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ABSTRACT: The study aimed at comparison of transcranial magnetic stimulation (TMS) parameters to MRI data in multiple sclerosis (MS), taking into account clinical course of the disease. TMS was conducted in 56 patients and in 10 age- and sex-matched healthy controls. According to stage of activity and variant of the course, the patients were divided into 2 groups: one at the stage of exacerbation and another--at the stage of remission with secondary progressive MS. Latency of segmental evoked motor response was similar in patients and controls. Statistically significant between-group difference or trend toward changing of some TMS parameters were found that indicates a slow-down of the impulse conducting along the cortico-spinal tract, which is characteristic of demyelinization process. The changes were more pronounced in secondary-progressive MS. According to MRI data, a square of the spinal cord on the level of the intervertebral disk center C2/C3 was significantly smaller in the group of patients with secondary progressive MS than in that with exacerbation of the disease. The TMS parameters correlated both with the level of the focal demyelinization process and with the square of the spinal cord on a level selected. It allows to estimate expression of atrophic changes caused, in its turn, not only by myelin loss but also by axon loss.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2006; Spec No 3:41-9. · 0.12 Impact Factor
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ABSTRACT: Pathophysiological peculiarities of demyelinated axons determine their high sensitivity to different exogenous factors and are the reason of instability of neurological signs in MS. One of the typical MS sing is high sensitivity to elevated temperature of the body. Even temporary elevation in body temperature may cause changes in impulse conduction in demyelinated fibres, which was proved by studies of evoked potentials and stabilometric studies. These disturbances may be associated with disorder of ions channels function. The role of other factors (metabolic and immunological disturbances, levels of cytokines and neurotransmitters) in temporary block of nerve conduction in MS is discussed. Further studies of the mechanisms of the lability of neurological sings in MS may lead to elaboration of new approaches to MS treatment.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2002; Suppl:15-9. · 0.12 Impact Factor
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ABSTRACT: To assess therapeutic and prophylactic effect of large-dose cerebrolysin (15 ml/day for 28 days) in hypertensive and atherosclerotic patients with cognitive disorders.
Cerebrolysin was given annually (15 ml/day for 28 days) for 2 years to 42 patients in a randomized double-blind placebo-controlled study. The effect was stated by clinical status, neuropsychological and neurophysiological data.
In mild disturbances of cognitive functions in patients with arterial hypertension and atherosclerosis courses of cerebrolysin with one-year interval produce stable improvement of subjective status, productivity of memory, attention and thinking which persist for at least a year after the course. The clinical data agree with positive trend in neurophysiological parameters of cognitive component of the response of evoked potentials P-300.
A course of 28-day annual treatment with cerebrolysin (15 ml/day) of patients with mild defects of cognitive functions stabilizes the process, leads to regression of cognitive disorders predicting vascular dementia.
Terapevticheskii arkhiv 02/2001; 73(4):22-7. · 0.14 Impact Factor
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I A Zavalishin,
V M Roĭkhel,
T S Gulevskaia, V V Gnezditskiĭ,
I E Shitikova,
D N Dzhibladze,
A I Kugoev,
G I Fokona,
L M Kondakova,
S G Sobolev,
V V Pogodina,
R P Chaĭkovskaia,
S M Lozhnikova,
A V Sakharova,
E M Kashina,
E B Sungurov
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ABSTRACT: The paper presents the data concerning usage of some original method of vital laboratory diagnostics of Creutzfeldt-Jacob disease that belongs to the group of prionic diseases. The method consisted in the inoculation of inoculative culture of rat Gasser ganglion's neurinoma by biologic materials investigated (serum and clot of blood) with the following passivation and investigation of the contaminated culture by means of both morphologic and electron microscopic methods. As an example of vital verificated case the wide pathomorphologic analysis of the biopsy sample of brain was presented. Besides, the efficiency of the investigation of cognitive evoked potentials (P300) together with EEG was also demonstrated as the method of objectification of the development of dementia in this disease.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/1998; 98(5):20-5. · 0.12 Impact Factor
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ABSTRACT: Characteristics of the auditory EP under conditions of stimulus recognition (the P300 technique) and parameters of the visual "nonspecific" EP to light flash were studied in healthy subjects of the wide age range (18-78 years old) and patients with vascular dementia of different severity. It was shown that P300 parameters depended on age in healthy patients and on expression of cognitive dysfunction in demented patients. The changes were more pronounced in dementia of the cortical type. The P300 to nonrelevant stimulus was not age-dependent and slightly changed at cognitive dysfunction. Parameters of the nonspecific visual responses (the latency and duration--the index of homeostatic regulation) and maximal amplitude (reflecting the extent of activation processes) were not age-dependent and changed both in subcortical and cortical dementia types (increase in response latency and duration). In cognitive dysfunctions of subcortical origin homeostatic changes in the form of increase in time of homeostatic regulation and deterioration of stabilization of brain electrical processes were more pronounced.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 48(4):707-18. · 0.33 Impact Factor
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Fiziologiia cheloveka 27(3):42-53.
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V M Roĭkhel,
G I Fokina,
L M Kondakova,
S G Sobolev,
V V Pogodina,
D N Dzhibladze, V V Gnezditskiĭ,
E M Kashina,
V V Peresedov,
E B Sungurov,
A I Kugoev,
R P Chaĭkovskaia,
E V Konovalova,
I E Shitikova,
I A Zavalishin
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ABSTRACT: An original method for life-time diagnosis of Greutzfeldt-Jakob's disease, a neurodegenerative disease belonging to transmissive spongiform encephalopathies, is proposed. It consists in inoculation of the examined biological materials (blood serum and clot) into a continuous culture of the rat Gasser's node neurinoma, followed by passages and study of the inoculated culture by morphological methods and electron microscopy.
Voprosy virusologii 42(5):203-5.
