • International journal of cardiology. 10/2014; 178C:181-183.
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    ABSTRACT: Phospholipid transfer protein (PLTP) accelerates the development of atherosclerosis in mouse models. We examined the role of PLTP in atherosclerotic plaque stability.
    Arteriosclerosis Thrombosis and Vascular Biology 10/2014; · 6.34 Impact Factor
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    ABSTRACT: Recently chemical small molecules have been proved an ideal and promising intervention for bone marrow-derived mesenchymal stem cell (BMSC)-based tissue regeneration therapies. In this study, we discovered the huge anti-aging potential of a bioactive small molecule, 6-amino-3,4-dihydro-2H-3-hydroxymethyl-1,4-benzoxazine (ABO), which can suppress a series of senescent phenotypes, enhancing proliferation and differentiation capacities in cultured rat BMSCs. We further illustrated that those beneficial effects were attributed to an improvement of cellular homeostasis, from intracellular degradation system to cytoskeletion organization. ABO could enhance autophagy and reduce intracellular oxidative stress, by facilitating lysosomal degradation. The direct target protein of ABO, ANXA7, was elevated and essential for autophagy induction and lysosomal protection against Baf-A1 upon ABO treatment. Hmbox1 was another critical protein elevated by ABO and probably downstream ANXA7. Intriguingly, the subcellular distribution of Hmbox1 was largely overlapped with cytoskeletal microfilaments and this might lead to a microfilament reorganization. ABO could decrease the level of Caveolin-1, indicating a remodeling in F-actin assembly and attracted our interest to investigate the interaction between Hmbox1, Caveolin-1 and ANXA7 in microfilament formation at cell membrane in the future study.
    RSC Advances 10/2014; · 3.71 Impact Factor
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    ABSTRACT: The LiNi0.6Co0.2Mn0.2O2 powder was coated with nano-Al2O3 particles via ultrasonic coating, and its electrochemical performances were improved greatly. The X-ray diffraction, scanning electron microscopy, transmission electron microscope and energy dispersive spectroscopy were employed to research the structure variation, surface appearance and coating status. The results show that the nano-Al2O3 particles are successfully coated and the thickness of coating layer is about 20–25 nm. The XRD test results indicate that appropriate amount of Al2O3 coated is beneficial to form a better layered structure with smaller cation disorder. The charge–discharge results show that LiNi0.6Co0.2Mn0.2O2 coated with Al2O3 of 1.0 wt.% has initial discharge capacity of 197.1 mA h g−1, initial coulombic efficiency of 91.2% at 0.2 C over 2.8–4.5 V and capacity retention of 91.0% much more than the pristine one of 82.9.0% after 30 cycles at 1 C. Especially, the rate capability of 1.0 wt.% Al2O3-coated sample is improved evidently, it shows a high discharge capacity of 153.5 mA h g−1 after 5 cycles under a 10 C rate, whereas the pristine one is only 126.3 mA h g−1 under the same conditions. The electrochemical impedance spectroscopy tests results also show that the impedance of LiNi0.6Co0.2Mn0.2O2 is significantly reduced by Al2O3 coating during the cycling.
    Journal of Alloys and Compounds 10/2014; 611:135–141. · 2.73 Impact Factor
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    ABSTRACT: Layer-structured LiTiO2 as coating layer is built on the surface of ternary layered LiNi0.5Co0.2Mn0.3O2 microspheres by using a facile infiltrative pre-coating approach. The uniform, nanoscale LiTiO2 coating layer doped with Ni2+ and Mn4+ ions strongly adheres to the host materials, which endows LiNi0.5Co0.2Mn0.3O2 microspheres with superior high-voltage cycling and thermal stabilities when used as cathode materials for Li-ion battery.
    J. Mater. Chem. A. 09/2014;
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    ABSTRACT: This study aimed to assess pulmonary vein isolation (PVI) efficacy on atrial fibrillation (AF) recurrence and to determine a predictive dispersion of atrial refractoriness (dERP) value for performing PVI in paroxysmal supraventricular tachycardia (PSVT) patients.
    Journal of Interventional Cardiac Electrophysiology 09/2014; · 1.39 Impact Factor
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    ABSTRACT: Apoptosis is a key event involved in diabetic cardiomyopathy. The expression of high mobility group box 1 protein (HMGB1) is up-regulated in diabetic mice. However, the molecular mechanism of high glucose (HG)-induced cardiomyocyte apoptosis remains obscure. We aimed to determine the role of HMGB1 in HG-induced apoptosis of cardiomyocytes. Treating neonatal primary cardiomyocytes with HG increased cell apoptosis, which was accompanied by elevated levels of HMGB1. Inhibition of HMGB1 by short-hairpin RNA significantly decreased HG-induced cell apoptosis by reducing caspase-3 activation and ratio of Bcl2-associated X protein to B-cell lymphoma/leukemia-2 (bax/bcl-2). Furthermore, HG activated E26 transformation-specific sequence-1 (Ets-1), and HMGB1 inhibition attenuated HG-induced activation of Ets-1 via extracellular signal-regulated kinase 1/2 (ERK1/2) signalling. In addition, inhibition of Ets-1 significantly decreased HG-induced cardiomyocyte apoptosis. Similar results were observed in streptozotocin-treated diabetic mice. Inhibition of HMGB1 by short-hairpin RNA markedly decreased myocardial cell apoptosis and activation of ERK and Ets-1 in diabetic mice. In conclusion, inhibition of HMGB1 may protect against hyperglycaemia-induced cardiomyocyte apoptosis by down-regulating ERK-dependent activation of Ets-1.
    Journal of Cellular and Molecular Medicine 09/2014; · 4.75 Impact Factor
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    ABSTRACT: Ticks are obligatory blood feeding ectoparasites, which continuously attach to their hosts for 1-2 weeks. There are many biologically active compounds in tick salivary glands interfering host haemostatic system and to successfully obtain blood meal. Several platelet aggregation inhibitors have been identified from ticks. A family of conserved peptides, which were identified from transcriptome analysis of many tick salivary glands, were found to contain unique primary structure including predicted mature peptides of 39-47 amino acid residues in length and a Pro/Glu(P/E)-Pro/His(P/H)- Lys-Gly-Asp(RGD) domain. Given their unique structure and RGD domain, they are considered a novel family of disintegrins that inhibit platelet aggregation. One of them (YY-39) was tested for its effects on platelets and thrombosis in vivo. YY-39 was found effectively to inhibit platelet aggregation induced by adenosine diphosphate (ADP), thrombin and thromboxane A2 (TXA2). Furthermore, YY-39 blocked platelet adhesion to soluble collagen and bound to purified GPIIb/IIIa in a dose-dependent manner. In in vivo experiments, YY-39 reduced thrombus weight effectively in a rat arteriovenous shunt model and inhibited thrombosis in a carrageenan-induced mouse tail thrombosis model. Combined with their prevalence in ticks and platelet inhibitory functions, this family of peptides might be conserved tick anti-haemostatic molecules.
    Peptides 08/2014; · 2.52 Impact Factor

