ABSTRACT: A 47-year-old Chinese woman, with a history of recurrent attacks of vertigo and vomiting for the past 5 years, presented with intermittent radicular pain in the left upper limb for the past 2 years. She also reported recurrent attacks of severe headache and neck pain for more than 10 years. The pain might be aggravated by coughing or sneezing and relieved after sleeping in the decubitus position. The MRI depicted Chiari malformation. A multidetector CT scan and three-dimensional CT reconstruction revealed partial aplasia of the left posterior arch of atlas of a small gap. The patient underwent plastic surgeries in Beijing. The disappearance of the recurrent pain syndrome was confirmed by follow-up after surgery.
Case Reports 01/2010; 2010.
ABSTRACT: To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD).
Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing.
The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P < 0.05).
The 462C/G polymorphism might be a specific genotype in Chinese patients with sporadic AD.
Chinese medical journal 08/2003; 116(8):1220-2. · 0.86 Impact Factor
ABSTRACT: To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI).
Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls.
The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group (P=0.011).
465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI.
Journal of Zhejiang University SCIENCE 4(6):749-52.