Young Jin Choi

Sejong General Hospital, Bucheon, Gyeonggi-do, South Korea

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Publications (193)422.13 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: To enhance the oral bioaccessibility of flavonoids including quercetin, naringenin, and hesperetin, we prepared the edible oil-based lipid nanoparticle (LNP) system. Flavonoid-loaded LNPs were similar to the blank LNP on physicochemical characteristics (z-average < 154.8 nm; polydispersity index < 0.17; and ζ-potential < -40.8 mV), and their entrapment efficiency was > 81% at 0.3 wt% flavonoid concentration of the lipid phase. In the simulated digestion assay (mouth, stomach, and small intestine), LNPs were hydrolyzed under the small intestine condition and protected successfully incorporated flavonoids (≥ 94%). Moreover, the relative bioaccessibility of flavonoids was > 71%, which was otherwise < 15%, although flavonoids were released rapidly from LNPs into the medium. In conclusion, since the flavonoids incorporated in LNPs were preserved well during oral digestion and improved in the bioaccessibility, the designed LNP system may serve as an encapsulation strategy to enhance the bioavailability of non-bioaccessible nutraceuticals in foods.
    Journal of Agricultural and Food Chemistry 10/2015; DOI:10.1021/acs.jafc.5b01495 · 3.11 Impact Factor
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    ABSTRACT: Palonosetron is the second-generation 5-hydroxytryptamine 3 receptor antagonist (5-HT3RA) that has shown better efficacy than the first-generation 5-HT3RA for prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately emetogenic chemotherapy (MEC). Granisetron transdermal delivery system (GTDS), a novel transdermal formulation, was developed to deliver granisetron continuously over 7 days. This study compared the efficacy and tolerability of the GTDS to palonosetron for the control of CINV following MEC. A total of 196 patients were randomized to GP or PG group. In this multicenter, randomized, open-label, cross-over, active-controlled, Phase IV study, GP group was assigned to receive transdermal granisetron (one GTDS patch, 7 days) in the first chemotherapy cycle, palonosetron (iv 0.25 mg/day, 1 days) in the second chemotherapy cycle before receiving MEC, and PG group was assigned to receive palonosetron in the first cycle and GTDS in the second cycle. Primary endpoint was the percentage of chemotherapy cycles achieving complete response (CR; defined as no emetic episodes and no rescue medication use) during the acute phase (0-24 h in post-chemotherapy; non-inferiority comparison with palonosetron). Total 333 cycles (165 in GTDS and 168 in palonosetron) were included in the per protocol analysis. The GTDS cycles showed non-inferiority to palonosetron cycles during the acute phase: CR was achieved by 124 (75.2 %) patients in the GTDS cycles and 134 (79.8 %) patients in the palonosetron cycles (treatment difference, -4.6 %; 95 % confidence interval, -13.6-4.4). There was no significant difference in CR rate during acute phase after the end of the first and second chemotherapy cycle between GP and PG group (p = 0.405, p = 0.074). Patients' satisfaction, assessed using Functional Living Index-Emesis (FLI-E), GTDS cycle were higher than those of palonosetron cycle in GP group (FLI-E score; median 1549.5 in GTDS cycle, median 1670.0 in palonosetron cycle). Both treatments were well tolerated and safe. Transdermal granisetron is a good alternative therapeutic option to palonosetron for preventing CINV after MEC.
    Supportive Care in Cancer 08/2015; DOI:10.1007/s00520-015-2865-8 · 2.50 Impact Factor
  • Quanli Hu · Young Jin Choi · Chi Jung Kang · Hyun Ho Lee · Tae-Sik Yoon
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    ABSTRACT: The reflectivity and consequent color of anodic aluminum oxide (AAO) containing maghemite (γ-Fe2O3) nanoparticles (NPs) were investigated. The hexagonally ordered pores of AAO were completely filled with maghemite NPs with ∼20 nm in diameter by the dip-coating process. The AAOs containing maghemite NPs have a reduced reflectivity of light at the wavelength below ∼600 nm, resulting in golden color. The reduced reflectivity and golden color of AAOs with NPs was explained by the absorption of light from blue to violet wavelength range by maghemite NPs. These results indicate the potential color-engineering of AAO by means of wavelength-selective absorption by incorporated NPs.
