-
STAR Collaboration,
L. Adamczyk,
J. K. Adkins,
G. Agakishiev,
M. M. Aggarwal,
Z. Ahammed,
I. Alekseev,
J. Alford,
C. D. Anson,
A. Aparin, [......],
X. P. Zhang,
Y. Zhang,
Z. P. Zhang,
F. Zhao,
J. Zhao,
C. Zhong,
X. Zhu,
Y. H. Zhu,
Y. Zoulkarneeva,
M. Zyzak
[show abstract]
[hide abstract]
ABSTRACT: Azimuthal angular correlations of charged hadrons with respect to the axis of
a reconstructed (trigger) jet in Au+Au and p+p collisions at $\sqrt{s_{NN}} =
200$ GeV in STAR are presented. The trigger jet population in Au+Au collisions
is biased towards jets that have not interacted with the medium, allowing
easier matching of jet energies between Au+Au and p+p collisions while
enhancing medium effects on the recoil jet. The associated hadron yield of the
recoil jet is significantly suppressed at high transverse momentum
($p_{T}^{assoc}$) and enhanced at low $p_{T}^{assoc}$ in Au+Au collisions,
which is indicative of medium-induced parton energy loss in ultrarelativistic
heavy-ion collisions.
02/2013;
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
R Loveless,
A Mohapatra,
M U Mozer,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: A study is presented of the mass and spin-parity of the new boson recently observed at the LHC at a mass near 125 GeV. An integrated luminosity of 17.3 fb^{-1}, collected by the CMS experiment in proton-proton collisions at center-of-mass energies of 7 and 8 TeV, is used. The measured mass in the ZZ channel, where both Z bosons decay to e or μ pairs, is 126.2±0.6(stat)±0.2(syst) GeV. The angular distributions of the lepton pairs in this channel are sensitive to the spin-parity of the boson. Under the assumption of spin 0, the present data are consistent with the pure scalar hypothesis, while disfavoring the pure pseudoscalar hypothesis.
Physical Review Letters 02/2013; 110(8):081803. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: Results are presented from a search for the pair production of third-generation scalar and vector leptoquarks, as well as for top squarks in R-parity-violating supersymmetric models. In either scenario, the new, heavy particle decays into a τ lepton and a b quark. The search is based on a data sample of pp collisions at sqrt[s]=7 TeV, which is collected by the CMS detector at the LHC and corresponds to an integrated luminosity of 4.8 fb^{-1}. The number of observed events is found to be in agreement with the standard model prediction, and exclusion limits on mass parameters are obtained at the 95% confidence level. Vector leptoquarks with masses below 760 GeV are excluded and, if the branching fraction of the scalar leptoquark decay to a τ lepton and a b quark is assumed to be unity, third-generation scalar leptoquarks with masses below 525 GeV are ruled out. Top squarks with masses below 453 GeV are excluded for a typical benchmark scenario, and limits on the coupling between the top squark, τ lepton, and b quark, λ_{333}^{'} are obtained. These results are the most stringent for these scenarios to date.
Physical Review Letters 02/2013; 110(8):081801. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
C Lazaridis,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: The polarizations of the Υ(1S), Υ(2S), and Υ(3S) mesons are measured in proton-proton collisions at sqrt[s]=7 TeV, using a data sample of Υ(nS)→μ^{+}μ^{-} decays collected by the CMS experiment, corresponding to an integrated luminosity of 4.9 fb^{-1}. The dimuon decay angular distributions are analyzed in three different polarization frames. The polarization parameters λ_{ϑ}, λ_{φ}, and λ_{ϑφ}, as well as the frame-invariant quantity λ[over ˜], are presented as a function of the Υ(nS) transverse momentum between 10 and 50 GeV, in the rapidity ranges |y|<0.6 and 0.6<|y|<1.2. No evidence of large transverse or longitudinal polarizations is seen in the explored kinematic region.
