Zhen Wang

Publications (2)3.38 Total impact

• Article: High-Performance Air Cooling Condenser With Liquid–Vapor Separation

  Di Wu, Zhen Wang, Gui Lu, Xiaofeng Peng
  [show abstract] [hide abstract]
  ABSTRACT: In this investigation, an innovative idea was introduced to design a new kind of high-performance air cooling condensers. This kind of condenser functions to automatically separate liquid from gas and makes condensation always occur in droplet and unsteady thin film condensation mode everywhere in the whole condenser, which results in very high average heat transfer coefficient. An introduction is presented to describe the basic principle and structure of the novel heat exchanger technology, particularly the understanding from the fundamental experimental investigations. Furthermore, a series of experiments was conducted to validate the high performance of an air-conditioning system with an innovative condenser. Though heat transfer area of the condenser was about 37% less, the performance was as good as or even better than that of the original one.
  Heat Transfer Engineering 10/2010; 31(12):973-980. · 0.89 Impact Factor
• Article: Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells.

  Qinxi Li, Zhiyun Ye, Jun Wen, Lin Ma, Ying He, Guili Lian, Zhen Wang, Luyao Wei, Di Wu, Bin Jiang
  [show abstract] [hide abstract]
  ABSTRACT: The tumor necrosis factor (TNF) can induce apoptosis in many cells including MCF-7 cells. To identify the genes responsible for TNF-induced apoptosis, we generated a series of TNF-resistant MCF-7 cell lines by employing retrovirus insertion-mediated random mutagenesis. In one of the resistant lines, gelsolin was found to be disrupted by viral insertion. Exogenous expression of gelsolin in this mutant cell line (Gel(mut)) restored the sensitivity to TNF-induced cell death and knock-down of gelsolin by siRNA conferred MCF-7 cells with resistance to TNF, indicating that gelsolin is required for TNF-induced apoptosis. Interestingly, the resistance of Gel(mut) cells to apoptosis induction is selective to TNF, since Gel(mut) and wild-type cells showed similar sensitivity to other death stimuli that were tested. Furthermore, TNF-induced ROS production in Gel(mut) cells was significantly decreased, demonstrating that gelsolin-mediated ROS generation plays a crucial role in TNF-induced apoptosis in MCF-7 cells. Importantly, caspase-mediated gelsolin cleavage is dispensable for TNF-triggered ROS production and subsequent apoptosis of MCF-7 cells. Our study thus provides genetic evidence linking gelsolin-mediated ROS production to TNF-induced cell death.
  Biochemical and Biophysical Research Communications 08/2009; 385(2):284-9. · 2.48 Impact Factor