Zhong Zhang

Peking University Health Science Center, Peping, Beijing, China

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Publications (57)135.16 Total impact

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    ABSTRACT: The solvothermal reactions of 2-hydroxyisophthalic acid (H3ipO) with M(NO3)2∙6H2O (M=Co, Ni) afforded two complexes [Co2(HipO)2(Py)2(H2O)2] (1) and [Ni(HipO)(Py)H2O] (2) (Py=pyridine). They exhibit similar zig-zag chain structures with the adjacent two metal centers connected by a anti-syn bridging carboxylate group from the HipO2- ligand. The magnetic measurements reveal the dominant antiferromagnetic interactions and spin-canting in 1 while ferromagnetic interactions in 2. Both of them exhibit magnetocaloric effect (MCE) with the resulting entropy change (−ΔSm) of 12.51 J kg−1 K−1 when ΔH=50 kOe at 3 K for 1 and 11.01 J kg−1 K−1 when ΔH=50 kOe at 3 K for 2, representing the rare examples of one-dimensional complexes with MCE.
    Journal of Solid State Chemistry 02/2015; · 2.20 Impact Factor
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    ABSTRACT: Four isostructural metal organic frameworks (MOFs), namely [Co6(HipO)6]·6H2O (), [Mn6(HipO)6]·6H2O (), [Cd6(HipO)6]·6H2O () and [Zn6(HipO)6]·7H2O () (H3ipO = 2-hydroxyisophthalic acid), were synthesized and structurally characterized. They have a 3D (4,6)-connected framework based on [24-MC-6] metallacrown clusters ([24-MC-6]-based MOFs). The arrangements of the 24-MC-6 metallacrown SBUs show a regular change indicated by the orientation of their symmetry axes, resulting in a special dense packing mode different from other [24-MC-6]-based MOFs. The analysis of SQUID measurements reveal that compound displays the dominant antiferromagnetic exchanges in 300-10 K between the adjacent Co(ii) ions and a ferromagnetic-like behavior at lower temperatures, whereas compound shows an antiferromagnetic interaction between the adjacent Mn(ii) ions. Compound exhibits a magnetocaloric effect (MCE) with the resulting entropy change (-ΔSm) of 15.20 J kg(-1) K(-1) for ΔH = 50 kG at 6 K, which is the highest value among the cobalt-based MOFs with MCE reported so far. The luminescence properties of compounds and were studied, both of them exhibit photoluminescence in the solid state at room temperature which can be ascribed to intraligand π→π* transitions.
    Dalton Transactions 07/2014; · 4.10 Impact Factor
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    ABSTRACT: Selective or complete methanolysis of nitrile-functionalized triazamacrocyclic derivatives has been accomplished by employing various Cd(II) salts as Lewis acid promoters. Length of pendant arm and counter-anions of different sizes and coordination abilities have been proved to play important effects in manipulating the extent of solvolysis of pendant nitrile groups.
    Inorganica Chimica Acta 05/2014; 415:14–21. · 2.04 Impact Factor
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    ABSTRACT: PTEN is one of the most frequently mutated genes in human cancer. It is known that PTEN has a wide range of biological functions beyond tumor suppression. Here, we report that PTENα, an N-terminally extended form of PTEN, functions in mitochondrial metabolism. Translation of PTENα is initiated from a CUG codon upstream of and in-frame with the coding region of canonical PTEN. Eukaryotic translation initiation factor 2A (eIF2A) controls PTENα translation, which requires a CUG-centered palindromic motif. We show that PTENα induces cytochrome c oxidase activity and ATP production in mitochondria. TALEN-mediated somatic deletion of PTENα impairs mitochondrial respiratory chain function. PTENα interacts with canonical PTEN to increase PINK1 protein levels and promote energy production. Our studies demonstrate the importance of eIF2A-mediated alternative translation for generation of protein diversity in eukaryotic systems and provide insights into the mechanism by which the PTEN family is involved in multiple cellular processes.