Physical Review Letters 02/2013; 110(8):081802. · 7.37 Impact Factor
-
STAR Collaboration,
L. Adamczyk,
J. K. Adkins,
G. Agakishiev,
M. M. Aggarwal,
Z. Ahammed,
I. Alekseev,
J. Alford,
C. D. Anson,
A. Aparin, [......],
X. P. Zhang,
Y. Zhang,
Z. P. Zhang,
F. Zhao,
J. Zhao,
C. Zhong,
X. Zhu,
Y. H. Zhu,
Y. Zoulkarneeva,
M. Zyzak
[show abstract]
[hide abstract]
ABSTRACT: Recent experimental results from the STAR collaboration suggest
event-by-event charge separation fluctuations perpendicular to the event plane
in non-central heavy-ion collisions. Here we present the correlator previously
used split into its two component parts to reveal correlations parallel and
perpendicular to the event plane. The results are from a high statistics 200
GeV Au+Au collisions data set collected by the STAR experiment at RHIC. We
explicitly count units of charge separation from which we find clear evidence
for more charge separation fluctuations perpendicular than parallel to the
event plane. We also employ a modified correlator to study the possible P-even
background in same and opposite charge correlations.
02/2013;
-
STAR Collaboration,
L. Adamczyk,
J. K. Adkins,
G. Agakishiev,
M. M. Aggarwal,
Z. Ahammed,
I. Alekseev,
J. Alford,
C. D. Anson,
A. Aparin, [......],
X. P. Zhang,
Y. Zhang,
Z. P. Zhang,
F. Zhao,
J. Zhao,
C. Zhong,
X. Zhu,
Y. H. Zhu,
Y. Zoulkarneeva,
M. Zyzak
[show abstract]
[hide abstract]
ABSTRACT: We present measurements of three-dimensional correlation functions of
like-sign low transverse momentum kaon pairs from sqrt(sNN)=200 GeV Au+Au
collisions. A Cartesian surface-spherical harmonic decomposition technique was
used to extract the kaon source function. The latter was found to have a
three-dimensional Gaussian shape and can be adequately reproduced by
Therminator event generator simulations with resonance contributions taken into
account. Compared to the pion one, the kaon source function is generally
narrower and does not have the long tail along the pair transverse momentum
direction. The kaon Gaussian radii display a monotonic decrease with increasing
transverse mass m_T over the interval of 0.55<=m_T<=1.15 GeV/c^2. While the
kaon radii are adequately described by the m_T-scaling in the outward and
sideward directions, in the longitudinal direction the lowest m_T value exceeds
the expectations from a pure hydrodynamical model prediction.
02/2013;
-
STAR Collaboration,
L. Adamczyk,
J. K. Adkins,
G. Agakishiev,
M. M. Aggarwal,
Z. Ahammed,
I. Alekseev,
J. Alford,
C. D. Anson,
A. Aparin, [......],
X. P. Zhang,
Y. Zhang,
Z. P. Zhang,
F. Zhao,
J. Zhao,
C. Zhong,
X. Zhu,
Y. H. Zhu,
Y. Zoulkarneeva,
M. Zyzak
[show abstract]
[hide abstract]
ABSTRACT: We present a study of the average transverse momentum ($p_t$) fluctuations
and $p_t$ correlations for charged particles produced in Cu+Cu collisions at
midrapidity for $\sqrt{s_{NN}} =$ 62.4 and 200 GeV. These results are compared
with those published for Au+Au collisions at same energies, to explore the
system size dependence. In addition to the collision energy and system size
dependence, the $p_t$ correlations results have been studied as functions of
the collision centralities, the ranges in $p_t$, the pseudo-rapidity $\eta$,
and the azimuthal angle $\phi$, for which the correlations are measured. The
square root of the measured $p_t$ correlations when scaled by mean-$p_t$ are
found to be independent of both colliding beam energy and system size studied.
The transport based model calculations are found to have a better quantitative
agreement with the measurements compared to models which incorporate only
jet-like correlations.
01/2013;
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: Evidence is presented for the associated production of a single top quark and W boson in pp collisions at sqrt[s]=7 TeV with the CMS experiment at the LHC. The analyzed data correspond to an integrated luminosity of 4.9 fb^{-1}. The measurement is performed using events with two leptons and a jet originated from a b quark. A multivariate analysis based on kinematic properties is utilized to separate the tt[over ¯] background from the signal. The observed signal has a significance of 4.0σ and corresponds to a cross section of 16_{-4}^{+5} pb, in agreement with the standard model expectation of 15.6±0.4_{-1.2}^{+1.0} pb.
