Yun Zhang

Guilin University of Technology, Ling-ch’uan, Guangxi Zhuangzu Zizhiqu, China

Are you Yun Zhang?

Claim your profile

Publications (515)1490.12 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: We describe the darkening and re-brightening photoluminescence (PL) of colloidal quantum dots (CQDs) in an aqueous environment with high proton concentration (i.e., low pH value). The PL intensity of CQDs suffers obvious decay in severe acidic condition, and can be enhanced again by an excitation of ultraviolet (UV) irradiation. Proton concentration and inorganic capping layer are responsible for dominating the proton-initiated darkening and UV-irradiated re-brightening PL processes of CQDs. A faster variation ratio of PL quantum yield (QY) than PL lifetime is revealed in the temporal decay of PL by steady state and time-resolved spectra.
    Journal of Nanoengineering and Nanomanufacturing. 12/2014; 4(4).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Silicon nanowire (SiNW) arrays with controllable size were fabricated by an Au catalyzed chemical etching combined with colloidal lithography. The diameter, center-to-center distance and interspacing of SiNWs can be controlled by the original size of polystyrene (PS) spheres and plasma etching parameters while the length of SiNWs can be easily tuned by the etching duration. Compared with polished silicon, the SiNW arrays show excellent antireflection property due to their multiple scattering or light trapping effects. A coating of aluminum-doped zinc oxide (AZO) film by atomic layer deposition (ALD), especially thicker AZO film, can further alleviate reflection over a wide wavelength range. The average reflectance of the SiNW arrays decreases from 14.0% to 2.7% in the wavelength range 400∼850 nm after a coating of ∼50 nm AZO. The investigations on the SiNWs coated by AZO film can provide helpful guideline for the design of nanowire based cells.
    Journal of Nanoengineering and Nanomanufacturing. 12/2014; 4(4).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cerium fluoride (CeF3) coated lithium-rich layered Li1.2Mn0.54Ni0.13Co0.13O2 particles are synthesized using a facile chemical deposition route. The structural and electrochemical properties of pristine and CeF3-coated electrodes are investigated by X-ray diffraction (XRD), thermogravimetric-differential scanning calorimetry (TG-DSC), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), galvanostatic charge/discharge tests, electrochemical impedance spectra (EIS) and cyclic voltammetry (CV). The results indicate that the cathode particles are uniformly covered with a CeF3 layer (∼10 nm thick) after 2 wt.% CeF3 surface coating. The coated electrode shows an enhanced initial coulombic efficiency of 80.8% compared to 75.2% for the pristine electrode. Moreover, the coated electrode demonstrates better cyclic performance, which exhibits capacity retention of 91.7% after 50 cycles compared with only 82.1% for the pristine one. Furthermore, the CeF3-coated electrode delivers a superior high-rate capacity of 103.1 mAh g-1 at 5C, higher than 82.2 mAh g-1 for the pristine one. The remarkably improved cycling stability and high-rate capacity of the surface-modified electrode is ascribed to the presence of a stable and thin CeF3 coating layer which effectively reduces the damage of electrode structure and suppresses the increase of impedance during cycling by preventing direct contact of electrode with electrolyte.
    11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to assess pulmonary vein isolation (PVI) efficacy on atrial fibrillation (AF) recurrence and to determine a predictive dispersion of atrial refractoriness (dERP) value for performing PVI in paroxysmal supraventricular tachycardia (PSVT) patients.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 09/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Apoptosis is a key event involved in diabetic cardiomyopathy. The expression of high mobility group box 1 protein (HMGB1) is up-regulated in diabetic mice. However, the molecular mechanism of high glucose (HG)-induced cardiomyocyte apoptosis remains obscure. We aimed to determine the role of HMGB1 in HG-induced apoptosis of cardiomyocytes. Treating neonatal primary cardiomyocytes with HG increased cell apoptosis, which was accompanied by elevated levels of HMGB1. Inhibition of HMGB1 by short-hairpin RNA significantly decreased HG-induced cell apoptosis by reducing caspase-3 activation and ratio of Bcl2-associated X protein to B-cell lymphoma/leukemia-2 (bax/bcl-2). Furthermore, HG activated E26 transformation-specific sequence-1 (Ets-1), and HMGB1 inhibition attenuated HG-induced activation of Ets-1 via extracellular signal-regulated kinase 1/2 (ERK1/2) signalling. In addition, inhibition of Ets-1 significantly decreased HG-induced cardiomyocyte apoptosis. Similar results were observed in streptozotocin-treated diabetic mice. Inhibition of HMGB1 by short-hairpin RNA markedly decreased myocardial cell apoptosis and activation of ERK and Ets-1 in diabetic mice. In conclusion, inhibition of HMGB1 may protect against hyperglycaemia-induced cardiomyocyte apoptosis by down-regulating ERK-dependent activation of Ets-1.
