W Li

Harbin Medical University, Charbin, Heilongjiang Sheng, China

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Publications (5)7.79 Total impact

  • Y. Li · F. Han · S. Yin · X. Yang · W. Li · Z. Qu · J. Bi · Y. Cheng · Q. Yue
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    ABSTRACT: Sonodynamic therapy (SDT) based on the power of ultrasonic can activate sonosensitizing drug (sonosensitizer) in tumor tissues to cure diseases, which was developed in Japan in recent decades and have characteristics including safe, effective, low toxic and low side effects. This article aims to have a brief description and discussion about SDT research progress in recent decades and give attention and awareness.
    Cancer Research and Clinic 03/2015; 27(3):204-206. DOI:10.3760/cma.j.issn.1006-9801.2015.03.019
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    J Ren · W Li · L Yan · W Jiao · S Tian · D Li · Y Tang · G Gu · H Liu · Z Xu
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    ABSTRACT: Cancerous inhibitor of protein phosphatase 2A (CIP2A) drives cellular transformation. The objective of this study was to detect the potential effects of CIP2A in renal cell carcinomas (RCCs). A total of 107 RCC patients were involved in the study. Cancerous inhibitor of protein phosphatase 2A expression was investigated by real-time PCR and immunohistochemistry. In vitro, we examined the expression of CIP2A and c-Myc and tested the migration and invasion capability of A498 and KRC/Y cells with scratch migration assay and Matrigel invasion assay after down-regulating CIP2A expression using siRNA. Cancerous inhibitor of protein phosphatase 2A was over-expressed in RCC tissues. Clear cell RCC showed an even higher-CIP2A expression level than papillary or chromophobe RCC did. The CIP2A immunostaining level was positively correlated with primary tumour stage, lymph node metastasis, distant metastasis, TNM stage and histological grade (all P<0.05). High-CIP2A expression implied poor survival for patients (P<0.05). Cancerous inhibitor of protein phosphatase 2A depletion by siRNA down-regulated c-Myc expression and attenuated the migration and invasion of RCC cells. Higher-CIP2A expression positively correlates with the aggressive phenotype of RCCs, and predicts poor prognosis for patients. Cancerous inhibitor of protein phosphatase 2A may be a novel target for prevention and treatment of RCC metastasis and recurrence.
    British Journal of Cancer 11/2011; 105(12):1905-11. DOI:10.1038/bjc.2011.492 · 4.84 Impact Factor
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    G Gu · Z Zhang · G Wang · F Han · L Han · K Wang · J Liu · W Li
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    ABSTRACT: This study investigated the effect of electroacupuncture pretreatment on the lipopolysaccharide (LPS)-induced inflammatory response and on acute kidney injury in adult male pathogen-free Wistar rats. Rats received electroacupuncture at the Zusanli (ST36) and Neiguan (PC6) acupoints, or electrical stimulation at sham points, for 30 min before stimulation with either 5 mg/kg LPS intravenously or normal saline. Plasma cytokines, plasma nitrite, renal inducible nitric oxide synthase (iNOS) and nuclear factor κB (NF-κB) activity were assessed 240 min after LPS or normal saline injection. Blood urea nitrogen (BUN), creatinine (Cr) and histopathological score for renal tubular damage were also measured. Electroacupuncture pretreatment significantly decreased LPS-induced plasma tumour necrosis factor-α and interleukin (IL)-1β, increased plasma IL-10, and decreased plasma nitrite, renal iNOS and NF-κB activity. It also significantly decreased LPS-induced BUN, Cr and the renal histopathological score. These findings suggest that electroacupuncture pretreatment at the ST36 and PC6 acupoints attenuated the LPS-induced inflammatory response and mitigated acute kidney injury.
    The Journal of international medical research 10/2011; 39(5):1783-97. DOI:10.1177/147323001103900521 · 1.44 Impact Factor
  • D Ren · Y Xing · M Lin · Y Wu · K Li · W Li · S Yang · T Guo · J Ren · J Ma · L Lan · L Huang
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    ABSTRACT: Chinese Erhualian pigs are known for prolificacy with distinct reproductive traits compared with Western commercial breeds. In this study, a four-generation intercross resource population was constructed using White Duroc boars and Chinese Erhualian sows as founder animals, and a total of 14 male reproductive traits were recorded in 411 F2/F3 boars including the testis and epididymis weights, the seminiferous tubular diameter and spermatogenesis at 60, 90 and 300 days of age, semen characteristics, serum testosterone concentration and libido level at 300 days of age. The White Duroc-Erhualian boars showed remarkable segregations in the traits measured except for the seminiferous tubular diameter and had high ratio (13.9%) of the abnormality of spermatogenesis, providing a good experimental population for detecting quantitative trait loci affecting these male reproductive traits. Furthermore, the correlations among nine male reproductive traits at 300 days of age indicated that the testis weight and the body weight were strongly correlated with the sperm production, supporting the two traits as important parameters for boar selection to increase sperm production and ultimately improve boar fertility. The libido level in the White Duroc-Erhualian boars that was evaluated by a new and easily recorded scoring system showed a significant correlation with serum testosterone concentration. Yet, both libido and serum testosterone concentration were not correlated with the sperm production. Results of this study provided new information on the male reproductive physiology and genetics in Chinese Erhualian and White Duroc boars.
    Reproduction in Domestic Animals 12/2008; 44(6):913-9. DOI:10.1111/j.1439-0531.2008.01117.x · 1.52 Impact Factor
  • B.Q. Gong · W.L. Liu · W.C. Qi · F. Han · W. Li

Publication Stats

41 Citations
7.79 Total Impact Points


  • 2011
    • Harbin Medical University
      Charbin, Heilongjiang Sheng, China
    • Shandong University
      • School of Medicine
      Chi-nan-shih, Shandong Sheng, China
  • 2008
    • Jiangxi Agricultural University
      Jiangxi, Gansu Sheng, China