Physical Review Letters 01/2013; 110(2):022003. · 7.37 Impact Factor
-
STAR Collaboration,
L. Adamczyk,
J. K. Adkins,
G. Agakishiev,
M. M. Aggarwal,
Z. Ahammed,
I. Alekseev,
J. Alford,
C. D. Anson,
A. Aparin, [......],
X. P. Zhang,
Y. Zhang,
Z. P. Zhang,
F. Zhao,
J. Zhao,
C. Zhong,
X. Zhu,
Y. H. Zhu,
Y. Zoulkarneeva,
M. Zyzak
[show abstract]
[hide abstract]
ABSTRACT: We report measurements of the third harmonic coefficient of the azimuthal
anisotropy, v_3, known as triangular flow. The analysis is for charged
particles in Au+Au collisions at $\sqrtsNN = 200$ GeV, based on data from the
STAR experiment at the Relativistic Heavy Ion Collider. Two-particle
correlations as a function of their pseudorapidity separation are fit with
narrow and wide Gaussians. Measurements of triangular flow are extracted from
the wide Gaussian, from two-particle cumulants with a pseudorapidity gap, and
also from event plane analysis methods with a large pseudorapidity gap between
the particles and the event plane. These results are reported as a function of
transverse momentum and centrality. A large dependence on the pseudorapidity
gap is found. Results are compared with other experiments and model
calculations.
01/2013;
-
L. Adamczyk,
J. K. Adkins,
G. Agakishiev,
M. M. Aggarwal,
Z. Ahammed,
I. Alekseev,
J. Alford,
C. D. Anson,
A. Aparin,
D. Arkhipkin, [......],
X. P. Zhang,
Y. Zhang,
Z. P. Zhang,
F. Zhao,
J. Zhao,
C. Zhong,
X. Zhu,
Y. H. Zhu,
Y. Zoulkarneeva,
M. Zyzak
[show abstract]
[hide abstract]
ABSTRACT: Elliptic flow ($v_{2}$) values for identified particles at mid-rapidity in
Au+Au collisions, measured by the STAR experiment in the Beam Energy Scan at
RHIC at $\sqrt{s_{NN}}=$ 7.7--62.4 GeV, are presented. A beam-energy dependent
difference of the values of $v_{2}$ between particles and corresponding
anti-particles was observed. The difference increases with decreasing beam
energy and is larger for baryons compared to mesons. This implies that, at
lower energies, particles and anti-particles are not consistent with the
universal number-of-constituent-quark (NCQ) scaling of $v_{2}$ that was
observed at $\sqrt{s_{NN}}=$ 200 GeV.
01/2013;
-
L. Adamczyk,
J. K. Adkins,
G. Agakishiev,
M. M. Aggarwal,
Z. Ahammed,
I. Alekseev,
J. Alford,
C. D. Anson,
A. Aparin,
D. Arkhipkin, [......],
X. P. Zhang,
Y. Zhang,
Z. P. Zhang,
F. Zhao,
J. Zhao,
C. Zhong,
X. Zhu,
Y. H. Zhu,
Y. Zoulkarneeva,
M. Zyzak
[show abstract]
[hide abstract]
ABSTRACT: Measurements of the elliptic flow, $v_{2}$, of identified hadrons
($\pi^{\pm}$, $K^{\pm}$, $K_{s}^{0}$, $p$, $\bar{p}$, $\phi$, $\Lambda$,
$\bar{\Lambda}$, $\Xi^{-}$, $\bar{\Xi}^{+}$, $\Omega^{-}$, $\bar{\Omega}^{+}$)
in Au+Au collisions at $\sqrt{s_{NN}}=$ 7.7, 11.5, 19.6, 27, 39 and 62.4 GeV
are presented. The measurements were done at mid-rapidity using the Time
Projection Chamber and the Time-of-Flight detectors of the STAR experiment
during the Beam Energy Scan program at RHIC. A significant difference in the
$v_{2}$ values for particles and the corresponding anti-particles was observed
at all transverse momenta for the first time. The difference increases with
decreasing center-of-mass energy, $\sqrt{s_{NN}}$ (or increasing baryon
chemical potential, $\mu_{B}$) and is larger for the baryons as compared to the
mesons. This implies that particles and anti-particles are no longer consistent
with the universal number-of-constituent quark (NCQ) scaling of $v_{2}$ that
was observed at $\sqrt{s_{NN}}=$ 200 GeV. However, for the group of particles
NCQ scaling at $(m_{T}-m_{0})/n_{q}>$ 0.4 GeV/$c^{2}$ is not violated within
$\pm$10%. The $v_{2}$ values for $\phi$ mesons at 7.7 and 11.5 GeV are
approximately two standard deviations from the trend defined by the other
hadrons at the highest measured $p_{T}$ values.
