Young Jin Choi

Sejong General Hospital, Bucheon, Gyeonggi-do, South Korea

Are you Young Jin Choi?

Claim your profile

Publications (204)502.64 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: In this study, a new type of targeted bacteriobots is prepared and investigated as a therapeutic strategy against solid tumors. Maleimide-functionalized hyaluronic acid (HA) polymer is synthesized and cross-linked with four-arm-thiolated polyethylene glycol (PEG-SH) to form HA microbeads with diameter of 8 μm through the Michael-type addition. Docetaxel (DTX)-loaded nanoparticles are encapsulated in HA-PEG microbeads and sustained in vitro drug-release pattern of the DTX from the HA-PEG microbeads is observed for up to 96 h. Dual-targeted bacteriobots are prepared using CD 44 receptor-targeted HA microbeads synthesized via microfluidics, followed by the attachment of the flagellar bacterium Salmonella typhimurium, which have been genetically engineered for tumor targeting, onto the surface of the HA microbeads by the specific interaction between streptavidin on the HA beads and biotin on the bacteria. After the attachment of bacteria, the bacteriobots show an average velocity of 0.72 μm s(-1) and high chemotactic migration velocity of 0.43 μm s(-1) towards 4T1 cells lysates. CD 44 receptor-specific cellular uptake is verified through flow cytometry analysis and confocal imaging, demonstrating enhanced intracellular uptake in CD 44 receptor positive tumor cells compared to normal cells. Therefore, the present study suggests that these bacteriobots have dual-tumor-targeting abilities displaying their potential for targeted anticancer therapy.
    Advanced Healthcare Materials 11/2015; DOI:10.1002/adhm.201500556 · 5.80 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In spite of recent significant research into various two-dimensional (2D) materials after the emergence of graphene, the development of a new 2D material that provides both high mobility and an appropriate energy band gap (which are crucial for various device applications) remains elusive. In this report, we demonstrate that the carrier transport behaviour of 2D Ti2CTx, which belongs to the family of 2D transition metal carbides and nitrides, can be tuned by modifying the surface group Tx (-OH, -F, and -O). Our results show that 2D Ti2C(OH)xFy and Ti2COx films can be obtained via simple chemical treatment, thermal annealing, and mechanical exfoliation processes. For the first time, we study the carrier transport properties of 2D Ti2CTx field effect transistors (FETs), obtaining the high field effect carrier mobilities of 10(4) cm(2) V(-1) s(-1) at room temperature. The temperature dependent resistivity of the Ti2COx film exhibits semiconductor like Arrhenius behaviour at zero gate voltage, from which we estimate the energy gap of 80 meV. One interesting feature of the FETs based on transition metal carbides is that the field effect mobility at room temperature is less sensitive to the measured transport gaps, which may arise from the dominant charge transport of activated carriers over the narrow energy gaps of the transition metal carbides. Our results open up the possibility that new 2D materials with high mobilities and appropriate band gaps can be achieved, and broaden the range of electronic device applications of Ti2CTx films.
    Nanoscale 11/2015; 7(46). DOI:10.1039/c5nr06513e · 7.39 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Carbon nanotubes (CNTs) have been investigated as field-emission sources owing to their highelectrical conductivity and high aspect ratio. However, practical applications demand that the emission lifetime of CNTs be further improved. Since ZnO demonstrates impressive electrical and thermal conductivity, when coated on the surface of CNTs, it can allow the CNT field emitters to endure high electrical stress and high temperature. Moreover, ZnO nanostructures protect the CNT emitters from being bombarded by high-energy ions, which are accelerated by the high electric field. From the result of emission lifetime measurements at the emission current density of 100 mA/cm2, we found that the emission lifetime was increased by more than a factor of 2 when ZnO had been coated onto the CNT emitters. The observation registers as an important contribution to the practical application of CNT emitters with long-term emission stability, as well as with high emission currents. In this work, we elucidate the detailed mechanism of long-term stability that can be achieved by coating ZnO nanostructures on the surface of CNTs.
