Tae Hoon Kim

Daegu University, Daikyū, Daegu, South Korea

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Publications (458)1218.95 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Transcription elongation regulates the expression of many genes, including oncogenes. Histone deacetylase (HDAC) inhibitors (HDACIs) block elongation, suggesting that HDACs are involved in gene activation. To understand this, we analyzed nascent transcription and elongation factor binding genome-wide after perturbation of elongation with small molecule inhibitors. We found that HDACI-mediated repression requires heat shock protein 90 (HSP90) activity. HDACIs promote the association of RNA polymerase II (RNAP2) and negative elongation factor (NELF), a complex stabilized by HSP90, at the same genomic sites. Additionally, HDACIs redistribute bromodomain-containing protein 4 (BRD4), a key elongation factor involved in enhancer activity. BRD4 binds to newly acetylated sites, and its occupancy at promoters and enhancers is reduced. Furthermore, HDACIs reduce enhancer activity, as measured by enhancer RNA production. Therefore, HDACs are required for limiting acetylation in gene bodies and intergenic regions. This facilitates the binding of elongation factors to properly acetylated promoters and enhancers for efficient elongation.
    Cell Reports 11/2015; 13(7). DOI:10.1016/j.celrep.2015.10.013 · 8.36 Impact Factor
  • Chul Hwan Park · Joohee Lee · Chisuk Oh · Kyung Hwa Han · Tae Hoon Kim ·
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    ABSTRACT: We evaluated the feasibility of sub-millisievert (mSv) coronary CT angiography (CCTA) using low tube voltage, prospective ECG gating, and a knowledge-based iterative model reconstruction algorithm. Twenty-four non-obese healthy subjects (M:F 13:11; mean age 50.2 ± 7.8 years) were enrolled. Three sets of CT images were reconstructed using three different reconstruction methods: filtered back projection (FBP), iterative reconstruction (IR), and knowledge-based iterative model reconstruction (IMR). The scanning parameters were as follows: step-and-shoot axial scanning, 80 kVp, and 200 mAs. On the three sets of CT images, the attenuation and image noise values were measured at the aortic root. The signal-to-noise ratio (SNR) and the contrast-to-noise ratio (CNR) were calculated at the proximal right coronary artery and the left main coronary artery. The qualitative image quality of the CCTA with IMR was assessed using a 4-point grading scale (grade 1, poor; grade 4, excellent). The mean radiation dose of the CCTA was 0.89 ± 0.09 mSv. The attenuation values with IMR were not different from those of other reconstruction methods. The image noise with IMR was significantly lower than with IR and FBP. Compared to FBP, the noise reduction rate of IMR was 69 %. The SNR and CNR of CCTA with IMR were significantly higher than with FBP or IR. On the qualitative analysis with IMR, all included segments were diagnostic (grades 2, 3, and 4), and the mean image quality score was 3.6 ± 0.6. In conclusion, CCTA with low tube voltage, prospective ECG gating, and an IMR algorithm might be a feasible method that allows for sub-millisievert radiation doses and good image quality when used with non-obese subjects.
    The international journal of cardiovascular imaging 11/2015; 31(Suppl 2). DOI:10.1007/s10554-015-0795-7 · 1.81 Impact Factor
  • Hyeongmin Kim · Chul Hwan Park · Kyung Hwa Han · Tae Hoon Kim ·
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    ABSTRACT: We evaluated the feasibility of using quantitatively measured thoracic components, as compared to body mass index (BMI), for predicting the image noise of coronary computed tomography angiography (CCTA). One hundred subjects (M:F = 64:36; mean age, 55 ± 8.8 years) who underwent prospective electrocardiography-gated CCTA and low-dose chest computed tomography (CT) were analyzed retrospectively. The image noise of the CCTA was determined by the standard deviation of the attenuation value in a region of interest on the aortic root level. On the low-dose chest CT, the areas of the thoracic components were measured at the aortic root level. An auto-segmentation technique with the following threshold levels was used: quantitatively measured area of total thorax [QMAtotal: -910 to 1000 Hounsfield units (HU)], lung (QMAlung: -910 to -200 HU), fat (QMAfat: -200 to 0 HU), muscle (QMAmuscle: 0-300 HU), soft tissue (fat + muscle, QMAsoft tissue: -200 to 300 HU), bone (QMAbone: 300-1000 HU) and solid tissue (fat + muscle + bone, QMAsolid tissue: -200 to 1000 HU). The relationship between image noise and variable biometric parameters including QMA was analyzed, and the linear correlation coefficients were used as indicators of the strength of association. Among the variable biometric parameters, including BMI, QMAsolid tissue showed the highest correlation coefficient with image noise in all subjects (r = 0.804), males (r = 0.716), females (r = 0.889), the overweight (r = 0.556), and the non-overweight subgroups (r = 0.783). QMAsolid tissue can be used as a potential surrogate predictor of the image noise level in low tube voltage CCTA.
