Tae Hoon Kim

Michigan State University, Ист-Лансинг, Michigan, United States

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Publications (399)976.04 Total impact

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    ABSTRACT: Purpose To investigate the diagnostic performance of coronary computed tomographic (CT) angiography for selecting candidates for coronary artery bypass graft (CABG) surgery according to the 2011 American College of Cardiology Foundation (ACCF) and American Heart Association (AHA) guidelines for CABG surgery and determine the added value of SYNTAX (Synergy between PCI with TAXUS and Cardiac Surgery) scoring for selecting CABG surgery candidates. Materials and Methods Approval was obtained from the Institutional Review Board, and informed consent was waived for this retrospective study. A total of 399 patients (mean age, 63.8 years; 244 men and 155 women) who underwent both coronary CT angiography and invasive coronary angiography were included. Eligible criteria for CABG surgery were established on the basis of the 2011 ACCF/AHA guidelines. Results from coronary CT angiography and invasive coronary angiography were retrospectively reviewed, and SYNTAX scores were determined. The diagnostic performance of coronary CT angiography for selecting CABG surgery candidates was calculated with invasive coronary angiography as the reference method. The diagnostic performance of coronary CT angiography alone, the CT-based SYNTAX score, and the combined coronary CT angiography with CT-based SYNTAX score were assessed by using a combination of invasive coronary angiography and invasive coronary angiography-based SYNTAX scores as a reference method. Statistical analyses were performed by using the generalized estimating equation, independent t test, Mann-Whitney U test, Wilcoxon signed rank test, Fisher exact test, and χ(2) statistics. Results The overall sensitivity, specificity, positive predictive value (PPV), and negative predictive value of coronary CT angiography for selecting CABG surgery candidates were 96.5%, 96.5%, 88.3%, and 99.0%, respectively. When a combination of invasive coronary angiography with an invasive coronary angiography-based SYNTAX score was used as a standard reference, combined coronary CT angiography with a CT-based SYNTAX score had higher specificity and PPV (98.3% and 86.0%, respectively) than did coronary CT angiography alone (84.5% and 40.4%, respectively; P < .0001). Conclusion Coronary CT angiography had diagnostic accuracy comparable to that of invasive coronary angiography for selecting CABG surgery candidates, and combining a CT-based SYNTAX score with coronary CT angiography can be a highly specific method for selecting CABG surgery candidates. (©) RSNA, 2015.
    Radiology 03/2015; DOI:10.1148/radiol.15141216 · 6.21 Impact Factor
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    ABSTRACT: Are STAT3 signaling molecules differentially expressed in endometriosis? Levels of phospho-STAT3 and HIF1A, its downstream signaling molecule, are significantly higher in eutopic endometrium from women with endometriosis when compared with women without the disease. Endometriosis is an estrogen-dependent inflammatory condition. Interleukin 6 (IL-6) is an inflammatory survival cytokine known to induce prolonged activation of STAT3 via association with the IL-6 receptor. Cross-sectional measurements of STAT3 and HIF1A protein levels in eutopic endometrium from women with endometriosis versus those without. Levels of phospho-STAT3 (pSTAT3) and HIF1A were examined in the endometrium of patients with and without endometriosis as well as in a non-human primate animal model using western blot and immunohistochemical analysis. Levels of pSTAT3 were significantly higher in the eutopic endometrium from women with endometriosis when compared with women without the disease in both the proliferative and secretory phases. HIF1A is known to be stabilized by STAT3 and IL-6. Our immunohistochemistry results show abundant HIF1A expression within the eutopic endometrial epithelial cells of women with endometriosis. Furthermore, pSTAT3 and HIF1A proteins are co-localized in endometriosis. This aberrant activation of pSTAT3 and HIF1A is confirmed by sequential analysis of eutopic endometrium using a baboon animal model of induced endometriosis. Lastly, we confirmed this IL-6 induction of both STAT3 phosphorylation and HIF1A mRNA expression in Ishikawa human endometrial adenocarcinoma cell line. Ishikawa cancer cell line was used to study a benign disease. The peritoneal fluid contains various inflammatory cytokines in addition to IL-6 and so it is possible that other cytokines may affect the activity and expression of STAT3 signaling molecules. Our results imply that aberrant activation of STAT3 signaling plays an important role in the pathogenesis of endometriosis. Our findings could progress in our understanding of the etiology and pathophysiology of endometriosis and potential therapeutic interventions by targeted pharmacological. This work was supported by NIH R01 HD067721 (to S.L.Y and B.A.L) and NIH R01 HD057873 and American Cancer Society Research Grant RSG-12-084-01-TBG (to J.-W.J.). There are no conflicts of interest. © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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    ABSTRACT: Gorham-Stout Syndrome (GSS) is a rare disease characterized by localized bone resorption. Any part of the skeleton may be affected; therefore, symptoms can vary depending on the site involved. Pathological analysis reveals lymphovascular proliferation and osteolysis in the affected lesion, but the etiology of the disease is poorly understood. When GSS occurs in the chest, chylothorax or respiratory failure may occur. Thus far, a standard treatment for GSS has not been established, and the prognosis remains unknown. The following case report describes a successfully treated case of GSS in a 16-year-old boy with an affected sternum and ribs.