    Journal of Nanoscience and Nanotechnology 11/2015; 15(11). DOI:10.1166/jnn.2015.11565 · 1.56 Impact Factor
  • Choongjin Ban · So Jeong Park · Seokwon Lim · Seung Jun Choi · Young Jin Choi ·
    [Show abstract] [Hide abstract]
    ABSTRACT: To enhance the oral bioaccessibility of flavonoids including quercetin, naringenin, and hesperetin, we prepared the edible oil-based lipid nanoparticle (LNP) system. Flavonoid-loaded LNPs were similar to the blank LNP on physicochemical characteristics (z-average < 154.8 nm; polydispersity index < 0.17; and ζ-potential < -40.8 mV), and their entrapment efficiency was > 81% at 0.3 wt% flavonoid concentration of the lipid phase. In the simulated digestion assay (mouth, stomach, and small intestine), LNPs were hydrolyzed under the small intestine condition and protected successfully incorporated flavonoids (≥ 94%). Moreover, the relative bioaccessibility of flavonoids was > 71%, which was otherwise < 15%, although flavonoids were released rapidly from LNPs into the medium. In conclusion, since the flavonoids incorporated in LNPs were preserved well during oral digestion and improved in the bioaccessibility, the designed LNP system may serve as an encapsulation strategy to enhance the bioavailability of non-bioaccessible nutraceuticals in foods.
    Journal of Agricultural and Food Chemistry 10/2015; DOI:10.1021/acs.jafc.5b01495 · 2.91 Impact Factor

  • Journal of the American College of Cardiology 10/2015; 66(15):B102-B103. DOI:10.1016/j.jacc.2015.08.943 · 16.50 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Y. J. Choi, L. Wang, and co-workers report on page 6170 a new application of an organic–inorganic hybrid perovskite (CH3NH3PbI3−xClx) in a resistive random-access-memory device. The memory device has a very simple structure consisting of Au/CH3NH3PbI3−xClx on conductive substrates, which exhibits a typical resistive-switching behavior and non-volatile properties with a low operating voltage, as well as good stability and reproducibility. This finding adds another important potential application of hybrid perovskites to their functionality library.
    Advanced Materials 10/2015; 27(40):6303-6303. DOI:10.1002/adma.201570272 · 17.49 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: Pegylated granulocyte-colony-stimulating factor (G-CSF) is frequently used to prevent febrile neutropenia (FN) in patients undergoing chemotherapy with a high risk of myelosuppression. This phase II/III study was conducted to determine the adequate dose of pegteograstim, a new formulation of pegylated G-CSF, and to evaluate the efficacy and safety of pegteograstim compared to pegfilgrastim. Methods: In the phase II part, 60 breast cancer patients who were undergoing DA (docetaxel and doxorubicin) or TAC (docetaxel, doxorubicin, and cyclophosphamide) chemotherapy were randomly selected to receive a single subcutaneous injection of 3.6 or 6.0 mg pegteograstim on day 2 of each chemotherapy cycle. The phase III part was seamlessly started to compare the dose of pegteograstim at selected in phase II with 6.0 mg pegfilgrastim in 117 breast cancer patients. The primary endpoint of both the phase II and III parts was the duration of grade 4 neutropenia in the chemotherapy cycle 1. Results: The mean duration of grade 4 neutropenia for the 3.6 mg pegteograstim (n = 33) was similar to that for the 6.0 mg pegteograstim (n = 26) (1.97 ± 1.79 days vs. 1.54 ± 0.95 days, p = 0.33). The 6.0 mg pegteograstim was selected to be compared with the 6.0 mg pegfilgrastim in the phase III part. In the phase III part, the primary analysis revealed that the efficacy of pegteograstim (n = 56) was non-inferior to that of pegfilgrastim (n = 59) [duration of grade 4 neutropenia, 1.64 ± 1.18 days vs. 1.80 ± 1.05 days; difference, -0.15 ± 1.11 (p = 0.36, 97.5 % confidence intervals = 0.57 and 0.26)]. The time to the absolute neutrophil count (ANC) recovery of pegteograstim (≥2000/μL) was significantly shorter than that of pegfilgrastim (8.85 ± 1.45 days vs. 9.83 ± 1.20 days, p < 0.0001). Other secondary endpoints showed no significant difference between the two groups. The safety profiles of the two groups did not differ significantly. Conclusions: Pegteograstim was shown to be as effective as pegfilgrastim in the reduction of chemotherapy-induced neutropenia in the breast cancer patients who were undergoing chemotherapy with a high risk of myelosuppression.
