V Gupta

Publications (2)14.91 Total impact

• Article: Structure of the crystalline complex of cytidylic acid (2'-CMP) with ribonuclease at 1.6 A resolution. Conservation of solvent sites in RNase-A high-resolution structures.

  J N Lisgarten, V Gupta, D Maes, L Wyns, I Zegers, R A Palmer, C G Dealwis, C F Aguilar, A M Hemmings
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  ABSTRACT: The X-ray structure of the inhibitor complex of bovine ribonuclease A with cytidylic acid (2'-CMP) has been determined at 1.6 A resolution and refined by restrained least squares to R = 0.17 for 11 945 reflections. Binding of the inhibitor molecule to the protein is confirmed to be in the productive mode associated with enzyme activity. A study of conserved solvent sites amongst high-resolution structures in the same crystal form reveals a stabilizing water cluster between the N and C termini.
  Acta Crystallographica Section D Biological Crystallography 12/1993; 49(Pt 6):541-7. · 12.62 Impact Factor
• Article: Pancreatic ribonuclease co-crystallizes with the dinucleotide dCpdG in two distinct forms.

  A Mills, V Gupta, N Spink, J Lisgarten, R A Palmer, L Wyns
  Acta Crystallographica Section B Structural Science 09/1992; 48 ( Pt 4):549-50. · 2.29 Impact Factor