    The international journal of cardiovascular imaging 10/2015; 31(Suppl 2). DOI:10.1007/s10554-015-0796-6 · 1.81 Impact Factor
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    ABSTRACT: Objectives: Controversy is continuing over the need for ventilation and the optimal compression-ventilation (CV) ratio during cardiopulmonary resuscitation (CPR). The aim of this study was to comparatively elucidate the effect on hemodynamics and arterial oxygen saturation of a single ventilation relative to two consecutive ventilations during CPR in a dog model of cardiac arrest. Methods: Twenty mongrel dogs were divided into two groups. After 3 minutes of ventricular fibrillation (VF), the single-ventilation group received CPR with a 30:1 CV ratio, and the two-ventilation group received CPR with a 30:2 CV ratio, all with room air for 7 minutes. Thereafter, continuous chest compressions and intermittent ventilation at rate of 10 per minute were followed for both groups for 10 minutes. Hemodynamic parameters, arterial blood gas profiles, and variables from CPR were compared at baseline and at 5, 10, 15, and 20 minutes after induction of VF. Results: Hemodynamic parameters including aortic systolic and diastolic pressures, right atrial systolic and diastolic pressures, coronary perfusion pressure, end-tidal carbon dioxide tension, and arterial blood gas profiles including arterial oxygen tension, arterial oxygen saturation, and arterial carbon dioxide tension were not different between two groups during CPR. In the 30:1 group, the period of compression interruption was shorter and chest compression fraction was higher than that in the 30:2 group (6 sec/min vs. 10.9 sec/min, p < 0.001; 90.0% vs. 81.8%, p < 0.001). Conclusions: CPR with a 30:1 CV ratio, compared to CPR with a 30:2 CV ratio, results in comparable arterial oxygenation saturation and hemodynamics.
    Academic Emergency Medicine 10/2015; DOI:10.1111/acem.12796 · 2.01 Impact Factor
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    ABSTRACT: AT-rich interactive domain 1A gene (ARID1A) loss is a frequent event in endometriosis-associated ovarian carcinomas. Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus, and 50% of women with endometriosis are infertile. ARID1A protein levels were significantly lower in the eutopic endometrium of women with endometriosis compared to women without endometriosis. However, an understanding of the physiological effects of ARID1A loss remains quite poor, and the function of Arid1a in the female reproductive tract has remained elusive. In order to understand the role of Arid1a in the uterus, we have generated mice with conditional ablation of Arid1a in the PGR positive cells (Pgrcre/+Arid1af/f; Arid1ad/d). Ovarian function and uterine development of Arid1ad/d mice were normal. However, Arid1ad/d mice were sterile due to defective embryo implantation and decidualization. The epithelial proliferation was significantly increased in Arid1ad/d mice compared to control mice. Enhanced epithelial estrogen activity and reduced epithelial PGR expression, which impedes maturation of the receptive uterus, was observed in Arid1ad/d mice at the peri-implantation period. The microarray analysis revealed that ARID1A represses the genes related to cell cycle and DNA replication. We showed that ARID1A positively regulates Klf15 expression with PGR to inhibit epithelial proliferation at peri-implantation. Our results suggest that Arid1a has a critical role in modulating epithelial proliferation which is a critical requisite for fertility. This finding provides a new signaling pathway for steroid hormone regulation in female reproductive biology and furthers our understanding of the molecular mechanisms that underlie dysregulation of hormonal signaling in human reproductive disorders such as endometriosis.