    Journal of Cellular and Molecular Medicine 09/2014; · 4.75 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Ticks are obligatory blood feeding ectoparasites, which continuously attach to their hosts for 1-2 weeks. There are many biologically active compounds in tick salivary glands interfering host haemostatic system and to successfully obtain blood meal. Several platelet aggregation inhibitors have been identified from ticks. A family of conserved peptides, which were identified from transcriptome analysis of many tick salivary glands, were found to contain unique primary structure including predicted mature peptides of 39-47 amino acid residues in length and a Pro/Glu(P/E)-Pro/His(P/H)- Lys-Gly-Asp(RGD) domain. Given their unique structure and RGD domain, they are considered a novel family of disintegrins that inhibit platelet aggregation. One of them (YY-39) was tested for its effects on platelets and thrombosis in vivo. YY-39 was found effectively to inhibit platelet aggregation induced by adenosine diphosphate (ADP), thrombin and thromboxane A2 (TXA2). Furthermore, YY-39 blocked platelet adhesion to soluble collagen and bound to purified GPIIb/IIIa in a dose-dependent manner. In in vivo experiments, YY-39 reduced thrombus weight effectively in a rat arteriovenous shunt model and inhibited thrombosis in a carrageenan-induced mouse tail thrombosis model. Combined with their prevalence in ticks and platelet inhibitory functions, this family of peptides might be conserved tick anti-haemostatic molecules.
    Peptides 08/2014; · 2.52 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To explore the potential therapeutic effects of angiotensin(1-7) (Ang(1-7)), an endogenous ligand of the Mas receptor, on streptozotocin-induced diabetic nephropathy, male Wistar rats were randomly divided into two groups: a control group and a diabetic model group. After 12 weeks, the diabetic rats were divided into subgroups for 4-week treatments consisting of no-treatment group, small-, moderate-, and large-dose Ang(1-7) groups, a valsartan group, a large-dose Ang(1-7) plus valsartan group, and an A779 (antagonist of the Mas receptor) group, each with 15 rats. Ang(1-7) improved renal function, attenuated glomeruli sclerosis, oxidative stress, and cell proliferation, decreased the expression of collagen IV, TGF-β1, VEGF, NOX4, p47phox, PKCα, and PKCβ1, and the phosphorylation of Smad3. In the rat mesangial HBZY-1 cell line, Ang(1-7) decreased high-glucose-induced oxidative stress, the proliferation and expression of NOX4, p47phox, and TGF-β1, the phosphorylation of Smad3, collagen IV, and VEGF, and the membrane translocation of PKCα and PKCβ1. A779 blocked the effects of Ang(1-7) both in vivo and in vitro. The effects of large-dose Ang(1-7) alone and in combination with valsartan were superior to valsartan alone, but the combination had no significant synergistic effect compared with Ang(1-7) alone. Thus, Ang(1-7) ameliorated streptozotocin-induced diabetic renal injury. Large-dose treatment was superior to valsartan in reducing oxidative stress and inhibiting TGFβ1/Smad3- and VEGF-mediated pathways.Kidney International advance online publication, 30 July 2014; doi:10.1038/ki.2014.274.
