ABSTRACT: To study the mechanism of Huanyuan injection in treating acute intracerebral hemorrhage.
Forty-five patients were divided into Huanyuan group and mannitol group who were treated with Huanyuan injection and mannitol intravenously for two weeks respectively. Meanwhile, the two groups were also treated with vitamin C, potassium chloride, etc, intravenously. Plasma endothelin (ET) and calcitonin gene-related peptide (CGRP) levels were determined before and after treatment.
After treatment for two weeks, changes of plasma ET and CGRP in mannitol group was insignificant (P > 0.05). Compared with the two treated group, There was obvious significance in plasma ET levels and CGRP content (P < 0.05).
Therapeutic mechanism of Huanyuan injection in treating acute intracerebral hemorrhage were correlated to reduce plasma ET and raise the CGRP levels.
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 02/2000; 20(2):97-8.