    Supportive Care in Cancer 10/2015; DOI:10.1007/s00520-015-2963-7 · 2.36 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The bacteria-based microrobot (Bacteriobot) is one of the most effective vehicles for drug delivery systems. The bacteriobot consists of a microbead containing therapeutic drugs and bacteria as a sensor and an actuator that can target and guide the bacteriobot to its destination. Many researchers are developing bacteria-based microrobots and establishing the model. In spite of these efforts, a motility model for bacteriobots steered by chemotaxis remains elusive. Because bacterial movement is random and should be described using a stochastic model, bacterial response to the chemo-attractant is difficult to anticipate. In this research, we used a population-scale approach to overcome the main obstacle to the stochastic motion of single bacterium. Also known as Keller-Segel's equation in chemotaxis research, the population-scale approach is not new. It is a well-designed model derived from transport theory and adaptable to any chemotaxis experiment. In addition, we have considered the self-propelled Brownian motion of the bacteriobot in order to represent its stochastic properties. From this perspective, we have proposed a new numerical modelling method combining chemotaxis and Brownian motion to create a bacteriobot model steered by chemotaxis. To obtain modeling parameters, we executed motility analyses of microbeads and bacteriobots without chemotactic steering as well as chemotactic steering analysis of the bacteriobots. The resulting proposed model shows sound agreement with experimental data with a confidence level <0.01.
    Biomicrofluidics 09/2015; 9(5):054116. DOI:10.1063/1.4932304 · 3.36 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Analog memristive and memcapacitive switching characteristics were investigated in Pt-Fe2O3 core-shell nanoparticles (NPs) assembly on p+-Si substrate. The Ti/NPs/p+-Si structure exhibited gradually changing resistance (memristive) and capacitance (memcapacitive) at the same time as repeating the application of voltage with respect to the polarity of voltage. As applying negative voltage at top Ti electrode, the resistance decreased and the capacitance increased due to the increase of diffusion capacitance at n-NPs/p+ -Si junction. On the other hand, applying the positive voltage increased resistance and decreased capacitance by increasing depletion width at the junction. The polarity-dependent resistance and capacitance changes are thought to be ascribed to the charging of the NPs assembly that alters the potential of the assembly. The concurrent analog memristive and memcapacitive characteristics also emulated the biological synaptic potentiation and depression motions, which is indicative of potential application to neuromorphic devices as well as analog nonvolatile memory and circuits.
    IEEE Transactions on Nanotechnology 09/2015; 14(5):1-1. DOI:10.1109/TNANO.2015.2445978 · 1.83 Impact Factor

  • Sensors and Actuators B Chemical 09/2015; DOI:10.1016/j.snb.2015.09.034 · 4.10 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The CH3 NH3 PbI3- x Clx organic-inorganic hybrid perovskite material demonstrates remarkable resistive switching behavior, which can be applicable in resistive random access memory devices. The simply designed Au/CH3 NH3 PbI3- x Clx /FTO structure is fabricated by a low-temperature, solution-processable method, which exhibits remarkable bipolar resistive switching and nonvolatile properties. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Advanced Materials 08/2015; DOI:10.1002/adma.201502889 · 17.49 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Palonosetron is the second-generation 5-hydroxytryptamine 3 receptor antagonist (5-HT3RA) that has shown better efficacy than the first-generation 5-HT3RA for prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately emetogenic chemotherapy (MEC). Granisetron transdermal delivery system (GTDS), a novel transdermal formulation, was developed to deliver granisetron continuously over 7 days. This study compared the efficacy and tolerability of the GTDS to palonosetron for the control of CINV following MEC. A total of 196 patients were randomized to GP or PG group. In this multicenter, randomized, open-label, cross-over, active-controlled, Phase IV study, GP group was assigned to receive transdermal granisetron (one GTDS patch, 7 days) in the first chemotherapy cycle, palonosetron (iv 0.25 mg/day, 1 days) in the second chemotherapy cycle before receiving MEC, and PG group was assigned to receive palonosetron in the first cycle and GTDS in the second cycle. Primary endpoint was the percentage of chemotherapy cycles achieving complete response (CR; defined as no emetic episodes and no rescue medication use) during the acute phase (0-24 h in post-chemotherapy; non-inferiority comparison with palonosetron). Total 333 cycles (165 in GTDS and 168 in palonosetron) were included in the per protocol analysis. The GTDS cycles showed non-inferiority to palonosetron cycles during the acute phase: CR was achieved by 124 (75.2 %) patients in the GTDS cycles and 134 (79.8 %) patients in the palonosetron cycles (treatment difference, -4.6 %; 95 % confidence interval, -13.6-4.4). There was no significant difference in CR rate during acute phase after the end of the first and second chemotherapy cycle between GP and PG group (p = 0.405, p = 0.074). Patients' satisfaction, assessed using Functional Living Index-Emesis (FLI-E), GTDS cycle were higher than those of palonosetron cycle in GP group (FLI-E score; median 1549.5 in GTDS cycle, median 1670.0 in palonosetron cycle). Both treatments were well tolerated and safe. Transdermal granisetron is a good alternative therapeutic option to palonosetron for preventing CINV after MEC.
    Supportive Care in Cancer 08/2015; DOI:10.1007/s00520-015-2865-8 · 2.36 Impact Factor
  • Youngje Jo · Seokwon Lim · Pahn-Shick Chang · Young Jin Choi ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Isoquercitrin is a phenolic compound well-known for having greater health benefits than quercitin, its aglycone derivative, and other related glycosides. However, isoquercitrin is rarely found in nature. Here, we optimized the conditions for the enzymatic transformation of isoquercitrin from rutin that was extracted from jujube leaf using the hesperidinase, enzyme complex containing β-d-glucosidase and α-l-rhamnosidase. The maximum productivity (2.57 ± 0.16 mg/mL) was experimentally found under the following conditions: 47.3 °C, 52.16 h, and pH 5.31, which agreed well with the predicted value (2.65 mg/mL). However, the achievement of this maximum yield was due to the absence of β-d-glucosidase activity. Further investigations using a β-d-glucosidase assay and reaction measurements under various conditions revealed that the β-d-glucosidase activity was not blocked by denaturation or known inhibitory factors. Currently, there are no recognized β-d-glucosidase inhibitors present in the jujube leaf; however, our observations strongly suggest that an unidentified β-d-glucosidase inhibitor exists in jujube leaf extract.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Tumor hypoxia is significant in promoting tumor progression and resistance to therapy, and hypoxia-inducible factor 1α (HIF-1α) is essential in the adaptive response of cells to hypoxia. The aim of the present study was to investigate the expression of hypoxic markers and evaluate their prognostic significance in soft tissue sarcoma (STS). A retrospective analysis of 55 patients with STS from Pusan National University Hospital (Busan, Korea) between 1998 and 2007 was conducted, using immunohistochemistry to analyze the expression of HIF-1α, carbonic anhydrase 9 (CA9), glucose transporter-1 (GLUT1) and vascular endothelial growth factor (VEGF). The association between the overexpression of these markers and clinicopathological characteristics, including the overall survival (OS) and progression-free survival (PFS) in cases of STS, were investigated. Overexpression of HIF-1α, CA9, GLUT1 and VEGF was shown in 54.5, 32.7, 52.7 and 25.5% of tumors, respectively, and all exhibited a significant association with high French Federation of Cancer Centers (FNCLCC) grade and high American Joint Committee on Cancer (AJCC) stage. Overexpression of HIF-1α and CA9 was associated with a shorter OS and a shorter PFS. On multivariate analysis, AJCC stage and HIF-1α overexpression had independent prognostic significance. In the group receiving chemotherapy (n=27), HIF-1α overexpression was independently associated with a decreased OS. These results indicate that overexpression of HIF-1α and CA9 is associated with poor prognosis, and that HIF-1α overexpression is an independent unfavorable prognostic factor in STS.