    Cell metabolism 04/2014; · 17.35 Impact Factor
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    ABSTRACT: Three linear trinuclear complexes [Zn3L3(HAMP)2]·2MeOH (1), [Zn3L3(HAMP)2]·2DMF·2EtOH (2), and [Zn3L3(HAMP)2]·DMF·EtOH (3) were separated from the reactions of ZnII salts with acenaphthenequinone dioxime (H2L) and 2-amino-2-methyl-1-propanol (HAMP) under different reaction conditions. They were structurally characterized by elemental analysis, IR spectroscopy, and single-crystal X-ray diffractional analysis. All of them present a similar linear trinuclear skeleton with the three ZnII ions linked by three L2– ligands. The coordination arrangements of their terminal ZnII ions and the coordination modes of the two HAMP ancillary ligands are different. 1 has two five-coordinate bipyramidal terminal ZnII ions with the two HAMP molecules chelated to the two terminal ZnII ions, while the two terminal metal ions in 3 are both tetracoordinate in tetrahedral arrangements with the two HAMP molecules in monodentate coordination modes. However, 2 shows different coordination modes (bipyramidal and tetrahedral) for the two terminal ZnII ions with the two HAMP molecules in chelated and monodentate coordination modes, respectively. Their luminescent properties were also investigated.
    Zeitschrift für anorganische Chemie 04/2014; 640(5). · 1.25 Impact Factor
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    ABSTRACT: The decomposition of 2-(1-hydroxy-2-methylpropan-2-yl-imino)-1,2-diphenylethanone in the presence of copper acetate promoted the formation of a two-dimensional homospin Cu(ii) ferrimagnet featuring S-shaped hexanuclear secondary building blocks and a new pentanodal topology.
    Dalton Transactions 03/2014; · 4.10 Impact Factor
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    ABSTRACT: An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for detecting Cu(2+) was synthesized and used for fluorescence imaging in HeLa cells. The probe was specifically localized in lysosomes and successfully applied to visualize Cu(2+) as well as to monitor Cu(2+) level changes in the lysosomes of living cells.
    Chemical Communications 10/2013; · 6.38 Impact Factor
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    ABSTRACT: Three 2-D layered coordination polymers with (4,4) topology, {[Cu(trzp)2(H2O)]·1.18H2O} n (1), {[Co(trzp)2(H2O)2]·2H2O} n (2), and {[Cd(trzp)2(H2O)]·2H2O} n (3), have been synthesized with the flexible, bifunctional ligand 1H-1,2,4-triazole-1-propionate (trzp−) as a two-connected bridge. In addition, a complicated 3-D MOF [Ag3(trzp)2(NO3)] n (4) has been obtained with the help of Ag…Ag interactions and trzp− as a four-connected linker. Htrzp and 1–4 have been characterized by single-crystal X-ray diffraction, elemental analysis, and infrared spectroscopy. The structural analysis showed that Htrzp has a gauche conformation in the solid state. However, both gauche and trans conformers of trzp− are observed in the crystals of 1; only one conformer of trzp− exists in the other three compounds (trans conformation in 2 and 3, and gauche conformation in 4). The thermal behaviors of 1–4 have been examined by thermal gravimetric analysis under nitrogen, which revealed that metal cyanide salts M(CN) n (M = Cu(II), Co(II), Cd(II), and Ag(I), n = 1 or 2) may be an intermediate pyrolytic decomposition product of the corresponding compounds.
    Journal of Coordination Chemistry 07/2013; 66(14). · 2.22 Impact Factor
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    ABSTRACT: The hydrothermal reactions of nitrate or chloride salts of Co(II), Zn(II), Cd(II), Hg(II) and Ag(I) with an unsymmetrical benzotriazole derivative 1H-1,2,3-benzotriazole-1-propionic acid (Hbtap) afforded five new metal–organic coordination polymers with formula of [M(btap)2(H2O)2]n (M = Co 1, Zn 2, Cd 3), [Hg(btap)Cl]n (4) and {[Ag(btap)]·H2O}n (5), which were characterized by X-ray diffraction and spectroscopic methods. The anionic btap− ligands in these complexes assume the same anti conformation, but show different coordination behaviors toward transition metal ions. Complexes 1, 2 and 3 are isostructural and reveal infinite one-dimensional (1D) looped-chain structures constructed by hexacoordinated metal centers and 2-connected btap− bridges. Complex 4 features 1D zigzag polymeric arrays, which are interlinked with each other resulting in a chiral three-dimensional (3D) 4-connected framework. In complex 5, the 3-connected ligands join Ag(I) atoms into a 1D ribbon motif. The photoluminescence spectra of three d10 metal complexes 2, 3 and 4 were measured at room temperature. The emission peaks of these complexes resemble that of the free ligand and can be ascribed to the intraligand π–π* transitions.
