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S Yamamura,
H Morishima,
T Kumano-go,
N Suganuma,
H Matsumoto,
H Adachi,
Y Sigedo,
A Mikami,
T Kai,
A Masuyama,
T Takano, Y Sugita,
M Takeda
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ABSTRACT: To study the effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly healthy subjects.
The study included 29 healthy elderly subjects aged 60-81 years.
Prospective, randomized, double-blind and placebo-controlled, with a crossover design. The study included two intervention periods of 3 weeks each, separated by a 3-week washout period. Subjects took 100 g of fermented milk drink or a placebo drink (artificially acidified milk) daily in the first supplementary period and the other drink in the second supplementary period. For each period, we measured sleep quality by means of actigraphy and a sleep questionnaire, and assessed the quality of life (QOL) by SF-36 health survey.
There was a significant improvement in sleep efficiency (P=0.03) and number of wakening episodes (P=0.007) in actigraph data after intake of fermented milk, whereas no significant changes were observed for the placebo. Fermented milk did not improve the SF-36 scores significantly from the baseline period. In the GH domain (general health perception) of the SF-36, however, there was marginal improvement as compared to the baseline period. Although the difference between fermented milk and placebo was not statistically significant for any of the sleep or QOL parameters, fermented milk produced slightly greater mean values for many parameters.
This short-term (3-week) intervention study indicates that Lactobacillus helveticus fermented milk may have a more favorable effect on improving sleep in healthy elderly people as compared with placebo.
European journal of clinical nutrition 10/2007; 63(1):100-5. · 3.07 Impact Factor
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ABSTRACT: Obesity is a common predisposition to gastroesophageal reflux disease (GERD) and obstructive sleep apnea syndrome (OSAS). By statistical analysis of the respondents to a questionnaire that was distributed to members of the Kansai Rugby Association, we examined whether weight gain increased the incidence of these diseases and whether GERD alone disturbs sleep. Prevalence distribution of GERD by age differed from another survey, which suggests that predispositions other than age may contribute to GERD. Weight gain tended to increase the incidence of GERD. In our epidemiological study, both GERD (particularly nocturnal reflux) and OSAS significantly contributed to sleep disturbance. Although GERD alone seemed to be one of several independent factors of sleep disturbance, it was not a weak factor.
Psychiatry and Clinical Neurosciences 07/2001; 55(3):255-6. · 2.13 Impact Factor
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T Watanabe,
A Mikami,
Y Shigedo,
M Motonishi,
H Honda,
K Kyotani,
S Uruha,
K Terashima,
Y Teshima, Y Sugita,
M Takeda
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ABSTRACT: Severity of negative esophageal pressure (Pes) and apnea hypopnea index (AHI) were investigated in six cases of upper airway resistance syndrome (UARS) and 11 cases of obstructive sleep apnea syndrome (OSAS). The severity of negative Pes was represented by the highest peak (Pes Max) and the number of increased episodes (more than 13.5 cmH2O) per h (NPesI13.5). There was no significant correlation between Pes indices and AHI. Pes Max and NPesI13.5 were not different among severe OSAS (AHI > 30), mild OSAS (AHI < 30) and UARS. Apnea hypopnea index failed to represent the severity of negative Pes, which is an important aspect of the pathophysiology of sleep-disordered breathing.
Psychiatry and Clinical Neurosciences 06/2000; 54(3):338-9. · 2.13 Impact Factor
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T Watanabe,
T Kumano-Go,
N Suganuma,
Y Shigedo,
M Motonishi,
H Honda,
K Kyotani,
S Uruha,
K Terashima,
Y Teshima,
M Takeda, Y Sugita
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ABSTRACT: Severity of negative esophageal pressure (Pes) and apnea hypopnea index (AHI) were investigated in 34 patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). The OSAHS patients were diagnostically classified as having obstructive sleep apnea syndrome (OSAS) or upper airway resistance syndrome (UARS). Diagnosis of OSAS was based on an AHI of more than 5, and that of UARS on an AHI of less than 5, EEG arousals which were associated with apnea, hypopnea and/or respiratory effort occurring more than 10 times per hour, and daytime sleepiness. Negative Pes was represented by the greatest peak (NPes Max) and the number of increased (more than 13.5 cmH2O) episodes per hour (NPesI13.5). There was no significant correlation between the AHI and Pes indices, but NPes Max and NPesI13.5 showed significant correlation (p<0.01). NPes Max and NPesI13.5 showed no significant differences among the severe OSAS (AHI>50; 8 cases), moderate OSAS (50>AHI>15; 10 cases), mild OSAS (15>AHI>5; 9 cases) and UARS (7 cases) groups. We conclude that AHI does not reflect the severity of the increase in negative Pes, which is an important aspect of the pathophysiology of OSAHS. Assessment of OSAHS based on AHI alone may therefore underestimate the risk of increased negative Pes in cases with reduced AHI.
Sleep research online: SRO 01/2000; 3(4):169-72.
