Publications (2)8.63 Total impact
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Article: Negative impacts of unreported COPD exacerbations on health-related quality of life at 1 year.
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ABSTRACT: Unreported chronic obstructive pulmonary disease (COPD) exacerbations are common, but their intermediate-to-long-term impacts on health-related quality of life (HRQoL) are unknown. The aim of the present study was to examine the impact of unreported exacerbations on HRQoL at 1 yr. A multicentric prospective cohort study in 491 COPD patients was conducted in China. HRQoL was measured using the St George's Respiratory Questionnaire (SGRQ). Other measurements included sociodemographic, clinical, psychosocial and treatment profiles. Patients were monitored monthly for 12 months to document exacerbations (at least one symptom worsening for > or =48 h). Patients were categorised into six groups: no exacerbation, one unreported exacerbation only, more than one unreported exacerbation only, one reported exacerbation only, more than one reported exacerbation only, and both unreported and reported exacerbations. Generalised estimating equations were used to estimate the adjusted associations between exacerbations and HRQoL change. A total of 466 unreported and 410 reported exacerbations were recorded. Compared with patients with no exacerbations, the change in SGRQ total score was similar amongst patients with one unreported exacerbation (adjusted mean change 1.22 points (95% CI -4.05-6.48)), but significantly worse among patients with more than one unreported exacerbation (4.61 (95% CI 0.09-9.13)). Development and evaluation of self-management programmes emphasising early recognition of exacerbations and consequent action appear to be warranted.European Respiratory Journal 11/2009; 35(5):1022-30. · 5.89 Impact Factor -
Article: Validation and clinical interpretation of the St George's Respiratory Questionnaire among COPD patients, China.
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ABSTRACT: Although the St George's Respiratory Questionnaires in Mandarin-Chinese (SGRQ-MC) have been used in China, few data are available on the translation and adaptation process, psychometric properties and clinical meaning. It is therefore difficult to adequately evaluate the equivalence of this instrument in Chinese populations. To evaluate the psychometric properties of a culturally translated SGRQ-MC, and to estimate clinically important differences (CID) for the SGRQ in chronic obstructive pulmonary disease (COPD) patients in China. SGRQ was translated into Mandarin using standardised forward and backward translation procedures. Health status and clinical data were collected at baseline in 491 patients with stable COPD and again after 1 week in 131 randomly selected patients. All patients were followed up monthly and assessed during exacerbations and at 1 year. The SGRQ-MC showed good internal consistency, test-retest reliability, convergent validity and known-group validity. Responsiveness was shown by significant changes in SGRQ-MC scores between stable stage and exacerbation (P<0.0001). The estimated CID for the total score ranged from 3.1 (95%CI -0.3-6.5) to 7.7 (95%CI -1.7-17.2). This SGRQ-MC is a reliable, valid and responsive instrument for quality of life evaluation in COPD patients in China. As it is culturally and clinically equivalent to other versions, measures can be compared among countries.The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 02/2009; 13(2):181-9. · 2.73 Impact Factor