    Kidney international. 07/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: To test the hypothesis that adoptive transfer of regulatory T cells (Tregs) may dose-dependently inhibit the formation of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice, we established an animal model of abdominal aortic aneurysm by angiotensin II infusion in apolipoprotein E knockout mice. Then mice received different treatment with PBS, low-dose Tregs, high-dose Tregs, or CD25-depleting PC61 antibody. Histopathologic analysis showed that the incidence of abdominal aortic aneurysm was 80%, 76%, 27%, and 71% in the PBS, low-dose Tregs, high-dose Tregs, and PC61 groups, respectively. Tregs treatment markedly decreased macrophage and CD4(+) T-cell infiltration and preserved the medial smooth muscle cells. Furthermore, Tregs decreased the levels of proinflammatory cytokines, matrix metalloproteinase-2 (MMP-2) and MMP-9, increased the expression of anti-inflammatory interleukin-10 and transforming growth factor-β, and suppressed apoptosis and oxidative stress. In vitro, Tregs inhibited the response of human aortic smooth muscle cells to angiotensin II and reduced the expression of proinflammatory cytokines, MMP-2 and MMP-9, possibly by inhibiting the activation of nuclear factor-κB and extracellular signal-regulate kinase 1/2. In addition, Tregs downregulated macrophage type 1-related genes and upregulated macrophage type 2-related genes. However, Tregs-mediated effects were largely reversed by disrupting cell-cell contact or using neutralizing antibodies against interleukin-10 and transforming growth factor-β. Adoptive transfer of Tregs dose-dependently prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice. The mechanisms may involve declined proinflammatory cytokine expression and MMP-2 and MMP-9 levels and enhanced anti-inflammatory cytokine expression, which is mediated by direct cell-cell contact and soluble mediators.
    Hypertension 07/2014; · 6.87 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The effect of Fe element on the structural and electrochemical performance of the Layered LiNi0.5Co0.2Mn0.3O2 materials with various Fe-doped amounts synthesized by high-temperature solid state method had been studied quantitatively and in detail. The structural and morphological of the prepared samples were characterized by X-ray diffraction patterns (XRD) and scanning electron microscopy (SEM). The study results show that the discharge capacity and cycling performance of the LiNi0.5Co0.2Mn0.3O2 all reduced by Fe doping, that is mainly attributed to the aggravated disorder degree of the layered structure and charge transfer resistance. Fe content should be controlled strictly in the layered LiNi1−x−yCoxMnyO2 cathode materials production process.
    Integrated Ferroelectrics 06/2014; 154(1). · 0.38 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: MTOR, a central regulator of autophagy, is involved in cancer and cardiovascular and neurological diseases. Modulating the MTOR signaling balance could be of great significance for numerous diseases. No chemical activators of MTOR have been found, and the urgent challenge is to find novel MTOR downstream components. In previous studies, we found a chemical small molecule, 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one (3BDO), that inhibited autophagy in human umbilical vein endothelial cells (HUVECs) and neuronal cells. Here, we found that 3BDO activated MTOR by targeting FKBP1A (FK506-binding protein 1A, 12 kDa). We next used 3BDO to detect novel factors downstream of the MTOR signaling pathway. Activation of MTOR by 3BDO increased the phosphorylation of TIA1 (TIA1 cytotoxic granule-associated RNA binding protein/T-cell-restricted intracellular antigen-1). Finally, we used gene microarray, RNA interference, RNA-ChIP assay, bioinformatics, luciferase reporter assay, and other assays and found that 3BDO greatly decreased the level of a long noncoding RNA (lncRNA) derived from the 3' untranslated region (3'UTR) of TGFB2, known as FLJ11812. TIA1 was responsible for processing FLJ11812. Further experiments results showed that FLJ11812 could bind with MIR4459 targeting ATG13 (autophagy-related 13), and ATG13 protein level was decreased along with 3BDO-decreased FLJ11812 level. Here, we provide a new activator of MTOR, and our findings highlight the role of the lncRNA in autophagy.
    Autophagy 06/2014; 10(6):957-971. · 12.04 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Trefoil factor 2 (TFF2) plays a protective role in gastric mucosa and may be involved in the progression of gastric cancer, but the detailed functions and underlying molecular mechanisms are not clear. The present study used a combination of clinical observations and molecular methods to investigate the correlation between abnormal expression of TFF2 and gastric cancer progression. TFF2 expression was evaluated by reverse transcription polymerase chain reaction (RT-PCR), quantitative PCR (qPCR), and western blot and immunohistochemistry analyses. TFF2 methylation levels were analyzed by genomic bisulfite sequencing method. The results showed that TFF2 mRNA and protein expression were decreased in gastric cancer tissues compared with the matched non-cancerous mucosa, and the decreased level was associated with the differentiation and invasion of gastric cancer. Moreover, the average TFF2 methylation level of CpG sites in the promoter region was 70.4% in three gastric cancer tissues, while the level in associated non-neoplastic tissues was 41.0%. Furthermore, the promoter hypermethylation of TFF2 was also found in gastric cancer cell lines, AGS and N87, and gene expression was significantly increased following treatment with a demethylating agent, 5-Aza-2'-deoxycytidine. In conclusion, TFF2 expression was markedly decreased in gastric cancer and promoter hypermethylation was found to regulate the downregulation of TFF2. TFF2 has been suggested as a tumor suppressor in gastric carcinogenesis and metastasis.