    Transition Metal Chemistry 04/2013; 38(3). · 1.40 Impact Factor
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    ABSTRACT: Prolyl hydroxylase 3 (PHD3) controls hypoxia-inducible factor-1 (HIF-1) degradation by oxygen dependent hydroxylation. PHD3 inhibitors are potential targets for HIF-1α activation, thereby treating a number of HIF-related diseases. We herein rationally designed a novel scaffold for PHD3 inactivation under the guidance of enzyme-ligand docking simulation studies. The potent inhibitors were able to non-covalently bind to the active site of PHD3, and to stabilize the core domain resisting to trypsin proteolysis. The conformational changes of the protein occurred concomitant with inhibitor binding, which thus deactivated the enzyme. The up-regulated levels of HIF-1α protein and downstream genes (glucose transporter-1 (GLUT-1) and vascular endothelial growth factor (VEGF)) suggest that the PHD inhibitors manage to mimic the cellular signalling effects of hypoxia. Interestingly, unlike available PHD inhibitors, the iron-chelating motif is not found in all azole compounds, among which we identified a unique compound 1-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-1H-benzo[d][1,2,3]triazole (BEBT) as the most effective inhibitor. BEBT binds to the enzyme with the lowest predicted binding energy, and activates HIF activity most significantly in cellular systems. This novel non-iron-chelating inhibitor offers a new target for the drug design towards hypoxia-related diseases therapy with possibly minimized iron-relating side effects.
    Medicinal Chemistry Communication 01/2013; 4(9):1222. · 2.63 Impact Factor
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    ABSTRACT: Eighteen Cu(ii) ions are consolidated by simple inorganic linkers alone to construct an S(6)-symmetric six-bladed impeller-like Cu(18) nanocluster driven by the concomitant decomposition reaction of a Schiff base, which affords a typical high-nuclearity inorganic cluster and a representative synthetic strategy. The magnetic measurements reveal dominant antiferromagnetic interaction in this cluster.
    Chemical Communications 10/2012; · 6.38 Impact Factor
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    ABSTRACT: The stable dinuclear [Cu(μ-C2O4)Cu]2+ entity is facially coordinated at each end by a N-nitrile functionalized triazamacrocycle, 1, 4, 7-tris(cyanomethyl)-1, 4, 7-triazacyclononane (L), to generate a centrosymmetric compound [Cu2L2(μ-C2O4)](ClO4)2·4DMF (1) containing a bis-bidentate oxalate bridge. The variable-temperature magnetic measurement for the crystallographically characterized compound exhibits quite strong antiferromagnetic coupling interaction between two oxalate-linked CuII atoms separated by 5.149 Å with a singlet-triplet energy gap of –345.5 cm–1. On the other hand, a mononuclear CoIII compound [CoL(N3)3]·2.5H2O (2) with monodentate azide terminal groups was synthesized. Structural elucidation by X-ray diffraction shows that the compound has crystallographically imposed C3 symmetry. Enantiomerically pure crystals were obtained upon crystallization indicated by a Flack parameter of 0.04(5).