    02/2015; 48(1):90-94. DOI:10.5090/kjtcs.2015.48.1.90
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    ABSTRACT: To test the effect of upper airway surgery on sleep quality in adults with obstructive sleep apnea (OSA) and the potential usefulness of electrocardiogram (ECG)-based cardiopulmonary coupling (CPC) analysis as metrics of sleep quality. Retrospective outcome research. A total of 62 consecutive adult patients with OSA, consisting of 36 with successful and 26 with unsuccessful outcomes, were included in the study. Mean age was 37.7 ± 8.9 years, and body mass index (BMI, kg/m(2) ) was 26.9 ± 2.3. We compared clinical characteristics (age, BMI, and Epworth Sleepiness Scale [ESS]), sleep (sleep efficiency, stage non-rapid eye movement [N]1, N2, N3, rapid eye movement, and arousal index [ArI]), respiratory (apnea index [AI], apnea-hypopnea index [AHI], and minimum arterial oxygen saturation [SaO2 ]), and CPC (high-frequency coupling [HFC], low frequency coupling [LFC], very-low-frequency coupling, and elevated low-frequency coupling [e-LFC]) parameters between the success and nonsuccess groups before and after surgery. Surgical success was defined when the postoperative AHI was both <20 per hour and 50% of the preoperative value. Sleep quality measured by CPC analysis improved significantly (HFC, P = .001; LFC, P = .002; e-LFC, P = .003), along with parallel reduction in ESS, respiratory parameters (AHI, AI, minimum SaO2 ), and sleep fragmentation (ArI) in the group with surgical success after upper airway surgery. Successful upper airway surgery can improve objective sleep quality in adult patients with OSA. CPC metrics of sleep quality are potentially useful to monitor therapeutic responses during long-term postoperative follow-up, as the ECG-based analysis is available as a standalone option outside laboratory polysomnography. 4 Laryngoscope, 2015. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.
