V. Bickert

Publications (2)0 Total impact

• Article: A Facile and Efficient Multi-Gram Synthesis of N-Protected 5-(Guanidinocarbonyl)-1H-pyrrole-2- …

  C. Schmuck, V. Bickert, M. Merschky, L. Geiger, D. Rupprecht, P. Wich, J. Dudaczek, T. Rehm, U. Machon
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  ABSTRACT: Page 1. FULL PAPER DOI: 10.1002/ejoc.200700756 A Facile and Efficient Multi-Gram Synthesis of N-Protected 5-(Guanidinocarbonyl)-1H-pyrrole-2-carboxylic Acids Carsten Schmuck,* [a] Volker Bickert, [a] Michael Merschky, [a] Lars Geiger, [a]
  01/2008;
• Article: A facile and efficient multi-gram synthesis of N-protected guanidinocarbonyl pyrrole carboxylic acids

  C. Schmuck, V. Bickert, M. Merschky, L. Geiger, D. Rupprecht, J. Dudaczek, P. Wich, T. Rehm, U. Machon
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  ABSTRACT: The synthesis of two versatile building blocks for supramolecular anion binding motifs, 5-(N-Boc-guanidinocarbonyl)-1H-pyrrole-2-carboxylic acid (1) and 5-(N-Cbz-guanidinocarbonyl)-1H-pyrrole-2-carboxylic acid (2) is reported. Using these building blocks, a guanidiniocarbonyl-pyrrole anion binding site can easily be introduced into more com-plex molecules by using standard amide coupling conditions. Both syntheses can be performed on a multi-gram scale. The products are obtained in pure form and can be stored as solids without decomposition.
  Eur. J. Org. Chem. 01/2008;