    Zeitschrift für anorganische Chemie 04/2012; 638(5). · 1.25 Impact Factor
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    ABSTRACT: Self-assembly between perchlorate salts of Cu(II), Zn(II) and Cd(II) with tri-substituted N-propionic acid functionalized 1,4,7-triazacyclononane (H3L1) or the mono-substituted one (HL2) results in the formation of four novel complexes [Cu5(H2O)6(L1)2](ClO4)4 (1), [Zn9(L1)4(H2O)18](ClO4)6·9H2O (2), [Cd2(H2L1)2](ClO4)2 (3) and [Cd(L2)]ClO4·CH3OH (4) with different aggregation modes. All these complexes were structurally characterized by solid state X-ray diffraction measurement. Complex 1 belongs to a homometallic 2D polymer, where each [Cu(L1)]− complex entity acts as a three-connected node joined to three Cu(II) ions through μ2 bridged propionate arms to afford a puckered honeycomb framework. In complex 2, two face-to-face arranged [Zn(L1)]− moieties clip three Zn(II) ions by virtue of pendant propionate arms generating a macrotricyclic metallacryptate. Two such metallacryptates are fused via co-sharing one lateral Zn(II) ion into an unprecedented nonazinccluster with a double-cage architecture. Complex 3 exhibits a discrete centrosymmetric dinuclear unit [Cd2(H2L1)2]2+ consisting of two pendant propionategroups linked to a [Cd2O2] core. Complex 4 reveals Cd(II) centers are associated through the unique propionate bridge of the L2− ligand leading to an infinite 1D zig–zag polymeric chain of [Cd(L2)]+ cations. Deduced from the structural investigations, the linkage patterns of the selected macrocyclic ligands towards metal centers may be exquisitely tuned according to the type of metals and the number of the coordinating pendant arms present in the macrocyclic ligands, and then the architectural variation of these metal–organic coordination species is achieved. In addition, magnetic studies for complex 1 show a weak CuCu antiferromagnetic coupling in the 2D honeycomb layer with a Weiss temperature of −4.31 K.
    CrystEngComm 01/2012; 14(4):1354-1363. · 3.86 Impact Factor
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    Zhong Zhang, Wei Lu, Difeng Wu
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    ABSTRACT: In the title compound, C(15)H(13)N(5), the N-containing heterocycles are linked by an ethyl-ene spacer in a gauche conformation, the N-C-C-C torsion angle along the linker being 60.1 (3)°. The dihedral angle between the terminal benzotriazole and benzimidazole rings is 39.02 (6)°. In the crystal, adjacent mol-ecules are connected by N-H⋯N hydrogen bonds, forming an infinite chain along the c axis. π-π stacking inter-actions [centroid-centroid distance = 3.8772 (7) Å] between the benzotriazole rings of neighbouring chains extend these chains into a supra-molecular sheet in the bc plane. Weak inter-molecular C-H⋯N inter-actions further stabilize the crystal structure.
    Acta Crystallographica Section E Structure Reports Online 12/2011; 67(Pt 12):o3167. · 0.35 Impact Factor
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    ABSTRACT: Abstract The reactions of a new compound of N-Carboxyphenylenesulfonyl-S-Carboxymethyl-l-Cysteine (Cs-cmc) with Zn(II) or Co(II) salts in the presence of 4,4′-bipyridine (4,4′-bipy) led to the decomposition of Cs-cmc and produced [Zn(4,4′-bipy)(H2O)4]X2 (X = p-sulfamoylbenzoate) 1 and [Co(4,4′-bipy)(H2O)4]Y·H2O (Y = p-sulfonatobenzoate) 2, in which the decomposition products of Cs-cmc exist as free counter-anions. The single crystal X-ray diffraction analyses revealed that compound 1 crystallizes in monoclinic C2/c space group with a = 18.748(4) Å, b = 11.520(2) Å, c = 12.751(3) Å, β = 90.290(4)°, V = 2753.9(10) Å, Z = 4 and compound 2 crystallizes in orthorhombic Pca21 space group with a = 12.114(3) Å, b = 11.369(2) Å, c = 14.770(3) Å, V = 2034.1(7) Å, Z = 4. It was revealed that 1D chains were constructed from metal ions and 4,4′-bipy in both compounds. The 1D chains interact with the counter-anions by hydrogen bonds, forming 3D supramolecular structures. Graphical Abstract The reactions of a new compound of N-Carboxyphenylenesulfonyl-S-Carboxymethyl-l-Cysteine(Cs-cmc) with Zn(II) or Co(II) salts in the presence of 4,4′-bipy led to the decomposition of (Cs-cmc) and produced two complexes.
