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Hiroshi Gyotoku,
Koichi Izumikawa,
Hideki Ikeda,
Takahiro Takazono,
Yoshitomo Morinaga,
Shigeki Nakamura,
Yoshifumi Imamura,
Tomoya Nishino,
Taiga Miyazaki,
Hiroshi Kakeya,
Yoshihiro Yamamoto,
Katsunori Yanagihara,
Akira Yasuoka,
Takashi Yaguchi,
Hideaki Ohno,
Yoshitsugu Miyzaki,
Katsuhiko Kamei, Tetsuro Kanda,
Shigeru Kohno
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ABSTRACT: Aspergillus udagawae and A. fumigatus share similar morphological features but they differ genetically. There is also an important clinical distinction as A. udagawae is less sensitive to amphotericin B than A. fumigatus. We encountered a rare case of bronchial infection due to A. udagawae that was successfully treated with voriconazole. An 82-year-old woman with diabetes mellitus complained of bloody sputum. Bronchoscopy revealed a white plugged region at the origin of the right bronchi B5. Cytological study revealed a clot composed of filamentous fungi and Aspergillus spp. was detected by culture. Molecular analysis revealed that the causative agent was A. udagawae, and voriconazole was used for the treatment. In comparison to A. fumigatus, the A. udagawae strain isolated in this case was less sensitive to amphotericin B, less virulent in immunosuppressed mice, and more sensitive to hydrogen peroxide, features that are almost identical to those of the previously reported isolates of the fungus. We should be aware of the emergence of new Aspergillus species that might pose a clinical threat.
Medical mycology: official publication of the International Society for Human and Animal Mycology 12/2011; 50(6):631-6. · 2.13 Impact Factor
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ABSTRACT: A 40-year-old man developed weakness and myalgia of the shoulders and brachia nine hours after eating a cowfish (Umisuzume, Lactoria diaphana). A clinical symptom showed rhabdomyolysis and serum creatine phosphokinase was elevated to 180,000 IU/L on day 3. Cardiopulmonary arrest and acute renal failure developed after 59 hours and hemodiafiltration was performed. Cerebral death was diagnosed on day 9 and the patient died on day 16. The case has the characteristic clinical course of palytoxin poisoning, which has also been reported as blue humphead parrotfish poisoning from other kinds of fish.
Internal Medicine 02/2008; 47(9):853-6. · 0.94 Impact Factor
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Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics 02/2007; 44(1):58-61.
