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ABSTRACT: Hepatocellular carcinoma is a common disorder worldwide which ranks 5th and 7th most common cancer among men and women. In recent years, different incidence trends have been observed in various regions, but the reasons are not completely understood. However, due to the great public efforts in HCC prevention and alternation of lifestyle, the roles of some well documented risk factors played in hepatocarcinogenesis might have changed. This paper summarizes both the environmental and host related risk factors of hepatocellular carcinoma including well established risk factors such as hepatitis virus infection, aflatoxin and alcohol, as well as possible risk factors such as coffee drinking and other dietary agents.
Asian Pacific journal of cancer prevention: APJCP 01/2012; 13(3):743-52. · 0.66 Impact Factor
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ABSTRACT: Lack of cancer incidence information for adolescents and young adults led us to describe incidence trends within the young population of 15 to 49 year-olds in urban Shanghai between 1973 and 2005.
During 1973 to 2005, data on 43,009 (45.8%) male and 50,828 (54.2%) female cancer cases aged 15-49 years from the Shanghai Cancer Registry were analyzed. Five-year age-specific rates, world age-standardized rates, percent change (PC), and annual percent change (APC) were calculated using annual data on population size and its estimated age structure.
During the 33-year study period, overall cancer incidence of adolescents and young adults among males marginally decreased by 0.5% per year (P<0.05). However, overall cancer incidence for females slightly increased by 0.8% per year (P<0.05). The leading cancer for males in rank were liver, stomach, lung, colorectal, and nasopharyngeal cancers and for females were breast, stomach, colorectal, thyroid, and ovarian cancers. Among specific sites, incidence rates significantly decreased for cancers of the esophagus, stomach, and liver in both sexes. In contrast, incidence rates significantly increased for kidney cancers, non-Hodgkin lymphoma, and brain and nervous system tumors in both sexes and increased for breast and ovarian cancers among females.
Overall cancer incidence rates of adolescents and young adults decreased in males whereas they increased in females. Our findings suggest the importance of further epidemiology and etiologic studies to further elucidate factors contributing to the cancer incidence trends of adolescents and young adults in China.
PLoS ONE 01/2012; 7(8):e42607. · 4.09 Impact Factor
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ABSTRACT: In China, hepatocellular carcinoma (HCC) incidence rates in several registry catchment populations are amongst the highest worldwide. The incidence rates in urban Shanghai were analyzed between 1976 and 2005 to describe and interpret the time trends. Age-specific and age-standardized rates were calculated and graphically presented. An age-period-cohort model was fitted to assess the effects of age at diagnosis, calendar period, and birth cohort on the changing HCC incidence rates. In total, 35,241 and 13,931 men and women were diagnosed with HCC during 1976-2005 in urban Shanghai. The age-standardized incidence rates in urban Shanghai were 33.9 per 10(5) among men and 11.4 per 10(5) among women in 1976-1980, but decreased in both sexes to 25.8 per 10(5) and 8.5 per 10(5), respectively by 2001-2005. Accelerating rates in birth cohorts born in the early-1930s and decelerating rates circa 1945 were observed in both sexes, with further accelerations noted in the late-1950s (in women) and early-1960s (in men). Given the parameterization, increases in risk of HCC were seen in successive male and female generations between 1900 and 1935, followed by a further increase among successive cohorts born around 1960, with a reduction in risk in the most recent generations. The incidence rates of HCC in urban Shanghai from 1976 to 2005 have declined in both sexes, with the complex but similar patterns observed in successive generations suggestive of a shared changing prevalence in risk factors in men and women, with a role possibly for HBV interventions reducing risk of HCC in cohorts born after 1960.
European Journal of Epidemiology 12/2011; 27(1):39-46. · 4.71 Impact Factor
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ABSTRACT: To evaluate the association between total fluid intake and the time of urination per day and the risk of bladder cancer.
A population-based case-control study was conducted in urban Shanghai, China, during January 1996 to December 1998. The study included 608 incident cases of bladder cancer and 607 age- and sex-matched controls. Unconditional logistic regression models were used to estimate the odds ratios (ORs) and their corresponding 95% confidence intervals (95%CIs) for bladder cancer associated with frequency of urination, after adjusted for age, gender, smoking status, history of occupation with high risk, history of bladder infections, body mass index and other confounding factors. The level of statistical significance was set at 0.05 (two-sided).