01/2013;
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
C Lazaridis,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: Results are presented from a search for heavy, right-handed muon neutrinos, N_{μ}, and right-handed W_{R} bosons, which arise in the left-right symmetric extensions of the standard model. The analysis is based on a 5.0 fb^{-1} sample of proton-proton collisions at a center-of-mass energy of 7 TeV, collected by the CMS detector at the Large Hadron Collider. No evidence is observed for an excess of events over the standard model expectation. For models with exact left-right symmetry, heavy right-handed neutrinos are excluded at 95% confidence level for a range of neutrino masses below the W_{R} mass, dependent on the value of M_{W_{R}}. The excluded region in the two-dimensional (M_{W_{R}}, M_{N_{μ}}) mass plane extends to M_{W_{R}}=2.5 TeV.
Physical Review Letters 12/2012; 109(26):261802. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: We report an investigation of the invariant mass spectrum of the two jets with highest transverse momentum in pp→W+2-jet and W+3-jet events to look for resonant enhancement. The data sample corresponds to an integrated luminosity of 5.0 fb^{-1} collected with the CMS detector at sqrt[s]=7 TeV. We find no evidence for the anomalous structure reported by the CDF Collaboration, and establish an upper limit of 5.0 pb at 95% confidence level on the production cross section for a generic Gaussian signal with mass near 150 GeV. Additionally, we exclude two theoretical models that predict a CDF-like dijet resonance near 150 GeV.
Physical Review Letters 12/2012; 109(25):251801. · 7.37 Impact Factor
-
D. Abbaneo,
G. Abbiendi,
M. Abbrescia,
S. Abdullin,
A. Abdulsalam,
B.S. Acharya,
D. Acosta,
J.G. Acosta,
A. Adair,
W. Adam, [......],
M.H. Zoeller,
O. Zorba,
P. Zotto,
W. Zou,
G. Zumerle,
M. Zupan,
A. Zuranski,
R. Zuyeuski,
M. Zvada,
P. Zych
[show abstract]
[hide abstract]
ABSTRACT: The Higgs boson was postulated nearly five decades ago within the framework of the standard model of particle physics and
has been the subject of numerous searches at accelerators around the world. Its discovery would verify the existence of a
complex scalar field thought to give mass to three of the carriers of the electroweak force—the W+, W–, and Z0 bosons—as well as to the fundamental quarks and leptons. The CMS Collaboration has observed, with a statistical significance
of five standard deviations, a new particle produced in proton-proton collisions at the Large Hadron Collider at CERN. The
evidence is strongest in the diphoton and four-lepton (electrons and/or muons) final states, which provide the best mass resolution
in the CMS detector. The probability of the observed signal being due to a random fluctuation of the background is about 1
in 3 × 106. The new particle is a boson with spin not equal to 1 and has a mass of about 1.25 giga–electron volts. Although its measured
properties are, within the uncertainties of the present data, consistent with those expected of the Higgs boson, more data
are needed to elucidate the precise nature of the new particle.
Science 12/2012; 338(6114):1569-1575. · 31.20 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: The suppression of the individual Υ(nS) states in PbPb collisions with respect to their yields in pp data has been measured. The PbPb and pp data sets used in the analysis correspond to integrated luminosities of 150 μb^{-1} and 230 nb^{-1}, respectively, collected in 2011 by the CMS experiment at the LHC, at a center-of-mass energy per nucleon pair of 2.76 TeV. The Υ(nS) yields are measured from the dimuon invariant mass spectra. The suppression of the Υ(nS) yields in PbPb relative to the yields in pp, scaled by the number of nucleon-nucleon collisions, R_{AA}, is measured as a function of the collision centrality. Integrated over centrality, the R_{AA} values are 0.56±0.08(stat)±0.07(syst), 0.12±0.04(stat)±0.02(syst), and lower than 0.10 (at 95% confidence level), for the Υ(1S), Υ(2S), and Υ(3S) states, respectively. The results demonstrate the sequential suppression of the Υ(nS) states in PbPb collisions at LHC energies.
