Tanja Rundek

Publications (6)5.36 Total impact

• Article: Recommendations for diabetic polyneuropathy treatment.

  Vanja Basić-Kes, Iris Zavoreo, Kresimir Rotim, Nathan Bornstein, Tanja Rundek, Vida Demarin
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  ABSTRACT: Diabetes is a chronic disease that requires continual medical care and patient self-management education in order to prevent acute complications and to reduce the risk of long-term complications. Diabetes is the leading known cause of neuropathy in developed countries, and neuropathy is the most common complication and the leading source of morbidity and mortality in diabetes patients. Diabetic polyneuropathy is primarily symmetric sensory neuropathy, initially affecting distal lower extremities. Patients have evidence of nerve damage at the time their diabetes is diagnosed in 10%-18% of cases, suggesting that even early impairment of glucose handling, classified as prediabetes, is associated with neuropathy. It is important to appreciate that there are other causes of neuropathy; these should be considered if there is any aspect of the history or clinical presentation suggesting features atypical of diabetic neuropathy. Diagnosis of diabetic neuropathy should be established according to clinical manifestations of the disease, laboratory findings (altered glucose metabolism) and results of electrophysiological examinations. Treatment of painful diabetic polyneuropathy rests on a two-pronged approach: modification of the underlying disease and control of pain symptoms. The goals of painful diabetic polyneuropathy pharmacotherapy should be reduction of pain for maximum relief commensurate with acceptable side effects and restoration/ improvement in functional measures and quality of life.
  Acta clinica Croatica 06/2011; 50(2):289-302. · 0.25 Impact Factor
• Article: Recommendations for the management of patients with carotid stenosis.

  Vida Demarin, Arijana Lovrencić-Huzjan, Silvio Basić, Vanja Basić-Kes, Ivan Bielen, Tomislav Breitenfeld, Boris Brkljacić, Liana Cambi-Sapunar, Anton Jurjević, Drago Kadojić, [......], Ivo Lovricević, Ivo Lusić, Marko Rados, Kresimir Rotim, Tanja Rundek, Sasa Schmidt, Zlatko Trkanjec, Vesna Vargek-Solter, Vinko Vidjak, Vlasta Vuković
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  ABSTRACT: These are evidence based guidelines for the management of patients with carotid stenosis, developed and endorsed by Croatian Society of Neurovascular Disorders, Croatian Society of Neurology, Croatian Society of Ultrasound in Medicine and Biology, Croatian Society for Radiology, Croatian Society of Vascular Surgery and Croatian Society of Neurosurgery. They consist of recommendations for noninvasive screening of patients with carotid stenosis, best medical treatment and interventions such as carotid endarterectomy and stent placement based on international randomized clinical trials.
  Acta clinica Croatica 03/2010; 49(1):101-18. · 0.25 Impact Factor
• Source

  Available from: Osman Sinanović

  Article: Recommendations for neuropathic pain treatment.

  Vida Demarin, Vanja Basić-Kes, Iris Zavoreo, Marijana Bosnar-Puretić, Kresimir Rotim, Velimir Lupret, Mladen Perić, Zeljko Ivanec, Lidija Fumić, Ivo Lusić, Anka Aleksić-Shihabis, Biserka Kovac, Mira Ivanković, Helena Skobić, Boris Maslov, Natan Bornstein, Kurt Niederkorn, Osman Sinanović, Tanja Rundek
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  ABSTRACT: Damage to the somatosensory nervous system poses a risk for the development of neuropathic pain. Such an injury to the nervous system results in a series of neurobiological events resulting in sensitization of both the peripheral and central nervous system. The symptoms include continuous background pain (often burning or crushing in nature) and spasmodic pain (shooting, stabbing or "electrical"). The diagnosis of neuropathic pain is based primarily on the history and physical examination finding. Although monotherapy is the ideal approach, rational polypharmacy is often pragmatically used. Several classes of drugs are moderately effective, but complete or near-complete relief is unlikely. Antidepressants and anticonvulsants are most commonly used. Opioid analgesics can provide some relief but are less effective than for nociceptive pain; adverse effects may prevent adequate analgesia. Topical drugs and a lidocaine-containing patch may be effective for peripheral syndromes. Sympathetic blockade is usually ineffective except for some patients with complex regional pain syndrome.
  Acta clinica Croatica 10/2008; 47(3):181-91. · 0.25 Impact Factor
• Article: Leukocyte lysosomal enzymes in Alzheimer's disease and Down's syndrome.