    PLoS Genetics 09/2015; 11(9):e1005537. DOI:10.1371/journal.pgen.1005537 · 7.53 Impact Factor
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    ABSTRACT: Objective: Post-contrast T1 values are closely related to the degree of myocardial extracellular space expansion. We determined the relationship between post-contrast T1 values and left ventricular (LV) diastolic function, LV remodeling, and neurohormonal activation in patients with dilated cardiomyopathy (DCM). Materials and methods: Fifty-nine patients with DCM (mean age, 55 ± 15 years; 41 males and 18 females) who underwent both 1.5T magnetic resonance imaging and echocardiography were enrolled. The post-contrast 10-minute T1 value was generated from inversion time scout images obtained using the Look-Locker inversion recovery sequence and a curve-fitting algorithm. The T1 sample volume was obtained from three interventricular septal points, and the mean T1 value was used for analysis. The N-Terminal pro-B-type natriuretic peptide (NT-proBNP) level was measured in 40 patients. Results: The mean LV ejection fraction was 24 ± 9% and the post-T1 value was 254.5 ± 46.4 ms. The post-contrast T1 value was significantly correlated with systolic longitudinal septal velocity (s'), peak late diastolic velocity of the mitral annulus (a'), the diastolic elastance index (Ed, [E/e']/stroke volume), LV mass/volume ratio, LV end-diastolic wall stress, and LV end-systolic wall stress. In a multivariate analysis without NT-proBNP, T1 values were independently correlated with Ed (β = -0.351, p = 0.016) and the LV mass/volume ratio (β = 0.495, p = 0.001). When NT-proBNP was used in the analysis, NT-proBNP was independently correlated with the T1 values (β = -0.339, p = 0.017). Conclusion: Post-contrast T1 is closely related to LV remodeling, diastolic function, and neurohormonal activation in patients with DCM.
    Korean journal of radiology: official journal of the Korean Radiological Society 09/2015; 16(5):1153-62. DOI:10.3348/kjr.2015.16.5.1153 · 1.57 Impact Factor
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    ABSTRACT: This research was conducted to develop effective and safe marine-derived antiviral compounds against norovirus. The ethyl acetate (EtOAc)-extract from Eisenia bicyclis exhibited strong antiviral activity against murine norovirus (MNV) as a norovirus surrogate. Among the phlorotannins from E. bicyclis, dieckol (DE) and phlorofucofuroeckol-A (PFF) were known to possess the strongest antibacterial activity. In this study, DE and PFF were evaluated for antiviral activity against MNV DE and PFF exhibited strong anti-MNV activity with 50% effective concentration (EC50) of 0.9 pM. However, PFF ex­hibited more effective antiviral activity against MNV with higher selective index (668.87) than that of DE (550.60), due to its lower cell toxicity against RAW 264.7. This is the first report on the anti-MNV activity of phlorotannins from seaweed. The results obtained in this study suggest that the phlorotannins could be used as a potential source of natural antiviral agents.
    09/2015; 30(3):241-246. DOI:10.4490/algae.2015.30.3.241
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    ABSTRACT: Adenotonsillar hypertrophy is the most common etiology in pediatric obstructive sleep apnea syndrome (OSAS), and adenotonsillectomy is the mainstay of treatment modalities. This study evaluates the long-term effectiveness of adenotonsillectomy in children with OSAS. Subjective symptoms evaluated with a 7-point Likert scale and objective respiratory disturbances evaluated by polysomnography were compared before and after adenotonsillectomy. A total of 17 children with OSAS aged 4-15 years (mean age, 6.65±3.02 years; male:female, 13:4) completed the study. The mean follow-up period was 57 months (range, 30 to 98 months). Significant changes were found in apnea-hypopnea index (from 12.49±12.96 to 1.96±2.01, P<0.001), apnea index (from 5.64±7.57 to 0.53±0.78, P=0.006), minimum SaO2 (from 81.88±14.36 to 92.76±4.31, P=0.003), snoring (from 43.28±70.63 to 10.70±13.72, P=0.042), and arousal index (from 19.58±7.57 to 11.36±3.99, P=0.006) after adenotonsillectomy. Significant changes were also found after surgery in most of symptoms including snoring, witnessed apnea, morning headache, mouth breathing, gasping during sleep, restless sleep, nasal obstruction, and difficulty with morning arousal. Long-term surgical cure rate and response rate were 47.1% (8/17) and 70.6% (12/17), respectively. Most of subjective OSAS symptoms and objective respiratory disturbances improved continuously about 5 years after adenotonsillectomy in children with OSAS. However, close follow-up and a sufficient observation period are necessary because of the risk for long-term incomplete resolution.
