Z Liu

Xiamen University, Amoy, Fujian, China

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Publications (372)626.19 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: A novel tumor suppressor CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) is reduced or undetectable in many kinds of cancers and inhibits tumor cells' malignant features. To explore its role in prostate cancer (PCa), we detected its expression patterns in prostate tissues and PCa cells, and determined its anti-proliferation functions in PCa cells in vitro and in vivo.
    11/2014;
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    ABSTRACT: The electrochemical behaviour of a carbon fibre reinforced epoxy matrix composite in 3.5% NaCl and 3.5% NaCl + 0.5 M CuSO4 electrolytes was examined by potentiodynamic polarisation, potentiostatic polarisation and scanning electron microscopy. Exposed carbon fibres on two defined regions (“front” and “side”) are a focus of the investigation. The large size of the exposed carbon fibres on the side region is responsible for a higher cathodic current density than the front region in the NaCl electrolyte. The deposition of copper on the front surface of composite confirmed that the significantly higher cathodic current resulted from the exposure of the fibres to the NaCl electrolyte. Galvanic coupling between the composite and individual aluminium alloys (AA7075-T6 and AA1050) was used to measure galvanic potentials and galvanic current densities. The highly alloyed AA7075-T6 alloy and its high population density of cathodic sites compared to the AA1050 acted to reduce the galvanic effect when coupled to the composite front or side regions.
    Applied Surface Science 09/2014; 314:233–240. · 2.54 Impact Factor
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    ABSTRACT: Large sized ordered mesoporous carbon film (OMCF) was prepared from the coassembly of resorcinol–formaldehyde (RF) resin and tetraethyl orthosilicate (TEOS) with poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (Pluronic F127) under the catalyst of sodium hydroxide or sodium carbonate. The evolution on morphology and structure of obtained OMCF was analysed by the techniques of X-ray diffraction, scanning electron microscopy, transmission electron microscopy, infrared spectroscopy and specific surface area analyser. The effects of addition of TEOS, catalyst types, F127 dosage and pyrolysis temperature were investigated on the morphology and structure of OMCF. The specific surface area of OMCF increases with elevating the R/F molar ratio or reducing the TEOS content. When the TEOS content surpasses 4?2%, large amount of silica fibres could be found on the surface of intact OMCF (silica/OMCF composites). In comparison with sodium carbonate, sodium hydroxide is more favourable as a catalyst to form OMCF.
    Materials Research Innovations 06/2014; 18(4):294-299.
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    ABSTRACT: In this study, a two-stage decode-and-forward cooperative network is investigated consisting of a source, a corresponding destination, an eavesdropper and several intermediate nodes. In this study, the authors present an analysis of overall secrecy rate considering both distributed relay selection and secure beamforming problems. The achievable rate constraint is newly included into the system model. This modelling framework offers a more reliable approximation of the practical wireless channel. The relay selection is formulated as a coalitional game with transferable utility, which decreases the computation complexity in solving the distributed relay selection problem. A new 'Max-Pareto order' is constructed, which not only considers the player value, but also reflects the dominated weight of coalition value. Moreover, a distributed merge-and-split coalition formation algorithm is presented in this study. This algorithm achieves the system performance close to the theoretical upper limit, but it requires much less computation consumption.