No significant trend was observed for the association between total fluid intake, time of nighttime urination and the risk of bladder cancer. Increasing time of urination during daytime was associated with decreased risk of bladder cancer (P for trend = 0.014). ORs (95%CIs) for subjects who voided 4 times, 5 times and 6 or more times per day [0.72 (0.49 - 1.05), 0.60 (0.41 - 0.87) and 0.62 (0.43 - 0.90), respectively], when compared with those with less than 4 times per day after adjustment of confounding factors. Data showed that smokers and nonsmokers who voided at least 6 times per day had the ORs of 0.72 (95%CI: 0.45 - 1.15) and 0.46 (95%CI: 0.25 - 0.87) when compared to their counterparts who voided 3 times or less per day during the daytime. Subjects who urinated at least 6 times per day and consumed more than 1500 ml of total fluid per day experienced a significant 57% reduction in risk compared to subjects who urinated 3 times or less and consumed less than 750 ml of total daily fluid intake.
Increased urination frequency and total fluid intake, especially among those who never smoked might be associated with a reduced risk of bladder cancer.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 10/2010; 31(10):1120-4.
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ABSTRACT: To explore the secular trend of incidence for nasopharyngeal carcinoma (NPC) in urban Shanghai during 1973 - 2005.
The incidence data from the population-based cancer registries in Shanghai was used in our analysis. We calculated the crude incidence rates, age-adjusted incidence rates, trucated rates and cumulative rates of NPC. The annual percentage change (APC) was used as an estimate of the secular trend.
Over 33 years, a total of 7889 incident NPC cases in urban Shanghai were registered for 5555 males and 2334 females, respectively. The incidence of NPC had remained stable in males during the period (APC = -0.250%, P = 0.340), but a decreasing trend was observed in females with an average reduction of -1.577% (P = 0.000) per year. During the period of 1973 - 1976 to 2001 - 2005, the crude incidence rates changed from 4.56 to 6.18 and from 3.96 to 2.41 per 100 000 in males and females, and the age-adjusted rates from 4.12 to 3.96 and from 2.18 to 3.42 per 100 000 in males and females, respectively.
From 1973 to 2005, the incidence of NPC was stable in males while having a decline in females, indicating that further epidemiological study and prevention for NPC should be addressed.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 11/2009; 30(11):1171-4.
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ABSTRACT: To explore the time trends of colorectal cancer incidence rates in urban Shanghai from 1973 to 2005.
Data on the incidence rates of colorectal cancer were obtained from a population-based cancer registry in Shanghai. A total of 32 962 colon cancer patients and 24 662 rectal cancer patients were registered. Population estimation were based on periodic censuses, with age- and sex-specific annual estimates derived for the remaining years. The rates were adjusted to the world standard population by using the direct method. Annul percent changes (APCs) in rates were estimated by means of a linear regression of the logarithm of the respective rates on calendar, weighted by the number of incidence cases.
The incidence rates of colorectal cancer increased steadily during 1973 to 2005, the age-adjusted incidence rates of colon cancer increased from 6.09 and 5.70 to 14.70 and 14.35 per 100 000 in male and female respectively. The APCs were 3.03% (t = 14.77, P < 0.01) and 3.21% (t = 22.15, P < 0.01). The rates of rectal cancer increased from 7.68 and 6.51 to 11.45 and 8.28 per 100 000 in male and female respectively. The APCs were 1.34% (t = 7.28, P < 0.01) and 0.93% (t = 7.34, P < 0.01). The top APCs for colon and rectal cancer in female were 5.86% and 2.79% at age above 85 and in male those were 4.64% and 2.38% at age of 80-. The APCs of colon cancer were greater than those of rectal cancer at the groups above 45 years old. The average ages when diagnosed were delayed from 57 - 60 to 66 - 70 during these 33 years. The average diagnosed ages of colon cancer were later than those of rectal cancer slightly (from 2003 to 2005, the onset age of male colon cancer: 68.61 +/- 12.17, male rectal cancer: 66.81 +/- 12.62, t = 4.90, P < 0.01; female colon cancer: 69.20 +/- 12.13, female rectal cancer: 67.75 +/- 12.54, t = 3.81, P < 0.01).
The incidence rates of colorectal cancer increased steadily during 1973 to 2005, especially for colon cancer. Further research is needed to identify the causes resulting in these changes.
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 10/2009; 43(10):875-9.
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ABSTRACT: To evaluate the association between cigarette smoking and risk of primary liver cancer (PLC) among middle-aged and elderly men in urban Shanghai.