    Clinical and Experimental Otorhinolaryngology 09/2015; 8(3):256-60. DOI:10.3342/ceo.2015.8.3.256 · 0.85 Impact Factor
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    ABSTRACT: CCCTC binding factor (CTCF) is involved in organizing chromosomes into mega base-sized, topologically associated domains (TADs) along with other factors that define sub-TAD organization. CTCF-Cohesin interactions have been shown to be critical for transcription insulation activity as it stabilizes long-range interactions to promote proper gene expression. Previous studies suggest that heterochromatin boundary activity of CTCF may be independent of Cohesin, and there may be additional mechanisms for defining topological domains. Here, we show that a boundary site we previously identified known as CTCF binding site 5 (CBS5) from the homeotic gene cluster A (HOXA) locus exhibits robust promoter activity. This promoter activity from the CBS5 boundary element generates a long noncoding RNA that we designate as boundary associated long noncoding RNA-1 (blncRNA1). Functional characterization of this RNA suggests that the transcript stabilizes long-range interactions at the HOXA locus and promotes proper expression of HOXA genes. Additionally, our functional analysis also shows that this RNA is not needed in the stabilization of CTCF-Cohesin interactions however CTCF-Cohesin interactions are critical in the transcription of blncRNA1. Thus, the CTCF-associated boundary element, CBS5, employs both Cohesin and noncoding RNA to establish and maintain topologically associated domains at the HOXA locus.
    PLoS ONE 08/2015; 10(8):e0136104. DOI:10.1371/journal.pone.0136104 · 3.23 Impact Factor
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    ABSTRACT: This study evaluates myocardial edema by quantitative T2 mapping in patients with acute myocardial infarction (AMI) and compares the lateral extent of myocardial edema with those of infarcted and dysfunctional myocardium. Cardiac magnetic resonance images (MRIs) of 31 patients (M:F=29:2, mean age: 52.5±10.8 years) with AMI were reviewed. On cine-MRI, all short axis images of the left ventricle (LV) were divided into 60 sectors. The regional wall motion of each sector was calculated as follows: systolic wall thickening (SWT,%) = ((LV wall thicknessES - LV wall thicknessED)/LV wall thicknessED)*100. Dysfunctional myocardium was defined as sectors with decreased SWT lower than 40%. On LGE-images, myocardial infarction was defined as an area of hyper-enhancement more than 5 SDs from the remote myocardium. On T2 map, myocardial edema was defined as an area in which T2 values were at least 2 SDs higher than those from remote myocardium. The lateral extents of infarcted myocardium, myocardial edema, and dysfunctional myocardium were calculated as the percentage of central angles ((central angle of the involved myocardium/360)*100 (%)) and then compared. The lateral extent of myocardial edema was slightly larger than that of infarcted myocardium (37.4±13.3% vs. 35±12.9%, p<0.01). The lateral extent of dysfunctional myocardium (50.6±15.3%) was significantly larger than that of infarcted myocardium or myocardial edema (p<0.001). The lateral extent of myocardial edema beyond the infarcted myocardium might be narrow, but the dysfunctional myocardium could be significantly larger than myocardial edema, suggesting stunned myocardium without edema. Copyright © 2015. Published by Elsevier Inc.