    IET Communications 05/2014; 8(8):1355-1363. · 0.72 Impact Factor
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    ABSTRACT: Steeper tapering of the cervical spinal canal as documented in recent studies is thought to have a role in the pathophysiology of Chiari malformation-associated syringomyelia. This study aimed to determine whether taper ratio of the cervical spinal canal differs between patients with distended and nondistended syringes. Seventy-seven adolescents (10-18 years) were divided into 2 groups: 44 with distended syrinx and 33 with nondistended syrinx. On T2-weighted MR images, anteroposterior diameter of the spinal canal was measured at each cervical level, and a linear trend line was fit by least squares regression to calculate the taper ratio. Taper ratios were compared between the 2 groups and further evaluated with respect to age and sex. In the nondistended group ND, the taper ratios for C1-C7, C1-C4, and C4-C7 averaged -0.73 ± 0.57, -1.61 ± 0.98, and -0.04 ± 0.54, respectively, all of which were significantly steeper than those observed in the distended group (P = .001, .004, and .033, respectively). Regarding the average diameters plotted by cervical level, the narrowest region of the canal was found to occur at C4 in both groups. In addition, no significant differences in taper ratio were noted between males and females, or between older (>14 years) and younger patients (≤14 years). Taper ratios of the cervical spinal canal were found to be different between patients with distended and nondistended syringes, indicating a reciprocal interaction between the syrinx and the cervical spine anatomy.
    American Journal of Neuroradiology 05/2014; · 3.17 Impact Factor
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    ABSTRACT: This study investigates by experiment the global characteristics of both moderate or intense low-oxygen dilution (MILD) oxy-combustion and air combustion of firing light oil and pulverized coal in a pilot-scale furnace. There are three burner configurations used, i.e., (I) central straight (primary) jet + swirl (secondary) jet, (II) central straight (primary) jet + two side symmetrical (secondary) jets, and (III) central straight (primary) jet + side asymmetrical jet. The furnace centerline temperature, species concentrations, and exhaust emissions are measured and compared for the MILD and conventional combustion cases. For light oil and pulverized coal, the MILD air combustion or oxy-combustion occurs with burner II or III, while the conventional combustion takes place when using burner I. For the light oil, the MILD oxy-combustion can be reached even using pure oxygen. As the MILD combustion is reached, a fairly uniform temperature distribution and low emissions of NO and CO are obtained. Note that burner III produces the largest internal recirculation of the flue gas, lowest peak temperature, and most uniform temperature, whereas the opposite occurs for burner I. Importantly, the MILD combustion is found to reduce the NO emission much more effectively in the oxy-combustion case than in the air combustion case. Moreover, the appearance of the MILD combustion of light oil and pulverized coal differs from the invisible MILD combustion of gaseous fuels. Dark sparks from burning oil droplets or char particles are present in the MILD combustion of light oil or pulverized coal. It is also revealed that the char burnout under the MILD combustion is weaker than that under the conventional combustion.
    Energy & Fuels. 01/2014; 28(2):1524–1535.
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    ABSTRACT: This study presents a detailed performance evaluation of comfort-constrained state-queueing model for integration of thermostatically controlled appliances (TCAs) as virtual generators (VGs). The configuration of VG models is presented. The heating mode of heating, ventilating and air-conditioning (HVAC) unit ?? heat pump is used as an example TCA load to demonstrate VG operation. First, an estimated baseline of the aggregated HVAC loads is obtained based on outdoor temperature forecasts using thermal dynamic models. Then, the control method of HVAC units for intra-hour load balancing is proposed. The effects of different comfort-constraints, outdoor temperature profiles and thermal deadbands are modelled to evaluate the performance of TCAs as VGs. The technical functionality of the TCA-VG is described and demonstrated by the modelling results.
    IET Generation Transmission & Distribution 01/2014; 8(4):591-599. · 1.41 Impact Factor
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    ABSTRACT: A ~ 100 nm thick sputter-deposited titanium layer on electropolished aluminium is used for the investigation of anodic film growth in 1 M H3PO4. It is found that the thin titanium layer could not provide sufficient current efficiency for titanium anodic film growth when anodized to the voltage over 80 V due to the occurrence of oxygen evolution. The ruptures of titanium anodic film and the sputtering layer are induced by the development of oxygen bubbles. The penetrated phosphoric acid electrolyte in the ruptured regions of sputtering titanium layer contacts with the aluminium substrate, which is leading to the anodic oxide growth of aluminium. The thickness of the titanium anodic film increases from 10 to 100 V, however, it is reduced from 100 to 150 V due to the thinning of titanium layer. Over 80 V, the sputtering layer at some regions where it is completely ruptured, the anodic film growth of titanium could not be created. A thicker aluminium anodic film is formed on such regions due to the direct connection with the electrolyte.