    The Laryngoscope 02/2015; DOI:10.1002/lary.25101 · 2.03 Impact Factor
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    ABSTRACT: Objective High mobility group box 1 (HMGB1) protein is a chromatin protein that functions as a proinflammatory cytokine when secreted in response to inflammatory stimuli. The purpose of this study was to determine the relationship between the HMGB1 level in nasal secretions and the severity of inflammation in chronic rhinosinusitis.Study DesignThis was a cross-sectional study.Methods Nasal secretions were obtained by irrigation of the affected sinonasal cavities with normal saline. Total 63 nasal lavage fluid samples were collected from 38 patients with chronic rhinosinusitis who underwent endoscopic sinus surgery. Levels of HMGB1 and tumor necrosis factor alpha, interleukin (IL)−1β, and IL-8 were determined by enzyme-linked immunoassay. Severity of inflammation was assessed by the Lund-Mackay scoring system, which is based on preoperative computed tomography scans. Concurrent medical disorders, presence of nasal polyps, septal deviation, and allergic rhinitis were also investigated.ResultsThe level of HMGB1 in nasal lavage fluid was positively correlated with the Lund-Mackay score. The score was the only factor associated with HMGB1 by univariate and multivariate analysis. Other cytokines, with the exception of IL-8, were not correlated with the Lund-Mackay score.Conclusion Our results showed that HMGB1 is secreted into the extracellular area space in the upper airway, and HMGB1 levels in nasal lavage fluid correlate with severity of inflammation, as assessed by the Lund-Mackay staging system for chronic rhinosinusitis. These results provide evidence for HMGB1 as an inflammatory mediator associated with the severity of chronic rhinosinusitis.Level of EvidenceN/A. Laryngoscope, 2015
    The Laryngoscope 01/2015; DOI:10.1002/lary.25172 · 2.03 Impact Factor
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    ABSTRACT: Naringin is the natural chief bitter flavonoid found in Citrus species. Herein, bitter naringin was treated with atmospheric pressure plasma to afford two new converted flavonoids, narinplasmins A (2) and B (3), along with the known compound, 2R-naringin. The structures of the two new naringin derivatives were elucidated on the basis of spectroscopic methods. The antioxidant activity of all isolates was evaluated based on 1,1-diphenyl-2-picrylhydrazyl and peroxynitrite (ONOO(-)) scavenging assays. The new flavanone glycoside 2 containing a methoxyalkyl group exhibited significantly improved antioxidant properties in these assays relative to the parent naringin. Copyright © 2015 Elsevier Ltd. All rights reserved.
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    ABSTRACT: To evaluate whether the extracellular volume fraction (ECV) measured using cardiac magnetic resonance (CMR) imaging can detect myocardial tissue changes in dilated cardiomyopathy (DCM) without late gadolinium enhancement (LGE). Forty-one DCM patients and 10 healthy volunteers underwent pre- and post-T1 mapping using a modified Look-Locker Inversion recovery sequence, LGE, and cine MRI on a 3-T CMR system. LGE-MR findings were used to divide DCM patients into two groups: Group A had no apparent LGE, and Group B had LGE apparent in at least one segment. The ECV of the left ventricle (LV) myocardium (16 segments) was calculated in the short-axis view as follows: ECV = [(ΔR1 of myocardium/ΔR1 of LV blood pool)] × (1 - hematocrit), where R1 = 1/T1, ΔR1 = post-contrast R1 - pre-contrast R1. The LV ejection fraction (LVEF) was obtained from cine MRI images. The mean myocardial ECV in LGE (-) segments in Group A + B was compared to that of controls. The mean myocardial ECV in Group A was compared to that of LGE (-) segments in Group B. The correlation between LV systolic function and the mean myocardial ECV of the whole myocardium was evaluated in all groups. Among the 41 DCM patients, 22 were in Group A, and 19 were in Group B. The mean ECV of DCM patents (n = 41, 568 segments, 30.7 % ± 5.9) was significantly higher (P < 0.001) than that of the control group (n = 10, 157 segments, 25.6 % ± 3.2). The ECV was inversely related to LVEF in Group A (r = -0.551, P = 0.008), Group B (r = -0.525, P = 0.021), and Group A + B (r = -0.550, P < 0.001). The ECV measured by MRI could be a useful parameter in evaluating diffuse myocardial changes in DCM patients.
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    ABSTRACT: The inductive role of dendritic cells (DC) in Th2 differentiation has not been fully defined. We addressed this gap in knowledge by focusing on signaling events mediated by the heterotrimeric GTP binding proteins Gαs, and Gαi, which respectively stimulate and inhibit the activation of adenylyl cyclases and the synthesis of cAMP. We show here that deletion of Gnas, the gene that encodes Gαs in mouse CD11c(+) cells (Gnas(ΔCD11c) mice), and the accompanying decrease in cAMP provoke Th2 polarization and yields a prominent allergic phenotype, whereas increases in cAMP inhibit these responses. The effects of cAMP on DC can be demonstrated in vitro and in vivo and are mediated via PKA. Certain gene products made by Gnas(ΔCD11c) DC affect the Th2 bias. These findings imply that G protein-coupled receptors, the physiological regulators of Gαs and Gαi activation and cAMP formation, act via PKA to regulate Th bias in DC and in turn, Th2-mediated immunopathologies.