    Magnetic Resonance Imaging 08/2015; DOI:10.1016/j.mri.2015.08.008 · 2.09 Impact Factor

  • Cancer Research 08/2015; 75(15 Supplement):2069-2069. DOI:10.1158/1538-7445.AM2015-2069 · 9.33 Impact Factor
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    ABSTRACT: The anti-inflammatory and immunomodulatory effects of macrolides include the ability to decrease mucus secretion, and inhibit inflammatory mediators in chronic rhinosinusitis. Nevertheless, their action mechanisms are yet to be determined. This study aims to investigate the effects of macrolide antibiotics (clarithromycin, azithromycin, and josamycin, the representative agents for 14-, 15-, and 16-membered macrolides) on the endogenous steroidal system in human sinonasal epithelial cells and mouse nasal mucosa. The effects of macrolides on the expression levels of steroid-converting enzymes (11β-hydroxysteroid dehydrogenase; 11β-HSD1 and 11β-HSD2), steroid-synthesizing enzymes (3β-HSD, CYP21, CYP11B1, and CYP11A1), and cortisol levels were elucidated in cultured human epithelial cells. In control and adrenalectomized mouse, these enzymes and corticosterone levels were evaluated in nasal mucosa and serum after administration of macrolides. The expression levels of 3β-HSD, CYP21, 11β-HSD1 and CYP11B1 increased in human epithelial cells treated with clarithromycin and azithromycin whereas the expression levels of 11β-HSD2 and CYP11A1 were not affected. Josamycin had no effects on the expression levels of these enzymes. Cortisol levels increased in epithelial cells treated with clarithromycin or azithromycin. The expression levels of 3β-HSD, CYP11A1, CYP21, CYP11B1, and 11β-HSD1 were up-regulated in nasal mucosa of mouse treated with clarithromycin or azithromycin, but not in adrenalectomized mouse. This study provides evidence that 14- and 15- membered macrolide antibiotics may affect the expression levels of steroid-synthesizing and -converting enzymes in human sinonasal epithelial cells and mouse nasal mucosa, contributing to increase the endogenous cortisol levels in sinonasal mucosa. This article is protected by copyright. All rights reserved.
    British Journal of Pharmacology 07/2015; DOI:10.1111/bph.13273 · 4.84 Impact Factor
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    ABSTRACT: Rotenone, isolated from roots of derris plant, has been shown to possess various biological activities, which lead to attempting to develop a potent drug against several diseases. However, recent studies have demonstrated that rotenone has the potential to induce several adverse effects such as a neurodegenerative disease. Radiolytic transformation of the rotenone with gamma-irradiation created a new product, named rotenoisin B. The present work was designed to investigate the anticancer activity of rotenoisin B with low toxicity and its molecular mechanism in hepatic cancer cells compared to a parent compound, rotenone. Our results showed rotenoisin B inhibited hepatic cancer cells' proliferation in a dose dependent manner and increased in apoptotic cells. Interestingly, rotenoisin B showed low toxic effects on normal cells compared to rotenone. Mitochondrial transmembrane potential has been decreased, which leads to cytochrome c release. Down regulation of anti-apoptotic Bcl-2 levels as well as the up regulation of proapoptotic Bax levels were observed. The cleaved PARP (poly ADP-ribose polymerase) level increased as well. Moreover, phosphorylation of extracellular signal regulated kinase (ERK) and p38 slightly up regulated and intracellular reactive oxygen species (ROS) increased as well as cell cycle arrest predominantly at the G2/M phase observed. These results suggest that rotenoisin B might be a potent anticancer candidate similar to rotenone in hepatic cancer cells with low toxicity to normal cells even at high concentrations compared to rotenone.