    Oncology letters 05/2014; 7(5):1525-1531. · 0.24 Impact Factor
  • International journal of cardiology 04/2014; · 6.18 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Aerolysins are virulence factors belonging to the bacterial β-pore-forming toxin superfamily. Surprisingly, numerous aerolysin-like proteins exist in vertebrates, but their biological functions are unknown. βγ-CAT, a complex of an aerolysin-like protein subunit (two βγ-crystallin domains followed by an aerolysin pore-forming domain) and two trefoil factor subunits, has been identified in frogs (Bombina maxima) skin secretions. Here, we report the rich expression of this protein, in the frog blood and immune-related tissues, and the induction of its presence in peritoneal lavage by bacterial challenge. This phenomena raises the possibility of its involvement in antimicrobial infection. When βγ-CAT was administrated in a peritoneal infection model, it greatly accelerated bacterial clearance and increased the survival rate of both frogs and mice. Meanwhile, accelerated Interleukin-1β release and enhanced local leukocyte recruitments were determined, which may partially explain the robust and effective antimicrobial responses observed. The release of interleukin-1β was potently triggered by βγ-CAT from the frog peritoneal cells and murine macrophages in vitro. βγ-CAT was rapidly endocytosed and translocated to lysosomes, where it formed high molecular mass SDS-stable oligomers (>170 kDa). Lysosomal destabilization and cathepsin B release were detected, which may explain the activation of caspase-1 inflammasome and subsequent interleukin-1β maturation and release. To our knowledge, these results provide the first functional evidence of the ability of a host-derived aerolysin-like protein to counter microbial infection by eliciting rapid and effective host innate immune responses. The findings will also largely help to elucidate the possible involvement and action mechanisms of aerolysin-like proteins and/or trefoil factors widely existing in vertebrates in the host defense against pathogens.
    Proceedings of the National Academy of Sciences 04/2014; · 9.81 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The protease-activated receptor 1 (PAR1) is a G-protein-coupled receptor that is irreversibly activated by either thrombin or metalloprotease 1. Due this irrevocable activation, activated internalization and degradation are critical for PAR1 signaling termination. Prohibitin (PHB) is evolutionarily conserved, ubiquitously expressed, pleiotropic protein and belongs to stomatin/prohibitin/flotillin/HflK/C (SPFH) domain family. In a previous study, we found that PHB localized on the platelet membrane and participated in PAR1-mediated human platelet aggregation, suggesting that PHB likely regulates the signaling of PAR1. Unfortunately, PHB's exact function in PAR1 internalization and degradation is unclear. In the current study, flow cytometry revealed that PHB expressed on the surface of endothelial cells (HUVECs) but not cancer cells (MDA-MB-231). Further confocal microscopy revealed that PHB dynamically associates with PAR1 in a time-dependent manner following induction with PAR1-activated peptide (PAR1-AP), though differently between HUVECs and MDA-MB-231 cells. Depletion of PHB by RNA interference significantly inhibited PAR1 activated internalization and led to sustained Erk1/2 phosphorylation in the HUVECs; however, a similar effect was not observed in MDA-MB-231 cells. For both the endothelial and cancel cells, PHB repressed PAR1 degradation, while knockdown of PHB led to increased PAR1 degradation, and PHB overexpression inhibited PAR1 degradation. These results suggest that persistent PAR1 signaling due to the absence of membrane PHB and decreased PAR1 degradation caused by the upregulation of intracellular PHB in cancer cells (such as MDA-MB-231 cells) may render cells highly invasive. As such, PHB may be a novel target in future anti-cancer therapeutics, or in more refined cancer malignancy diagnostics.