    Materials Characterization. 01/2014; 98:102–106.
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    ABSTRACT: We present a diode-pumped Pr:${rm LiYF}_{4}$ (Pr:YLF) laser at 695.8 nm by suppressing the higher gain transitions near 640, 670, 698, and 721 nm. With an InGaN laser diode as the pump source, the output power of the laser centered at 695.8 nm in $sigma$ polarization was up to 51 mW, corresponding to a slope efficiency of 12.6% and a threshold power of 229 mW with respect to absorbed pump power. To the best of our knowledge, this is the first Pr:YLF laser emitting at 695.8 nm in $sigma$ polarization.
    IEEE Photonics Technology Letters 01/2014; 26(7):675-677. · 2.04 Impact Factor
  • Q. Xia, Z. Liu, X. Guo
    5th IAHR International Symposium on Hydraulic Structures; 01/2014
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    ABSTRACT: The aim of the study was to investigate and compare the clinical manifestations between HLA-B27(+) and HLA-B27(-) ankylosing spondylitis (AS) patients in order to obtain knowledge of the impact of HLA-B27 status on AS, and to inform clinical treatment. A nationwide epidemiological investigation was performed from November 2008 to October 2010. The demographic data and clinical characteristics, and the status of HLA-B27 were collected using questionnaires and laboratory assay, respectively. A total of 2144 patients (78.5% males and 78.4% HLA-B27(+) AS patients) participated in this study. The percentages of males, patients with family history, and involvement of lumbar spine, thoracic spine and hip joints, were observed to be significantly higher in the HLA-B27(+) AS patients than in their HLA-B27(-) AS peers.
    Tissue Antigens 11/2013; 82(5):338-43. · 2.93 Impact Factor
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    ABSTRACT: Tuberous sclerosis complex 1 (TSC1) and TSC2 are suppressors of mechanistic target of rapamycin (mTOR). mTOR is the major component of two protein complexes: mTOR complex 1 (mTORC1) and mTORC2. Inactive mutation of either TSC1 or TSC2 unleashes mTOR signaling and consequently causes TSC, a benign tumor syndrome affecting multiple organs. We report here that expression of αB-crystallin was upregulated in Tsc1-/- or Tsc2-/- mouse embryonic fibroblasts, Eker rat uterine leiomyoma-derived Tsc2-deficient ELT3 cells, mutant Tsc2-associated mouse kidney tumors, and human lung lymphangioleiomyomatosis nodules. αB-crystallin was transcriptionally activated by mTOR complex 2 (mTORC2): nuclear factor-kappa B (NFκB) signaling cascade. The augmented αB-crystallin was critical for the migration, invasion and apoptotic resistance of Tsc2-defective cells. Disruption of αB-crystallin suppressed Tsc2-null cell proliferation and tumorigenesis. Therefore, enhanced αB-crystallin has an essential role in TSC1/2 complex deficiency-mediated tumorigenesis, and inhibition of αB-crystallin may complement the current therapy for TSC.Oncogene advance online publication, 30 September 2013; doi:10.1038/onc.2013.401.