    International Journal of Molecular Sciences 07/2015; 16(8):16806-15. DOI:10.3390/ijms160816806 · 2.86 Impact Factor
  • Chul Hwan Park · Tae Hoon Kim · Seok Jin Haam · Sungsoo Lee ·
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    ABSTRACT: We compared the costal cartilage and rib length between prepubertal patients with symmetric pectus excavatum and age- and sex-matched controls without anterior chest wall depression to evaluate if rib overgrowth is a contributing factor for pectus excavatum METHODS: The sample included 18 prepubertal patients <10years old with symmetric pectus excavatum and 18 age-and sex-matched controls without chest wall deformity. The full lengths of the fourth to sixth ribs and costal cartilage were measured using three-dimensional volume-rendered computed tomography and curved multiplanar reformatting techniques. The rib and costal cartilage lengths, total combined rib and costal cartilage length, and costal index ([length of cartilage/length of rib]×100 [%]) at the fourth to sixth levels were compared between the groups. The rib lengths in the patient group were significantly longer than in the control group for the 6th right rib and 4th, 5th, and 6th left ribs. The costal cartilage lengths and costal indices were not different between two groups. In patients with symmetric pectus excavatum aged <10years old, several of the ribs were longer than those of controls, suggesting that abnormal rib overgrowth may be a contributing factor responsible for pectus excavatum rather than cartilage overgrowth. Copyright © 2015. Published by Elsevier Inc.
    Journal of Pediatric Surgery 07/2015; DOI:10.1016/j.jpedsurg.2015.07.010 · 1.39 Impact Factor
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    ABSTRACT: Sclerosing pneumocytoma (SP) of the lung is a rare benign neoplasm. Here, we describe an unusual presentation of SP with a wax-and-wane pattern of growth in a 47-year-old woman. Tumor diameter decreased over a 3-year follow-up period and then increased on serial follow-up computed tomography scans. The mass showed high signal intensity on both T1- and T2-weighted chest magnetic resonance imaging (MRI) and early enhancement with a plateau on dynamic MRI. We speculate that intratumoral bleeding and resorption processes accounted for the changes in tumor size.
    Korean journal of radiology: official journal of the Korean Radiological Society 07/2015; 16(4):947-50. DOI:10.3348/kjr.2015.16.4.947 · 1.57 Impact Factor
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    ABSTRACT: The actions of glucocorticoids in target tissues depend on the local metabolism of glucocorticoids catalyzed by 11β hydroxysteroid dehydrogenase (HSD) 1 and 2. Glucocorticoids are the most effective anti-inflammatory drugs in the treatment of nasal polyps. However, the mechanisms that underlie the anti-inflammatory effects are unclear. The present study analyzed the expression of 11β-HSD1, 11β-HSD2, and steroidogenic enzymes (cytochrome P450, family 11, subfamily B, polypeptide 1 [CYP11B1]; cytochrome P450, family 11, subfamily A, polypeptide 1 [CYP11A1]) in nasal polyp tissues, and endogenous cortisol levels in nasal polyp-derived epithelial cells. The expression levels and distribution pattern of 11β-HSD1, 11β-HSD2, CYP11B1, and CYP11A1 were determined in nasal polyp tissues or nasal polyp-derived epithelial cells by using real-time polymerase chain reaction, Western blot, and immunohistochemistry testing. The expression levels of cortisol by using enzyme-linked immunosorbent assay were determined in cultured polyp-derived epithelial cells treated with adrenocorticotrophic hormone (ACTH), 11β-HSD1 inhibitor, or small interfering ribonucleic acid technique. The effect of glucocorticoids on the expression levels of these enzymes was investigated in cultured cells. Expressed in nasal polyp tissues and nasal polyp-derived epithelial cells were 11β-HSD1, 11β-HSD2, CYP11B1, and CYP11A1. Cortisol production in cultured epithelial cells was decreased in cells treated with 11β-HSD1 small interfering ribonucleic acid or inhibitor, compared with nontreated cells. Cultured cells treated with adrenocorticotropic hormone induced increased cortisol production. 11β-HSD1 expression levels were upregulated in cells treated with glucocorticoid. Analysis of these results indicated that 11β-HSD1 expressed in polyp-derived epithelial cells may be involved in the anti-inflammatory function of glucocorticoid in the treatment of nasal polyps, which contributes to increased levels of endogenous cortisol.