    Proceedings of the National Academy of Sciences 01/2015; 112(5). DOI:10.1073/pnas.1417972112 · 9.81 Impact Factor
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    ABSTRACT: Background Mitogen inducible gene 6 (Mig-6) has an important role in the regulation of cholesterol homeostasis and bile acid synthesis. However, the physiological functions of Mig-6 in the liver remain poorly understood.Methods To investigate Mig-6 functioning in the liver, we used conditionally ablated Mig-6 using the Albumin-Cre mouse model (Albcre/+Mig-6f/f; Mig-6d/d). Mig-6f/f and Mig-6d/d male mice were sacrificed after a 24 hr fast and thereafter refed. The fasting glucose and insulin were measured, and western blot analyses were performed to measure the levels of EGFR, ERK1/2, AKT, mTOR, JNK, and IRS-1 in the liver tissue samples. Mig-6 small interfering RNA (siRNA) was applied on the human hepatocellular carcinoma cell line HepG2 cell, and western blot analyses were performed in HepG2 cells.ResultsThe serum fasting glucose levels were significantly higher in the Mig-6d/d mice compared to the Mig-6f/f mice. On an insulin tolerance test, insulin sensitivity was decreased in Mig-6d/d mice compared to the Mig-6f/f mice. Furthermore, the expression levels of Gck, G6pc, and Pck1 were significantly decreased in the liver of Mig-6d/d mice. The phosphorylation levels of EGFR, ERK1/2, AKT, mTOR, JNK, and IRS-1 were increased in Mig-6d/d mice compared to the Mig-6f/f mice.Conclusion Liver-specific ablation of Mig-6 caused hyperglycemia by hepatic insulin resistance. The increased EGFR signaling in Mig-6 ablation caused JNK activation and eventually induced insulin resistance by increasing serine 307 phosphorylation of IRS-1. It is the first report of Mig-6 involvement in hepatic insulin resistance and a new mechanism that explains hepatic insulin resistance.
    Journal of Diabetes 01/2015; DOI:10.1111/1753-0407.12261 · 2.94 Impact Factor
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    ABSTRACT: We assessed the effect of a low-dose β-blocker on heart rate (HR), HR variability (HRV) and image quality of prospective electrocardiography-gated coronary CT angiography (CCTA) in healthy subjects with low HR.
    01/2015; 72(2):83. DOI:10.3348/jksr.2015.72.2.83
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    ABSTRACT: Patients with non-small cell lung cancer (NSCLC) and simultaneously having brain metastases at the initial diagnosis, presenting symptoms related brain metastasis, survived shorter duration and showed poor quality of life. We analyzed our experiences on surgical treatment of brain metastasis in patients with NSCLC. We performed a single-center, retrospective review of 36 patients with NSCLC and synchronous brain metastases between April 2006 and December 2011. Patients were categorized according to the presence of neurological symptoms and having a brain surgery. As a result, 14 patients did not show neurological symptoms and 22 patients presented neurological symptoms. Symptomatic 22 patients were divided into two groups according to undergoing brain surgery (neurosurgery group; n=11, non-neurosurgery group; n=11). We analyzed overall surgery (OS), intracranial progression-free survival (PFS), and quality of life. Survival analysis showed there was no difference between patients with neurosurgery (OS, 12.1 months) and non-neurosurgery (OS, 10.2 months; p=0.550). Likewise for intracranial PFS, there was no significant difference between patients with neurosurgery (PFS, 6.3 months) and non-neurosurgery (PFS, 5.3 months; p=0.666). Reliable neurological one month follow up by the Medical Research Council neurological function evaluation scale were performed in symptomatic 22 patients. The scale improved in eight (73%) patients in the neurosurgery group, but only in three (27%) patients in the non-neurosurgery group (p=0.0495). Patients with NSCLC and synchronous brain metastases, presenting neurological symptoms showed no survival benefit from neurosurgical resection, although quality of life was improved due to early control of neurological symptoms.