    Journal of Industrial and Engineering Chemistry 04/2015; 24:293-296. DOI:10.1016/j.jiec.2014.09.044 · 3.51 Impact Factor
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    ABSTRACT: Tumor hypoxia is significant in promoting tumor progression and resistance to therapy, and hypoxia-inducible factor 1α (HIF-1α) is essential in the adaptive response of cells to hypoxia. The aim of the present study was to investigate the expression of hypoxic markers and evaluate their prognostic significance in soft tissue sarcoma (STS). A retrospective analysis of 55 patients with STS from Pusan National University Hospital (Busan, Korea) between 1998 and 2007 was conducted, using immunohistochemistry to analyze the expression of HIF-1α, carbonic anhydrase 9 (CA9), glucose transporter-1 (GLUT1) and vascular endothelial growth factor (VEGF). The association between the overexpression of these markers and clinicopathological characteristics, including the overall survival (OS) and progression-free survival (PFS) in cases of STS, were investigated. Overexpression of HIF-1α, CA9, GLUT1 and VEGF was shown in 54.5, 32.7, 52.7 and 25.5% of tumors, respectively, and all exhibited a significant association with high French Federation of Cancer Centers (FNCLCC) grade and high American Joint Committee on Cancer (AJCC) stage. Overexpression of HIF-1α and CA9 was associated with a shorter OS and a shorter PFS. On multivariate analysis, AJCC stage and HIF-1α overexpression had independent prognostic significance. In the group receiving chemotherapy (n=27), HIF-1α overexpression was independently associated with a decreased OS. These results indicate that overexpression of HIF-1α and CA9 is associated with poor prognosis, and that HIF-1α overexpression is an independent unfavorable prognostic factor in STS.
    Oncology letters 04/2015; 9(4):1699-1706. DOI:10.3892/ol.2015.2914 · 0.99 Impact Factor
  • Young Mi Seol · Young Jin Choi · Byung Joo Lee · Soo Geun Wang
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    ABSTRACT: Cervical metastases from unknown primary tumors are rare and no clear therapeutic options are available. This study was performed to assess the efficacy and safety profiles of induction chemotherapy followed radiotherapy in patients with cervical lymph node metastases from unknown primary cancer. Patients with histological diagnosis of cervical lymph-node metastasis from carcinoma with an unknown primary cancer underwent induction chemotherapy followed by radiotherapy. All patients had squamous cell carcinoma. Induction chemotherapy consisted of 3–4 cycles every 3 weeks of docetaxel (day 1.70 mg/m2) and cisplatin (day 1.75 mg/m2). Radiation therapy (RT) was started with in 10 weeks of the last cycle of chemotherapy, and it was administered 5 days per week. It was given in daily fractions of (1.8) Grays (Gy) of 2 Gy and the total dose to the primary tumor was 70–74 Gy. Neck dissection was reserved for residual disease after definitive radiotherapy. Overall survival, recurrent free survival, and locoregional control were calculated using the Kaplan–Meier method. Twenty one patients with an unknown primary cancer underwent induction chemotherapy and radiotherapy. After induction chemotherapy, 6 patients achieved CR and 8 patients achieved PR. The overall response rate after radiation, was 90.4 % (19 of 21 patients). Neutropenia and infection were the most common grade 3–4 adverse event during induction chemotherapy. Mucositis and dermatitis were the most common grade 3–4 toxicities during radiotherapy. With a median follow-up of 50.6 months, the estimated 2 years OS rates were 71 ± 6 %, respectively. The median OS was 42 months (95 % confidence interval CI 8–65 months). The recurrent-free survival rate at 2 years was 57 %, respectively. In the patients with responder to induction chemotherapy, superior relapse free survival and overall survival rate observed. No occurrence of primary cancer was observed during the follow-up period. Induction chemotherapy followed RT for unknown primary cancer has provided good overall and disease-free survival in all the patients with an acceptable rate of complications. The use of induction chemotherapy and radiation therapy for more advanced disease led to good clinical results with reasonable toxicities.