A nested case-control study was conducted based on a cohort of 18,244 men who were 45-64 years of age in 1986-1989 and had no history of cancer at recruitment in Shanghai. As of 31 Dec 2000, a total of 213 incident cases of PLC were identified. 1094 matched controls were randomly selected among the cohort subjects who were free of cancer and alive at the time of cancer diagnosis of the index case. The matching criteria were date of birth (within 2 years), date of biospsy specimen collection (within 1 month), and neighborhood of residence at recruitment. Conditional logistic regression models were used to estimate adjusted odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).
After controlling for potential confounders, cigarette smoking (ever vs. never) was associated with risk of PLC (OR = 1.91; 95% CI: 1.28-2.86). Risk of PLC increased with increasing number of cigarettes smoked per day, as well as duration of cigarette smoking, pack-years of cigarettes consumed over lifetime and earlier age started smoking. The ORs were 2.16 (95% CI = 1.37-3.40), 2.14 (95% CI = 1.18-3.87), 2.12 (95% CI = 1.21-3.74) and 2.57 (95% CI = 1.50-4.40) for men who smoked 20 cigarettes or more daily, smoked for 40 or more years, consumed more than 37 pack-years of cigarettes, and began smoking before 20 years of age, respectively.
This study confirms that cigarette smoking is an independent risk factor for primary liver cancer among males in Shanghai.
Zhonghua zhong liu za zhi [Chinese journal of oncology] 02/2009; 31(1):20-3.
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ABSTRACT: Few studies on trend analysis in cancer incidence of the elderly people in China. The purpose of this study was to analyze time trends in urologic cancer incidence of the elderly people during the period 1973-1999 in Shanghai.
The registered cancer cases were coded according to the 3-digit rubrics of the ninth revision of the International Classification of Diseases (ICD-9). Population estimates were based on periodic censuses, with age- and sex-specific annual estimates derived by linear inter- and extrapolation for the remaining years. The age-standardized rates adjusted to the world population were calculated for nine 3-year periods. Annual percent changes in incidence were estimated by means of a linear regression of the respective rates on the mid-point of calendar years, weighted by the number of cases.
During the 27-year period, cancers of prostate, bladder, and kidney have risen substantially among elderly male residents in Shanghai. The annual percent changes were 6.60%, 1.15%, and 5.30%, respectively. Among the elderly women, the rate of kidney cancer increased rapidly, with the annual percent change of 4.87%. The 75 years and older age group in women had substantial increases in incidence rates of bladder cancer.
From 1973 to 1999, the incidence rates of the commonly urologic cancers increased substantially among the elderly residents in Shanghai, except for female bladder cancer.
Ai zheng = Aizheng = Chinese journal of cancer 06/2004; 23(5):555-8.
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ABSTRACT: To introduce statistical methods of time trend analysis on cancer rates.
Cancer incidence data collected by the Shanghai Cancer Registry during 1991 to 1999 was used in the analysis to calculate the crude and age-adjusted rates, percent changes (PCs) and annual percent changes (APCs). APCs were estimated by a linear regression of the logarithm on the incidence rates during the nine years. It also introduced a method for partitioning a linear trend in age-adjusted rates into site-specific contributions to the overall floating trend. 95% confidence intervals for the APCs and contributions were described in the paper.
A decreasing rates were observed for cancers of stomach and esophagus among both men and women in urban Shanghai from 1991 to 1999. The increasing rates among men would include cancers of colon, rectum, gall bladder, pancreas, prostate, urinary bladder, kidney and leukemia. The rates of cancers among women increased for colon, rectum, lung, breast, gall bladder, endometrium, ovary, urinary bladder and kidney. The changes of above cancers over time were statistically significant (P < 0.05 or P < 0.01), but rates for other cancer sites changed little. The APCs (weighted method) and contributions for the cancers of stomach, esophagus, colon, rectum and prostate were -2.99% and -65.72%, -2.90% and -17.07%, 12.30% and 21.46%, 2.94% and 18.62%, and 3.11% and 15.09% among men, and -6.05% and -39.55%, -1.08% and -35.19%, 2.81% and 28.64%, and 3.69% and 15.70% for the cancers of stomach, esophagus, breast and colon in women, respectively.
APC, and related statistics could be used to describe and analyze the time trend of cancer rates rather than PC or/and graphical method alone.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 03/2004; 25(2):173-7.