    Yonsei Medical Journal 01/2015; 56(1):103-11. DOI:10.3349/ymj.2015.56.1.103 · 1.26 Impact Factor
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    ABSTRACT: Calcifying fibrous tumors (CFTs) are rare benign mesenchymal tumors consisting of hyalinized collagenous fibrotic tissue with a lymphoplasmacytic infiltrate and dystrophic calcifications. Radiographic features have seldom been described, and there are no reports describing magnetic resonance imaging (MRI) findings. Here, we report a pleural CFT in a 47-year-old woman. The tumor mimicked an intrapulmonary lesion on initial computed tomography scans but migrated inferiorly and presented as an extra-pulmonary lesion on MRI. The tumor showed iso-signal intensity on T1-weighted images (WIs), low signal intensity on T2WIs, and slight rim enhancement on enhanced T1WIs.
    01/2015; 72(2):123. DOI:10.3348/jksr.2015.72.2.123
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    ABSTRACT: Caffeic acids are known to have anti-oxidant, anti-inflammatory, immunomodulatory, and tissue reparative effects. The purposes of this study were to determine the effect of caffeic acid on transforming growth factor (TGF) β1-induced myofibroblast differentiation and collagen production, and to determine whether caffeic acid is involved in the antioxidant effect in nasal polyp-derived fibroblasts (NPDFs). NPDFs were pretreated with caffeic acid (1-10 µM) for 2 hours and stimulated with TGF-β1 (5 ng/mL) for 24 hours. The expression of α-smooth muscle actin (SMA), collagen types I and III, and Nox4 mRNA was determined by a reverse transcription-polymerase chain reaction, and the expression of α-SMA protein was determined by actin ned by immunofluorescence microscopy. The amount of total soluble collagen production was analyzed by the Sircol collagen dye-binding assay. The reactive oxygen species (ROS) generated by NPDFs were determined using 2',7'-dichlorfluorescein-diacetate. siNox4 was used to determine the effect of Nox4. The expression of α-SMA and production of collagen were significantly increased following TGF-β1 treatment. In contrast, the level of expression of α-SMA and the level of production of collagen were decreased by pretreatment with caffeic acid. The activation of Nox4 and the subsequent production of ROS were also reduced by pretreatment with caffeic acid. The expression of α-SMA was prevented by inhibition of ROS generation with siNox4. Caffeic acid may inhibit TGF-β1-induced differentiation of fibroblasts into myofibroblasts and collagen production by regulating ROS.
    Clinical and Experimental Otorhinolaryngology 12/2014; 7(4):295-301. DOI:10.3342/ceo.2014.7.4.295 · 0.84 Impact Factor
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    ABSTRACT: Background: Psoriasin is known to be expressed in diverse organs, where it exerts antimicrobial activity. Psoriasin is also involved in the local host defense mechanism against pathogens. We hypothesized that allergy-related T-helper cell type 2 (Th2) cytokines may regulate the expression of psoriasin. Methods: We treated normal human nasal epithelial (NHNE) cells with IL-4 or IL-13. Using human nasal tissues, we compared the expression level of psoriasin. We performed real-time polymerase chain reaction and Western blot assays using NHNE cells. Immunohistochemical staining and Western blot assays were performed with human nasal tissues. Furthermore, we studied the antimicrobial activity of nasal secretions from normal and allergic rhinitis patients. Results: IL-13 markedly down-regulated psoriasin expression at the gene and protein levels in NHNE cells, and it also decreased the amount of psoriasin protein that was secreted into the extracellular compartment in NHNE cells. IL-4 had no statistically significant effect. Results from immunohistochemical staining and Western blot assays showed that psoriasin expression was decreased in allergic rhinitis patients compared with control subjects. Nasal secretions of allergic rhinitis patients exhibited decreased antimicrobial activity compared with control subjects. Conclusion: We found that Th2 cytokines regulated psoriasin expression in NHNE cells, and psoriasin expression was decreased in allergic rhinitis patients compared with control subjects. The decreased expression of psoriasin may be related to the reduction in antimicrobial capacity of nasal secretions under allergic conditions, resulting in an increase in susceptibility to viruses or bacterial infections.
