Publications (7)1.51 Total impact
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Article: Antibodies to dopamine as neuromodulators of behavioral responses of mice of different genotypes.
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ABSTRACT: The possibility of long-term changes in the innate characteristics of the behavior of mice of different genotypes (C57Bl/6 and BALB/c) after active immunization with dopamine-BSA conjugates was studied. These experiments revealed significant differences in the effects of anti-dopamine antibody on behavioral responses in an open field and neurotransmitter contents of brain structures in mice of different lines. Immunization with the dopamine-protein conjugate led to increases in the functional activity of the corresponding brain receptors, to different extents in mice of different lines.Neuroscience and Behavioral Physiology 07/2003; 33(5):507-12. -
Article: Neuromodulatory effects of serotonin antibodies on behavioral responses, neurotransmitter content in the central nervous system, and ligand-binding activity of central serotonin receptors in C57BL/6 and BALB/c mice.
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ABSTRACT: Effects of active immunization with the serotonin-protein conjugate on open-field behavior, learning and retention of the conditioned passive avoidance response, neurotransmitter contents in brain structures, and functional activity of central serotonin receptors were studied on C57Bl/6 and BALB/c mice. Serotonin antibodies produced opposite effects on the studied parameters in genetically different mouse strains.Bulletin of Experimental Biology and Medicine 08/2001; 132(1):630-2. · 0.27 Impact Factor -
Article: Neuromodulatory Effects of Serotonin Antibodies on Behavioral Responses, Neurotransmitter Content in the Central Nervous System, and Ligand-Binding Activity of Central Serotonin Receptors in C57Bl/6 and BALB/c Mice
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ABSTRACT: Effects of active immunization with the serotonin-protein conjugate on open-field behavior, learning and retention of the conditioned passive avoidance response, neurotransmitter contents in brain structures, and functional activity of central serotonin receptors were studied on C57Bl/6 and BALB/c mice. Serotonin antibodies produced opposite effects on the studied parameters in genetically different mouse strains.Bulletin of Experimental Biology and Medicine 06/2001; 132(1):630-632. · 0.27 Impact Factor -
Article: Anti-dopamine antibodies: effects on behavior in an "open field," pain sensitivity, CNS monoamine content, and functional activity of immunocytes in C57Bl/6 mice.
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ABSTRACT: Single i.p. doses of anti-dopamine antibodies were given to C57Bl/6 mice. This resulted in inhibition of motor activity in a large proportion of the animals in the "open field" test, which lasted five days. Hyperalgesia, detected 1.5 h and 1 day after doses of antibody, was replaced by analgesia on day 5. There was a sharp reduction in the levels of dopamine and its metabolites in the cerebral cortex at 1 and 5 days; the serotonin level was increased 1 day after doses of antibody, and was significantly decreased at 5 days. There was no effect on cells of the immune system. The possible mechanisms of the neurotropic action of these antibodies are discussed.Neuroscience and Behavioral Physiology 31(1):7-13. -
Article: [The effect of serotonin antibodies on the behavior of C57Bl/6 mice in an open field and on the level of monoamines in the brain structures].
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ABSTRACT: Mice of C57BL/6 strain were singly injected intraperitoneally with antibodies (AB) to serotonin (5-HT). The "open-field" testing in different periods after the AB injection revealed a depression of behavior within 1.5 h which changed for activation within 1 day and, again, depression within 5 days after the injection. The analysis of neurotransmitter content in the sensorimotor cortex and hypothalamus revealed increased levels of serotonin and, especially, dopamine in the cortex within 1 day. The cortex serotonin level within 5 days was also increased. The possible mechanisms are discussed of neurotropic action of AB to 5-HT.Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 48(2):251-9. · 0.33 Impact Factor -
Article: [Dopamine antibodies: effect on the "open field" behavior, pain sensitivity, monoamine levels in the central nervous system, and functional activity of immunocytes in C57Bl/6 mice].
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ABSTRACT: Dopamine antibodies (AB) were singularly injected to C57B1/6 mice intraperitoneally. The locomotor activity in the open field was suppressed for 5 days in the majority of the animals. Hyperalgesia revealed 1.5 h and 1 day after the AB injection changed for analgesia on the 5th day. A sharp reduction of the brain level of dopamine and its metabolite was revealed 1 and 5 days after the AB injection, the serotonin content was increased within 1 day and decreased within 5 days after the injection. No action of the AB on cells of the immune system was observed. The possible mechanisms of the AB neurotropic action are discussed.Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 49(5):799-807. · 0.33 Impact Factor -
Article: [Dopamine antibodies as neuromodulators of behavioral reactions in mice of different genotypes].
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ABSTRACT: A possibility of the long-term modification of inborn behavioral features of different mice genotypes (C57B1/6 and BALB/c) by active immunization with dopamine-bovine serum albumin conjugate was investigated. Significant interstrain differences were found in the effects of dopamine antibodies on the open-field behavior and the content of neurotransmitters in the brain cortex and striatum. It was shown that the active immunization of mice to dopamine produces an increase in the functional activity of brain dopamine receptors. The extent, to which this increase is pronounced, is genotype-dependent.Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 52(3):320-5. · 0.33 Impact Factor