    Oncogene 09/2013; · 8.56 Impact Factor
  • Z Liu, W Dai, L Jiang, Y Cheng
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    ABSTRACT: Leucine-rich repeat-containing G protein-coupled receptor 5(LGR5) was identified as the stem cell marker of colon cancer stem cells(CSCs),which were considered as the main criminal cells initiation and reinitiation of colon cancer. We intended to demonstrate and further explain the relationship between LGR5 and colon cancer in mice model and patients. In our research, we used transcriptional methods and immunohistochemistry to investigate the LGR5 gene and protein expression, examined proliferating cell nuclear antigen(PCNA) and Ki67 which were the classic markers for cell proliferation in LGR5 protein positive and negative colon cancer among mice model and patients. Our results showed that LGR5 mRNA and protein expression was significantly over-expressed in 193/366 patients and 24/40mice model with primary colon cancer contrasted with matched normal tissues; significantly higher LGR5 gene expression was detected in pT4 cases than that in pT3 cases; PCNA and Ki67 expression was much more increase in colon cancer cells with positive LGR5 expression than those with negative LGR5 expression;LGR5 positive cancer not only in mice model but also in patients have shorter survival rate compared with LGR5 negative cancer. All our study manifested that LGR5 took on an important effect in the initiation and progression of colon cancer, provided also more helpful evidence for clinical diagnosis and an useful indicator for adjuvant therapy. Keywords: LGR5, colon cancer , survival rate.
    Neoplasma 09/2013; · 1.57 Impact Factor
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    ABSTRACT: Podoplanin is highly expressed in human cancers. However, mechanisms regulating podoplanin expression remain elusive. Here we show that podoplanin promotes tumorigenesis of oral squamous cell carcinoma (OSCC) and precancerous cells both in vitro and in vivo, and the ErbB3-binding protein-1 (Ebp1) can be activated in oral tumorigenesis and can serve as a transcriptional activator to drive podoplanin expression in the malignant progression. Most of the OSCC cell lines have no detectable podoplanin protein in low-density cultures. However, the protein becomes detectable in high-density cultures and is required for in-vivo tumor formation of OSCC and oral premalignancies. In a high-density culture condition, podoplanin expression can be triggered at both mRNA and protein levels. In this condition, we showed that Ebp1 is upregulated, translocated from the cytoplasm to the nucleus and binds to the podoplanin promoter to result in a dramatic increase of podoplanin mRNA and protein. Ebp1 downregulation significantly reduced podoplanin expression levels in OSCC cells with a decreased anchorage-dependent growth, invasion and wound healing. Conversely, Ebp1 overexpression enhanced these malignant features through podoplanin upregulation both in vitro and in vivo. In 81 patients with oral premalignant lesions, we found that Ebp1 expression is strongly related to OSCC development. We conclude that Ebp1 has a key role in the upregulation of podoplanin and may contribute to oral tumorigenesis.Oncogene advance online publication, 26 August 2013; doi:10.1038/onc.2013.354.
    Oncogene 08/2013; · 8.56 Impact Factor
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    ABSTRACT: CKLF-like MARVEL transmembrane domain containing member 3 (CMTM3) is silenced in many kinds of cancers and inhibits tumor cells growth. We investigated the expression and role of CMTM3 in clear cell renal cell carcinoma (ccRCC). The expression of CMTM3 was detected in ccRCC tissue microarray, specimens, and cell lines by immunohistochemistry, quantitative real-time polymerase chain reaction (qRT-PCR) and western blot, respectively. After transfected with CMTM3 plasmid or vector, the proliferation and migration of ccRCC 786-0 cells were determined by MTT assay and transwell assay, respectively. Furthermore, the anchorage-independent growth of transfected cells was assessed using soft agar colony formation assay. CMTM3 was down-regulated in 84 % (63/75) of ccRCC tissues and its expression had no correlation with the gender, age, clinical staging and histologic grade. CMTM3 protein was undetectable by western blot in most detected ccRCC specimens and two RCC cell lines (786-0 and ACHN). qRT-PCR analysis showed that CMTM3 mRNA was dramatically down-regulated in 40 ccRCC cancer tissues as compared with the paired adjacent normal ones. Restoration of CMTM3 significantly suppressed the anchorage-independent growth, proliferation and migration of 786-0 cells. These results indicate that CMTM3 is significantly down-regulated in ccRCC and exerts remarkable tumor-suppressive functions in 786-0 cells. Reduction of CMTM3 expression may contribute to the pathogenesis of ccRCC and CMTM3 may be a potentially target for therapeutic strategy.