    Journal of Chemical Crystallography 10/2011; 41(10). · 0.48 Impact Factor
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    ABSTRACT: The reactions of PbCl2 with 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (H3iso) gave two complexes [Pb(H2iso)2(H2O)]n (1) and [Pb(Hiso)(H2O)]n (2), which were characterized by IR spectroscopy, elemental analysis, thermogravimetric analysis, powder X-ray diffraction and single crystal X-ray diffraction analysis. The two complexes display different topologies. 1 shows a three-dimensional framework with the Schläfli symbol (4.85)(4.82) no matter if the weak Pb–O bonds are included or not. However, 2 presents a 3,3-connected two-dimensional sheet with the Schläfli symbol (4.82)(4.82) based on the calculation of only the normal Pb–O bonds and a 5,5-connected 3D network with the Schläfli symbol (415.64)(44.68.82) when the weak Pb–O bonds are also included. The fluorescent studies reveal an emission attributed to intraligand emission for 1 and an emission assigned to LMCT for 2.
    Journal of Solid State Chemistry 05/2011; 184(5):1063-1069. · 2.20 Impact Factor
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    ABSTRACT: PTEN phosphatase is a potent tumor suppressor that regulates multiple cellular functions. In the cytoplasm, PTEN dephosphorylates its primary lipid substrate, phosphatidylinositol 3,4,5-trisphosphate, to antagonize the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. It has also become increasingly evident that PTEN functions in the nucleus and may play an important part in transcription regulation, but its nuclear targets remain elusive. In this report, we demonstrate the transcription factor cyclic AMP response element-binding protein (CREB) is a protein target of PTEN phosphatase and that PTEN deficiency leads to CREB phosphorylation independent of the PI3K/AKT pathway. Using confocal immunofluorescence and reciprocal immunoprecipitation, we further show that PTEN colocalizes with CREB and physically interacts with CREB. Moreover, we use both in vitro and in vivo experiments to show PTEN can dephosphorylate CREB in a phosphatase-dependent manner, suggesting that CREB is a substrate of PTEN nuclear phosphatase. Loss of Pten results in an elevated RNA level of multiple CREB transcriptional targets and increased cell proliferation, which can be reversed by a nonphosphorylatable CREB mutant or knockdown of CREB. These data reveal a mechanism for PTEN modulation of CREB-mediated gene transcription and cell growth. Our study thus characterizes PTEN as a nuclear phophatase of a transcription factor and identifies CREB as a novel protein target of PTEN phosphatase, which contributes to better understanding of PTEN function in the nucleus.
    Cancer Research 03/2011; 71(8):2821-5. · 9.28 Impact Factor
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    ABSTRACT: Hypoxia inducible factor 1α (HIF-1α) becomes an important regulation factor within the histiocyte when it is under the hypoxia condition. Recently, prolyl hydroxylases (PHDs) have been identified to inactivation HIF-lα by hydroxylation. In this study, polynitrogen compounds were screened as HIF-1α PHD3 inhibitors. The coding region of human PHD3 DNA was optimized by using synonymous codons according to the code bias of Escherichia coli. Soluble and active human PHD3 was expressed in the E. coli with a Trx fusion tag under a lower induction temperature of 25°C. Mass spectrometry analysis of the resultant peptide product indicated a mass increase of 16 daltons, consistent with hydroxylation of the proline residue in the HIF-1α (556-574) peptide substrate. Polynitrogen compounds (1-4) inhibited the enzymatic hydroxylation of HIF-1α peptide in a concentration-dependent manner, and the apparent IC(50) values were 29.5, 16.0, 12.8 and 60.4 μM respectively. Double reciprocal (1/V versus 1/[HIF-1α peptide]) plots showed that these compounds are noncompetitive inhibitors of the hydroxylation by recombinant human PHD3 with K(i) values of 67.0, 25.3, 67.3, and 82.1 μM respectively. On the other hand, the metal complexes of these polynitrogen compounds (1-4) cannot inhibit the catalytical activity of PHD3. We hypothesized that the inhibitory mechanism of PHD3 activity by polynitrogen compounds is due to their binding to iron to form stable coordination complexes. Our results in this study indicated that polynitrogen compounds (1-4) could be potential inhibitors of PHD3 to regulate the transcriptional activity of HIF-1α.
