Toshiyuki Hata

Kagawa University, Takamatu, Kagawa, Japan

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Publications (357)822.87 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: We present our first experience of using transvaginal four-dimensional (4D) color Doppler with a glass-body rendering mode and spatiotemporal image correlation software (STIC) to construct an image of persistent truncus arteriosus in the first trimester of pregnancy. Transvaginal two-dimensional (2D) echocardiography and color Doppler demonstrated a single ventricular outflow trunk overriding a ventricular septal defect dividing into two branches. Transvaginal 4D color Doppler with the glass-body mode and STIC clearly showed truncus arteriosus straddling both ventricles and giving rise to the pulmonary artery and aorta. The right pulmonary vessels were also visualized. The spatial relationship between the great vessels could be identified using 4D color Doppler. We recommend its use in complex cardiac anomalies, providing potential advantages over the use of 2D sonography alone in the first trimester of pregnancy. This article is protected by copyright. All rights reserved.
    Ultrasound in Obstetrics and Gynecology 04/2015; DOI:10.1002/uog.14868 · 3.14 Impact Factor
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    ABSTRACT: We present our first experience of using HDlive and the HDlive silhouette mode to construct an image of a circumvallate placenta in the second trimester of pregnancy. Two-dimensional (2D) ultrasound revealed an increased placental thickness with rolled up edges protruding into the uterine cavity. Color Doppler ultrasound revealed the absence of blood flow at these margins. HDlive clearly showed central placental depression surrounded by rolled up edges around the placental circumference. HDlive silhouette mode clearly depicted the placental margins as well as superficial chorionic vessels on the fetal placental surface. HDlive as well as HDlive silhouette mode showed new images of the circumvallate placenta. These techniques have the potential to be a supplement to 2D sonography in diagnosing placental abnormalities. This article is protected by copyright. All rights reserved.
    Ultrasound in Obstetrics and Gynecology 03/2015; DOI:10.1002/uog.14839 · 3.14 Impact Factor
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    ABSTRACT: The aim of this study was to assess the relationship between the cerebral blood volume (CBV) measured by near-infrared time-resolved spectroscopy (TRS) and pathological change of the brain in a hypoxic-ischemic (HI) piglet model. Twenty-one anesthetized newborn piglets, including three sham controls, were studied. An HI event was induced by low inspired oxygen. CBV was measured using TRS (Hamamatsu TRS-10). Data were collected before, during, and 6hours after the insult. CBV was calculated as the change from the end of the insult. The piglets were allowed to recover from anesthesia for 6hours after the insult. At the age of 5 days, the brains of the piglets were perfusion-fixed, and histologic evaluations of brain tissue were performed. The extent of histopathological damage was graded in 0.5-unit intervals on a 9-step scale. CBV increments were well correlated with histopathological scores, especially at 1 and 3hours after resuscitation. Spearman's rank-correlation coefficients at 1, 3, and 6hours after resuscitation in the gray matter were 0.9016, 0.9127, and 0.6907, respectively. We conclude that an increased CBV after HI insult indicates more marked histological brain damage. CBV measurement immediately after resuscitation provides a more precise prediction of the histological outcome. Copyright © 2015. Published by Elsevier Ltd.
    International Journal of Developmental Neuroscience 02/2015; 42. DOI:10.1016/j.ijdevneu.2015.02.009 · 2.92 Impact Factor
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    ABSTRACT: We present our first experience of using HDlive and the HDlive inversion mode to construct an image of fetal meconium peritonitis at 34 weeks and 2 days of gestation. Conventional two-dimensional (2D) ultrasound revealed multiple cystic dilatations with a thickened intestinal wall, and calcifications in the fetal abdominal cavity. HDlive showed irregularly thickened intestinal walls, and the presence of fine, granular meconium inside them. The HDlive inversion mode clearly showed these cystic dilatations of the intestine with irregular caliber changes, continuous with each other, suggesting a diagnosis of meconium peritonitis. HDlive and its inversion mode images seemed to be more readily discernible than those obtained by conventional three-dimensional ultrasound and its inversion mode. Therefore, HDlive can be considered as virtual endoscopy, with potential advantages relative to conventional 2D ultrasound.
