Y Maeda

Publications (4)3.77 Total impact

• Article: Lasers and flashlamps in research on the mechanism of muscle contraction

  G. Rapp, K. J. V. Poole, Y. Maeda, G. C. R. Ellis-Davies, J. H. Kaplan, J. McCray, R. S. Goody
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  ABSTRACT: High intensity pulsed light sources are currently being used in two major applications in muscle research. The first of these involves rapid photolytic release of metabolites, e.g. adenosine triphosphate or calcium ions, from inert, photosensitive precursors. This allows rapid kinetic experiments in muscle fibres which would otherwise be impossible because of the long diffusion times even of small molecules into the lattice of thick and thin filaments. Examples of the use of lasers and flash lamps for this purpose will be given, with particular emphasis on dynamic structural investigations using synchrotron radiation as a high intensity X-ray source for monitoring structural changes by low angle diffraction. The second application involves the use of solid state lasers to produce powerful light pulses in the infrared region to achieve temperature jumps in muscle fibres. This, in conjunction with the use of synchrotron radiation, allows the kinetics of interesting structural transitions in muscle fibres to be studied.
  Berichte der Bunsengesellschaft für physikalische Chemie. 05/2010; 93(3):410 - 415.
• Article: Phase I study of paclitaxel plus irinotecan combination therapy for patients with refractory and advanced gastric cancer

  T. KOBAYASHI, T. SAKAGAMI, H. KOIZUKA, N. YAMAMOTO, T. SASAKI, Y. MAEDA, Y. OMURO, R. OKAMOTO, M. MIKOSHIBA, E. SASAKI, T. MATSUMOTO, H. MIWA
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  ABSTRACT: Background No adequate second-line chemotherapy regimen for advanced gastric cancer is available.AimsTo determine the safety and optimal dose of paclitaxel/irinotecan as a second-line chemotherapy for patients with advanced and recurrent gastric cancer.Patients and methodsSixteen patients with refractory and advanced measurable gastric cancer who were resistant to 5-FU plus cis-diamminedichloroplatinum (CDDP) therapy (FP) were enrolled. Paclitaxel/irinotecan was given intravenously on days 1, 8, and 15 in repeated 4-week cycles. Paclitaxel/irinotecan doses were escalated in a stepwise fashion as follows: 50/40 mg/m2, 50/50 mg/m2, 50/60 mg/m2, 60/60 mg/m2, 60/70 mg/m2 in levels I, II, III, IV and V, respectively.ResultsBecause of one patient with Grade 3 febrile neutropenia at level I, three more patients were enrolled in level I. Doses were consequently escalated, and in level IV, Grade 3 febrile neutropenia occurred in one patient. Since an additional patient in level IV had grade 4 neutropenia, Level IV was judged as the maximum tolerated dose (MTD). The recommended dose and schedule for phase II study is paclitaxel 50 mg/m2 and irinotecan 60 mg/m2 on days 1, 8, and 15 every 4 weeks. Partial response was observed in 4 of 16 patients.Conclusion Paclitaxel/irinotecan combination regimen at the level III dosage was safe and well tolerated.
  Alimentary Pharmacology & Therapeutics 01/2007; 24(s4):266 - 271. · 3.77 Impact Factor
• Conference Proceeding: Design of damping control parameters for peg-in-hole by industrial manipulator considering cycle time

  N. Yamanobe, Y. Maeda, T. Arai, T. Kato, T. Sato, K. Hatanaka
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  ABSTRACT: Designing appropriate force control parameters is necessary in robotic assembly for successful operations. Moreover, obtaining control parameters that can shorten the cycle time to perform operations is very important in industrial applications. In this paper, we present a method to design damping control parameters that can shorten the cycle time and show the effectiveness of the parameters obtained through the method. In the method, sub-optimal parameters are obtained through repetitive simulations of assembly operations in order to estimate the cycle time because it is difficult to calculate the cycle time analytically. We apply the method to peg-in-hole operations and show experimental results using the control parameters obtained through the method.
  Intelligent Robots and Systems, 2004. (IROS 2004). Proceedings. 2004 IEEE/RSJ International Conference on;
• Conference Proceeding: Designing of damping control parameters for peg-in-hole considering cycle time

  N. Yamanobe, Y. Maeda, T. Arai
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  ABSTRACT: It is necessary to design appropriate parameters of force control in robotic assembly so as to achieve successful operations. Moreover, obtaining control parameters that can shorten the cycle time to perform operations is very important in industrial applications. In this paper, we propose a method to obtain control parameters through repetitive simulation of an assembly operation in order to estimate the cycle time because it is difficult to calculate the cycle time analytically. First, a simulator of a robotic peg-in-hole operation is developed based on preliminary experiments. We then formulate our proposed method as an optimization problem and solve the problem using the simulator. Finally, results of the optimization are presented.
  Robotics and Automation, 2004. Proceedings. ICRA '04. 2004 IEEE International Conference on;