    Biochimica et Biophysica Acta 04/2014; · 4.66 Impact Factor
  • International journal of cardiology 04/2014; · 6.18 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Process parameters play a highly significant role in the final quality of parts produced using dynamic injection molding. Many researches have made great efforts in obtaining an optimum set of process parameters for improving molded part qualities with various optimization methods. However, this work has failed to provide sufficient information to adjust process parameters in the face of variable environmental conditions and various injection machines to ensure robust, high-quality injection moldings. Current conditions are too cumbersome and require technologists to perform repeated, detailed optimization procedures on the mass production plant floor. An offline method for prediction of process windows is proposed in this article. The process window is significant for robust manufacturing, and optimization of process parameters. Considering that it is an irregular region in a multi-dimensional space respecting to process parameters, numerical simulations based on DOE method were designed to offline build relationships between process parameters and part qualities. Then the simulation results were classified as positive or negative class, thereby yielding simulation sample data. Finally, the process window was verified using an SVM classifier and a set of simulation samples. Injection molding of an experimental production plate using various process parameters was conducted to verify the reliability of the predicted process window. The results show that, within tolerable deviations, the predicted window of experimental parts is in accordance with verification experiments. The proposed method demonstrates an ability to rapidly obtain a suitable set of process parameters for achieving consistency in part quality with low cost and high efficiency. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40804.
    Journal of Applied Polymer Science 04/2014; · 1.40 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A novel method to improve the sensitivity of molecularly imprinted polymer sensors was developed. Oxytetracycline (OTC), which was selected as the template molecule, was first rebound to the imprinted cavities. Gold nanoparticles were then labeled with the amino groups of OTC molecules via electrostatic adsorption and non-covalent interactions. Copper ions were catalytically reduced by the gold nanoparticles, and copper was deposited onto the electrode. The deposited copper was electrochemically dissolved, and its oxidative currents were recorded by differential pulse voltammetry (DPV). OTC could be determined indirectly within the concentration range of 3.0×10(-10) to 1.5×10(-7)molL(-1) with a detection limit of 6.8×10(-11)molL(-1).
    Analytica chimica acta 03/2014; 817:17-22. · 4.31 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In this paper, we report for the first time an electrochemical biosensor for single-step, reagentless, and picomolar detection of a sequence-specific DNA-binding protein using a double-stranded, electrode-bound DNA probe terminally modified with a redox active label close to the electrode surface. This new methodology is based upon local repression of electrolyte diffusion associated with protein-DNA binding that leads to reduction of the electrochemical response of the label. In the proof-of-concept study, the resulting electrochemical biosensor was quantitatively sensitive to the concentrations of the TATA binding protein (TBP, a model analyte) ranging from 40 pM to 25.4 nM with an estimated detection limit of ∼10.6 pM (∼80 to 400-fold improvement on the detection limit over previous electrochemical analytical systems).
    The Analyst 03/2014; · 4.23 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study is to investigate the dynamic alterations of cardiac connexin 43 (Cx43), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the setting of different ventricular fibrillation (VF) duration. In this study, thirty-two dogs were randomly divided into sham control group, 8-min VF group, 12-min VF group, and 30-min VF group. Cx43 and phosphorylated Cx43 (p-Cx43) in tissues were detected by western blot and immunofluorescence analysis. MMP-2 and TIMP-2 were detected by western blot and immunohistochemistry analysis. The results showed that Cx43 levels in three VF groups were significantly decreased compared with sham control group. p-Cx43 levels in 12-min and 30-min VF groups were significantly reduced compared with sham control group. The ratio of p-Cx43/Cx43 was also decreased in VF groups. Compared with sham controls, no significant difference was observed between the sham control group and 8-min VF group in MMP-2 level, but MMP-2 level increased in 12-min and 30-min VF groups. The ratios of MMP-2/TIMP-2 were higher in VF groups, and were correlated with the duration of VF. A remarkable correlation was observed between the ratio of p-Cx43/Cx43 and MMP-2/TIMP-2 (r = -0.93, P < 0.01). In conclusion, the alteration of Cx43 and/or p-Cx43 levels and the imbalance of MMP-2 and TIMP-2 may contribute to the initiation and/or persistence of VF. Maneuvers managed to modulate Cx43 level or normalize the balance of MMP-2/TIMP-2 are promising to ameliorate prognosis of VF.
