Xiaoyan Zhou

Publications (3)8.42 Total impact

• Article: No reflow-like pattern in intramyocardial coronary artery suggests myocardial ischemia in patients with hypertrophic cardiomyopathy.

  Woo-Shik Kim, Shinichi Minagoe, Naoko Mizukami, Xiaoyan Zhou, Keiichiro Yoshinaga, Kunitsugu Takasaki, Toshinori Yuasa, Koichi Kihara, Shuichi Hamasaki, Yutaka Otsuji, Akira Kisanuki, Chuwa Tei
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  ABSTRACT: To evaluate intramyocardial coronary flow velocity pattern by transthoracic Doppler echocardiography and its clinical significance in patients with hypertrophic cardiomyopathy (HCM). In 48 patients with HCM who had angiographically normal coronary artery, coronary flow velocity in the left anterior descending coronary artery (LAD) and intramyocardial coronary artery (IMCA) derived from LAD were evaluated using transthoracic Doppler echocardiography. Two clearly different flow patterns in the IMCA were observed in patients with HCM. Twenty-seven HCM patients (group A) had slow deceleration slope in the IMCA flow (average diastolic deceleration time, 989+/-338; range, 585-1680) and the remaining 21 patients (group B) had steep deceleration slope with diastolic deceleration time <300 ms, resulting in a no reflow-like pattern in the IMCA flow (average diastolic deceleration time, 166+/-67; range, 55-280). There were no significant differences in the clinical characteristics and LAD flow velocity profiles between the two groups. The incidence of cardiovascular symptoms (chest pain or syncope) was significantly higher in group B than in group A (67% vs. 26%, p<0.01). Additionally, exercise-induced ischemia as detected by thallium-201 scintigraphy was significantly more frequent in group B than in group A (6 of 9 (67%) vs. 0 of 9 (0%), p<0.01). Two different intramyocardial coronary flow velocity patterns are observed in patients with HCM using transthoracic Doppler echocardiography. No reflow-like pattern in the IMCA is strongly related to myocardial ischemia in the absence of epicardial coronary artery stenosis, suggesting that coronary microvascular dysfunction may be a causative mechanism.
  Journal of Cardiology 08/2008; 52(1):7-16. · 1.28 Impact Factor
• Article: Evaluation of left ventricular ejection fraction by tissue locus imaging.

  Kumiko Natsugoe, Yutaka Otsuji, Xiaoyan Zhou, Hui Zhang, Akira Kisanuki, Shiro Yoshifuku, Toshiro Kumanohoso, Keiko Yuge, Shuichi Hamasaki, Sadatoshi Biro, Shinichi Minagoe, Masumi Ochi, Chuwa Tei
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  ABSTRACT: The newly developed echocardiographic technique called "tissue locus imaging" (TLI) can visualize temporal series of images in a single picture by maintaining the display of previous images with a shading function; therefore, it can display the whole systolic shift of the mitral leaflets toward the apex in a single picture and can potentially offer useful information on left ventricular (LV) function. In 36 consecutive patients with varying degrees of LV dysfunction (15 with coronary artery disease, 9 with cardiomyopathy, 3 with hypertension, 2 with aortic stenosis, 1 with aortic regurgitation, and 6 controls), the systolic shift of the mitral leaflets (X) by TLI showed a significant correlation with the LV ejection fraction (Y) by 2-dimensional echocardiography (Y = 7.2 x+13, r(2) = 0.83, p <0.01). TLI enables the evaluation and visualization of LV systolic function by displaying the whole systolic shift of the mitral leaflets toward the apex.
  The American Journal of Cardiology 08/2004; 94(2):273-5. · 3.37 Impact Factor
• Article: Impact of atrial fibrillation on tricuspid and mitral annular dilatation and valvular regurgitation.

  Xiaoyan Zhou, Yutaka Otsuji, Shiro Yoshifuku, Toshinori Yuasa, Hui Zhang, Kunitsugu Takasaki, Keiko Matsukida, Akira Kisanuki, Shinichi Minagoe, Chuwa Tei
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  ABSTRACT: To investigate the effects of atrial fibrillation (AF) on the mitral and tricuspid valves, the corresponding annular dilatation and valvular regurgitation were compared with 2-dimensional and Doppler echocardiography in 31 consecutive patients with lone AF and 28 normal controls. Mid-systolic mitral and tricuspid annular areas were measured from 2 diameters in 2 orthogonal apical echocardiograms. Percent (%) mitral regurgitant (MR) or tricuspid regurgitant (TR) jet area to the left or right atrial area was evaluated and % MR or TR jet area >20% was considered moderate or significant. Both the mitral and tricuspid annular areas in patients with lone AF were significantly larger compared with the controls (mitral: 9.5 +/- 1.2 vs 6.6 +/- 0.9 cm2, lone AF vs control, p < 0.01) (tricuspid: 12.0 +/- 2.0 vs 7.5 +/- 0.9 cm2, p < 0.01). The % increase in the annular area relative to the mean normal value was significantly greater in the tricuspid valve (44 +/- 18 vs 60 +/- 28%, p < 0.01). Moderate or severe MR was not observed and the incidence of moderate or severe valve regurgitation (% jet area >20%) was significantly higher in the tricuspid valve (0/31 vs 11/31, MR vs TR, p < 0.01) in patients with lone AF. The % TR jet area showed significant correlation with tricuspid annular area (r2 = 0.65, p < 0.001). Lone AF is associated with annular dilatation of both mitral and tricuspid valves, but the annular dilatation and valvular regurgitation are significantly greater in the tricuspid valve.
  Circulation Journal 10/2002; 66(10):913-6. · 3.77 Impact Factor