    American journal of rhinology & allergy 12/2014; 28(6). DOI:10.2500/ajra.2014.28.4087 · 2.18 Impact Factor
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    ABSTRACT: Generally, the mortality rate for cases of carbamate poisoning is low, but fatalities secondary to methomyl poisoning have been reported including a case report of cardiac toxicity following short-term exposure to methomyl. There have been no reports, however, regarding patterns of cardiac toxicity after exposure to methomyl. Therefore, we investigated the prevalence and patterns of myocardial injury using a biochemical marker, troponin I (TnI), and evaluated cardiac function using transthoracic echocardiography (TTE). We conducted a retrospective review of 14 consecutive methomyl poisoning cases that were diagnosed and treated at the emergency department of the Wonju Severance Christian Hospital between January 2009 and December 2013. On ECG analysis, ST depression and T-wave inversion were seen in five patients (35.7 %) and one patient (7.1 %), respectively. On cardiac biochemical marker analysis, initial TnI was elevated in 11 patients (78.6 %). TTE was performed in nine patients among the 11 patients in whom TnI was found to be elevated. Of the nine patients that underwent TTE, three patients (33.3 %) showed a reduced ejection fraction (EF), and RWMA was noted in two patients. There were two patients (22.2 %) that had both reduced systolic function and RWMA. One patient did not regain normal systolic function on admission. None of the three patients with reduced EF received any specific treatment to support cardiac function. One patient expired due to pneumonia, and one patient was transferred as moribund. We followed up on 12 patients who survived to discharge for 6-44 months. One patient (8.3 %) was died to follow-up, and 11 patients survived without any further complications. Methomyl exposure can cause direct myocardial injury and reversible cardiac dysfunction. Monitoring of TnI levels and TTE for evaluation of cardiac function may be useful in the workup of patients suffering from methomyl poisoning.
    Cardiovascular Toxicology 11/2014; DOI:10.1007/s12012-014-9295-6 · 2.06 Impact Factor
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    ABSTRACT: Background To evaluate whether the overgrowth of costal cartilage exists in patients with pectus excavatum, we compared the length of the costal cartilage and ribs between patients with asymmetric pectus excavatum and controls without chest wall deformity using three-dimensional computed tomography. Materials and Methods Nineteen adult patients with asymmetric pectus excavatum and 19 age and sex matched controls without chest wall deformity were enrolled. We measured the full lengths of the fourth to sixth ribs and costal cartilage using three-dimensional volume-rendered computed tomography images and curved multiplanar reformatting techniques. The lengths of ribs and costal cartilage, their summations, and the costal index ([length of cartilage/length of rib] × 100 [%]) were compared on the asymmetrically depressed side of patients (Group A), the opposite side of the same patients (Group B), and controls (Group C) at the fourth to sixth levels. Results The lengths of the ribs of groups A and B were significantly longer (p < 0.001) than those of group C (299.4 ± 14.9 mm vs. 302.9 ± 15.3 mm vs. 288.9 ± 12.2 at the fourth level, 312.3 ± 14.1 mm vs. 318.4 ± 14.6 mm vs. 303.2 ± 12.7 mm at the fifth level, and 322.2 ± 17.2 mm vs. 325.2 ± 17.5 mm vs. 309.4 ± 12.3 mm at the sixth level). The costal cartilage lengths did not differ (p > 0.05) among the three groups (53.1 ± 7.3 mm vs. 54.6 ± 8.6 mm vs. 52.9 ± 5.2 at the fourth level, 71.9 ± 9.6 mm vs. 72.3 ± 9.9 mm vs. 69.2 ± 7.1 mm at the fifth level, and 100.1 ± 15.2 mm vs. 104.2 ± 15.8 mm vs. 99.1 ± 9.1 mm at sixth level). The summations of the rib and costal cartilage lengths were longer in groups A and B than in group C. The costal indices were not different among the three groups at the fourth, fifth, and sixth rib levels. Conclusion In patients who had asymmetric pectus excavatum with a ≥ 21-degree angle of sternal rotations, the ribs but not the costal cartilage were longer than those of controls. These findings suggest that cartilage overgrowth is not the main factor responsible for asymmetric pectus excavatum, and it could instead be related to abnormal rib growth.