    Molecular and Cellular Biochemistry 03/2014; · 2.33 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The therapeutic potential of antimicrobial peptides (AMPs) has been evaluated in many infectious diseases. However, the topical application of AMPs for ocular bacterial infection has not been well investigated. The AMP OH-CATH30, which was identified in the king cobra, exhibits potent antimicrobial activity. In this study, we investigated the therapeutic potential of OH-CATH30 in Pseudomonas aeruginosa keratitis. Ten isolates of P. aeruginosa from individuals with keratitis were susceptible to OH-CATH30, but not to cefoperazone, ciprofloxacin, gentamicin, and levofloxacin. The microdilution checkerboard assay showed that OH-CATH30 exhibited synergistic activity with ciprofloxacin and levofloxacin against antibiotic-resistant P. aeruginosa. Meanwhile, P. aeruginosa did not develop resistance to OH-CATH30 even after exposure at 0.5× the minimum inhibitory concentration for up to 25 subcultures. Furthermore, treatment with OH-CATH30, alone or in combination with levofloxacin, significantly improved the clinical outcomes of rabbit keratitis induced by antibiotic-resistant P. aeruginosa. Taken together, our data indicate that the topical application of OH-CATH30 is efficacious against drug-resistant P. aeruginosa keratitis. In addition, our study highlights the potential application of AMPs in treating ocular bacterial infections.
    Antimicrobial Agents and Chemotherapy 03/2014; · 4.57 Impact Factor

Publication Stats

3k Citations
1,490.12 Total Impact Points

Institutions

  • 2014
    • Guilin University of Technology
      Ling-ch’uan, Guangxi Zhuangzu Zizhiqu, China
  • 2011–2014
    • Chinese Academy of Sciences
      • • National Laboratory for Infrared Physics
      • • Graduate School
      • • Key Laboratory of Animal Models and Human Disease Mechanisms
      Peping, Beijing, China
  • 2008–2014
    • Huazhong University of Science and Technology
      • • State Key Laboratory of Material Processing and Die & Mould Technology
      • • State Key Laboratory of Laser Technology
      Wu-han-shih, Hubei, China
    • Texas Heart Institute
      Houston, Texas, United States
  • 2003–2014
    • Shandong University
      • • School of Stomatology
      • • Key Laboratory for Cardiovascular Remodelling and Function Research
      • • School of Information Science and Engineering
      • • School of Life Science
      Chi-nan-shih, Shandong Sheng, China
  • 1994–2014
    • Kunming Institute of Zoology CAS
      • State Key Laboratory of Genetic Resources and Evolution
      Yün-nan, Yunnan, China
  • 2013
    • Karolinska Institutet
      • Department of Microbiology, Tumor and Cell Biology (MTC)
      Stockholm, Stockholm, Sweden
  • 2012–2013
    • Fujian Medical University
      Zayton, Fujian, China
    • Northeast Institute of Geography and Agroecology
      • Graduate School
      Beijing, Beijing Shi, China
  • 2011–2012
    • Shenyang Agricultural University
      Feng-t’ien, Liaoning, China
    • Lanzhou Veterinary Research Institute
      Kao-lan-hsien, Gansu Sheng, China
  • 2006–2012
    • Tianjin Medical University
      T’ien-ching-shih, Tianjin Shi, China
  • 2005–2012
    • University of Jinan (Jinan, China)
      Chi-nan-shih, Shandong Sheng, China
  • 2008–2011
    • Sichuan University
      • • College of Materials Science and Engineering
      • • Department of Urology
      Chengdu, Sichuan Sheng, China
  • 2006–2011
    • Hunan University
      • College of Chemistry and Chemical Engineering
      Changsha, Hunan, China
  • 2009
    • Taishan Medical University
      Taishan, Jiangxi Sheng, China
  • 2008–2009
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2004–2008
    • Baylor College of Medicine
      • Division of Cardiothoracic Surgery
      Houston, TX, United States
  • 2007
    • Shandong University of Traditional Chinese Medicine
      Shan-tang, Jiangxi Sheng, China