    Indian Journal of Otolaryngology and Head & Neck Surgery 03/2015; 67(Suppl 1):74-8. DOI:10.1007/s12070-014-0773-8 · 0.05 Impact Factor
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    ABSTRACT: There are limited data about long-term outcomes for biodegradable polymer biolimus-eluting stent (BES) versus durable polymer everolimus-eluting stent (EES) in patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). We sought to compare the two-year efficacy and safety of BES versus EES in AMI patients. A total of 707 consecutive patients with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction who underwent PCI with BES (n=171) or EES (n=536) between July 2008 and June 2012 were enrolled in this study. The efficacy endpoint (target vessel failure; a composite of cardiac death, target vessel-related myocardial infarction, and target vessel revascularization) and the safety endpoint (a composite of all cause death, myocardial infarction, and stent thrombosis) at two years were compared in crude and propensity score-matched cohorts. After two years, target vessel failure occurred in 13 patients treated with BES and 49 patients treated with EES (7.6% versus 9.1%; adjusted hazard ratio [HR], 1.09; 95% confidence interval [CI], 0.58-2.04; p=0.78). The rates of composite safety endpoint at two years were not different between two groups (BES 7.6% versus EES 10.8%; adjusted HR, 0.87; 95% CI, 0.47-1.62; p=0.66). The rates of stent thrombosis did not differ between two groups (BES 0.6% versus EES 1.3%; adjusted HR, 0.63; 95% CI, 0.06-6.20; p=0.69). These findings were substantiated by similar results in the propensity score-matched cohort. In the treatment of patients with AMI, BES showed similar efficacy and safety compared to those of EES for up to two years. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    International Journal of Cardiology 01/2015; 183C:190-197. DOI:10.1016/j.ijcard.2015.01.036 · 6.18 Impact Factor
  • IEEE Transactions on Nanotechnology 01/2015; DOI:10.1109/TNANO.2015.2445978 · 1.62 Impact Factor
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    ABSTRACT: Uniformly sized hexagonal shaped manganese oxide (MnO) nanoparticles were chemically synthesized. The bipolar resistive switching characteristics were investigated in the Ti/MnO/Pt structure. The nanoparticles were assembled as close-packed monolayer with a thickness of 30 nm by dip-coating and annealing procedures. The bipolar resistive switching behaviors in Ti/MnO/Pt device could be caused by the formation and rupture of conductive filaments in the nanoparticles. The temperature dependence of resistance was discussed. The resistance of HRS presented a negative temperature dependence at high temperature, indicating a typical semiconducting behavior. The resistance of LRS increased with the elevated temperature exhibiting a metallic state. Ohmic conduction, space charge limited conduction (SCLC), and Schottky conduction have been investigated for the conduction and switching mechanism.
    Semiconductor Science and Technology 01/2015; 30(1). DOI:10.1088/0268-1242/30/1/015017 · 2.21 Impact Factor
  • Eun Ji Yoo · Il Kwon Shin · Tae Sik Yoon · Young Jin Choi · Chi Jung Kang
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    ABSTRACT: Binary transition metal oxides such as ZnO, TiO2, and MnO; and their various structures such as thin film, nanowire, and nanoparticle assembly; have been widely investigated for use in insulators in resistive random access memory (ReRAM), considered a next-generation nonvolatile memory device. Among the various driving mechanisms of resistive switching in insulating materials, the conductive filament model is one of the most widely accepted. Studies on spatially confined structures such as one-dimensional nanostructures and zero-dimensional nanoparticles to reveal the detailed filament constructing mechanism are warranted because low-dimensional nanostructures can provide more localized properties with a narrow dispersion of operational parameter values compared with thin-film structures. We investigated the resistive switching characteristics of ZnO nanowire (NW) structures. The NWs were grown on an Au/Ti/SiO2/Si substrate via the hydrothermal method. The empty space between the top and bottom electrodes was filled with a photoresist to prevent direct connection between the electrodes. The top electrode (Cr) and bottom electrode (Au), both with a thickness of ∼100 nm, were deposited by DC sputtering. The current–voltage (I–V) measurements were performed using a semiconductor characterization system. Additionally, the local current image and the point I–V characteristics for each NW were examined by replacing the top electrode with a conducting atomic force microscope tip. The Au–ZnO NW–Cr devices exhibited bipolar resistive switching behavior.