    Clinical and Translational Oncology 08/2013; · 1.28 Impact Factor
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    ABSTRACT: Multidrug resistance (MDR) is usually correlated with the poor prognosis of gastric cancer. In this study, we revealed a total of 11 microRNAs (miRNA) that regulated MDR of gastric cancer via high-throughput functional screening, and miR-508-5p reversed MDR most efficiently among these candidate miRNAs. The overexpression of miR-508-5p was sufficient to reverse cancer cell resistance to multiple chemotherapeutics in vitro and sensitize tumours to chemotherapy in vivo. Further studies showed that miR-508-5p could directly target the 3'-untranslated regions of ABCB1 and Zinc ribbon domain-containing 1 (ZNRD1), and suppress their expression at the mRNA and protein levels. Meanwhile, the suppression of ZNRD1 led to a decrease in ABCB1. These findings suggest that a miR-508-5p/ZNRD1/ABCB1 regulatory loop has a critical role in MDR in gastric cancer. In addition, miR-508-5p could be used as a prognostic factor for overall survival in gastric cancer. These data reveal an important role for miR-508-5p in the regulation of MDR in gastric cancer, and suggest the potential application of miR-508-5p in drug resistance prediction and treatment.Oncogene advance online publication, 29 July 2013; doi:10.1038/onc.2013.297.
    Oncogene 07/2013; · 8.56 Impact Factor
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    ABSTRACT: a b s t r a c t We report continuous-wave orange laser operation at 607.5 nm of a 8 mm long 0.2at% Pr:LiYF 4 single crystal with an improved laser slope efficiency. Using a single InGaN laser diode emitting at ∼444 nm as a pump source, an output power of ∼200 mW was achieved with a threshold absorbed pump power of ∼150 mW and a laser slope efficiency of nearly 42%. M 2 factors of 1.40 and 1.28 were measured in the x and y directions, respectively, attesting to the good quality of the output laser beam. & 2013 Elsevier B.V. All rights reserved.
  • Z. LIU, T. JIANG, Y. WANG
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    ABSTRACT: Objective: Fluocinolone acetonide was commonly used as anti-inflammatory steroid drug, however, little is known whether it has a potential osteogenic role. In this study, we verified fluocinolone acetonide not only could have the anti-inflammatory effect, but also initiate the osteogenic potential in dental pulp cells (DPCs). Method: DPCs were treated with E. coli LPS in the absence/presence of fluocinolone acetonide or NF-kappa B inhibitor, the anti-inflammatory effect of fluocinolone acetonide was investigated by detection of inflammatory cytokines including IL-1β, TNF-a and IL-10 through real-time PCR and ELISA; while the osteogenic potential of fluocinolone acetonide was assessed by detection of the mineralization-related biomarkers including alkaline phosphate (ALP), Runx2 and osteocalcin through real-time PCR, ELISA and Western blot. Meanwhile, the status of NF-κB was evaluated by electrophoretic mobility shift assay (EMSA) and detection of p-p65 expression by Western blotting. Result: In DPCs, fluocinolone acetonide significantly down-regulated the pro-inflammatory cytokines IL-1β and TNF-a expression and up-regulated anti-inflammatory mediator IL-10 expression by real time PCR and ELISA. EMSA and p-p65 western blot assays showed that fluocinolone acetonide could inhibit LPS-caused inflammation process through blockage of NF-κB pathway. Whereas LPS could decrease the expression of the mineralization-related biomarkers including ALP, Runx2 and OCN, and these effects could be further partly recovered by down-regulation of NF-κB activity. Conclusion: Inflammation caused by LPS depressed the ostegenesis process of DPCs. Fluocinolone acetonide could initiate the ostegenesis process of DPCs, as well as function as anti-inflammatory role through inhibition of NF-κB pathway.