    Oncology letters 04/2015; 9(4):1699-1706. DOI:10.3892/ol.2015.2914 · 1.55 Impact Factor
  • Quanli Hu · Young Jin Choi · Chi Jung Kang · Hyun Ho Lee · Tae-Sik Yoon ·
    [Show abstract] [Hide abstract]
    ABSTRACT: The reflectivity and consequent color of anodic aluminum oxide (AAO) containing maghemite (γ-Fe2O3) nanoparticles (NPs) were investigated. The hexagonally ordered pores of AAO were completely filled with maghemite NPs with ∼20 nm in diameter by the dip-coating process. The AAOs containing maghemite NPs have a reduced reflectivity of light at the wavelength below ∼600 nm, resulting in golden color. The reduced reflectivity and golden color of AAOs with NPs was explained by the absorption of light from blue to violet wavelength range by maghemite NPs. These results indicate the potential color-engineering of AAO by means of wavelength-selective absorption by incorporated NPs.
    Journal of Industrial and Engineering Chemistry 04/2015; 24:293-296. DOI:10.1016/j.jiec.2014.09.044 · 3.51 Impact Factor
  • Young Mi Seol · Young Jin Choi · Byung Joo Lee · Soo Geun Wang ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Cervical metastases from unknown primary tumors are rare and no clear therapeutic options are available. This study was performed to assess the efficacy and safety profiles of induction chemotherapy followed radiotherapy in patients with cervical lymph node metastases from unknown primary cancer. Patients with histological diagnosis of cervical lymph-node metastasis from carcinoma with an unknown primary cancer underwent induction chemotherapy followed by radiotherapy. All patients had squamous cell carcinoma. Induction chemotherapy consisted of 3–4 cycles every 3 weeks of docetaxel (day 1.70 mg/m2) and cisplatin (day 1.75 mg/m2). Radiation therapy (RT) was started with in 10 weeks of the last cycle of chemotherapy, and it was administered 5 days per week. It was given in daily fractions of (1.8) Grays (Gy) of 2 Gy and the total dose to the primary tumor was 70–74 Gy. Neck dissection was reserved for residual disease after definitive radiotherapy. Overall survival, recurrent free survival, and locoregional control were calculated using the Kaplan–Meier method. Twenty one patients with an unknown primary cancer underwent induction chemotherapy and radiotherapy. After induction chemotherapy, 6 patients achieved CR and 8 patients achieved PR. The overall response rate after radiation, was 90.4 % (19 of 21 patients). Neutropenia and infection were the most common grade 3–4 adverse event during induction chemotherapy. Mucositis and dermatitis were the most common grade 3–4 toxicities during radiotherapy. With a median follow-up of 50.6 months, the estimated 2 years OS rates were 71 ± 6 %, respectively. The median OS was 42 months (95 % confidence interval CI 8–65 months). The recurrent-free survival rate at 2 years was 57 %, respectively. In the patients with responder to induction chemotherapy, superior relapse free survival and overall survival rate observed. No occurrence of primary cancer was observed during the follow-up period. Induction chemotherapy followed RT for unknown primary cancer has provided good overall and disease-free survival in all the patients with an acceptable rate of complications. The use of induction chemotherapy and radiation therapy for more advanced disease led to good clinical results with reasonable toxicities.