    Journal of Nanoscience and Nanotechnology 12/2014; 14(12):9459-64. DOI:10.1166/jnn.2014.10157 · 1.34 Impact Factor
  • Choongjin Ban · Seokwon Lim · Pahn-Shick Chang · Young Jin Choi
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    ABSTRACT: Aggregation of unstable particles in water limits the application of lipid nanoparticle (LNP) systems to foods despite the capability to encapsulate lipophilic bioactive components. Here, we exploit a preparation process that can reduce the aggregation of LNPs. Sonication during the cooling step (post-sonication) for 4, 5 or 6 min was applied to increase the covering effect of Tween 20 on the particle. Additionally, LNPs were prepared using fully hydrogenated canola oil (FHCO) blended with 0-30 wt% liquid canola oil (LCO) of the lipid phase. Surfactant surface load data indicate that the post-sonication might make non-emulsifying Tween 20 diffuse from aqueous phase to droplet surfaces, which could decrease the crystallinity index (CI) of LNPs due to the inhibition of lipid crystallization. Moreover, the LCO content in lipid matrix could decrease the CI, which could reduce forming hydrophobic patches on the particle surface. Therefore, the post-sonication and the LCO addition in the matrix could effectively prevent the aggregation among hydrophobic patches. This improved colloidal stability of LNPs was verified by the particle shape in transmission electron microscopy and the gelation test. Consequently, LNPs fabricated using 6 min post-sonication and 30 wt% LCO in the lipid exhibited the greatest stability (size: 202.3 nm; CI: 57.5%; and Tween 20 surface load: 10.29 mg m-2).This study may serve as a basis for further researches that aim to develop delivery systems for functional foods.
    Journal of Agricultural and Food Chemistry 11/2014; 62(47). DOI:10.1021/jf503489v · 3.11 Impact Factor
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    ABSTRACT: Hysteresis and threshold switching characteristics were investigated in the indium-gallium-zinc-oxide (IGZO) thin-film-transistors (TFTs) with inserted Pt-Fe2O3 core–shell nanocrystals (NCs) layer between source/drain and IGZO channel. The output curves showed the hysteresis with threshold drain voltage and the transfer curves showed the hysteresis with the shift of threshold gate voltage. These hysteresis, threshold switching, and shift of threshold voltage in both output and transfer curves are caused by charging of inserted NCs. These unique features demonstrated the memory and on/off switching operation by controlling both threshold gate and drain voltages through charging NCs.
    Semiconductor Science and Technology 11/2014; 29(11). DOI:10.1088/0268-1242/29/11/115017 · 2.21 Impact Factor
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    ABSTRACT: The fabrication of 3 × 3 crossbar arrays measuring 20 μm in width was demonstrated. The bipolar resistive switching characteristics in manganese oxide nanoparticles were investigated in the crossbar structure of top electrode (Au)/nanoparticle assembly/bottom electrode (Ti) on SiO2/Si substrate. The monodisperse manganese oxide nanoparticles measuring 13 nm in diameter were chemically synthesized by thermal decomposition of manganese acetate in the presence of oleic acid at high temperature. The nanoparticles were assembled as a layer measuring 30 nm thick by repeated dip-coating and annealing steps. The Au/nanoparticle assembly/Ti devices performed the bipolar behavior associated with the formation and sequential rupture of multiple conducting filaments in applying bias on Au electrode. When the voltage was swept from to +5 V to the Au top electrode, the reset voltage was observed at ∼4.4 V. As the applied voltage swept from 0 to −5 V, the set voltage occurred at ∼−1.8 V.
    Journal of Nanoscience and Nanotechnology 11/2014; 14(11). DOI:10.1166/jnn.2014.9878 · 1.34 Impact Factor
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    ABSTRACT: Objectives We sought to evaluate the impact of final kissing balloon inflation (FKBI) after simple stent implantation for the treatment of non-left main true coronary bifurcation lesions in patients with acute coronary syndrome (ACS). Background Whether FKBI should be mandatory after simple stent implantation for the treatment of coronary bifurcation lesion is controversial. Besides, ACS patients who have undergone bifurcation percutaneous coronary intervention with simple stent implantation may experience worse prognosis compared to stable angina pectoris patients. Methods Two hundred and fifty one eligible patients (67.7% male, mean age 61.7 ± 10.4 years) were enrolled. The study population was divided into two groups according to the performance of FKBI. The primary end points were major adverse cardiac event (MACE); target lesion revascularization (TLR), non-fatal myocardial infarction (MI) and cardiac death during the follow-up period. Results Over a mean follow-up period of 3.0 ± 1.9 years, there were 29 MACEs (10 TLR, 6 non-fatal MI, and 13 cardiac deaths), representing an event rate of 11.6%. Kaplan–Meier survival analysis revealed that FBKI group had favorable outcome compared to non-FKBI group with regard to hard events (p = 0.010) as well as composite MACEs (p = 0.008). In multivariable analysis, FKBI was a significant predictor of composite MACEs [hazard ratio 0.398 (95% confidence interval 0.190–0.836, p = 0.015)] and hard events [hazard ratio 0.325 (95% confidence interval 0.130–0.811, p = 0.016)]. Conclusions In terms of prognosis, performing FKBI after simple stent implantation for the treatment of non-left main true coronary bifurcation lesions may be mandatory in ACS patients.
