X Han

Publications (2)8.3 Total impact

• Article: Vibration of workpieces during aggressive turning operations

  X Han, M Wang, H Ouyang
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  ABSTRACT: Turning is a widely used metal cutting operation. Because of the dynamic interaction between the cutter and the workpiece, vibration is excited during turning operations. If the vibration is severe, there will be degradation of surface quality of the workpiece, excessive wear and breakage of the cutter. Chatter can also take place. This paper presents a dynamic model for aggressive turning operations and considers the influence on vibration of the time-dependent reduction of workpiece diameter. The workpiece is modelled as a beam rotating about its longitudinal axis and the cutter provides a moving load. Simulated numerical examples are presented.
  Journal of Physics Conference Series 08/2009; 181(1):012032.
• Article: Cyclin D1 as a universally expressed mantle cell lymphoma-associated tumor antigen for immunotherapy.

  M Wang, L Sun, J Qian, X Han, L Zhang, P Lin, Z Cai, Q Yi
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  ABSTRACT: Mantle cell lymphoma (MCL) accounts for 5-10% of all non-Hodgkin lymphomas and has the worst prognosis among all lymphomas. The hallmark of MCL is a t(11;14) translocation that results in overexpression of cyclin D1 by tumor cells of virtually all patients. In this study, we examined whether cyclin D1 could be an effective tumor-associated antigen for immunotherapy. We identified cyclin D1 peptides for HLA-A(*)0201 and generated peptide-specific CD8(+) T-cell lines from HLA-A(*)0201(+) blood donors and MCL patients. These cell lines proliferated in response to cyclin D1 peptide-pulsed stimulatory cells. Moreover, the T cells efficiently lysed peptide-pulsed but not unpulsed T2 cells and autologous dendritic cells; cyclin D1(+) and HLA-A(*)0201(+) human MCL lines MINO, SP53, Jeko-1 and Granta 519; and more importantly, HLA-A(*)0201(+) primary lymphoma cells from MCL patients. No killing was observed with HLA-A(*)0201(-) primary lymphoma cells or HLA-A(*)0201(+) normal blood cells, including B cells. These results indicate that these T cells are potent cytotoxic T cells and recognize cyclin D1 peptides naturally presented by patient lymphoma cells in the context of HLA-A(*)0201 molecules. Taken together, our work identifies cyclin D1 as a potentially important antigen for immunotherapy of MCL.
  Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 03/2009; 23(7):1320-8. · 8.30 Impact Factor