Publications (3)5.75 Total impact
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Article: Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
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ABSTRACT: To assess the association between the C to T transition in the methylenetetrahydro folate reductase gene (MTHFR C677T) and the C to T transition in the serine hydroxymethyltransferase ( 1 )gene (SHMT ( 1 ) C1420T) and the increased risk of carcinogenesis of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) in a population of high incident region of Northern China. The polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism and PCR-confronting two-pair primers analysis respectively among 1051 cancer patients (584 ESCC and 467 GCA) and 540 healthy controls. The MTHFR 677T/T genotype significantly increased susceptibility to both ESCC and GCA compared with the C/C genotype, the adjusted OR was 2.13 (95% CI = 1.50-3.02) and 1.28 (95% CI = 1.07-1.53, respectively. For the SHMT ( 1 ) C1420T polymorphism, the C/C genotype was significantly associated with the increased risk of ESCC and GCA, compared with the C/T genotype (the adjusted OR = 1.43 and 1.35, 95% CI = 1.02-2.00 and 1.11-1.63, respectively). The interactive influence of the MTHFR and SHMT ( 1 ) polymorphisms in the risk of ESCC and GCA was also observed. The association between the MTHFR C677T and SHMT ( 1 ) C1420T polymorphisms and the risk of ESCC and GCA was demonstrated.Cancer Causes and Control 04/2007; 18(2):143-52. · 2.88 Impact Factor -
Article: Association of MTHFR C677T and SHMT1 C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China
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ABSTRACT: ObjectiveTo assess the association between the C to T transition in the methylenetetrahydro folate reductase gene (MTHFR C677T) and the C to T transition in the serine hydroxymethyltransferase 1 gene (SHMT 1 C1420T) and the increased risk of carcinogenesis of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) in a population of high incident region of Northern China. MethodsThe polymorphisms were genotyped by polymerase chain reaction–restriction fragment length polymorphism and PCR-confronting two-pair primers analysis respectively among 1051 cancer patients (584 ESCC and 467 GCA) and 540 healthy controls. ResultsThe MTHFR 677T/T genotype significantly increased susceptibility to both ESCC and GCA compared with the C/C genotype, the adjusted OR was 2.13 (95% CI = 1.50–3.02) and 1.28 (95% CI = 1.07–1.53, respectively. For the SHMT 1 C1420T polymorphism, the C/C genotype was significantly associated with the increased risk of ESCC and GCA, compared with the C/T genotype (the adjusted OR = 1.43 and 1.35, 95% CI = 1.02–2.00 and 1.11–1.63, respectively). The interactive influence of the MTHFR and SHMT 1 polymorphisms in the risk of ESCC and GCA was also observed. ConclusionThe association between the MTHFR C677T and SHMT 1 C1420T polymorphisms and the risk of ESCC and GCA was demonstrated.Cancer Causes and Control 02/2007; 18(2):143-152. · 2.88 Impact Factor -
Article: Ecosystem service values and restoration in the urban Sanyang wetland of Wenzhou, China
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ABSTRACT: Over the course of a year, we conducted a study on future restoration work in the Sanyang wetland, a degraded permanent river wetland that is close to the center of Wenzhou city, China. Our main objective was to plan the restoration by using both structural indices and a valuation of the wetland's ecosystem services, thereby linking the science to human welfare. Based on field surveys and research into the history of the study area, we calculated both the potential and current values of the main ecosystem services. The results showed that the potential value at the Sanyang wetland was 55,332 yuan ha−1 yr−1, while the current value was only 5807 yuan ha−1 yr−1. In other words, 89.5% of the service value needs to be restored for the wetland to reach its potential value. We recommend that the service provided by the wetland's ability to purify the environment needs to be the top priority in restoration. In addition, water and sediment quality should also be greatly improved.Ecological Engineering.