    IADR/AADR/CADR General Session and Exhibition 2013; 03/2013
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    ABSTRACT: Objectives: The third gaseous transmitter hydrogen sulfide (H2S) is considered as one of the main contributors for halitosis. However, little is known about the direct effect of H2S on the behavior of oral squamous cell carcinoma (SCC) cells. In this study, we investigated the cell cycle regulator role of H2S in the oral SCC cell by using NaHS, a donor of H2S. Methods: Oral squamous cell carcinoma cells (Cal27 and GNM) were treated with different concentrations of NaHS, then subjected to cell proliferation, cell cycle, real time PCR and western blot assays. Results: CCK8 results showed that both Cal27 and GNM cells were significantly increased in cell number after NaHS treatment, while cell cycle analysis showed that NaHS-treated Cal27 or GNM cells could accelerate the cell cycle progression compared with untreated control. Real time PCR disclosed that check point genes RB1, Wee1, and CHEK1 were significantly down-regulated by NaHS, subsequently confirmed by western blot using antibodies against to p-RB1 or Wee1 and CHEK1 down-stream proteins including p-Cdc2 and p-CHEK2, respectively. Conclusions: H2S has a potential to accelerate cell cycle progress through the down-regulation of the expression of the checkpoint genes in oral SCC cell lines.
    IADR/AADR/CADR General Session and Exhibition 2013; 03/2013
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    ABSTRACT: This paper presents a comparative study of nanocrystallisation and the wear resistance of electroless plated Ni-P/Ni-W-P duplex coatings with a single Ni-W-P coating before and after high- power diode laser treatment. Effects of the laser operating parameters on microstructures, in terms of crystallisation, porosity formation, phase transformation and grain growth, were investigated using scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) and quantitatively X-ray Diffraction (XRD). Microhardness and wear behaviour of the coatings before and after laser treatment were evaluated by measurement of coating surface and cross-section hardness as well as un-lubricated friction and wear tests. The results revealed that in the case of laser treatment, the Ni-P/Ni-W-P duplex coatings offered better wear resistance than the single Ni-W-P coating, while the as-plated, single Ni-W-P coating showed better wear resistance than the Ni-P/Ni-W-P duplex coatings. Adhesive wear mechanism prevails in the laser-treated coatings when subjected to wear test against hardened steel material. The effects of microstructural characteristics in the coatings, in particularly the grain size of Ni3P phase and the degree of crystallisation, on the adhesive wear behaviour have been investigated and found to be dominant besides the effect of hardness.
    Crystal Research and Technology 02/2013; 48(2). · 1.12 Impact Factor

Publication Stats

2k Citations
626.19 Total Impact Points

Institutions

  • 2013–2014
    • Xiamen University
      • Department of Electronic Engineering
      Amoy, Fujian, China
    • Peking University School of Stomatology
      Peping, Beijing, China
    • Peking University People's Hospital
      Peping, Beijing, China
  • 2011–2014
    • Peking University
      • State Key Laboratory on Advanced Optical Communication Systems and Networks
      Peping, Beijing, China
  • 2003–2014
    • The University of Manchester
      • School of Materials
      Manchester, England, United Kingdom
    • Huazhong University of Science and Technology
      • • State Key Laboratory of Coal Combustion (SKLCC)
      • • State Key Laboratory of Laser Technology
      Wu-han-shih, Hubei, China
    • Tianjin University
      • State Key Laboratory of Precision Measurement Technology and Instruments
      T’ien-ching-shih, Tianjin Shi, China
    • University of New Brunswick
      • Department of Chemical Engineering
      Fredericton, New Brunswick, Canada