    International Journal of Cardiology 10/2014; 177(3). DOI:10.1016/j.ijcard.2014.10.029 · 6.18 Impact Factor
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    ABSTRACT: Double-layered microparticles for enzyme-triggered release in the gastrointestinal tract were prepared by spray-chilling a water/oil/water emulsion, which could be a promising candidate for the targeted delivery of water-soluble bioactive compounds. Based on response surface methodology, the optimum conditions for 2nd emulsifier content, concentration ratio of the single emulsion to the coating material, and dispersion fluid temperature were 201.5μmol, 0.30, and 10.1°C, respectively. Morphological characterisation using an FE-SEM indicated that double-layered microparticles with diameters of 7-10μm were spherical and possessed scores of inner droplets. Release profiles generated using in vitro digestion models revealed that the core of double-layered microparticles was gradually released by enzymatic degradation when exposed to the simulated intestinal environment. The accumulative release reached 59.8±0.2% within a residence time of 3h, whereas they were resistant to gastric release-stimuli, such as extremely low pH and pepsin (below 2.4±0.6%).
    Food Chemistry 10/2014; 161:53–59. DOI:10.1016/j.foodchem.2014.03.125 · 3.39 Impact Factor
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    ABSTRACT: We observed giant enhancement of Raman intensity from 4-Mpy molecules adsorbed on semiconducting one-dimensional ZnO nanostructures, nanowires and nanocones, without involving any noble metals. Interestingly, the enhancement is strongly dependent on the geometry of ZnO nanostructures and can mainly be explained by the cavity-like structural resonance of the electric field. Our results can be applied to systematically create hot spots for Raman signal enhancement using one-dimensional semiconducting nanomaterials.
    Nanoscale 10/2014; 6(24). DOI:10.1039/C4NR04527K · 7.39 Impact Factor
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    ABSTRACT: Biocompatibility, sensing, and self-actuation are very important features for a therapeutic biomedical microrobot. As a new concept for tumor theragnosis, this paper proposes a monocyte-based microrobots, which are combining the phagocytosis and engulfment activities containing human acute monocytic leukemia cell line (THP-1) with various sized polystyrene microbeads are engulfed instead of a therapeutic drug. For the validation of the blood vessel barrier-penetrating activity of the monocyte-based microrobot, we fabricate a new cell migration assay with monolayer-cultured endothelial cell (HUVEC), similar with the blood vessels. We perform the penetrating chemotactic motility of the monocyte-based microrobot using various types of the chemo-attractants, such as monocyte chemotactic protein (MCP)-1, human breast cancer cell lines (MCF7)-cell lysates, and -contained alginate spheroids. The monocyte-based microrobot show chemotactic transmigrating motilities similar with what an actual monocyte does. This new paradigm of a monocyte-based microrobot having various useful properties such as biocompatibility, sensing, and self-actuation can become the basis of a biomedical microrobot using monocytes for diagnosis and therapy of various diseases. Biotechnol. Bioeng. © 2014 Wiley Periodicals, Inc.