    Ultrasound in Obstetrics and Gynecology 01/2015; 45(4). DOI:10.1002/uog.14778 · 3.14 Impact Factor
  • 01/2015; 9:44-50. DOI:10.5005/jp-journals-10009-1388
  • 01/2015; 9:51-60. DOI:10.5005/jp-journals-10009-1389
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    ABSTRACT: We assessed placental perfusion based on placental vascular sonobiopsy (PVS) at 18-22 weeks of gestation in a low-risk population to predict fetal growth restriction (FGR) or pregnancy-induced hypertension [PIH; gestational hypertension (GH) and preeclampsia (PE)]. PVS using three-dimensional (3D) power Doppler ultrasound with the VOCAL imaging analysis program was performed in 226 pregnancies [FGR, 25; appropriate-for-gestational age (AGA) 191; and large-for-gestational age (LGA), 10] [PIH, 13 (GH, 7 and PE, 6) and non-PIH, 213] at 18-22 weeks of gestation. 3D power Doppler indices such as the vascularization index (VI), flow index (FI), and vascularization flow index (VFI) using PVS were calculated in each placenta. There were no significant differences in VI, FI, or VFI values among FGR, AGA, and LGA pregnancies. No significant differences in VI, FI, or VFI values between PHI and non-PIH pregnancies were noted. There were also no significant differences in VI, FI, or VFI values between GH and PE pregnancies. 3D power Doppler placental vascular indices at 18-22 weeks could not be used to predict high-risk pregnancies that develop FGR or PIH in a low-risk population.
    Archives of Gynecology and Obstetrics 12/2014; 292(1). DOI:10.1007/s00404-014-3603-z · 1.28 Impact Factor
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    ABSTRACT: BACKGROUND AND AIM: Rejection of liver grafts is a difficult issue that has not been resolved. Preoperative replacement of liver cells in the graft with cells from the intended recipient may attenuate rejection. We investigated whether preoperative transplantation of recipient BMCs to the donor replaced liver allograft cells and attenuated rejection. METHODS: We used a rat model of allogeneic liver transplantation (LT) from DA to LEW rats. In BMC group, DA rats received BMC transplants from LacZ-transgenic Lewis rats at 1 week before LT. In Control group, DA rats received no preoperative treatment. We evaluated graft damage at 7 d after LT and the survival of the recipient rats. RESULTS: Rats in the BMC group experienced prolonged survival that was abrogated by the administration of gadolinium chloride to donors at 24 h before LT. Serum concentrations of total bilirubin and hyaluronic acid on day 7 were significantly lower in the BMC group, and histopathological analyses revealed that rejection of the liver graft was attenuated. X-gal staining and Immunohistostaining of the liver graft revealed that BMCs engrafted in the sinusoidal space differentiated into Kupffer cells. CONCLUSIONS: Preoperative transplantation of recipient BMCs to liver transplant donors replaced donor KCs and attenuated post-LT rejection, indicating that this strategy may increase the success of liver transplantation. This article is protected by copyright. All rights reserved.
    Journal of Gastroenterology and Hepatology 12/2014; · 3.63 Impact Factor
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    ABSTRACT: BACKGROUND AND AIM: Rejection of liver grafts is a difficult issue that has not been resolved. Preoperative replacement of liver cells in the graft with cells from the intended recipient may attenuate rejection. We investigated whether preoperative transplantation of recipient BMCs to the donor replaced liver allograft cells and attenuated rejection. METHODS: We used a rat model of allogeneic liver transplantation (LT) from DA to LEW rats. In BMC group, DA rats received BMC transplants from LacZ-transgenic Lewis rats at 1 week before LT. In Control group, DA rats received no preoperative treatment. We evaluated graft damage at 7 d after LT and the survival of the recipient rats. RESULTS: Rats in the BMC group experienced prolonged survival that was abrogated by the administration of gadolinium chloride to donors at 24 h before LT. Serum concentrations of total bilirubin and hyaluronic acid on day 7 were significantly lower in the BMC group, and histopathological analyses revealed that rejection of the liver graft was attenuated. X-gal staining and Immunohistostaining of the liver graft revealed that BMCs engrafted in the sinusoidal space differentiated into Kupffer cells. CONCLUSIONS: Preoperative transplantation of recipient BMCs to liver transplant donors replaced donor KCs and attenuated post-LT rejection, indicating that this strategy may increase the success of liver transplantation. This article is protected by copyright. All rights reserved.