    Indian Journal of Otolaryngology and Head & Neck Surgery 03/2015; 67(Suppl 1):74-8. DOI:10.1007/s12070-014-0773-8 · 0.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: There are limited data about long-term outcomes for biodegradable polymer biolimus-eluting stent (BES) versus durable polymer everolimus-eluting stent (EES) in patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). We sought to compare the two-year efficacy and safety of BES versus EES in AMI patients. A total of 707 consecutive patients with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction who underwent PCI with BES (n=171) or EES (n=536) between July 2008 and June 2012 were enrolled in this study. The efficacy endpoint (target vessel failure; a composite of cardiac death, target vessel-related myocardial infarction, and target vessel revascularization) and the safety endpoint (a composite of all cause death, myocardial infarction, and stent thrombosis) at two years were compared in crude and propensity score-matched cohorts. After two years, target vessel failure occurred in 13 patients treated with BES and 49 patients treated with EES (7.6% versus 9.1%; adjusted hazard ratio [HR], 1.09; 95% confidence interval [CI], 0.58-2.04; p=0.78). The rates of composite safety endpoint at two years were not different between two groups (BES 7.6% versus EES 10.8%; adjusted HR, 0.87; 95% CI, 0.47-1.62; p=0.66). The rates of stent thrombosis did not differ between two groups (BES 0.6% versus EES 1.3%; adjusted HR, 0.63; 95% CI, 0.06-6.20; p=0.69). These findings were substantiated by similar results in the propensity score-matched cohort. In the treatment of patients with AMI, BES showed similar efficacy and safety compared to those of EES for up to two years. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    International Journal of Cardiology 01/2015; 183C:190-197. DOI:10.1016/j.ijcard.2015.01.036 · 4.04 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Uniformly sized hexagonal shaped manganese oxide (MnO) nanoparticles were chemically synthesized. The bipolar resistive switching characteristics were investigated in the Ti/MnO/Pt structure. The nanoparticles were assembled as close-packed monolayer with a thickness of 30 nm by dip-coating and annealing procedures. The bipolar resistive switching behaviors in Ti/MnO/Pt device could be caused by the formation and rupture of conductive filaments in the nanoparticles. The temperature dependence of resistance was discussed. The resistance of HRS presented a negative temperature dependence at high temperature, indicating a typical semiconducting behavior. The resistance of LRS increased with the elevated temperature exhibiting a metallic state. Ohmic conduction, space charge limited conduction (SCLC), and Schottky conduction have been investigated for the conduction and switching mechanism.
    Semiconductor Science and Technology 01/2015; 30(1). DOI:10.1088/0268-1242/30/1/015017 · 2.19 Impact Factor
  • Eun Ji Yoo · Il Kwon Shin · Tae Sik Yoon · Young Jin Choi · Chi Jung Kang ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Binary transition metal oxides such as ZnO, TiO2, and MnO; and their various structures such as thin film, nanowire, and nanoparticle assembly; have been widely investigated for use in insulators in resistive random access memory (ReRAM), considered a next-generation nonvolatile memory device. Among the various driving mechanisms of resistive switching in insulating materials, the conductive filament model is one of the most widely accepted. Studies on spatially confined structures such as one-dimensional nanostructures and zero-dimensional nanoparticles to reveal the detailed filament constructing mechanism are warranted because low-dimensional nanostructures can provide more localized properties with a narrow dispersion of operational parameter values compared with thin-film structures. We investigated the resistive switching characteristics of ZnO nanowire (NW) structures. The NWs were grown on an Au/Ti/SiO2/Si substrate via the hydrothermal method. The empty space between the top and bottom electrodes was filled with a photoresist to prevent direct connection between the electrodes. The top electrode (Cr) and bottom electrode (Au), both with a thickness of ∼100 nm, were deposited by DC sputtering. The current–voltage (I–V) measurements were performed using a semiconductor characterization system. Additionally, the local current image and the point I–V characteristics for each NW were examined by replacing the top electrode with a conducting atomic force microscope tip. The Au–ZnO NW–Cr devices exhibited bipolar resistive switching behavior.
    Journal of Nanoscience and Nanotechnology 12/2014; 14(12):9459-64. DOI:10.1166/jnn.2014.10157 · 1.56 Impact Factor
  • Choongjin Ban · Seokwon Lim · Pahn-Shick Chang · Young Jin Choi ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Aggregation of unstable particles in water limits the application of lipid nanoparticle (LNP) systems to foods despite the capability to encapsulate lipophilic bioactive components. Here, we exploit a preparation process that can reduce the aggregation of LNPs. Sonication during the cooling step (post-sonication) for 4, 5 or 6 min was applied to increase the covering effect of Tween 20 on the particle. Additionally, LNPs were prepared using fully hydrogenated canola oil (FHCO) blended with 0-30 wt% liquid canola oil (LCO) of the lipid phase. Surfactant surface load data indicate that the post-sonication might make non-emulsifying Tween 20 diffuse from aqueous phase to droplet surfaces, which could decrease the crystallinity index (CI) of LNPs due to the inhibition of lipid crystallization. Moreover, the LCO content in lipid matrix could decrease the CI, which could reduce forming hydrophobic patches on the particle surface. Therefore, the post-sonication and the LCO addition in the matrix could effectively prevent the aggregation among hydrophobic patches. This improved colloidal stability of LNPs was verified by the particle shape in transmission electron microscopy and the gelation test. Consequently, LNPs fabricated using 6 min post-sonication and 30 wt% LCO in the lipid exhibited the greatest stability (size: 202.3 nm; CI: 57.5%; and Tween 20 surface load: 10.29 mg m-2).This study may serve as a basis for further researches that aim to develop delivery systems for functional foods.