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T Watanabe,
A Mikami,
M Taniguchi,
M Motonishi,
H Honda,
K Kyotani,
S Uruha,
K Terashima,
Y Teshima,
I Egawa, Y Sugita,
M Takeda
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ABSTRACT: Polysomnographic findings and clinical symptoms were investigated in 14 cases of upper airway resistance syndrome. The mean scores of the Epworth sleepiness scale and self-rating depression scale in eight cases were 13.5 and 38.6, respectively. The mean sleep latency of the multiple sleep latency test in four cases was 10.2 min. Seven cases were treated with continuous positive airway pressure (CPAP), and one with hormone replacement therapy. The most common symptom was daytime sleepiness. Five cases had hypertension. CPAP reduced increasing negative esophageal pressure (Pes) and frequency of EEG arousals, and improved hypertension in one case. Hormone replacement therapy ameliorated increasing negative Pes and clinical symptoms.
Psychiatry and Clinical Neurosciences 05/1999; 53(2):331-3. · 2.13 Impact Factor
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ABSTRACT: We report cases of four patients with mild obstructive sleep apnea syndrome (OSAS) with frequent breathing-related electroencephalogram (EEG) arousals which led to excessive daytime sleepiness. In spite of a relatively low apnea hypopnea index (AHI), sleep was disrupted by frequent EEG arousals associated with respiratory effort as observed in upper airway resistance syndrome. The effects of sleep stage and sleep position on EEG arousals were also investigated. We consider that AHI alone is not a sufficient index to assess severity of OSAS, and it is very important to examine microarousals by the alteration of esophageal pressure in addition to the effect of sleep position.
Psychiatry and Clinical Neurosciences 05/1999; 53(2):307-9. · 2.13 Impact Factor
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ABSTRACT: We investigated the alteration of esophageal pressure (Pes) in 10 patients with upper-airway sleep-disordered breathing (UASDB) and the relationship among Pes, breathing patterns and EEG arousals. Increased negative Pes without apnea or hypopnea, appeared not only in upper airway resistance syndrome but also in obstructive sleep apnea syndrome. This phenomenon produced frequent EEG microarousals leading to sleep fragmentation and daytime sleepiness. Moreover, increased negative Pes occasionally continued for more than 20 min without an EEG arousal, which might be considered to be one of the factors to cause complications of UASDB.
Psychiatry and Clinical Neurosciences 05/1998; 52(2):216-7. · 2.13 Impact Factor
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ABSTRACT: Two cases of sleep disordered-breathing in climacteric were reported. Polysomnography including esophageal pressure (Pes) measurement was performed. Case 1 was diagnosed as upper airway resistance syndrome. Case 2 was diagnosed as obstructive sleep apnea syndrome, while many episodes of upper airway resistance also existed. Hormone replacement therapy improved clinical symptoms, and in case 1, Pes nadir was improved but incidence of arousals which was induced by breathing disturbances was not significantly changed. Sleep disordered-breathing should be suspected as a cause of sleep disorder even in females, especially in climacteric age. Pes measurement and evaluation of arousals is required. Hormone replacement therapy may release the upper airway resistance.
Psychiatry and Clinical Neurosciences 05/1998; 52(2):231-2. · 2.13 Impact Factor
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Neurology 06/1994; 44(5):987-8. · 8.31 Impact Factor
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ABSTRACT: We compared the sleep characteristics of seven healthy elderly people complaining of nocturnal somnambulism-like behaviors with those of 14 age-matched healthy elderly people who had never shown such behavior. Polysomnographic data revealed the appearance of "Stage 1-REM with tonic electromyographic (EMG) activity" sometimes accompanied by abnormal behavior in the first group, but the sleep architecture and parameters showed no significant difference between the two groups except for higher REM density in the first group. "Stage 1-REM with tonic EMG," observed in the first group was considered equivalent to REM sleep without muscle atonia. It is suggested that both reduced activity of tonic phenomena (muscle atonia) and increased activity of phasic phenomena (higher REM density) of REM sleep are essential for the induction of somnambulism-like behaviors during sleep in healthy elderly subjects.
Biological Psychiatry 08/1991; 30(1):4-14. · 8.28 Impact Factor
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The Japanese journal of psychiatry and neurology 04/1991; 45(1):180-1.
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ABSTRACT: Nocturnal sleep was examined in 12 patients with degenerative diseases involving the brain stem and in 2 patients with late cerebellar cortical atrophy (LCCA). A peculiar sleep state, characterized by the concomitant appearance of a low-voltage mixed frequency EEG, rapid eye movements (REMs) and tonic EMG in mental muscles, repeatedly appeared during nocturnal sleep in all of the 12 patients with degenerative diseases involving the brain stem and it was called stage 1-REM after Tachibana et al. In 8 of the 12 patients, delirious or oneiric behavior appeared during, or soon after, the episodes of stage 1-REM. Inner experiences reported by one of the subjects well corresponded to his behavior during the episode of stage 1-REM. Stage 1-REM was not observed during nocturnal sleep of the patients with LCCA. These results indicate that a degenerative lesion in the brain stem induced stage 1-REM and delirious behavior during nocturnal sleep through abolishing muscle atonia of REM sleep and causing dissociation of the functional components characterizing REM sleep.