    • Dalian University of Technology
      Lü-ta-shih, Liaoning, China
  • 2006–2013
    • Fourth Military Medical University
      • • State Key Laboratory of Cancer Biology
      • • Department of Gastroenterology
      Xi’an, Liaoning, China
    • Ocular Surface Center
      Miami, Florida, United States
  • 2009–2012
    • National University of Defense Technology
      • College of OptoElectronic Science and Engineering
      Ch’ang-sha-shih, Hunan, China
    • Xi'an Jiaotong University
      Ch’ang-an, Shaanxi, China
    • Beijing University of Posts and Telecommunications
      Peping, Beijing, China
  • 1996–2012
    • Chinese Academy of Sciences
      • • Key Laboratory of Materials Physics
      • • State Key Laboratory of Electroanalytical Chemistry
      • • Institute of Genetics and Developmental Biology
      • • Institute of Modern Physics
      Peping, Beijing, China
  • 2009–2011
    • University of Maryland, Baltimore
      • Department of Pharmaceutical Sciences (PSC)
      Baltimore, MD, United States
  • 2010
    • Tongji University
      • State Key Laboratory of Marine Geology
      Shanghai, Shanghai Shi, China
    • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
      Shanghai, Shanghai Shi, China
    • Shanghai Jiao Tong University
      Shanghai, Shanghai Shi, China
    • University of Wisconsin, Madison
      • Reed Center for Photonics
      Madison, MS, United States
  • 2006–2009
    • Peking Union Medical College Hospital
      • Department of Obstetrics and Gynecology
      Peping, Beijing, China
  • 1994–2009
    • Nanjing University
      • • Department of Physics
      • • School of Medicine
      Nanjing, Jiangsu Sheng, China
  • 2008
    • Ocean University of China
      Tsingtao, Shandong Sheng, China
    • Huazhong Agricultural University
      • College of Fisheries
      Wuhan, Hubei, China
  • 2007
    • Stanford University
      • Department of Electrical Engineering
      Palo Alto, California, United States
    • Chinese Academy of Medical Sciences
      Peping, Beijing, China
  • 1995–2007
    • Tsinghua University
      • • Department of Chemistry
      • • Department of Chemical Engineering
      Beijing, Beijing Shi, China
    • Academia Sinica
      • Institute of Physics
      T’ai-pei, Taipei, Taiwan
    • Institute of physics china
      Peping, Beijing, China
  • 2001–2006
    • Northeast Institute of Geography and Agroecology
      • • Institute of Geology and Geophysics
      • • State Key Laboratory of Electroanalytical Chemistry
      • • Institute of Genetics and Developmental Biology
      • • Institute of Biochemistry and Cell Biology
      Beijing, Beijing Shi, China
    • Shanghai Institutes for Biological Sciences
      Shanghai, Shanghai Shi, China
  • 2005
    • Intelligent Hearing Systems, Miami, FL USA
      Miami, Florida, United States
  • 2001–2002
    • Nanjing Medical University
      • Department of Nephrology
      Nanjing, Jiangsu Sheng, China
  • 2000–2001
    • Wayne State University
      • Department of Chemistry
      Detroit, MI, United States
    • Sichuan University
      • Department of General Surgery
      Hua-yang, Sichuan, China
    • RIKEN
      Вако, Saitama, Japan
    • The Hong Kong University of Science and Technology
      • Department of Physics
      Kowloon, Hong Kong
    • Shanxi Medical University
      • Department of Obstetrics and Gynecology
      Yangkü, Shanxi Sheng, China
  • 1995–2001
    • Third Military Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
  • 1994–2000
    • Sun Yat-Sen University of Medical Sciences
      中山, Guangdong, China
  • 1996–1997
    • Beijing Hospital
      Peping, Beijing, China
  • 1992–1996
    • Chinese PLA General Hospital (301 Hospital)
      Peping, Beijing, China
  • 1993
    • The University of Hong Kong
      • Department of Physics
      Hong Kong, Hong Kong
  • 1990
    • National Institute for the Control of Pharmaceutical and Biological Products
      Peping, Beijing, China