    Journal of Agricultural and Food Chemistry 11/2014; 62(47). DOI:10.1021/jf503489v · 2.91 Impact Factor

Publication Stats

2k Citations
502.64 Total Impact Points


  • 2013-2015
    • Sejong General Hospital
      Bucheon, Gyeonggi-do, South Korea
  • 2006-2015
    • Myongji University
      • Department of Physics
      Sŏul, Seoul, South Korea
    • Ajou University
      • Department of Physics
      Sŏul, Seoul, South Korea
  • 1998-2015
    • Pusan National University
      • • Department of Internal Medicine
      • • Department of Polymer Science and Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2014
    • Chonnam National University
      • School of Mechanical Systems Engineering
      Gwangju, Gwangju, South Korea
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 1997-2014
    • Seoul National University
      • • College of Agriculture and Life Sciences
      • • Department of Agricultural Biotechnology
      • • Department of Electrical and Computer Engineering
      • • Inter-University Semiconductor Research Center
      Sŏul, Seoul, South Korea
  • 2008-2013
    • Catholic University of Korea
      • • Department of Pathology
      • • Department of Obstetrics and Gynecology
      • • College of Medicine
      Sŏul, Seoul, South Korea
    • Chonbuk National University
      • Semiconductor Physics Research Center
      Sŏul, Seoul, South Korea
    • University of Cambridge
      • Department of Engineering
      Cambridge, England, United Kingdom
    • University of Texas Southwestern Medical Center
      • Department of Physiology
      Dallas, Texas, United States
  • 1998-2013
    • Kyung Hee University
      • • College of Oriental Medicine
      • • Department of Physics
      Sŏul, Seoul, South Korea
  • 2007-2012
    • Hallym University Medical Center
      • • Department of Cardiology
      • • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Samsung Medical Center
      • Division of Breast and Endocrine Surgery
      Sŏul, Seoul, South Korea
  • 2011
    • Gyeongsang National University
      • School of Materials Science and Engineering
      Shinshū, Gyeongsangnam-do, South Korea
  • 2009-2011
    • Chungbuk National University
      • College of Veterinary Medicine
      Chinsen, North Chungcheong, South Korea
    • Sogang University
      • Department of Chemical and Biomolecular Engineering
      Seoul, Seoul, South Korea
  • 2004-2011
    • Chungnam National University
      • • College of Medicine
      • • Department of Mechanical Design Engineering
      Daiden, Daejeon, South Korea
    • Korea Institute of Science and Technology
      • Interaction and Robotics Research Center
      Seoul, Seoul, South Korea
  • 2010
    • Eulji University
      Daiden, Daejeon, South Korea
    • Taihan Electric Wire CO., LTD.
      안양시, Gyeonggi-do, South Korea
    • Dong-A University
      Tsau-liang-hai, Busan, South Korea
    • University of Science and Technology, Beijing
      Peping, Beijing, China
  • 2007-2009
    • Washington State University
      • School of Mechanical and Materials Engineering
      پولمن، واشینگتن, Washington, United States
  • 2000-2009
    • Hallym University
      • College of Medicine
      Sŏul, Seoul, South Korea
    • University of Ulsan
      Ulsan, Ulsan, South Korea
  • 2006-2008
    • Sungkyunkwan University
      Sŏul, Seoul, South Korea
  • 2005-2006
    • University of California, Davis
      • Department of Food Science and Technology
      Davis, California, United States