W Brück

Publications (2)8.97 Total impact

• Article: [Differential diagnosis of lymphoid infiltrates in the central nervous system : Experience of the Network Lymphomas and Lymphomatoid Lesions in the Nervous System.]

  W Brück, A Brunn, W Klapper, T Kuhlmann, I Metz, W Paulus, M Deckert
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  ABSTRACT: The differential diagnosis of lymphoid lesions in the central nervous system covers a broad spectrum of neoplastic and inflammatory disorders. Complex cases benefit from the combined expertise in the fields of hematopoietic and neuroepithelial tumors as well as neuroimmunology. The Network Lymphomas and Lymphomatoid Lesions in the Nervous System (NLLLN) recommends performing a biopsy prior to any therapeutic intervention as a precise diagnosis was impossible in approximately 50 % of patients pretreated with corticosteroids. This is based on the analysis of approximately 1,000 cases in the past 4 years. In addition to total NLLLN experiences the characteristics, pathogenesis and differential diagnosis of primary lymphoma of the central nervous system are discussed.
  Der Pathologe 03/2013; · 0.67 Impact Factor
• Article: Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma.

  M Deckert, A Engert, W Brück, A J M Ferreri, J Finke, G Illerhaus, W Klapper, A Korfel, R Küppers, M Maarouf, M Montesinos-Rongen, W Paulus, U Schlegel, H Lassmann, O D Wiestler, R Siebert, L M DeAngelis
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  ABSTRACT: Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathogenesis of this lymphoma entity, which is associated with an inferior prognosis as compared with DLBCL outside the CNS. This unfavorable prognosis stimulated intense efforts to improve therapy and induced recent series of clinical studies, which addressed the role of radiotherapy and various chemotherapeutic regimens. This review combines the discussion of diagnosis, differential diagnosis and recent progress in studies addressing the molecular pathogenesis as well as therapeutic options in PCNSL.
  Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 08/2011; 25(12):1797-807. · 8.30 Impact Factor