Publication Stats

4k Citations
1,583.21 Total Impact Points


  • 2014
    • Guilin University of Technology
      Ling-ch’uan, Guangxi Zhuangzu Zizhiqu, China
  • 2011–2014
    • Chinese Academy of Sciences
      • • National Laboratory for Infrared Physics
      • • Graduate School
      • • Key Laboratory of Animal Models and Human Disease Mechanisms
      Peping, Beijing, China
  • 2008–2014
    • Huazhong University of Science and Technology
      • • State Key Laboratory of Material Processing and Die & Mould Technology
      • • State Key Laboratory of Laser Technology
      Wu-han-shih, Hubei, China
    • Texas Heart Institute
      Houston, Texas, United States
  • 2003–2014
    • Shandong University
      • • School of Stomatology
      • • Key Laboratory for Cardiovascular Remodelling and Function Research
      • • School of Information Science and Engineering
      • • School of Life Science
      Chi-nan-shih, Shandong Sheng, China
  • 1994–2014
    • Kunming Institute of Zoology CAS
      • State Key Laboratory of Genetic Resources and Evolution
      Yün-nan, Yunnan, China
  • 2013
    • Karolinska Institutet
      • Department of Microbiology, Tumor and Cell Biology (MTC)
      Stockholm, Stockholm, Sweden
  • 2012–2013
    • Fujian Medical University
      Zayton, Fujian, China
    • Northeast Institute of Geography and Agroecology
      • Graduate School
      Beijing, Beijing Shi, China
  • 2011–2012
    • Shenyang Agricultural University
      Feng-t’ien, Liaoning, China
  • 2006–2012
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China
  • 1993–2012
    • University of Jinan (Jinan, China)
      Chi-nan-shih, Shandong Sheng, China
  • 2008–2011
    • Sichuan University
      • • College of Materials Science and Engineering
      • • Department of Urology
      Chengdu, Sichuan Sheng, China
  • 2006–2011
    • Hunan University
      • College of Chemistry and Chemical Engineering
      Changsha, Hunan, China
  • 2009
    • Taishan Medical University
      Taishan, Jiangxi Sheng, China
  • 2008–2009
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2004–2008
    • Baylor College of Medicine
      • Division of Cardiothoracic Surgery
      Houston, TX, United States
  • 2007
    • Shandong University of Traditional Chinese Medicine
      Shan-tang, Jiangxi Sheng, China