  Svjetlana Kalanj-Bognar, Tanja Rundek, Ivana Furac, Vida Demarin, Cedomir Cosović
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  ABSTRACT: Previous studies suggested the possibility of accelerated lysosomal degradation of brain gangliosides in Alzheimer's disease (AD). As AD pathology affects both neural and nonneural tissues, the aim of this study was to determine possible changes of glycosphingolipid metabolism in available peripheral cells in AD and Down's syndrome (DS). The activities of several lysosomal enzymes involved in catabolism of gangliosides and sulfatides were measured in leukocytes from subjects with dementia of the Alzheimer type, DS, and age-matched controls, by fluorimetry and spectrophotometry using specific substrates. The results showed a statistically significant increase of beta-galactosidase activity in both dementia of the Alzheimer type and DS leukocytes when compared with age-matched controls (p <.01 and p <.05, respectively; Student's t test). Not significantly increased activities of beta-galactosidase, beta-hexosaminidase, beta-hexosaminidase A, and slightly decreased activity of arylsulfatase A were observed in control leukocytes with aging. Our results indicate that a metabolic dysfunction and the acceleration of at least some lysosomal catabolic pathways are present in AD and DS nonneural cells.
  The Journals of Gerontology Series A Biological Sciences and Medical Sciences 01/2002; 57(1):B16-21. · 4.60 Impact Factor
• Article: Preporuke za liječenje bolesnika s karotidnom stenozom

  Vida Demarin, Arijana Lovrenčić-Huzjan, Silvio Bašić, Vanja Bašić-Kes, Ivan Bielen, Tomislav Breitenfeld, Boris Brkljačić, Liana Cambi-Sapunar, Anton Jurjević, Drago Kadojić, [......], Ivo Lovričević, Ivo Lušić, Marko Radoš, Krešimir Rotim, Tanja Rundek, Saša Schmidt, Zlatko Trkanjec, Vesna Vargek-Solter, Vinko Vidjak, Vlasta Vuković
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  ABSTRACT: These are evidence based guidelines for the management of patients with carotid stenosis, developed and endorsed by Croatian Society of Neurovascular Disorders, Croatian Society of Neurology, Croatian Society of Ultrasound in Medicine and Biology, Croatian Society for Radiology, Croatian Society of Vascular Surgery and Croatian Society of Neurosurgery. They consist of recommendations for noninvasive screening of patients with carotid stenosis, best medical treatment and interventions such as carotid endarterectomy and stent placement based on international randomized clinical trials.
  Acta Clinica Croatica; Vol.49 No.1.
• Source

  Available from: Arijana Lovrenčić-Huzjan

  Article: The Changing Incidence of Cerebrovascular Disease in Zagreb over a Ten-Year Period

  Arijana Lovrenčić-Huzjan, Iris Zavoreo, Tanja Rundek, Vida Demarin
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  ABSTRACT: During the last decade Croatia was faced with war and population migration that entailed socioeconomic changes, modification of lifestyle, risk factors and health care, thus influencing the incidence and outcome of stroke. Data on patients admitted to University Department of Neurology in the years 1990 and 1999 were compared to estimate the incidence and prevalence of stroke and stroke subtypes, risk factors and outcome. In 1999, the number of stroke patients was almost twofold that recorded in 1990 and stroke patients were by 5 years younger. In 1999, there were more first-ever strokes (the incidence of crude first stroke increased by 57%), whereas the number of recurrent strokes increased in men and decreased in women. The proportion of ischemic stroke and subarachnoid hemorrhage did not significantly change, whereas parenchymatous hemorrhage increased in women. Hypertension was more common (83% versus 62%), whereas the prevalence of other risk factors did not change significantly. Patients were more often discharged for home care instead of rehabilitation center care. Mortality decreased in men and increased in women, whereas case fatality and crude mortality decreased leading to an increased stroke burden.
  Acta Clinica Croatica; Vol.45 No.1.