    Journal of Gastroenterology and Hepatology 12/2014; DOI:10.1111/jgh.12872. · 3.63 Impact Factor
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    [Show abstract] [Hide abstract]
    ABSTRACT: BACKGROUND AND AIM: Rejection of liver grafts is a difficult issue that has not been resolved. Preoperative replacement of liver cells in the graft with cells from the intended recipient may attenuate rejection. We investigated whether preoperative transplantation of recipient BMCs to the donor replaced liver allograft cells and attenuated rejection. METHODS: We used a rat model of allogeneic liver transplantation (LT) from DA to LEW rats. In BMC group, DA rats received BMC transplants from LacZ-transgenic Lewis rats at 1 week before LT. In Control group, DA rats received no preoperative treatment. We evaluated graft damage at 7 d after LT and the survival of the recipient rats. RESULTS: Rats in the BMC group experienced prolonged survival that was abrogated by the administration of gadolinium chloride to donors at 24 h before LT. Serum concentrations of total bilirubin and hyaluronic acid on day 7 were significantly lower in the BMC group, and histopathological analyses revealed that rejection of the liver graft was attenuated. X-gal staining and Immunohistostaining of the liver graft revealed that BMCs engrafted in the sinusoidal space differentiated into Kupffer cells. CONCLUSIONS: Preoperative transplantation of recipient BMCs to liver transplant donors replaced donor KCs and attenuated post-LT rejection, indicating that this strategy may increase the success of liver transplantation. This article is protected by copyright. All rights reserved.
    Journal of Gastroenterology and Hepatology 12/2014; DOI:10.1111/jgh.12872 · 3.63 Impact Factor
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    ABSTRACT: We present a case of vertical, bridging uterine synechia in the central part of the uterine cavity diagnosed by conventional two-dimensional (2D) sonography and HDlive at 29 weeks and 5 days of gestation. 2D sonography showed a uterine synechia located vertically in the central part of the uterine cavity, dividing the lower uterine cavity into two parts. HDlive clearly revealed triangular, vertical, and bridging uterine synechia with foot protrusion and umbilical cord prolapse in the lower uterine cavity. The low, liquor-filled amniotic cavity was divided by a thin membrane. MRI confirmed the vertical structure dividing the uterus with umbilical cord prolapse. Emergency cesarean section was performed at 37 weeks and 1 day of gestation because of onset of labor, and a female infant weighing 2,380 g was delivered with an umbilical artery pH of 7.25, and Apgar score of 6/9 at 1 and 5 min, respectively. The vertical, bridging synechia in the central part of uterine cavity was confirmed during the operation.
    Journal of Medical Ultrasonics 10/2014; 41(4). DOI:10.1007/s10396-014-0549-5 · 0.74 Impact Factor
  • Placenta 10/2014; 35(10):A9. DOI:10.1016/j.placenta.2014.08.032 · 3.29 Impact Factor
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    ABSTRACT: We present our first experience of constructing an image of an early-stage complete hydatidiform mole employing HDlive. Conventional 2D sonography showed massive, lobulated, and mixed masses and intrauterine anechoic fluid collection. Smooth, lobulated masses were clearly recognized using HDlive. Small, irregular, cystic spaces inside the masses were also evident. HDlive provided anatomically realistic features akin to macroscopic specimens for physicians and pathologists, owing to the complete depiction of the inner surface of an early-stage nonhydropic mole.