    American Journal of Rhinology and Allergy 07/2015; 29(4):246-50. DOI:10.2500/ajra.2015.29.4185 · 1.81 Impact Factor
  • Ha Yeong Lee · In-Chul Lee · Jae Hoon Kw · Tae Hoon Kim ·

    06/2015; 22(3):437-442. DOI:10.11002/kjfp.2015.22.3.437
  • Yoon-Moon Park · Taewan Kim · Hyun-Seok Kim · Tae Hoon Kim · Yoo Jin Park ·

    Wonye kwahak kisulchi = Korean journal of horticultural science and technology / 06/2015; 33(3):375-382. DOI:10.7235/hort.2015.14135 · 0.34 Impact Factor
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    ABSTRACT: The aim of this study was to evaluate the effect of adenotonsillectomy on immediate Eustachian tube (E-tube) function in children with adenotonsillar hypertrophy. All children who were scheduled to undergo adenotonsillectomy were assessed. Physical examinations were performed on the preoperative day, and on postoperative days 1 and 2. Exams included visual inspection of the tympanic membrane and tympanometry including measurement of middle ear pressure (MEP) (daPa). The children were divided into four types (AA, CA, CC, and BB types) based on the tympanometric results of postoperative days 1 and 2. A total of 50 ears from 25 children (mean age±standard deviation [SD]=8.6±3.2; male/female=10/15; mean body mass index±SD [kg/m(2)]=18.5±3.7) were included. The rates of AA, CA, CC, and BB types were 10% (5/50), 14% (7/50), 74% (37/50), and 2% (1/50), respectively. On postoperative day 2, 76% of cases were abnormal or unresolved (38/50), while 24% were normal or resolved (12/50). There were significant decreases in MEP both before and after adenotonsillectomy (p's<0.001). However, there were no significant differences in the MEPs measured on postoperative days 1 and 2. There were no significant differences between the right and left ears with regard to the MEPs on the preoperative day, or postoperative days 1 and 2. Immediate E-tube dysfunction is a relatively common complication in children after adenotonsillectomy. Therefore, in the setting of immediate E-tube dysfunction, it is important to properly plan postoperative care and management. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    International journal of pediatric otorhinolaryngology 06/2015; 79(9). DOI:10.1016/j.ijporl.2015.06.025 · 1.19 Impact Factor

Publication Stats

7k Citations
1,218.95 Total Impact Points


  • 2015
    • Daegu University
      Daikyū, Daegu, South Korea
    • University of California, San Diego
      San Diego, California, United States
  • 2012-2015
    • Michigan State University
      • Department of Obstetrics, Gynecology, and Reproductive Biology
      Ист-Лансинг, Michigan, United States
    • National Cancer Center Korea
      • Specific Organs Cancer Branch
      Kōyō, Gyeonggi-do, South Korea
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2009-2015
    • Daegu Haany University
      Daikyū, Daegu, South Korea
    • Pukyong National University
      Tsau-liang-hai, Busan, South Korea
    • Yale University
      • Department of Genetics
      New Haven, Connecticut, United States
  • 2005-2015
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • The Australian Society of Otolaryngology Head & Neck Surgery
      Evans Head, New South Wales, Australia
  • 2002-2015
    • Sejong General Hospital
      Bucheon, Gyeonggi-do, South Korea
  • 1999-2015
    • Korea University
      • • College of Medicine
      • • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2014
    • Dong-A University
      Tsau-liang-hai, Busan, South Korea
    • Daegu Fatima Hospital
      Yeoncheon Gun, South Korea
    • Seoul National University Hospital
      • Department of Plastic and Reconstructive Surgery
      Sŏul, Seoul, South Korea
    • University of Texas at Dallas
      Richardson, Texas, United States
    • The Richard Stockton College of New Jersey
      New Jersey, United States
    • Gangneung Asan Hospital
      Sŏul, Seoul, South Korea
  • 2013-2014
    • Dankook University
      • Department of Chemical Engineering
      Eidō, Chungcheongbuk-do, South Korea
    • Kyungnam University
      Changnyeong, Gyeongsangnam-do, South Korea
    • Sahmyook University
      Sŏul, Seoul, South Korea
    • Daewoo Engineering and Construction
      Sŏul, Seoul, South Korea
  • 2007-2014
    • Yale-New Haven Hospital
      • Department of Pathology
