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Publications (9)2.46 Total impact

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    ABSTRACT: Small cell carcinomas are fairly common neoplasms in the lung, but tumors featuring similar histological profiles may occur in extrapulmonary organs. Three cases of small cell carcinomas occurring in the prostate (case 1), stomach (case 2), and pancreas (case 3) are presented. Production of hormones was demonstrated immunohistochemically in all cases. In case 2 alpha-fetoprotein (AFP) was elevated in the serum and observed immunohistochemically in tumor cells. Production of AFP is a distinctive feature, which has not been reported in the pulmonary and extrapulmonary cases of small cell carcinoma. Amplification and/or expression of myc gene family have been suggested to be related to the prognosis of pulmonary small cell carcinoma. Amplification of myc genes was not detected in any of our cases, but c-myc protein was demonstrated immunohistochemically in tumor cells of case 1.
    Indian Journal of Cancer 01/1995; 31(4):268-73. · 1.13 Impact Factor
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    ABSTRACT: A case of small cell carcinoma of the prostate reported here was studied by immunohistochemical and electron microscopic procedures. Most tumour cells were positive for argyrophil (Grimelius) stain and had dense core neurosecretory granules in the cytoplasm. But immunohistochemical staining revealed vasoactive intestinal polypeptide and calcitonin only in a few cells, and it was still obscure what kinds of hormones were produced in this tumour. By dot blot hybridization, our case showed no amplification of myc family gene which is suggested to be associated with a poor clinical outcome in pulmonary small cell carcinoma.
    International Urology and Nephrology 02/1993; 25(4):379-84. · 1.33 Impact Factor
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    ABSTRACT: Two cell lines designated IC-KMS and D-KMS were established from human adenovirus type 12-induced tumors of C3Hf/OK mouse. The cell lines retained the characteristics of the original tumor i.e., production of numerous C-type and intracisternal A-type particles, integration of Ad12 E1 region DNA and amplification of the myc gene family. Chromosomal analysis revealed chromosome aberrations in both IC-KMS and D-KMS cells. The modal chromosome number of IC-KMS cells was 54 and that of D-KMS cells was 48. Metacentric chromosomes and minichromosomes were found. Trisomy of chromosome 3, 7 and 12 was seen frequently in D-KMS cells. Although DNA aneuploidy was revealed by flow cytometry, the DNA indices of these cells showed no relation to the copy number of integrated Ad12 DNA. These cells have been propagated by serial culture during the past 17 months. Production of endogenous virus particles is a unique characteristic of IC-KMS and D-KMS cells. These cell lines would be useful materials for examining the contribution of Ad12 carcinogenesis to activation of endogenous virus particles, and also the correlation between Ad12 carcinogenesis and cancer-related genes.
    Acta pathologica japonica 05/1992; 42(4):242-8.
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    ABSTRACT: A case of epithelial myoepithelial carcinoma is reported. Histologically, this tumor shows tubular and solid growth pattern. The inner layer of the tubules is composed of cells with an eosinophilic cytoplasm that is surrounded by cells with clear cytoplasms. Clear cells also manifest a solid growth pattern. Immunohistochemical and electron microscopic examinations has revealed that the cells with an eosinophilic cytoplasm have the characteristics of the ductal epithelium and that the clear cells have the characteristics of the myoepithelium. Immunohistochemically, keratin positive clear cells and S-100 protein positive ductal cells were found in our case. This suggests the existence of cells having both ductal and myoepithelial characteristics and this inspected tumor had derived from multipotential cells of intercalated ducts.
    Gan no rinsho. Japan journal of cancer clinics 11/1990; 36(12):2153-7.
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    ABSTRACT: A case of type I Gaucher's disease in a 39-year-old male is reported. Autopsy showed marked enlargement of the spleen (3,070 g) and infiltration of typical Gaucher's cells in the spleen, liver, bone, marrow, gastrointestinal tract, lymph nodes and adrenal glands. The diagnosis of Gaucher's disease was ascertained by the very low beta-glucosidase activity of cultured subcutaneous fibroblasts and the high content of glucocerebroside in the spleen tissue. A peculiar finding in this case was prominent deposition of brown pigment in endothelial cells of the spleen and smooth muscles fibers of the gastrointestinal tract, urinary bladder and prostate. Histochemical examination revealed that the granules in endothelial cells and smooth muscle fibers were ceroid. Such deposition of ceroid has never been reported previously in Gaucher's disease. Ceroid deposition in generalized smooth muscle fibers is known as brown bowel syndrome, and is highly suggestive of severe vitamin E deficiency. Although other symptoms of vitamin E deficiency were not noticed in this case, some malnutritional condition might play a role in prominent deposition of ceroid in lysosomes, possibly together with deficient activity of a lysosomal enzyme.
    Acta pathologica japonica 07/1990; 40(6):425-30.
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    ABSTRACT: Discussed herein is an autopsied case of a 30-year-old male with Idiopathic Interstitial Pneumonia (IIP) manifesting a markedly elevated CA 19-9 in the serum (maximum, over 120,000 U/ml). Despite a careful examination, no malignant lesion was found. The postmortem examination revealed a marked elevation of CA 19-9 in the serum and in the lung tissue. Further immunohistochemically regenerative bronchiolar and alveolar epithelial cells were more intensely positive for CA 19-9 than in our controls. These CA 19-9 positive cells for the most part, were found to stain with alcian blue. It is considered that IIP induces activation of sialyl-transferase in these cells.
    Gan no rinsho. Japan journal of cancer clinics 02/1989; 35(1):69-73.
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    ABSTRACT: An autopsy case of a clear cell carcinoma of the salivary gland with a cerebellum invasion and a metastasis to the lung is reported. This case has been classified as a monomorphic variant, although we were unable to demonstrate the presence of glycogens in the cytoplasm of the tumor cells. Ultrastructurally, most of the proliferating cells were immature cells with few organelles. The tumor cells were unable to be differentiated into ductal cells and myoepithelial cells. Recently, the tumor has been determined to be a low grade malignancy. Obviously, this tumor had a malignant character, with a cerebellum invasion and a metastasis to the lung.
    Gan no rinsho. Japan journal of cancer clinics 11/1988; 34(12):1705-9.
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    ABSTRACT: A case of eosinophilic granuloma of the lymph nodes is reported. Two finger-tip-sized masses were recognized in the left postauricular region in a 4-month-old female. Both masses had distended peripheral sinuses occupied by proliferating cells with nuclear indentation. These foci were accompanied with a central necrosis and eosinophils that had infiltrated into the dermis, and were observed also in the efferent lymph duct. Immunohistochemically these cells were positive for S 100 beta, OKT 4, and OKT 6, and were weakly positive for S 100 alpha. These findings suggest that proliferating cells in the T-zone histiocyte lineage might have been somewhat different in this case from usual cases of eosinophilic granuloma.
    Gan no rinsho. Japan journal of cancer clinics 04/1988; 34(3):326-30.
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    ABSTRACT: Two cases of an IBL-like T-cell lymphoma are reported, in one case of which the histological changes could be observed throughout its course. Although both cases were difficult to differentiate from true IBL in their early stage, focal proliferation of pale cells appeared in their first specimens and gradually, the characteristics of lymphoma grew manifest. Immunohistochemical studies of both cases revealed lymphoma cells having the characteristics of helper/inducer T lymphocytes. Electron-Microscopic examination showed no particular differences in the morphology of the tumor cells between our case and the case previously reported as being an IBL-like T-cell lymphoma of a suppressor/cytotoxic character.
    Gan no rinsho. Japan journal of cancer clinics 03/1988; 34(2):196-200.