The Japanese journal of psychiatry and neurology 01/1991; 44(4):681-92.
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ABSTRACT: A patient with obstructive sleep apnea has been treated by means of a mandibular repositioning appliance made of silicone rubber. The patient is a male and 54 years old with a slim body and complained a excessive daytime sleepiness and unsatisfied sleep. A lateral head plate revealed retruded mandible and narrow A-P diameter in the lower part of oropharynx. Moderate frequency of apnea was found in the initial all-night polysomnographic recording. The mandible has been brought forward by 5 mm and downward by 11 mm, which enlarges the diameter of oropharynx anterio-posteriorly by 2-3 mm. Since the appliance has been inserted during bed-time, the daytime sleepiness and unsatisfied sleep has been eliminated. The second polysomnographic recording revealed significant increment of deep NREM sleep and REM sleep and decrement of arousal during sleep after insertion of the appliance. It is indicated, therefore, that the application of the mandibular repositioning appliance is one of the effective methods for the treatment of obstructive sleep apnea.
[Osaka Daigaku shigaku zasshi] The journal of Osaka University Dental Society 07/1990; 35(1):400-9.
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ABSTRACT: We reported the case of a 13-year-old anorectic girl with epileptic seizures who showed marked favorable responses to sodium valproate and clonazepam. These two anticonvulsants were effective not only for controlling her epileptic seizures, but also against anorexia nervosa itself. The mechanism of their action to anorexia nervosa is unknown, but repeated EEGs and a trial of sodium valproate with or without clonazepam may be useful in evaluating the diverse pathologies of anorexia nervosa which seems to be a heterogeneous clinical entity.
The Japanese journal of psychiatry and neurology 04/1989; 43(1):77-84.
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ABSTRACT: Fm theta occurred not only during mental tests in the waking state but also during nocturnal sleep in which it was most frequent during REM and secondarily most frequent during stage 1 of NREM sleep. As for the inner experience of the subjects, they frequently reported dream and distinct mentations on awakening from REM sleep whether or not it was accompanied by Fm theta. They reported dream and distinct mentations more frequently when awakened from stage 1 of NREM sleep with Fm theta than when awakened from stage 1 of NREM sleep without Fm theta. Relationship of Fm theta to mental activity during sleep was briefly discussed.
Electroencephalography and Clinical Neurophysiology 02/1987; 66(1):66-70.
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ABSTRACT: Mazindol, a new anorexiant, was administered at a daily dose of 0.5-4 mg to 10 narcoleptic subjects aged 21-63 years. All the patients suffered from sleep attacks and one or more of the REM-related symptoms. Eight patients received only mazindol, and two patients received mazindol simultaneously with clomipramine or flurazepam. Sleep attacks were reduced in nine patients, and cataplexy was also markedly reduced in four patients. Mild adverse reactions were reported in six patients: two patients complained of headache, four of nocturnal sleep disturbance, and two of reduced appetite. Most side effects disappeared spontaneously or after dose reduction, and none of the patients had to stop medication. The results suggest that mazindol is effective not only for sleep attacks but also for cataplexy. It is recommended as a treatment for mild cases of narcolepsy.
Sleep 02/1986; 9(1 Pt 2):265-8. · 5.05 Impact Factor
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ABSTRACT: The CSF pressure was measured continuously at the lumbar level during nocturnal sleep in 3 patients with sleep apnea hypersomnia syndrome. Nocturnal sleep was very unstable with frequent episodes of obstructive sleep apnea. When the patients were awake and relaxed in the supine position, their CSF pressure was stable and within the normal range. Episodic marked elevations of CSF pressure occurred frequently during sleep, and each elevation was preceded and accompanied by an episode of sleep apnea or hypopnea. Significant correlations were found between the duration of apneic episodes and increase of CSF pressure, and between decrease of SaO2 or TcPO2 and increase of CSF pressure. The duration of sleep apnea was longer, increase of CSF pressure was greater, and decreases of SaO2 and TcPO2 were more marked during REM sleep than during NREM sleep. It is suggested that the frequent marked episodic elevations of CSF pressure are caused by an increase in the intracranial vascular volume occurring mainly in response to transient hypercapnia and hypoxia, which are induced by pulmonary hypoventilation during the episodes of sleep apnea.
Electroencephalography and Clinical Neurophysiology 04/1985; 60(3):214-9.
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ABSTRACT: Potential distribution of vertex sharp wave characterizing stages 1 and 2 of NREM sleep and saw-toothed wave recorded in REM sleep were studied in 6 healthy young adults. Like the vertex sharp wave, saw-toothed wave appeared in a wide area on the scalp with the maximal amplitude at Cz and its equipotential lines showed concentric circles with their center at Cz, its amplitude decreasing with distance from Cz. The main component of saw-toothed wave was a positive wave with longer duration (about 250 msec) and lower amplitude than vertex sharp wave (about 200 msec in duration), the main component of which was a negative wave.
Electroencephalography and Clinical Neurophysiology 08/1984; 58(1):73-6.
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Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 02/1982; 84(8):559-76.
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Rinsho shinkeigaku = Clinical neurology 04/1981; 21(3):218-27.