Physical Review Letters 11/2012; 109(22):222301. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: A search for physics beyond the standard model is performed in events with at least three jets and large missing transverse momentum produced in proton-proton collisions at a center-of-mass energy of sqrt[s]=7 TeV. No significant excess of events above the expected backgrounds is observed in 4.98 fb^{-1} of data collected with the CMS detector at the Large Hadron Collider. The results are presented in the context of the constrained minimal supersymmetric extension of the standard model and more generically for simplified models. For the simplified models of gluino-gluino and squark-squark production, gluino masses below 1.0 TeV and squark masses below 0.76 TeV are excluded in case the lightest supersymmetric particle mass is below 200 GeV. These results significantly extend previous searches.
Physical Review Letters 10/2012; 109(17):171803. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: The transverse energy (E_{T}) in Pb-Pb collisions at 2.76 TeV nucleon-nucleon center-of-mass energy (sqrt[s_{NN}]) has been measured over a broad range of pseudorapidity (η) and collision centrality by using the CMS detector at the LHC. The transverse energy density per unit pseudorapidity (dE_{T}/dη) increases faster with collision energy than the charged particle multiplicity. This implies that the mean energy per particle is increasing with collision energy. At all pseudorapidities, the transverse energy per participating nucleon increases with the centrality of the collision. The ratio of transverse energy per unit pseudorapidity in peripheral to central collisions varies significantly as the pseudorapidity increases from η=0 to |η|=5.0. For the 5% most central collisions, the energy density per unit volume is estimated to be about 14 GeV/fm^{3} at a time of 1 fm/c after the collision. This is about 100 times larger than normal nuclear matter density and a factor of 2.6 times higher than the energy density reported at sqrt[s_{NN}]=200 GeV at the Relativistic Heavy Ion Collider.
Physical Review Letters 10/2012; 109(15):152303. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: A search is performed in pp collisions at sqrt[s]=7 TeV for exotic particles decaying via WZ to final states with electrons and muons. The data sample corresponds to an integrated luminosity of approximately 5 fb^{-1}. No significant excess is observed in the data above the expected standard model background. Upper bounds at 95% confidence level are set on the production cross section of the W^{'} boson described by the sequential standard model and on the W^{'} WZ coupling. W^{'} bosons with masses below 1143 GeV are excluded. Limits are also set in the context of low-scale technicolor models, under a range of assumptions concerning the model parameters.
Physical Review Letters 10/2012; 109(14):141801. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: The dimuon invariant mass spectrum is searched in the range between 5.5 and 14 GeV for a light pseudoscalar Higgs boson a, predicted in a number of new physics models, including the next-to-minimal supersymmetric standard model. The data sample used in the search corresponds to an integrated luminosity of 1.3 fb^{-1} collected in pp collisions at sqrt[s]=7 TeV with the CMS detector at the LHC. No excess is observed above the background predictions and upper limits are set on the cross section times branching fraction σ×B(pp→a→μ^{+}μ^{-}) in the range of 1.5-7.5 pb. These results improve on existing bounds on the abb[over ¯] coupling for m_{a}<m_{Υ(1S)} and are the first significant limits for m_{a}>m_{Υ(3S)}. Constraints on the supersymmetric parameter space are presented in the context of the next-to-minimal model.
Physical Review Letters 09/2012; 109(12):121801. · 7.37 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Generalized pustular psoriasis (GPP) is an episodic and potentially life-threatening disease characterized by widespread eruptions of sterile pustules and bright erythematous skin accompanied by fever, chills, and rigors. It is driven by the coordinated action of a number of cytokines and growth factors, including the interleukin-1 family, which is composed of 11 cytokines and 9 cell surface receptors that are primary mediators of inflammation.(1-2) Interleukin-36 receptor antagonist (IL-36Ra) encoded by IL36RN gene, is one of the members in this family and an antagonist of three cytokines: interleukin-36α, interleukin-36β, and interleukin-36γ.(3) Recently, specific mutations in IL-36RN gene have been reported to be causative genetic defects in both familial and sporadic GPP cases.(3-5) Therefore, we conducted an IL-36Ra mutation analysis to investigate whether GPP in Han Chinese could be explained by the same pathogenesis.
British Journal of Dermatology 08/2012; · 3.67 Impact Factor