    The Thoracic and Cardiovascular Surgeon 11/2014; DOI:10.1055/s-0034-1395394 · 1.08 Impact Factor
  • Circulation 11/2014; 130(20):1832-4. DOI:10.1161/CIRCULATIONAHA.114.010779 · 14.95 Impact Factor
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    ABSTRACT: PTEN mutations are the most common genetic alterations in endometrial cancer. Loss of PTEN and subsequent AKT activation stimulate ERα-dependent pathways that play an important role in endometrial tumorigenesis. The major pathologic phenomenon of endometrial cancer is the loss of ovarian steroid hormone control over uterine epithelial cell proliferation and apoptosis. However, the precise mechanism of PTEN/AKT signaling in endometrial cancer remains poorly understood. The progesterone signaling mediator MIG-6 suppresses estrogen signaling and it has been implicated previously as a tumor suppressor in endometrial cancer. In this study, we show that MIG-6 also acts as a tumor suppressor in endometrial cancers associated with PTEN deficiency. Transgenic mice where Mig-6 was overexpressed in PR-expressing cells exhibited a relative reduction in uterine tumorigenesis caused by Pten deficiency. ERK1/2 was phosphorylated in uterine tumors and administration of an ERK1/2 inhibitor suppressed cancer progression in PRcre/+Ptenf/f mice. In clinical specimens of endometrial cancer, MIG-6 expression correlated inversely with ERK1/2 phosphorylation during progression. Taken together, our findings suggest that Mig-6 regulates ERK1/2 phosphorylation and that it is crucial for progression of PTEN-mutant endometrial cancers, providing a mechanistic rationale for the evaluation of ERK1/2 inhibitors as a therapeutic treatment in human endometrial cancer.
    Cancer Research 11/2014; 74(24). DOI:10.1158/0008-5472.CAN-14-0794 · 9.28 Impact Factor
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    ABSTRACT: Lower abdominal soft tissue transfer is the standard procedure for breast reconstruction. However, abdominal wall weakness and herniation commonly occur postoperatively at the donor site. To reduce the morbidities of the donor site, the superficial inferior epigastric artery (SIEA) flap was introduced, but inconsistent anatomy of the SIEA has reduced its utility. In the present study, the anatomy of the superficial inferior epigastric vessels in Korean women was determined with regards to breast reconstructive surgery.
    11/2014; 41(6):702-8. DOI:10.5999/aps.2014.41.6.702
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Publication Stats

6k Citations
976.04 Total Impact Points

Institutions

  • 2012–2015
    • Michigan State University
      • Department of Obstetrics, Gynecology, and Reproductive Biology
      Ист-Лансинг, Michigan, United States
    • National Cancer Center Korea
      • Specific Organs Cancer Branch
      Kōyō, Gyeonggi Province, South Korea
  • 2009–2015
    • Daegu Haany University
      Daikyū, Daegu, South Korea
    • Yonsei University Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • University of Massachusetts Boston
      Boston, Massachusetts, United States
    • Yale University
      • School of Medicine
      New Haven, Connecticut, United States
    • Pukyong National University
      Tsau-liang-hai, Busan, South Korea
  • 1999–2015
    • Korea University
      • • College of Medicine
      • • Department of Chemistry
      Sŏul, Seoul, South Korea
  • 2014
    • Gangneung Asan Hospital
      Sŏul, Seoul, South Korea
    • Dong-A University
      Tsau-liang-hai, Busan, South Korea
    • Seoul National University Hospital
      • Department of Plastic and Reconstructive Surgery
      Sŏul, Seoul, South Korea
    • University of Texas at Dallas
      Richardson, Texas, United States
    • The Richard Stockton College of New Jersey
      New Jersey, United States
  • 2013–2014
    • Dankook University
      • Department of Chemical Engineering
      Eidō, Chungcheongbuk-do, South Korea
    • Kyungnam University
      Changnyeong, Gyeongsangnam-do, South Korea
    • Sahmyook University
      Sŏul, Seoul, South Korea
    • Daewoo Engineering and Construction
      Sŏul, Seoul, South Korea
  • 2007–2014
    • Yale-New Haven Hospital
      • Department of Pathology
      New Haven, Connecticut, United States
    • Dongseo University
      • Department of Systems and Management Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2006–2014
    • Korea Advanced Institute of Science and Technology