    Journal of Medical Ultrasonics 10/2014; 41(4):507-509. DOI:10.1007/s10396-014-0539-7 · 0.74 Impact Factor
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    ABSTRACT: Enteric duplication cysts are rare congenital anomalies, but their antenatal diagnosis is becoming more common because of advances in ultrasonography. With the latest state-of-the-art technology, HDlive facilitates a more realistic anatomical visualization of different fetal organ structures, making diagnosis more precise. We present a case of antenatal HDlive imaging of an enteric duplication cyst. A 26-year-old pregnant Japanese woman was referred to our ultrasound clinic because of a fetal intra-abdominal cyst at 27 weeks of gestation. Two-dimensional (2D) ultrasound revealed a sonolucent, ellipsoid structure in the subhepatic area. Magnetic resonance imaging yielded the same findings. However, irregular internal echoes appeared at 33 weeks of gestation. There was no vascularity on color Doppler. HDlive clearly depicted a more realistic image of the circular mass, which was thick walled, with a large amount of debris inside, and showed no communication with adjacent structures. Careful monitoring was conducted for these unusual findings. A day after delivery, an emergency operation was performed because the infant had sudden signs and symptoms of obstruction. Intra-operative findings were ileus and a necrotic ileal duplication cyst confirmed by histopathologic studies. Complications of enteric duplication cyst can arise at any time of life, and so thorough monitoring may be recommended. The findings of irregular internal echoes and a large amount of debris inside the cyst are relatively characteristic features of a complicated cyst. HDlive gives us additional information on the actual appearance of a complicated cyst that may be difficult to obtain using conventional 2D sonography alone. HDlive can be very useful in the antenatal surveillance of enteric duplication cysts.
    Journal of Medical Ultrasonics 10/2014; 41(4):511-514. DOI:10.1007/s10396-014-0548-6 · 0.74 Impact Factor
  • Placenta 10/2014; 35(10):A8. DOI:10.1016/j.placenta.2014.08.027 · 3.29 Impact Factor
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    ABSTRACT: Objective To assess the frequency of fetal facial expressions at 20–24 weeks of gestation using four-dimensional (4D) ultrasonography and to determine whether there was any correlation between facial expression and gestational age (20–34 weeks). Methods The facial expressions of 23 healthy fetuses were examined using 4D ultrasound at 20–24 weeks. Each fetus was recorded continuously for 15 minutes. The frequencies of mouthing, yawning, smiling, tongue expulsion, scowling, sucking, and blinking were assessed and the data combined with those expressions observed at 25–34 weeks of gestation in two previous studies (n = 34) to determine the correlation between gestational age and each of the facial expressions. Results Mouthing was significantly more frequent than the other six facial expressions at 20–24 weeks (P < 0.05). Yawning was significantly more frequent than smiling, scowling, and blinking (P < 0.05), and sucking was significantly more frequent than smiling, scowling, and blinking (P < 0.05). The frequency of yawning, smiling, tongue expulsion, scowling, and blinking increased with gestational age (P < 0.05). Mouthing movement and sucking frequencies remained constant between 20 and 34 weeks. Conclusion Frequencies of complicated facial expressions such as smiling and scowling may increase with advancing gestation owing to the development of the fetal brain and central nervous system.
    International Journal of Gynecology & Obstetrics 09/2014; 126(3). DOI:10.1016/j.ijgo.2014.03.036 · 1.56 Impact Factor
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    ABSTRACT: The investigators present their experience with normal fetal cardiac structures and congenital heart anomalies reconstructed using 4-dimensional color Doppler with glass-body rendering mode and spatiotemporal image correlation. Two normal fetuses and 6 fetuses with congenital heart anomalies (1 case each of ventricular septal defect, Ebstein's anomaly, hypoplastic left heart syndrome, and ductus arteriosus aneurysm and 2 of double-outlet right ventricle) at 26 to 36 weeks' gestation were studied using 4-dimensional color Doppler with glass-body rendering mode. In normal fetal hearts, blood flow through the 4 cardiac chambers and crisscross arrangements of the pulmonary artery and aorta were clearly recognized. In the fetus with a ventricular septal defect, significant shunt flow through the defect between the left and right ventricles was evident. In the fetus with Ebstein's anomaly, giant tricuspid regurgitant flow was noted. In the fetus with hypoplastic left heart syndrome, large tricuspid regurgitant flow was identified. In the fetuses with double-outlet right ventricles, large aortas and small pulmonary arteries leaving the right ventricles in parallel were clearly shown. In the fetus with a ductus arteriosus aneurysm, an enlarged ductus arteriosus following the pulmonary artery was clearly depicted. In conclusion, fetal 4-dimensional color Doppler may assist in the evaluation of spatial relations between the great vessels and both ventricles and differences in the sizes of the great vessels and cardiac chambers.