      New Haven, Connecticut, United States
    • Dongseo University
      • Department of Systems and Management Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2006-2014
    • Korea Advanced Institute of Science and Technology
      • • Graduate School of Medical Science and Engineering
      • • Department of Physics
      • • Department of Aerospace Engineering
      • • Department of Mechanical Engineering
      Sŏul, Seoul, South Korea
    • Electronics and Telecommunications Research Institute
      Sŏul, Seoul, South Korea
  • 2004-2014
    • Yonsei University
      • • Department of Radiology
      • • Natural Science Research Institute
      Sŏul, Seoul, South Korea
    • Korea Atomic Energy Research Institute (KAERI)
      • Advanced Radiation Technology Institute
      Daiden, Daejeon, South Korea
  • 2001-2014
    • Pusan National University
      • • Department of Horticultural Bioscience
      • • Department of Molecular Biology
      • • Division of Electrical and Electronics Engineering
      • • Department of Physics
      Tsau-liang-hai, Busan, South Korea
    • University of Minnesota Duluth
      Duluth, Minnesota, United States
  • 2009-2013
    • Wonju Severance Christian Hospital
      Genshū, Gangwon, South Korea
    • Korea Institute of Machinery and Materials
      Sŏul, Seoul, South Korea
    • Northeastern University
      • Department of Mechanical and Industrial Engineering
      Boston, Massachusetts, United States
  • 2006-2013
    • Sungkyunkwan University
      • School of Advanced Materials Science and Engineering (AMSE)
      Sŏul, Seoul, South Korea
  • 2005-2013
    • Seoul National University
      • • Department of Electrical and Computer Engineering
      • • Department of Earth and Environmental Sciences
      • • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
    • Ludwig Institute for Cancer Research
      La Jolla, California, United States
  • 2011-2012
    • University of Maryland, College Park
      • Department of Mechanical Engineering
      CGS, Maryland, United States
    • Yeungnam University
      • College of Pharmacy
      Onyang, South Chungcheong, South Korea
    • International St. Mary's Hospitals
      Chemulpo, Incheon, South Korea
    • University of Ulsan
      Urusan, Ulsan, South Korea
    • The Ohio State University
      • Department of Psychology
      Columbus, Ohio, United States
    • Catholic University of Korea
      Sŏul, Seoul, South Korea
  • 2010-2012
    • Kyungpook National University
      • College of Pharmacy
      Sangju, North Gyeongsang, South Korea
  • 2009-2012
    • Inje University
      • Department of Nano Engineering
      Kŭmhae, South Gyeongsang, South Korea
    • Baylor College of Medicine
      • Department of Molecular & Cellular Biology
      Houston, Texas, United States
  • 2010-2011
    • Inje University Paik Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2005-2010
    • Chung-Ang University
      • College of Medicine
      Sŏul, Seoul, South Korea
  • 2001-2010
    • Korea Research Institute of Chemical Technology
      Daiden, Daejeon, South Korea
  • 2008
    • Gyeongsang National University
      • School of Materials Science and Engineering
      Chinju, South Gyeongsang, South Korea
    • Changwon National University
      Changnyeong, South Gyeongsang, South Korea
  • 2007-2008
    • Kunsan National University
      • Department of Oceanography
      Gunzan, North Jeolla, South Korea
  • 2006-2008
    • Samsung Electro-Mechanics
      Sŏul, Seoul, South Korea
  • 1999-2008
    • Fairchild Semiconductor
      San José, California, United States
  • 2006-2007
    • Chungnam National University
      • Department of Advanced Organic Materials and Textile System Engineering
      Daiden, Daejeon, South Korea
  • 2005-2006
    • Okayama University
      • Faculty of Pharmaceutical Science
      Okayama, Okayama, Japan
  • 1999-2005
    • Pohang University of Science and Technology
      • • Department of Chemistry
      • • Department of Electronic and Electrical Engineering
      Geijitsu, Gyeongsangbuk-do, South Korea
  • 2002-2004
    • Korea Photonics Technology Institute
      Sŏul, Seoul, South Korea
  • 2003
    • Kyung Hee University Medical Center
      Sŏul, Seoul, South Korea
  • 2000-2002
    • Sejong Institute
      Sŏngnam, Gyeonggi-do, South Korea