    Biotechnology and Bioengineering 10/2014; 111(10). DOI:10.1002/bit.25270 · 4.16 Impact Factor
  • Journal of the American College of Cardiology 09/2014; 64(11):B28. DOI:10.1016/j.jacc.2014.07.123 · 15.34 Impact Factor
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    ABSTRACT: The fabrication of 3 x 3 crossbar arrays with a width of 20 mu m is demonstrated. The bipolar resistive switching characteristics in Pt-Fe2O3 core-shell nanopartides are investigated in the crossbar structure of top electrode (Au)/Pt-Fe2O3 nanoparticle assembly/bottom electrode (Ti) on SiO2/Si substrate. The monodisperse Pt-Fe2O3 nanoparticles with the diameter similar to 15 nm are chemically synthesized by the preferential oxidation of Fe and then pileup of Pt into the core in the presence of oleic acid and oleylamine at high temperature. The nanoparticles are assembled as a layer with a thickness of 50 nm by repeated dip-coating. The Pt cores in the core-shell nanoparticles act as electron traps. The bipolar resistive switching behavior in Au/nanoparticle assembly/Ti device could be caused by the electron trapping and detrapping of the nanoparticles. The resistance ratio of HRS to LRS is similar to 57 at a reading voltage of 0.5 V. The value of reset voltage is 3.4 V and that of set voltages is -1.0 V.
    Microelectronic Engineering 09/2014; 127:40–43. DOI:10.1016/j.mee.2014.04.023 · 1.34 Impact Factor
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    ABSTRACT: Purpose The aim of this study is to identify the prognostic factors of distant metastasis (DM) after induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CRT) for locoregionally advanced head and neck cancer (HNC). Materials and Methods A total of 321 patients with HNC who underwent IC followed by CRT treated between January 2005 and December 2010 were analyzed retrospectively. IC consisted of three courses of docetaxel (70 mg/m2) and cisplatin (75 mg/m2) every three weeks, followed by radiotherapy of 66-70 Gy/2 Gy per fraction/5 fractions per week concurrent with weekly cisplatin (40 mg/m2). Tumor/nodal stage, primary site, tumor differentiation, lower neck node involvement (level IV, VB, and supraclavicular regions), number of concurrent chemotherapy cycles, overall duration of radiotherapy, and response to IC were assessed as potential prognostic factors influencing DM and survival outcome. Results The five-year loco-regional recurrence and DM rates were 23.6% and 18.2%. N stage, overall duration of radiotherapy, lower neck node involvement, and response to IC were significant factors for DM. With a median follow-up period of 52 months (range, 4 to 83 months), the 5-year progression-free, DM-free, and overall survival rates were 41.2%, 50.7%, and 55.1%, respectively. Lower neck node involvement (p=0.008) and poor response to IC (p < 0.001) showed an association with significantly inferior DM-free survival. Conclusion Even with the addition of IC, the DM rate and survival outcome were poor when metastatic lower neck lymph nodes were present or when patients failed to respond after receiving IC.
    Cancer Research and Treatment 08/2014; 47(1). DOI:10.4143/crt.2013.212 · 2.98 Impact Factor
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    ABSTRACT: Long-term outcomes are imperative to confirm safety of drug-eluting stents. There have been 2 randomized controlled trials comparing everolimus-eluting stents (EESs) and Resolute zotarolimus-eluting stents (ZES-Rs). To date, long-term clinical outcomes of these stents were limited to only 1 report, which has recently reported 4-year comparisons of these stents. Therefore, more evidence is needed regarding long-term clinical outcomes of the second-generation stents. This study compared the long-term clinical outcomes of EES with ZES-R in "all-comer" cohorts up to 3-year follow-up. The EXCELLENT and RESOLUTE-Korea registries prospectively enrolled 3,056 patients treated with EES and 1,998 with ZES-R, respectively, without exclusions. Stent-related composite outcomes (target lesion failure) and patient-related composite events up to 3-year follow-up were compared in crude and propensity score-matched analyses. Of 5,054 patients, 3,830 patients (75.8%) had off-label indication (2,217 treated with EES and 1,613 treated with ZES-R). The stent-related outcome (189 [6.2%] vs 127 [6.4%], p = 0.812) and the patient-related outcome (420 [13.7%] vs 250 [12.5%], p = 0.581) did not differ between EES and ZES-R, respectively, at 3 years, which was corroborated by similar results from the propensity score-matched cohort (hazard ratio [HR] 0.92, 95% confidence interval [CI] 0.70 to 1.20, p = 0.523 and 0.85, 95% CI 0.70 to 1.02, p = 0.081, for stent- and patient-related outcomes, respectively). The rate of definite or probable stent thrombosis up to 3 years (22 [0.7%] vs 10 [0.5%], p = 0.370) was also similar. The rate of very late definite or probable stent thrombosis was very low and comparable between the 2 stents (3 [0.1%] vs 1 [0.1%], p = 0.657). In multivariate analysis, chronic renal failure (adjusted HR 3.615, 95% CI 2.440 to 5.354, p <0.001) and off-label indication (adjusted HR 1.782, 95% CI 1.169 to 2.718, p = 0.007) were the strongest predictors of target lesion failure at 3 years. In conclusion, both stents showed comparable safety and efficacy at 3-year follow-up in this robust real-world registry with unrestricted use of EES and ZES-R. Overall incidences of target lesion failure and definite stent thrombosis, including very late stent thrombosis, were low, even in the patients with off-label indications, suggesting excellent long-term safety and sustained efficacy of both types of second-generation drug-eluting stents.