      • • Graduate School of Medical Science and Engineering
      • • Department of Physics
      • • Department of Aerospace Engineering
      • • Department of Mechanical Engineering
      Sŏul, Seoul, South Korea
    • Electronics and Telecommunications Research Institute
      Sŏul, Seoul, South Korea
  • 2004–2014
    • Yonsei University
      • • Department of Emergency Medicine
      • • Department of Radiology
      • • Natural Science Research Institute
      Sŏul, Seoul, South Korea
  • 2001–2014
    • Pusan National University
      • • Department of Horticultural Bioscience
      • • Department of Molecular Biology
      • • Division of Electrical and Electronics Engineering
      • • Department of Physics
      Tsau-liang-hai, Busan, South Korea
  • 2010–2013
    • Wonju Severance Christian Hospital
      Genshū, Gangwon, South Korea
    • Kyungpook National University Hospital
      • Department of Neurology
      Sŏul, Seoul, South Korea
  • 2009–2013
    • Northeastern University
      • Department of Mechanical and Industrial Engineering
      Boston, Massachusetts, United States
  • 2005–2013
    • Ludwig Institute for Cancer Research
      La Jolla, California, United States
    • Seoul National University
      • • Department of Agricultural Biotechnology
      • • Department of Earth and Environmental Sciences
      • • Department of Materials Science and Engineering
      Sŏul, Seoul, South Korea
    • The Australian Society of Otolaryngology Head & Neck Surgery
      Evans Head, New South Wales, Australia
  • 2011–2012
    • Yeungnam University
      • College of Pharmacy
      Onyang, South Chungcheong, South Korea
    • University of Maryland, College Park
      • Department of Mechanical Engineering
      CGS, Maryland, United States
    • Inje University Paik Hospital
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
    • Asan Medical Center
      Sŏul, Seoul, South Korea
    • International St. Mary's Hospitals
      Chemulpo, Incheon, South Korea
  • 2010–2012
    • Korea Institute of Machinery and Materials
      Sŏul, Seoul, South Korea
    • Kyungpook National University
      • • College of Pharmacy
      • • Mobile Display Research Center
      Sangju, North Gyeongsang, South Korea
  • 2009–2012
    • Inje University
      • Department of Nano Engineering
      Kŭmhae, South Gyeongsang, South Korea
  • 2005–2012
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
  • 2009–2011
    • The Ohio State University
      • Department of Psychology
      Columbus, Ohio, United States
  • 2009–2010
    • Baylor College of Medicine
      • Department of Molecular & Cellular Biology
      Houston, Texas, United States
  • 2005–2010
    • Chung-Ang University
      • College of Medicine
      Sŏul, Seoul, South Korea
  • 2004–2010
    • Korea Atomic Energy Research Institute (KAERI)
      • Advanced Radiation Technology Institute
      Taiden, Daejeon, South Korea
  • 2001–2010
    • Korea Research Institute of Chemical Technology
      Daiden, Daejeon, South Korea
  • 2008
    • Gyeongsang National University
      • School of Materials Science and Engineering
      Chinju, South Gyeongsang, South Korea
    • Hanyang University
      • College of Medicine
      Ansan, Gyeonggi, South Korea
    • Changwon National University
      Changnyeong, South Gyeongsang, South Korea
  • 2007–2008
    • Kunsan National University
      • Department of Oceanography
      Gunzan, North Jeolla, South Korea
    • Samsung Electro-Mechanics
      Sŏul, Seoul, South Korea
  • 2006–2007
    • Chungnam National University
      • Department of Advanced Organic Materials and Textile System Engineering
      Daiden, Daejeon, South Korea
    • Sungkyunkwan University
      Sŏul, Seoul, South Korea
  • 2005–2006
    • Okayama University
      • Faculty of Pharmaceutical Science
      Okayama, Okayama, Japan
  • 1999–2005
    • Pohang University of Science and Technology
      • • Department of Chemistry
      • • Department of Electronic and Electrical Engineering
      Geijitsu, Gyeongsangbuk-do, South Korea
  • 2002–2004
    • Korea Photonics Technology Institute
      Sŏul, Seoul, South Korea
    • Sejong General Hospital
      Bucheon, Gyeonggi Province, South Korea
  • 2000–2002
    • Sejong Institute
      Sŏngnam, Gyeonggi-do, South Korea
  • 1999–2002
    • Fairchild Semiconductor
      San José, California, United States