    Journal of inorganic biochemistry 03/2011; 105(3):391-9. · 3.25 Impact Factor
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    ABSTRACT: The reactions of new chiral organic ligands trimesoyltri(L-alanine) (L-TMTAH(3)) or trimesoyltri(D-alanine) (D-TMTAH(3)) with transition metal salts in the presence of an ancillary ligand of 4,4'-bipyridine gave two pairs of three dimensional frameworks [Co(3)(L-TMTA)(2)(4,4'-bpy)(4)]·28H(2)O (1), [Co(3)(D-TMTA)(2)(4,4'-bpy)(4)]·28H(2)O (2) [Ni(3)(L-TMTA)(2)(4,4'-bpy)(4)]·2C(2)H(5)OH·14H(2)O (3) and [Ni(3)(D-TMTA)(2)(4,4'-bpy)(4)]·2C(2)H(5)OH·14H(2)O (4). These compounds were characterized by elemental analysis, IR, and X-ray powder diffraction analysis and the structures of 1-3 were determined from X-ray single crystal diffraction analysis. Complexes 1-4 feature linear trinuclear secondary building blocks [M(3)(COO)(4)](2+) formed via the connection of three metal ions by four carboxylato groups from four TMTA(3-) ligands. Every adjacent two linear trinuclear secondary building blocks are linked by one and three 4,4'-bipyridine molecules along the a and c axis, respectively, to form two-dimensional sheets, which are further connected by TMTA(3-) ligands to construct a porous three dimensional framework with one-dimensional channels. Compound 3 was taken as an example to investigate the adsorption properties of compounds 1-4. It revealed a saturated hydrogen uptake of 216.6 cm(3) g(-1) (2.0 wt%) at 11.1 atm measured at 77 K, a maximum CO(2) uptake of 119.4 cm(3) g(-1) (23.5 wt%) at 19.5 atm measured at 298 K and a saturated CH(4) uptake of 77.8 cm(3) g(-1) (5.6 wt%) at 27.1 atm measured at 298 K. The magnetic studies of complexes 1 and 3 indicate the presence of antiferromagnetic interactions between the metal ions in the two compounds.
    Dalton Transactions 03/2011; 40(9):1911-8. · 4.10 Impact Factor
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    ABSTRACT: A novel fluorescent sensor composed of a naphthalene functionalized tetraazamacrocycle ligand 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3-methyl naphthalene (1) and Zn(2+) has been designed and prepared, which can be utilized for selective and ratiometric sensing of pyrophosphate (PPi) over other phosphate-containing anions in aqueous solution at physiological pH. Notably, the water soluble 1 itself also exhibits a selective enhanced fluorescent response to Zn(2+), and the complex 1-Zn(2+) thus formed eventually fulfils the synergic Zn(2+) coordination-altered strategy with PPi. Furthermore, the ratiometric sensing of 1-Zn(2+) towards PPi performed well even in blood serum milieu. Finally, the sensor 1-Zn(2+) was successfully employed to monitor a real-time assay of inorganic pyrophosphatase (PPase) by means of ratiometric fluorescent measurements for the first time.
    Dalton Transactions 03/2011; 40(9):1984-9. · 4.10 Impact Factor

Publication Stats

197 Citations
135.16 Total Impact Points

Institutions

  • 2011–2014
    • Peking University Health Science Center
      Peping, Beijing, China
  • 2007–2014
    • Guangxi Normal University
      • College of Chemistry and Chemical Engineering
      Pakhoi, Guangxi Zhuangzu Zizhiqu, China
  • 2005–2014
    • Nanjing University
      • • State Key Laboratory of Coordination Chemistry
      • • Department of Chemical Engineering
      Nan-ching, Jiangsu Sheng, China
  • 2007–2010
    • University of Jinan (Jinan, China)
      Chi-nan-shih, Shandong Sheng, China