    The American Journal of Cardiology 08/2014; 114(9). DOI:10.1016/j.amjcard.2014.07.065 · 3.43 Impact Factor

Publication Stats

1k Citations
422.13 Total Impact Points

Institutions

  • 2013–2015
    • Sejong General Hospital
      Bucheon, Gyeonggi-do, South Korea
  • 2006–2015
    • Myongji University
      • Department of Physics
      Sŏul, Seoul, South Korea
    • Ajou University
      • Department of Physics
      Sŏul, Seoul, South Korea
  • 1998–2015
    • Pusan National University
      • • Department of Internal Medicine
      • • Department of Polymer Science and Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2014
    • Chonnam National University
      • School of Mechanical Systems Engineering
      Gwangju, Gwangju, South Korea
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 1997–2014
    • Seoul National University
      • • College of Agriculture and Life Sciences
      • • Department of Agricultural Biotechnology
      • • Department of Electrical and Computer Engineering
      • • Inter-University Semiconductor Research Center
      Sŏul, Seoul, South Korea
  • 2008–2013
    • Catholic University of Korea
      • • Department of Pathology
      • • Department of Obstetrics and Gynecology
      • • College of Medicine
      Sŏul, Seoul, South Korea
    • University of Cambridge
      • Department of Engineering
      Cambridge, England, United Kingdom
    • Chonbuk National University
      • Semiconductor Physics Research Center
      Sŏul, Seoul, South Korea
    • University of Texas Southwestern Medical Center
      • Department of Physiology
      Dallas, Texas, United States
    • Purdue University
      West Lafayette, Indiana, United States
  • 1998–2013
    • Kyung Hee University
      • • College of Oriental Medicine
      • • Department of Physics
      Sŏul, Seoul, South Korea
  • 2007–2012
    • Hallym University Medical Center
      • • Department of Cardiology
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Samsung Medical Center
      • Division of Breast and Endocrine Surgery
      Sŏul, Seoul, South Korea
  • 2011
    • Gyeongsang National University
      Shinshū, Gyeongsangnam-do, South Korea
  • 2009–2011
    • Chungbuk National University
      • College of Veterinary Medicine
      Chinsen, North Chungcheong, South Korea
    • Sogang University
      • Department of Chemical and Biomolecular Engineering
      Seoul, Seoul, South Korea
  • 2004–2011
    • Chungnam National University
      • • College of Medicine
      • • Department of Mechanical Design Engineering
      Daiden, Daejeon, South Korea
    • Korea Institute of Science and Technology
      • Interaction and Robotics Research Center
      Seoul, Seoul, South Korea
  • 2010
    • Eulji University
      Daiden, Daejeon, South Korea
    • Dong-A University
      Tsau-liang-hai, Busan, South Korea
    • University of Science and Technology, Beijing
      Peping, Beijing, China
  • 2007–2009
    • Washington State University
      • School of Mechanical and Materials Engineering
      پولمن، واشینگتن, Washington, United States
  • 2000–2009
    • Hallym University
      • College of Medicine
      Sŏul, Seoul, South Korea
    • University of Ulsan
      Ulsan, Ulsan, South Korea
  • 2006–2008
    • Sungkyunkwan University
      Sŏul, Seoul, South Korea
  • 2005–2006
    • University of California, Davis
      • Department of Food Science and Technology
      Davis, California, United States