    The American Journal of Cardiology 08/2014; 114(10). DOI:10.1016/j.amjcard.2014.08.025 · 3.43 Impact Factor
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    ABSTRACT: Background Our objective is to present our experience of facial dysmorphism reconstructed employing conventional three-dimensional (3D) ultrasound and HDlive in fetuses with autosomal trisomies. Methods Seven fetuses with autosomal trisomies (one case of trisomy 13, three of trisomy 18, and three of trisomy 21) at 16–38 weeks’ gestation were studied using 3D ultrasound and HDlive. Results In one case of trisomy 21 at 29 weeks and 5 days, upward slanting eyes, a flattened nose, low-set ears, and the corners of the mouth turned down were noted employing HDlive. In the other two cases of trisomy 21, both techniques showed the same facial findings. In one case of trisomy 18 at 27 weeks and 6 days, a small head accompanied by a prominent back portion of the head, low-set ears, a small jaw, upturned nose, narrow eyelid folds, and widely spaced eyes were identified using HDlive. In the other two cases of trisomy 18, HDlive showed more detailed features of the fetal face compared to conventional 3D ultrasound. In the single case of trisomy 13 at 31 weeks and 1 day, cleft lip and close-set eyes were recognized with both 3D ultrasound and HDlive. Conclusion HDlive can provide clearer facial images than conventional 3D ultrasound. In particular, HDlive is superior to conventional 3D ultrasound for the depiction of eye fissures because of its shadowing effect. HDlive may be a useful diagnostic modality for the antenatal evaluation of subtle fetal facial dysmorphism.
    Journal of Medical Ultrasonics 07/2014; 41(3):339-342. DOI:10.1007/s10396-014-0523-2 · 0.74 Impact Factor
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    Gastrointestinal Endoscopy 05/2014; DOI:10.1016/j.gie.2014.04.023 · 4.90 Impact Factor
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    ABSTRACT: To investigate oxidative stress (OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage. Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant (60% hepatectomy); orthotopic liver transplantation (OLT) with whole liver graft (100% OLT); and split OLT (SOLT) with 40% graft (40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OS-induced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase (PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase (MMP)-9, MMP-2, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery.
    02/2014; 6(2):72-84. DOI:10.4254/wjh.v6.i2.72

Publication Stats

2k Citations
822.87 Total Impact Points

Institutions

  • 1998–2015
    • Kagawa University
      • Department of Perinatology and Gynecology
      Takamatu, Kagawa, Japan
  • 2010–2013
    • Kyoto University
      • Department of Hepato-pancreato-biliary Surgery and Transplantation
      Kioto, Kyōto, Japan
  • 2012
    • Mayo Foundation for Medical Education and Research
      • Department of Neuroscience
      Rochester, MI, United States
  • 2009
    • Osaka City University
      Ōsaka, Ōsaka, Japan
  • 1983–1999
    • Shimane University
      • Department of Obstetrics and Gynecology
      Matsue-shi, Shimane-ken, Japan
  • 1997
    • Tango Central Hospital
      Kioto, Kyōto, Japan
  • 1991–1994
    • Baylor College of Medicine
      • Department of Obstetrics and Gynecology
      Houston, Texas, United States
  • 1993
    • West Georgia Obstetrics and Gynecology
      Georgetown, Georgia, United States